Clinical trials: Obesity, Prediabetes
Prediabetes, Obesity
The Effect of Hypocaloric Diet Associated With tDCS on Weight Loss and Metabolic Profile
To compare four weeks of transcranial direct current stimulation (tDCS) versus placebo associated with a reduced caloric diet on weight loss, glycemic control and regulators of hunger and satiety in overweight or obese subjects…
- Conditions
- Prediabetes, Obesity, Weight Loss, Diabetes
- Trial name
- NCT02683902
- Testing
- Active tDCS, Hypocaloric diet
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Type 2 Diabetes, Obesity
The Dose Effects of Isomaltulose and Sucrose on Glycaemic and Insulinemic Response
This study will determine the glycaemic and insulinaemic response and sensory profile of the drinks with various ratios sucrose:isomaltulose.
- Conditions
- Type 2 Diabetes, Obesity, Pre Diabetes
- Trial name
- NCT04653207
- Testing
- Glucose Solution 1, Glucose Solution 2, Glucose Solution 3
- Where
- Singapore
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Disabilities, Obesity and Overweight
Development of an Inclusive Adaptive Treatment Strategy for Weight Loss in People With Prediabetes Using a Sequential Multiple Assignment Randomized Trial
This is a sub-study to NCT04745572 to include a new cohort of participants with disabilities. This 16-week study will use an experimental approach called the Sequential Multiple Assignment Randomized Trial to help determine which…
- Conditions
- Disabilities, Obesity and Overweight, Prediabetes
- Trial name
- iADAPT (NCT06976307)
- Testing
- High Carbohydrate Diet, Reduced Carbohydrate Diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Prediabetes, Type 2 Diabetes
Pathobiology and Reversibility of Prediabetes in a Biracial Cohort
The reasons for the epidemics of diabetes and prediabetes, and why individuals from certain populations suffer at higher rates are not well known.
- Conditions
- Prediabetes, Type 2 Diabetes, Obesity
- Trial name
- PROP-ABC (NCT02027571)
- Testing
- Intensive Lifestyle Intervention (ILI)
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- University of Tennessee
Physical Inactivity, Cardiovascular Risk Factor
The Clinical Referral to Activity Study
The main aim of this effort is to test a physical activity intervention, for adult clinical care patients at risk of developing cardiovascular disease.
- Conditions
- Physical Inactivity, Cardiovascular Risk Factor, Obesity, Blood Pressure
- Trial name
- NCT04743856
- Testing
- ActiveGOALSv2, PAT
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Glucose Metabolism Disorders (Including Diabetes Mellitus), Overweight and Obesity
Effect of Two Alcohol-free Beers With Different Carbohydrates Composition on Lipids and Glucose Metabolism
This a controlled, double-blind, randomized, cross designed study to determine the effect of an alcohol-free beer with low glycemic index carbohydrates (isomaltulose) and a resistant maltodextrin, comparing to an alcohol-free…
- Trial name
- NCT03337828
- Testing
- Alcohol-free beer with regular composition, Alcohol-free beer with modified composition
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Instituto Aragones de Ciencias de la Salud
Prediabetic State
Effects of Branch Chain Amino Acids on Glucose Tolerance in Obese Pre-Diabetic Subjects
Branching chain amino acids (BCAA) have both beneficial and detrimental effects of on metabolism have been established and therefore warrants further investigation.
- Trial name
- BCAA (NCT02684565)
- Testing
- BCAA High Protein supplement, BCAA Low Protein supplement
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Los Angeles
Obesity, Pre-diabetes
SGLT2 Inhibitor Effects on Inflammation and Heart Disease in Obesity Pilot
Obesity is associated with increased cardiometabolic disease risk due, in part, to heightened chronic inflammation arising from adipose tissue.
- Trial name
- NCT04907214
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Vanderbilt University Medical Center
Prediabetes, Overweight
Evaluation of Prevent in Underserved Populations
The goal of this study is to evaluate an online Diabetes Prevention Program adapted for patients with prediabetes in safety net health care settings.
- Conditions
- Prediabetes, Overweight, Obesity
- Trial name
- PUP (NCT02664064)
- Testing
- Prevent
- Where
- 3 sites in United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Omada Health, Inc.
Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities, Overweight (BMI > 25)
AIM-WEIGHT: AI-Guided Microbiome-Targeted Nutritional Intervention for Weight Loss
AIM-WEIGHT is a clinical study evaluating whether a fixed microbiome-targeted nutritional supplement can support weight loss in adults with overweight or obesity who do not have prediabetes or diabetes.
- Trial name
- AIM-WEIGHT (NCT07736547)
- Testing
- AI-Guided Microbiome-Targeted Nutritional Supplement, Lifestyle counselling
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Varol TUNALI
Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk Adults
The purpose of this clinical trial is to find out whether one type of fish oil works better than another at improving metabolic health in people who are at high risk of developing type 2 diabetes.
- Conditions
- Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetes / Type 2 Diabetes, Obesity & Overweight
- Trial name
- END-T2D (NCT07575438)
- Testing
- Fish Oil, Corn oil control
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- May Faraj, PDt, PhD
Sedentary Time, Cardiovascular Diseases
WatchWell: Simple and Practical Strategies to Reduce the Negative Health Impact of Sedentary Screen Time
The purpose of this study is to determine the feasibility, acceptability, efficacy, and participant adherence in using home-based technologies and wearable devices and simple, practical strategies to reduce the negative impact…
- Conditions
- Sedentary Time, Cardiovascular Diseases, Prediabetes, Obesity
- Trial name
- NCT06963736
- Testing
- Blue light, Eating, Standing
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Glucose Intolerance, Obesity
Identification of Predictors of Success for Lifestyle Modifications in Overweight Pre-diabetic Subjects
The primary objective of the study is to identify baseline and early predictors of favorable and unfavorable response to lifestyle intervention.
- Trial name
- NCT00969007
- Testing
- Lifestyle modification counselling
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- Marie-France Langlois
Type 2 Diabetes, Obesity
The Impact of the Glycaemic Index (GI) on Daily Blood Glucose Profiles and Food Intake in Young Chinese Adult Males
This study is carried out to find out the inclusion of high and low glycaemic Index (GI) foods to daily meals impact on 24 hour blood glucose fluctuations and food intake.
- Conditions
- Type 2 Diabetes, Obesity, Prediabetes
- Trial name
- NCT02340507
- Testing
- Rice and bread (high GI), Rice and bread (low GI)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Overweight and Obesity, PreDiabetes
Effect of Time-restricted Eating on Behaviour and Metabolism in Overweight Individuals at High Risk of Type 2 Diabetes
The aim of the present study is to investigate effects of 12 weeks time-restricted eating on behaviour and metabolism in individuals with overweight or obesity at high risk of type 2 diabetes.
- Trial name
- RESET (NCT03854656)
- Testing
- Time-restricted eating
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kristine Færch
Obesity, Overweight
The Influence of Physical Activity on the Gut Microbiome of Pre-Diabetic Adults
The present study is a 100-participant randomized controlled 2-arm parallel trial that employs a metagenomic approach to examine how 8 weeks of supervised moderate-intensity treadmill walking exercise (MWE) for 30-45 min 3…
- Conditions
- Obesity, Overweight, Overweight and Obesity, PreDiabetes
- Trial name
- NCT04931836
- Testing
- Physical Activity Intervention
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Minnesota
Obesity, Insulin Resistance
Treating the Endothelium to Restore Insulin Sensitivity
A study of 12 weeks' treatment with losartan or placebo, to test the hypothesis that RAS inhibition will improve insulin' vascular actions and therefore improve insulin sensitivity in skeletal muscle.
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Pre-diabetes
- Trial name
- NCT00402194
- Testing
- Losartan
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obesity
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals
Background: Roflumilast is a drug used to treat chronic obstructive pulmonary disease (COPD). It is designed to help reduce lung inflammation.
- Trial name
- NCT01862029
- Testing
- Roflumilast
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Metabolism and Nutrition Disorder, Obesity
Effect of Liraglutide on Body Weight in Non-diabetic Obese Subjects or Overweight Subjects With Co-morbidities: SCALE™ - Obesity and Pre-diabetes
This trial is conducted in Africa, Asia, Europe, Oceania, North America and South America. The aim of this clinical trial is to evaluate the potential of liraglutide to induce and maintain weight loss over 56 weeks in obese…
- Trial name
- NCT01272219
- Testing
- liraglutide
- Where
- 226 sites in United States, Argentina and 27 more
- Volunteers
- 3,731 people
- Sponsor
- Novo Nordisk A/S
Obesity, Pre-diabetes
Better Me Within Trial to Improve Lifestyle Behaviors in African Americans
This study describes a community-based participatory research (CBPR) approach to design a novel faith-enhancement to the diabetes prevention program (DPP) for AA women.
- Trial name
- NCT04082702
- Testing
- Faith-enhanced diabetes prevention program, Standard diabetes prevention program
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- Baylor Research Institute