Clinical trials: Obesity, Prediabetes
Prediabetes, Gestational Diabetes Mellitus
Assessing the Effectiveness of a Weight Watchers-based Lifestyle Intervention for the Primary Prevention of Type 2 Diabetes
This study is a randomized pilot study to assess the applicability of the Weight Watchers model for lifestyle modification to the primary prevention of type 2 diabetes.
- Conditions
- Prediabetes, Gestational Diabetes Mellitus, Obesity
- Trial name
- NCT02000024
- Testing
- Weight Watchers, National Diabetes Education Program
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Indiana University
Glucose Metabolism Disorder
Study of the Reversibility of Glucose Intolerance Caused by Chronic Aspartame Consumption
Experiments have shown that some artificial sweeteners like those in diet soda can cause changes in how the body responds to and uses sugar.
- Trial name
- NCT02520258
- Testing
- Oral glucose tolerance test (OGTT), Diet soda containing aspartame only
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Obesity & Overweight, Prediabetes / Type 2 Diabetes
Blood-based sEV Proteins for Early Detection of 2 Diabetes
The prevalence of diabetes in China is a significant concern. In 2019, 116.4 million adults were living with diabetes, a number expected to climb to 147.2 million by 2045. Type 2 diabetes (T2D) constitutes 95% of these cases .
- Trial name
- sEV-T2D (NCT07728591)
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Prediabetes
A Clinical Study to Evaluate the Effects of Akkermansia Muciniphila and Berberine on Prediabetes Among Obese Subjects.
The Akkermania muciniphila may play an important role in the occurrence and development of Prediabetes. The purpose of this study was to evaluate the safety and efficacy of AKK in the treatment of Prediabetes among obese…
- Trial name
- NCT05720299
- Testing
- Akkermansia muciniphila, Berberine
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Yu Chen
Hyperinsulinemia, Insulin Resistance
Effect of Insulin Lowering on Lipogenesis
The goal of this clinical trial is to compare a one-week course of diazoxide (2 mg/kg per dose x 14 doses) and placebo in people with obesity and insulin resistance (IR) with metabolic dysfunction-associated steatotic liver…
- Conditions
- Hyperinsulinemia, Insulin Resistance, Non-Alcoholic Fatty Liver Disease, Prediabetic State
- Trial name
- NCT07403604
- Testing
- Diazoxide Oral Suspension, 2 mg per kg per dose, Deuterated water (2H2O/D2O), 70%, Insulin Suppression Test (IST)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Columbia University
Weight Loss, Metabolic Syndrome
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
The use of continuous glucose monitoring (CGM) in earlier data has inspired behavioral changes leading to improved adherence to an exercise plan in individuals and eating habits in people with diabetes.
- Conditions
- Weight Loss, Metabolic Syndrome, Diabetes Mellitus, Type 2, Central Obesity
- Trial name
- NCT05874635
- Testing
- Continuous Glucose Monitor Device
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Signos Inc
Prediabetes, Obese
Inflammation Inhibition in Prediabetic Humans
Prediabetes, characterized by elevated fasting blood sugar or exaggerated blood sugar response to sugar ingestion, effects over 79 million adult Americans and is a precursor to the development of Type 2 diabetes.
- Trial name
- INCITE (NCT01977417)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Psoriasis, Plaque Psoriasis
Role of Insulin Action in Psoriasis Pathogenesis
The goal of this study is to collect more information from people with plaque psoriasis and to determine if insulin plays a role in the pathogenesis of psoriasis.
- Conditions
- Psoriasis, Plaque Psoriasis, Insulin Resistance, PreDiabetes
- Trial name
- NCT06242847
- Testing
- Oral glucose tolerance test (OGTT), Skin punch biopsy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Obesity, PreDiabetes
Cardiovascular Effects of GLP-1 Receptor Activation
This project tests the principle hypothesis that stable glucagon like peptide-1 (GLP-1) analogues have specific GLP1R-dependent beneficial effects on vascular endothelial function, fibrinolysis and inflammation in obesity that…
- Trial name
- NCT03101930
- Testing
- Liraglutide, Sitagliptin, hypocaloric diet
- Where
- United States
- Volunteers
- 329 people
- Sponsor
- Vanderbilt University Medical Center
Neurodevelopmental Disorders, Irritability
AP Metabolism Transcriptomics
It is known from the literature that treatment with antipsychotic drugs (AP) induces, even before changes in blood chemistry parameters, changes in gene transcription that are evident at the level of peripheral blood mononuclear…
- Trial name
- NCT06814314
- Testing
- Transcriptomic investigation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Eugenio Medea
Obesity & Overweight, Prediabetes
Precision Nutrition for Obesity and Prediabetes Prevention in Under-supported Communities
This randomized controlled trial will evaluate the effectiveness of a culturally sensitive precision nutrition intervention for improving obesity- and diabetes-related outcomes among African American and Hispanic/Latino adults…
- Trial name
- PNOD (NCT07850531)
- Testing
- Precision Nutrition Intervention, Standard Nutrition Counseling
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Prairie View A&M University
Weight Loss, Obesity
Weight Loss Using a Feedback Device in Obese People With the Metabolic Syndrome
The purpose of this study is to determine if a weight loss app (VA MOVE!® Coach App) along with regularly scheduled telephone counseling, will motivate obese people with metabolic syndrome to lose weight and improve the symptoms…
- Conditions
- Weight Loss, Obesity, Pre-Diabetes, Metabolic Syndrome
- Trial name
- NCT03491930
- Testing
- VA MOVE! Coach app, Telephone Coaching, Standard of Care for weight loss.
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rockefeller University
Pre Diabetic, Obesity & Overweight
PREdiabetes GLycemic Impact and Data Evaluation
This prospective, randomized controlled trial evaluates whether real-time continuous glucose monitoring (CGM) improves glycemic control and lifestyle adherence in adults with prediabetes compared to conventional self-monitoring…
- Conditions
- Pre Diabetic, Obesity & Overweight, Insulin Resistance
- Trial name
- PRE-GLIDE (NCT07599072)
- Testing
- CGM Sibionics, On-Call Extra Glucometer
- Where
- 3 sites in Ukraine
- Volunteers
- 80 people
- Sponsor
- Nazarii Kobyliak
Menopause, Prediabetes
Effects of Novel Estrogens on Glucose and Lipids in Postmenopausal Prediabetic Women Veterans
The purpose of this study is to determine the effect of a novel menopause hormone therapy on blood sugar (glucose) and blood and liver fats (lipids) in obese menopausal women Veterans.
- Conditions
- Menopause, Prediabetes, Obesity
- Trial name
- CE/BZA (NCT05073237)
- Testing
- conjugated estrogens/bazedoxifene (CE/BZA)
- Where
- United States
- Sponsor
- VA Office of Research and Development
Obesity, PreDiabetes
The Possible Effects of Roflumilast on Obesity Related Disorders
Evaluation of the possible effects of roflumilast on weight, glucose and lipid metabolism, insulin resistance, oxidative stress and inflammatory process in prediabetic obese subjects.
- Trial name
- NCT04800172
- Testing
- Roflumilast
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Tanta University
Prediabetes, Type 2 Diabetes
Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes
The objective of this study is to investigate the impact of hypocaloric time-restricted eating (TRE) at different day times (early versus late TRE) on glucose metabolism and other cardiometabolic parameters in individuals with…
- Conditions
- Prediabetes, Type 2 Diabetes, Obesity &Amp; Overweight
- Trial name
- GLYCOTIME (NCT07171281)
- Testing
- Early Time-Restricted Eating, Late Time-Restricted Eating
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Obesity, Impaired Glucose Tolerance
The Effect of Exenatide on Weight and Hunger in Obese, Healthy Women
This study will look at the effect of exenatide, a drug which has been approved for the treatment of type 2 diabetes, on body weight, appetite and energy expenditure among moderately obese women without diabetes.
- Trial name
- NCT00456885
- Testing
- exenatide
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Prediabetes, Metabolic Syndrome
Family-Centered Diabetes Project - Sharing Wisdom
This is a randomized trial of an educational intervention to reduce the risk of diabetes among urban American Indian women
- Conditions
- Prediabetes, Metabolic Syndrome, Overweight, Obesity
- Trial name
- NCT00438126
- Testing
- A lifestyle educational program
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pre Diabetes, Obesity
Balanced (Egg) Protein During Obesity Reduction: Differential Responses of Insulin Resistance by Race
The purpose of the trial is to assess the effects of combining regular, generous intakes of high quality protein (with substantial amounts provided from whole eggs and egg whites) with calorie restriction on insulin resistance…
- Trial name
- EGGSPDITe (NCT03771261)
- Testing
- Weight Loss, Egg Protein
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Duke University
Prediabetes, Obesity (Body Mass Index >30 kg/m2)
Behavioral Approach for Latinas Addressing Nutrition, Cravings, and Eating Patterns to Prevent Type 2 Diabetes
Adapt the Regulation of Cues (ROC) treatment program for Latinas to see if it can treat prediabetes and prevent developing of Type 2 Diabetes and reduce weight.
- Trial name
- BALANCE (NCT07478263)
- Testing
- Regulation of Cues
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego