Clinical trials: Obesity, Prediabetes
Overweight and Obesity, PreDiabetes
Effects of Gelesis200 on Appetite Parameters, Food Intake, and Glycemic Control in Overweight or Obese Prediabetic Subjects: A Sub-Study of LIGHT-UP
This study evaluates the effects of Gelesis200 on Appetite Parameters, Food Intake, and Glycemic Control in Overweight or Obese Prediabetic Subjects: A Sub-Study of LIGHT-UP.
- Conditions
- Overweight and Obesity, PreDiabetes, Type2 Diabetes
- Trial name
- MATCH (NCT03622424)
- Testing
- Gelesis200
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Gelesis, Inc.
Impaired Glucose Tolerance, Obesity
Enhancing Fitness in Older Pre-diabetic Veterans
This study targets older adults (ages 60 and over) who are overweight (body mass index 25-40) with impaired fasting glucose (100 - 125).
- Conditions
- Impaired Glucose Tolerance, Obesity, Diabetes
- Trial name
- NCT00594399
- Testing
- Physical Activity Counseling
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- US Department of Veterans Affairs
Diabetes Mellitus, Type 2, Prediabetic State
Serum Sphingolipidomic Analyses in Healthy, Diabetic and Prediabetic Subjects
This study is designed to compare the serum sphingolipidomic analyses in healthy, pre-diabetic and diabetic subjects. age, sex and BMI are matched among these three groups.
- Trial name
- NCT02826759
- Testing
- diabetes
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pre Diabetes, Obesity
Stand up for Your Health With a Sit-stand Desk
More than 84 million - or 1 out of every 3 U.S. adults - have prediabetes, a condition that if not treated often leads to type 2 diabetes within five years.
- Conditions
- Pre Diabetes, Obesity, Metabolic Syndrome, Sedentary Behavior
- Trial name
- NCT05585190
- Testing
- Control, Sit-Stand Desk at Work
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Medical College of Wisconsin
Obesity, Abdominal Obesity
Acupuncture for Prediabetes With Combined Obesity
The clinical trial aims to evaluate the efficacy and safety of acupuncture in reducing weight and waist circumference while modulating glucose and lipid metabolism in Prediabetes with Combined Obesity.
- Conditions
- Obesity, Abdominal Obesity, PreDiabetes
- Trial name
- NCT06359418
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Pre Diabetes, Obesity
Beta Glucan and Acetate Production
Based on our hypothesis that orally administered resistant starch and beta glucan will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we…
- Trial name
- NCT03714646
- Testing
- beta glucan and resistant starch, beta gluten
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Type 2, Obesity
Egg Consumption and Glycemic Control in Individuals With Pre- and Type II-diabetes
The intent of this study is to examine the extent to which daily incorporation of egg into a diet improves glycemic control, insulin sensitivity, lipid profiles, and body composition in overweight and obese adults with pre- and…
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Pre Diabetes
- Trial name
- NCT03272074
- Testing
- Egg and egg white
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Florida State University
Lipid Profile
Hypoglycemic Potential of Garcinia Cambogia (Garcinia Gummi-gutta (L.) N.Robson) Rind Powder Among Pre-diebetic Obese Patients
Garcinia cambogia, rich in hydroxycitric acid (HCA), has been suggested to promote weight loss and improve metabolic parameters. Evidence regarding its efficacy in pre-diabetic obese adults remains limited.
- Trial name
- NCT07419074
- Testing
- Garcinia cambogia rind powder
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Insulin Sensitivity
The Effect of Blueberries on Enhancing Insulin Sensitivity in Humans: A Pilot Study
The purpose of this study is to evaluate the effect of blueberry powder on insulin sensitivity in obese, non-diabetic, and insulin resistant subjects.
- Trial name
- BLUEBERRY (NCT01005420)
- Testing
- Blueberry Powder
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
CARDIOMETABOLIC CONDITIONS, Obesity
The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older
This is a multisite clinical trial of healthy lifestyle programs for middle-to-older-aged adults (50 -74 years) to improve their weight and, therefore, reduce risk for chronic disease.
- Conditions
- CARDIOMETABOLIC CONDITIONS, Obesity, Pre-diabetes, Metabolic Syndrome
- Trial name
- PIVOT (NCT05654142)
- Testing
- Base intervention, Augmented Intervention
- Where
- 3 sites in United States
- Volunteers
- 1,029 people
- Sponsor
- University of Illinois Chicago
PreDiabetes, Obesity
Clinical Trial of Crocus Kozanis Administration in Obese Children and Adolescents
The study aims to investigate possible effects of per os Crocus Kozanis administration in children and adolescents with obesity
- Conditions
- PreDiabetes, Obesity, Dyslipidemias
- Trial name
- NCT05572749
- Testing
- Crocus Kozanis, Metformin
- Where
- Greece
- Volunteers
- 75 people
- Sponsor
- Aristotle University Of Thessaloniki
Prediabetes, Obesity
Healthy Living Partnership to Prevent Diabetes
The Healthy Living Partnership to Prevent Diabetes (HELP PD) is a 300-participant randomized trial designed to test the effectiveness of a lay-health counselor led community-based diabetes prevention program in reducing blood…
- Trial name
- HELP PD (NCT00631345)
- Testing
- Group-Based Lifestyle Intervention (Phases 1 and 2), Individual Education Program (All Phases), Self-Directed Maintenance (Phase 3)
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pre-Diabetes
Detection of Pre-Diabetes in Overweight and Obese Children
Descriptive cross section study To detect prediabetes in overweight and obese children and adolescents in Assiut Governorate and to find out the possible risk factors.
- Trial name
- NCT06117358
- Volunteers
- 100 people
- Sponsor
- Assiut University
Overweight, Obesity
Effect of Dietary Habits on Metabolic Health
The goal of this application is to understand the connection between people's eating habits and the risk for developing diabetes, obesity, and cardiovascular disease.
- Conditions
- Overweight, Obesity, Prediabetes, Meals
- Trial name
- NCT02298790
- Testing
- Meal schedule
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
NAFLD, Obesity
Ernährungs-Interventions-Fettleber-Studie (Interventional Study on Nutritional Effects on NAFLD)
Epidemiological data and studies in animal models suggest, that polyunsatured fatty acids (PUFA) rather than mono-unsatured fatty acids (MUFA) are associated with lower hepatic lipid content (HCL) and may facilitate a decrease of…
- Conditions
- NAFLD, Obesity, Prediabetes, Dyslipoproteinemia
- Trial name
- UFOP-2 (NCT02458586)
- Testing
- Dietary intervention / counseling
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Insulin Resistance, Impaired Glucose Tolerance
Using a Complex Carbohydrate Mixture to Steer Fermentation and Improve Metabolism in Adults With Overweight and Prediabetes (DISTAL)
The purpose of this study is to investigate the effects of a fibre mixture added to a high-protein diet on metabolic, gut and brain health.
- Conditions
- Insulin Resistance, Impaired Glucose Tolerance, PreDiabetes, Overweight and Obesity
- Trial name
- DISTAL (NCT05354245)
- Testing
- Fibre supplement (potato-pectin), High-protein diet
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Type 2 Diabetes, Obesity
Energy Flux and Fat Oxidation Using Low and High Glycaemic Index Foods
Purpose: This study is carried out to determine the effect of GI on 24 hour blood glucose profiles and energy regulation in Asians when fed a normal diet modulated with sweeteners.
- Conditions
- Type 2 Diabetes, Obesity, PreDiabetes
- Trial name
- NCT03031886
- Testing
- low glycaemic index intervention, high glycaemic index intervention
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Healthy, Obese
Circadian Rhythmicity in Cold-induced Thermogenesis
This study aims to investigate whether maximum cold-induced non-shivering thermogenesis (e.g. thermogenesis as a consequence of BAT activity) differs between morning and evening.
- Conditions
- Healthy, Obese, Glucose Intolerance
- Trial name
- COLDR (NCT04406922)
- Testing
- Personalized cooling protocol
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Insulin Resistance, Prediabetic State
Human Models of Selective Insulin Resistance: Alpelisib, Part I
The goal of this clinical trial is to understand how the blood sugar-lowering hormone insulin works in healthy adults versus those who are at risk for type 2 diabetes.
- Conditions
- Insulin Resistance, Prediabetic State, Overweight and Obesity, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT06354088
- Testing
- Alpelisib 300 mg, [1-13C] sodium acetate, [6,6-2H2] D-glucose
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Columbia University
Metabolic Syndrome
Composition & Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome
The investigators previous research has suggested that lipid (fatty) composition in the muscle cells of mice plays a key role in their insulin sensitivity.
- Trial name
- COMP-SR (NCT02122666)
- Testing
- muscle biopsy
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine