Clinical trials: Obesity, Severe
Morbid Obesity, Postoperative Pain
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens
Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia has been studied, but up to date no data are…
- Conditions
- Morbid Obesity, Postoperative Pain, Postoperative Bowel Function, Postoperative Ambulation
- Trial name
- NCT01249872
- Testing
- GROUP A : 0 mg MORPHINE-0.1% LEVOBUPIVACAINE, GROUP B : 1 mg MORPHINE- 0.1% LEVOBUPIVACAINE, GROUP C : 2 mg MORPHINE-0.1% LEVOBUPIVACAINE
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Patras
Endoscopic Sleeve Gastroplasty
Endoscopic Sleeve Gastroplasty for Morbid Obesity
Obesity and its related metabolic disorders are increasingly a heavy health burden to many parts of the world. Weight control is a well-known important step in avoiding type 2 diabetes mellitus (T2DM).
- Trial name
- NCT03124485
- Testing
- Endoscopic Sleeve Gastroplasty, Laparoscopic Sleeve Gastrectomy
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Chinese University of Hong Kong
COVID, Severe Acute Respiratory Syndrome
Obesity and Mortality of Critically Ill Patients With COVID-19
Disproportionate impact of COVID-19 in patients with obesity is now well established. Obesity is associated with severe forms of COVID-19 and may be a risk factor of intensive care unit (ICU) admission.
- Conditions
- COVID, Severe Acute Respiratory Syndrome, Obesity, Comorbidities and Coexisting Conditions
- Trial name
- COV-OB-ICU (NCT04425213)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Central Hospital, Nancy, France
Obesity, Morbid, Obesity
Topiramate in Adolescents With Severe Obesity
The prevalence of severe pediatric obesity is on the rise and youth with this condition are at elevated risk for developing chronic diseases such as cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM).
- Conditions
- Obesity, Morbid, Obesity, Weight Loss
- Trial name
- NCT01859013
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Minnesota
Morbid Obesity
Comparison of Gastric Bypass and Sleeve Gastrectomy in Metabolic and Cardiovascular Indices
Morbidly obese patients undergoing either Roux en Y gastric bypass or sleeve gastrectomy were examined preoperatively, 3, 6, and 12 months after surgery.
- Trial name
- NCT03851874
- Testing
- Bariatric surgery
- Volunteers
- 28 people
- Sponsor
- National and Kapodistrian University of Athens
Obesity, Morbid
Comparison of Two Types of Face Mask Ventilation in Obese Patients
Two types of face masks : cuffed and uncuffed were evaluated for artificial ventilation in obese patients. After induction to anesthesia patients were ventilated with both types of masks using anesthesia machine with the same…
- Trial name
- NCT06219460
- Testing
- Ventilation using two types of face masks
- Where
- Poland
- Volunteers
- 108 people
- Sponsor
- Medical University of Lodz
Cardiopulmonary Disease
SGA for TEE: Safe Alternative to Deep Sedation for Patients With High-risk Cardiopulmonary Disease.
Increasingly, transesophageal echos (TEEs) are being done on high risk patients. A TEE is a short procedure done with deep sedation, but poses an increased risk of apnea/ hypoxemia in those with pulmonary disease.
- Trial name
- SGA-TEE (NCT04939220)
- Testing
- TEE with SGA, TEE with Deep Sedation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Obesity
Prebariatric Surgery Physical Exercise Training in Telehealth
The aim of our study is to evaluate the feasibility of a supervised training session using telehealth in the "Clinique medico-chirurgicale du traitement de l'obésité de Sherbrooke" (CMCTO) and its impact on health, physical…
- Trial name
- TelePreSET (NCT02083913)
- Testing
- Telehealth supervised exercise training
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Université de Sherbrooke
Obesity, Morbid
Randomized Controlled Trial of Fecal Microbiota Transplantation in Severe Obesity
This is a randomized, double-blinded and placebo controlled prospective trial with sixty patients to investigate the effect of fecal microbiota transplantation (FMT) on body weight in patients with severe obesity.
- Trial name
- RCTFMTOb (NCT03273855)
- Testing
- Fecal microbiota transplantation
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital of North Norway
Polycystic Ovary Syndrome, Severe Obesity
Effect of Metabolic Surgery on Live Birth Rate of Offspring in Obesity Polycystic Ovarian Syndrome Patients
This is a experimental study, which subjects are obese PCOS patients requiring LSG surgery. Aim to investigate the effects of LSG surgery in PCOS patients whether increases the live birth rate of the offspring.
- Conditions
- Polycystic Ovary Syndrome, Severe Obesity, Laparoscopic Sleeve Gastrectomy
- Trial name
- NCT04151459
- Testing
- Metformin
- Where
- China
- Volunteers
- 18 people
- Sponsor
- RenJi Hospital
Bardet Biedl Syndrome (BBS), Bardet Biedl Syndrome
Real-World Effects of MC4R Agonist Therapy in BBS and Severe Genetic Obesity
Bardet-Biedl syndrome (BBS) and other rare disorders associated with impairment of the melanocortin-4 receptor (MC4R) pathway are characterized by severe early-onset obesity, hyperphagia, and substantial morbidity.
- Conditions
- Bardet Biedl Syndrome (BBS), Bardet Biedl Syndrome, Bardet-Biedl Syndrome (BBS), Alstrom Syndrome
- Trial name
- REAL-MC4 (NCT07674290)
- Testing
- Setmelanotide
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Tom Hühne
Bariatric Surgery, Hormonal Response
Comparison of Hormonal Response to a Mixed-Meal Tolerance Test After Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy With Duodenojejunal Bypass in Patients With Super Morbid Obesity
Obesity is a major global health problem. Bariatric surgery is the most effective treatment, leading to substantial weight loss and improvement in obesity-related comorbidities.
- Conditions
- Bariatric Surgery, Hormonal Response, Post Bariatric Hypoglycemia
- Trial name
- CU BYPASS-DJB (NCT07747779)
- Testing
- Sleeve gastrectomy with duodenojejunal bypass, Roux-en-Y gastric bypass
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- Chulalongkorn University
Morbid Obesity
Effect of Limb Length Ratio on Roux-en-Y Gastric Bypass Outcomes (CLIMB II Study)
The investigators propose a randomized controlled trial comparing BP and roux limb lengths measuring 30 and 15% respectively of patient's total small bowel length versus current standard practice using fixed lengths.
- Trial name
- CLIMBII (NCT06293703)
- Testing
- Surgery
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- Salvador Navarrete
Hypoxia, Hysteroscopy
The Effects of Remimazolam on the Incidence of Severe Hypoxia During Sedated Hysteroscopy for Assisted Reproduction in Overweight or Obese Patients
Hypoxia is a common adverse event during sedated hysteroscopy for assisted reproduction, and it is more likely to occur in overweight or obese patients.
- Conditions
- Hypoxia, Hysteroscopy, Overweight or Obesity
- Trial name
- RP (NCT06187896)
- Testing
- remimazolam, Propofol
- Where
- China
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
Morbid Obesity, Gastroesophageal Reflux
MGB/OAGB and LSG Effects on Lower Esophageal Sphincter (LES) Function
Background While several articles have reported about the effects of laparoscopic sleeve gastrectomy (LSG) on the lower esophageal sphincter (LES), to date, just one paper has discussed this issue with regard the Mini/One…
- Conditions
- Morbid Obesity, Gastroesophageal Reflux, Bariatric Surgery Candidate
- Trial name
- NCT02987673
- Testing
- MGB/OAGB, LSG
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Mario Musella MD
Severe Obesity, Hypoxia
Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures
The study evaluated the effect of non-invasive positive pressure ventilation (NIPPV) to decrease the incidence of desaturation events in patients with severe obesity undergoing upper endoscopy.
- Trial name
- NCT03529461
- Testing
- Non-invasive positive pressure ventilation through nasal mask, Rescue non-invasive positive pressure ventilation through nasal mask, Secondary rescue maneuvers
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bristol Hospital
Depression - Major Depressive Disorder, Psychological Well Being
Peer-Supported E-Health Intervention for College Student Weight Management and Mental Health
This study will test whether adding peer support and online education can help college students manage their weight and improve their mood: we plan to enroll 300 full-time university students and randomly assign them to one of…
- Conditions
- Depression - Major Depressive Disorder, Psychological Well Being, Obesity Prevention
- Trial name
- NCT06966661
- Testing
- Peer Support Intervention, Peer Support and eHealth Intervention
- Where
- China
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Jinan University Guangzhou
Morbid Obesity
Laparoscopic Sleeve Gastrectomy Short Term Follow up
Laparoscopic Sleeve Gastrectomy (LSG), Also known as longitudinal or vertical gastrectomy. LSG was initially considered a first-stage operation in high-risk patients before bilio-pancreatic diversion or Roux-en-Y gastric bypass…
- Trial name
- NCT03465956
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mohamed Gamal Thabet
Non-alcoholic Fatty Liver Disease, Morbid Obesity
Ursodeoxycholic Acid in Bariatric Surgery
In an open-label trial, 20 otherwise healthy morbidly obese patients scheduled for bariatric surgery will be administered 20 mg/kg/day ursodeoxycholic acid for three weeks until the day before surgery.
- Trial name
- NCT01548079
- Testing
- Ursodeoxycholic Acid (UDCA)
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Obesity, Morbid Obesity
Long Term Effect of Very-low-calories Ketogenic Diet on Weight Control and Cardiovascular Brisk Factors (KETOHEART)
The growing obesity pandemic has a major impact on global cardiovascular (CVD)-related morbidity and premature mortality, severely compromising the quality of life of those affected and significantly increasing costs for the…
- Trial name
- KETOHEART (NCT05781269)
- Testing
- VLCKD, r-MedDiet
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano