Clinical trials: Obesity, Severe
Obesity
Long Term Follow up After 1 Year Initial Lifestyle Intervention
The effect of non-surgical methods for obesity treatment are not fully documented. This study focus on the long term effect of an intensiv follow up (the "Evje Model") compared to a regular follow up.
- Trial name
- NCT00477399
- Testing
- Long term follow up after intensive lifestyle intervention
- Where
- Norway
- Sponsor
- Tor-Ivar Karlsen
Crohn's Disease, Obesity or Overweight
Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
The main purpose of this study is to evaluate the efficacy and safety of mirikizumab and placebo compared with mirikizumab and concomitantly administered tirzepatide in adult participants with moderately to severely active CD and…
- Trial name
- COMMIT-CD (NCT06937099)
- Testing
- Mirikizumab, Tirzepatide
- Where
- 183 sites in United States, Austria and 20 more
- Volunteers
- 290 people
- Sponsor
- Eli Lilly and Company
Morbid Obesity, Sleeve Gastrectomy
Safety of an Early Discharge Protocol After Sleeve Gastrectomy
Evaluate the safety and efficacy of an early discharge protocol (23 hours, overnight stay) after scheduled sleeve gastrectomy.
- Conditions
- Morbid Obesity, Sleeve Gastrectomy, Early Discharge, Safety Issues
- Trial name
- NCT03070457
- Testing
- Early discharge, Conventional protocol
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Morbid Obesity
Laparoscopic Gastric Bypass vs LAP-BAND for Treatment of Morbid Obesity
PURPOSE Obesity is a growing problem in the United States. Severe obesity, known as "morbid obesity", is defined as being 100 pounds in excess of ideal body weight.
- Trial name
- NCT00247377
- Testing
- Gastric bypass surgery, Lap-Band
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- University of California, Irvine
Obesity
Gastric Bypass and Peripheral Activity of the Endocannabinoid System
The aim of the study is to precise the effect of a large amount of weight loss induced by gastric bypass on the endocannabinoid system (plasma and adipose tissue) of morbidly obese patients and to determine the influence of a…
- Trial name
- CCENDO (NCT01003873)
- Testing
- Evaluation of the endocannabinoid system, Biopsy of visceral and peripheral adipose tissue, Evaluation of metabolic parameters
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Obesity, Cardiovascular Diseases
A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease
The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD). The study will last about 113 weeks.
- Trial name
- TRIUMPH-3 (NCT05882045)
- Testing
- Retatrutide
- Where
- 169 sites in United States, Argentina and 8 more
- Volunteers
- 1,946 people
- Sponsor
- Eli Lilly and Company
Morbid Obesity
One Anastomosis Gastric Bypass for Severe Obesity in 6,722 Patients: Early Outcomes From the Assuta Surgery Registry
Background: One-anastomosis gastric bypass (OAGB) is an emerging type of bariatric metabolic surgery (BMS). Our study aimed to evaluate the short-term (≤30-day) postoperative safety of OAGB.
- Trial name
- NCT05481853
- Testing
- One Anastomosis Gastric Bypass
- Where
- Israel
- Volunteers
- 6,722 people
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Severe Coronary Artery Disease, Obesity
Chronic Inflammatory Activation in Fat Tissue: An Atherogenic Factor in Severe Coronary Artery Disease
Chronic inflammatory activation in fat tissue can be the link between adiposity and an increased risk for atherosclerosis. The aim of this study is to investigate how molecular alterations in fat tissue can be influenced by…
- Conditions
- Severe Coronary Artery Disease, Obesity, Impaired Glucose Tolerance
- Trial name
- KFO (NCT00510705)
- Testing
- exercise training, exercise training + metformin, exercise training + glitazone
- Where
- Germany
- Volunteers
- 29 people
- Sponsor
- University of Leipzig
Obesity, Morbid, Anal Incontinence
Impact of Bariatric Surgery in Patients With Morbid Obesity
The main objective is to compare the prevalence of anal incontinence (AI) before and after bariatric surgery in obese patients. Inclusion: Patients who are scheduled for a bariatric surgical procedure after a multidisciplinary…
- Conditions
- Obesity, Morbid, Anal Incontinence, Image, Body
- Trial name
- IVBIA (NCT04009356)
- Testing
- bariatric surgical procedures
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Calcium Metabolism Disorders, Morbid Obesity
Effects of Sleeve Gastrectomy on Calcium Metabolism and the Skeleton
In this pre-post observational study, the investigators will enroll and follow a cohort of about 50 adults undergoing sleeve gastrectomy surgery for weight loss.
- Trial name
- NCT02778490
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- San Francisco Veterans Affairs Medical Center
Glucagon Like Peptide-1 (GLP-1, Delayed Gastric Emptying
GLP_1 RA Ultrasound Study
The purpose of the study is to determine whether patients taking GLP-1 RAs have increased residual (left behind), gastric (stomach), contents due to delayed gastric emptying when following standard preoperative fasting guidelines.
- Conditions
- Glucagon Like Peptide-1 (GLP-1, Delayed Gastric Emptying, Risk of Aspiration, Diabetes
- Trial name
- NCT06581120
- Testing
- Glucagon-Like Peptide-1 receptor agonists, Point of Care Gastric Ultrasound
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Obesity, Overweight
Interactive Obesity Treatment Approach for Obesity Prevention in Adults With Early Serious Mental Illness: iOTA-SMI
Using a design-for-dissemination approach, this application proposes to use combined methods to adapt and pilot test an interactive obesity treatment approach (iOTA) for obesity prevention in early serious mental illness (eSMI)…
- Conditions
- Obesity, Overweight, Severe Mental Disorder
- Trial name
- iOTA-eSMI (NCT03980743)
- Testing
- iOTA text messaging intervention, Health Education text messaging intervention
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Washington University School of Medicine
Psoriasis
Open Label Study Etanercept's Maintenance Dose in Obese Patients With Moderate to Severe Plaque Type Psoriasis
This is a single-center, open-label, pilot study. A total of 30 subjects (15 in each study arm) will be enrolled in this 6 month study to evaluate whether the addition of narrow band UVB (NB-UVB) phototherapy can enhance the…
- Trial name
- NCT00800982
- Testing
- Narrow band (310-312 nm) ultraviolet light B phototherapy, etanercept
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Bariatric Surgery Candidate
Assessment of Knee Arthrosis After Bariatric Surgery
Impact of loss of weight on knee arthrosis has not been thoroughly studied. The primary goal of this study is to compare the MRI parameters (aspect of cartilage and oedema of spongious sub-chondral bone) before and one year after…
- Trial name
- BASIK (NCT01207024)
- Testing
- knee MRI
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Morbid Obesity
Laparoscopic Sleeve Gasterectomy With or Without Pyloric Botulinum Neurotoxin Injection
Leakage is the most common complication after laparoscopic sleeve gastrectomy which may amount to 20% in some studies. We hypothesize that Clostridium botulinum neurotoxin A (BTX-A) injection into the pyloric sphincter during the…
- Trial name
- NCT02325141
- Testing
- laparoscopic sleeve gastrectomy
- Volunteers
- 130 people
- Sponsor
- Mansoura University
Gastric Bypass, Morbid Obesity
Simplified Technique for Performing Laparoscopic Gastric Bypass
This study will include all eligible patients who have undergone or who will undergo a laparoscopic gastric bypass procedure at Madigan Army Medical Center using a specific surgical technique developed by the Principal…
- Trial name
- NCT06782256
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Madigan Army Medical Center
Morbid Obesity
Impact of Reverse Trendelenburg on ONSD in Obesity Surgery
This prospective randomized controlled trial aims to investigate the effect of reverse Trendelenburg positioning applied before pneumoperitoneum on optic nerve sheath diameter (ONSD) and, consequently, intracranial pressure…
- Trial name
- ONSD (NCT07639502)
- Testing
- Pre-pneumoperitoneum Reverse Trendelenburg Group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Morbid Obesity, Weight Loss
Endoscopic Surgery for Bariatric Revision After Weight Loss Failure
Morbid obesity and its associated metabolic diseases are on the rise in the United States. Currently, the best treatment for obesity is bariatric surgery where both roux-en-Y gastric bypass and sleeve gastrectomy offer…
- Trial name
- NCT01871896
- Testing
- Endoscopic Suturing to Create Early Satiety
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Bariatric Surgery, Morbid Obesity
Comparison of Three Hypoabsortive Surgical Techniques for Treatment of Type IV Morbid Obesity
Morbid obesity is the first non-traumatic cause of death in the western population and it is also progressively beginning to affect the developing countries.
- Trial name
- BAR-3 (NCT04861961)
- Testing
- DS vs. SADI-S vs. OAGBP
- Where
- Spain
- Volunteers
- 186 people
- Sponsor
- Hospital Universitari de Bellvitge