Clinical trials: Obesity, Severe
Insomnia, Morbid Obesity
M-Health Administered Sleep Treatment to Enhance Recovery in Bariatric Populations (MASTER)
This study is a longitudinal clinical trial designed to assess the feasibility of sleep intervention (Cognitive Behavioral Therapy for Insomnia (CBT-I)) in individuals with insomnia following bariatric surgery.
- Trial name
- MASTER (NCT04619771)
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stony Brook University
Obesity, Weight Loss
Changes in Anthropometric, Biochemical and DNA Damage Parameters After 3-weeks VLCD in Severely Obese Patients
Obesity manifest with inflammation, hyperglycaemia and dyslipidaemia. These conditions disturb redox system by generating excessive reactive oxygen species (ROS) and causing oxidative stress (OS) leading to DNA damage.
- Conditions
- Obesity, Weight Loss, DNA Damage
- Trial name
- NCT05007171
- Testing
- Very low calorie diet
- Where
- Croatia
- Volunteers
- 22 people
- Sponsor
- Special Hospital for Extended Treatment of Duga Resa
Perioperative Complication, Laparascopic Sleeve Gastrectomy
Body Mass Index and Obesity Surgery Mortality Risk Score in Perioperative Complications of Laparoscopic Sleeve Gastrectomy
The term obesity is defined as body mass index (BMI) 30 and over, and morbid obesity is considered as BMI greater than 40 (1).Its incidence in the general population is approximately 20% according to Organisation for data of…
- Conditions
- Perioperative Complication, Laparascopic Sleeve Gastrectomy, BMD, Obesity, Morbid
- Trial name
- NCT04427644
- Testing
- Laparascopic Sleeve Gastrectomy, İnterventional radiologic drainage, Complte Blood Count and Biochemical evaluation
- Volunteers
- 1,617 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Psychotic Disorder, Obesity
Multicomponent Risk Factor Intervention for People With a Severe Mental Illness: a Feasibility Study
This study is a feasibility study of a multi-component intervention to enhance healthy living among young people with psychotic disorders, specifically targeting smoking and weight.
- Conditions
- Psychotic Disorder, Obesity, Behavior, Addictive
- Trial name
- NCT00350311
- Testing
- nicotine transdermal patch/lozenge
- Where
- 4 sites in Australia
- Volunteers
- 43 people
- Sponsor
- The University of New South Wales
Obesity, Weight Loss
Self-compassion and Nutrition (SCAN) Study
The purpose of this study is to examine the feasibility of two approaches for improving long-term weight loss success among individuals with severe obesity.
- Trial name
- NCT04289636
- Testing
- Behavioral weight loss program, Self-compassion, Nutrition and cooking education
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Morbid Obesity
Laparoscopic Adjustable Gastric Banding Versus Laparoscopic Sleeve Gastrectomy
The investigators aim to determine the clinical and metabolic outcomes of two available bariatric restrictive procedures: laparoscopic adjustable gastric banding (LAP-BAND) and laparoscopic sleeve gastrectomy for the treatment of…
- Trial name
- NCT00434655
- Testing
- Laparoscopic restrictive procedure
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- North Texas Veterans Healthcare System
Morbid Obesity
Pilot Study of the Endolumik Gastric Calibration Tube for Bariatric Surgery
The pilot study will be a First In Human Clinical Trial to evaluate the Endolumik Gastric Calibration Tube and associated methods in a human clinical cohort of 20-30 bariatric patients at two high-volume bariatric programs.
- Trial name
- NCT05486325
- Testing
- Endolumik Gastric Calibration Tube (EGCT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Endolumik, Inc
Obesity, Morbid
Laparoscopic Single Anastomosis Sleeve Ileal Bypass Versus Laparoscopic Sleeve Gastrectomy for Morbid Obesity
This study will compare two bariatric surgical interventions in terms of weight loss, gastroesophageal reflux, and effects on obesity-related comorbid conditions in morbidly obese patients.
- Trial name
- NCT05611697
- Testing
- Single anastomosis sleeve ileal bypass, Sleeve gastrectomy
- Where
- 2 sites in Norway
- Volunteers
- 220 people
- Sponsor
- Oslo University Hospital
Morbid Obesity, Metabolic Syndrome
FMT in Obesity: RYGB vs. LEAN vs. Autologous FMT
This double-blinded proof-of-concept study is proposed to explore the effects of fecal microbiota transfer (FMT) in human subjects.
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes, PreDiabetes
- Trial name
- DACH (NCT06268990)
- Testing
- Fecal microbiota transplantation
- Where
- Austria
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wiebke Kristin Fenske
Morbid Obesity, Pulmonary Embolism
Laparoscopic Bariatric Surgery: Two Regimens of Venous Thromboprophylaxis: Prospective Randomized Study
Obese patients undergoing bariatric surgery warrant VTE prophylaxis because they are at high risk for developing a fatal pulmonary embolism or postthrombotic syndrome.
- Trial name
- NCT02128178
- Testing
- Enoxaparin 40 mg 2 hours before arm, Enoxaparin 40 mg 12 hours before arm
- Where
- Egypt
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Hypogonadism, Severe Obesity
Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot)
After the age of 40, there is a gradual decline in the production of testosterone. Among obese men, the decline in testosterone levels is exacerbated by the suppression of the hypothalamic-pituitary-gonadal axis by…
- Trial name
- NCT02959853
- Testing
- Anastrazole, weight loss
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Baylor College of Medicine
Obesity, Morbid Obesity
Effectiveness and Tolerability of Phentermine in Patients Under Bariatric Surgery
Surgical management of Morbid Obesity is increasingly frequent. A low-calorie diet is recommended with the main goal of reducing intrahepatic fat infiltration, fat tissue and making easier the surgery.
- Conditions
- Obesity, Morbid Obesity, Bariatric Surgery, Non-alcoholic Fatty Liver
- Trial name
- NCT03849729
- Testing
- Phentermine
- Where
- Mexico
- Volunteers
- 92 people
- Sponsor
- Hospital Juarez de Mexico
Morbid Obesity
Energy Expenditure and Gastric Bypass Surgery Study
The aim of this study is to assess whether the energy you burn daily increases after you have bariatric surgery. Until now, there hasn't been an effective way of measuring all activity on a daily basis.
- Trial name
- Energy (NCT00671957)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Adolescent Obesity, Hypertension,Essential
Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise
The main objective of this project is to analyze the effect of a tailor-made, one-to-one, exercise program (aiming to treat and handle obesity-related comorbidities in adolescents with severe obesity at high risk of…
- Conditions
- Adolescent Obesity, Hypertension,Essential, Non-Alcoholic Fatty Liver Disease, Dyslipidemias
- Trial name
- THOR-X (NCT06520800)
- Testing
- Treatment and handling obesity-related comorbidities in adolescents through exercise
- Volunteers
- 24 people
- Sponsor
- University of Lisbon
Morbid Obesity
Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy
The sleeve gastrectomy that has been utilized as a first-stage bariatric procedure to reduce surgical risk in high-risk patients by induction of weight loss is now gaining popularity as a standalone procedure for the treatment of…
- Trial name
- NCT00667706
- Testing
- laparoscopic operation Sleeve Gastrectomy, laparoscopic operation Roux-en-Y Gastric bypass
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization
Morbid Obesity
Design and Validation of a Preoperative Calculator for "Textbook Outcome" After Bariatric Surgery (BARCINO)
The present study aims to design, develop and validate a preoperative calculator for "Textbook Outcome" after bariatric surgery, in order to calculate the possibility of not achieving "Textbook outcome" based on the…
- Trial name
- BARCINO (NCT06044116)
- Where
- Spain
- Volunteers
- 6,000 people
- Sponsor
- Hospital Universitari de Bellvitge
Severe Obesity
Effects of Bile Acids and Bile Acid Sequestrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass
The purpose of this study is to examine the effects of bile acid and bile acids sequestrants on GLP-1 Secretion, during a meal, in patients after Roux-en-Y gastric bypass.
- Trial name
- NCT02876484
- Testing
- Colesevelam, Chenodeoxycholic Acid, Water
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Hvidovre University Hospital
Morbid Obesity
Hunger/Satiety's Physiopathologic Study in Morbidly Obese Patients
The mechanisms that regulate appetite in the morbidly obese are multifactorial and not well-known. Different peripheral signals (such as ghrelin or cholecystokinin) play an important role in the central regulation of appetite and…
- Trial name
- NCT02414893
- Testing
- Sleeve gastrectomy
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari del Maresme
Severe Preeclampsia
Protocols for Magnesium Sulfate Maintenance Dose in Overweight and Obese Women Diagnosed With Preeclampsia
There is still no evidence of the appropriate dose to be used. Serum magnesium sulfate concentration is not measured regularly, thus we may be using sub-therapeutic level or reaching a toxic level.Overweight and obese women have…
- Trial name
- NCT06486025
- Testing
- maintenance magnesium sulphate1g/h, maintenance magnesium sulphate2g/h
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Morbid Obesity
Effect Physical Exercise in Morbid Obesity
This objective study to verify the effect of physical training with and without behavioral cognitive therapy, compared with controls, in functional capacity and cardio-metabolic profile in individuals with morbidly obese
- Trial name
- NCT02406976
- Testing
- G1 -Exercise, G2- Exercise and Lifestyle, G3- Control
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas de Porto Alegre