Clinical trials: Obesity, Severe
Morbid Obesity Requiring Bariatric Surgery
Banded Versus Conventional Laparoscopic Roux-en-Y (GABY)
Banded Versus Conventional Laparoscopic Roux-en-Y Gastric Bypass (GABY). The aim of this novel study is to evaluate, if an additional restrictive silastic ring can avoid dilation of the gastro-entero anastomosis and adjacent…
- Trial name
- GABY (NCT01015469)
- Testing
- Conventional laparoscopic Roux-en-Y gastric bypass, conventional laparoscopic Roux-en-Y gastric bypass with additional restrictive silastic ring
- Where
- 14 sites in Austria, Belgium and 5 more
- Volunteers
- 384 people
- Sponsor
- ClinTrio Ltd.
Obese, Limb Deformities
Longitudinal Changes in Lower Extremity Alignment and Mechanical Axis Parameters After Bariatric Surgery in Patients With Morbid Obesity: A Prospective Observational Study
The goal of this prospective observational study is to understand whether major weight loss after bariatric surgery is associated with changes in the alignment of the lower limbs in adults with morbid obesity.
- Conditions
- Obese, Limb Deformities, Arthritis
- Trial name
- BARILIMBSALIGN (NCT07794566)
- Testing
- Obese.
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Obstructive Sleep Apnea, Obesity
UBT251 Injection Phase Ⅲ Study (OSA-PAP)
UBT251 will be compared with placebo (an inactive substance identical in appearance) to evaluate its therapeutic effect in participants with moderate-to-severe obstructive sleep apnea maintained on positive airway pressure…
- Trial name
- UNISHAPE-OSA-2 (NCT07806851)
- Testing
- UBT251
- Volunteers
- 150 people
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Metabolic Syndrome, Morbid Obesity
Interindividual Postexercise Hypotension Response in Morbid Obesity
A quasi-experimental study developed in sedentary morbidly obese men and women (age 43.6±11.3 y; body mass index [BMI] ≥40 kg/m2) were assigned to a CT group of ET plus RT (ET+RT; n=19; BMI 47.8±16.7) or RT plus ET order group…
- Trial name
- NCT05504629
- Testing
- Concurrent training order 1, RT+ET
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Universidad Nacional Andres Bello
Morbid Obesity
Impact of Reverse Trendelenburg on ONSD in Obesity Surgery
This prospective randomized controlled trial aims to investigate the effect of reverse Trendelenburg positioning applied before pneumoperitoneum on optic nerve sheath diameter (ONSD) and, consequently, intracranial pressure…
- Trial name
- ONSD (NCT07639502)
- Testing
- Pre-pneumoperitoneum Reverse Trendelenburg Group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Severe Obesity
Comorbidity After Gastric Bypass
To evaluate effect on comorbid disease and weight loss in the long-term (>five years) after Roux-en-Y gastric bypass (RYGB) surgery for severe obesity.
- Trial name
- NCT02710786
- Testing
- Gastric bypass
- Where
- Sweden
- Volunteers
- 25,000 people
- Sponsor
- Uppsala University
Difficult Intubation, Morbid Obesity
A Comparison of McGrath MAC Versus C-MAC Videolaryngoscopes in Morbidly Obese Patients
Along with the technological advances in medicine, videolaryngoscope is the most commonly preferred technique for intubation of expected difficult airway management such as morbidly obese patients.
- Conditions
- Difficult Intubation, Morbid Obesity, Videolaryngoscopy
- Trial name
- mcgrath&cmac (NCT03657927)
- Testing
- C-MAC videolaryngoscope, McGrath MAC videolaryngoscope
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Inonu University
Obesity, Morbid, Gastroesophageal Reflux (GERD)
AJYR+GV vs RYGB for GERD
This study focuses on gastroesophageal reflux disease (GERD), a condition in which stomach acid flows back into the esophagus (the tube that carries food from the mouth to the stomach), causing heartburn and other symptoms.
- Trial name
- NCT07768202
- Testing
- sleeve gastrectomy with Roux-en-Y antrojejunal anastomosis, AJYR+SG, Roux-en-Y gastric bypass, RYGB
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Victor Dib Institute
Morbid Obesity
Single Anastomosis Duodeno-Ileal Bypass vs Standard Duodenal Switch as a Second Step After Sleeve Gastrectomy in the Super-Morbid Obese Patient
Single-Anastomosis Duodeno-Ileal bypass with a 250 cm common/alimentary loop is a modification of standard duodenal switch in which a Roux-en-Y duodeno-ileal anastomosis is performed at 250 cm from the cecum and a 60 cm to 100 cm…
- Trial name
- SADI vs CD (NCT01685177)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital San Carlos, Madrid
Morbid Obesity
Chronobiological Determinants of Gut Microbiome
The aim of this study is to examine how the number of daily eating occasions and the timing of energy intake influence gut microbiome composition in both morbidly obese and non-obese individuals.
- Trial name
- ChronoNutr (NCT07303036)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Obstructive Sleep Apnea, Morbid Obesity
Epigenetics Modifications in Morbid Obesity and Obstructive Sleep Apnea Patients: The EPIMOOSA Study
This study evaluates epigenetics in morbid obese patients who are waiting for bariatric surgery. A home cardiopulmonary polygraphy is performed to evaluate for the presence of sleep-disordered breathing.
- Conditions
- Obstructive Sleep Apnea, Morbid Obesity, Epigenetic Disorder
- Trial name
- EPIMOOSA (NCT03995836)
- Testing
- CPAP, Bariatric Surgery
- Volunteers
- 70 people
- Sponsor
- Aragon Institute of Health Sciences
Severe Obesity
Pigeon Peas (Cajanus Cajan) : a Natural Anti-inflammatory Facilitating Weight Loss in Obese Patients Returning to Sport?
Adult obesity is due to an excess of body fat. This corresponds to all the fat in the body (or adipose tissue). It is opposed to the lean mass which corresponds to the weight of muscles, organs and viscera.
- Trial name
- OBESICA (NCT05493592)
- Testing
- Standardized physical activity protocol associated with the consumption of Cajanus cajan (EXACAJAN)
- Where
- Martinique
- Volunteers
- 124 people
- Sponsor
- University Hospital Center of Martinique
Morbid Obesity, Exercise
Semi-supervised Exercise Program Before Bariatric Surgery
Background: Patients awaiting bariatric surgery, apart from suffering higher BMI, show a large number of comorbidities and a low physical fitness.
- Conditions
- Morbid Obesity, Exercise, Bariatric Surgery
- Trial name
- NCT03975244
- Testing
- Exercise program
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Elche
Bariatric Surgery, Morbid Obesity
Pharmacokinetics of Rivaroxaban After Bariatric Surgery
Data on pharmacokinetics of rivaroxaban after bariatric surgery and in morbid obesity are sparse. The aim of this study is to assess the pharmacokinetic and pharmacodynamic parameters of rivaroxaban, used at a therapeutic…
- Trial name
- ABSORB (NCT04180436)
- Testing
- rivaroxaban 20 mg once daily 8 days
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Obesity, Morbid Obesity
Obesity-related Inflammation in Patients Prior to and After Bariatric Surgery
This study investigates the chronic long-term health condition of obesity and its effect on neutrophil function and the inflammatory response
- Trial name
- NCT03283644
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Obesity & Overweight
Weight Trajectories and Predictive Factors After Semaglutide in Patients With Grade 3 and Complicated Obesity
SEMAFOLLOW is a real-world follow-up study examining the outcomes of individuals treated with WEGOVY® (semaglutide 2.4 mg) under the temporary authorisation for use (ATU) and early access programme in France.
- Trial name
- SEMAFOLLOW (NCT07423481)
- Testing
- SEMAFOLLOW questionnaire
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- Nantes University Hospital
Morbid Obesity, Labor Pain
DPE Technique in Labor Epidural for Morbidly Obese Women
The primary purpose of this study is to determine differences in block quality between the "dural-puncture epidural" (DPE) and standard epidural (EPL) techniques for labor analgesia in the morbidly obese patient.
- Trial name
- NCT03074695
- Testing
- Dural puncture epidural (DPE), Standard Epidural (EPL)
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Duke University
Polycystic Ovary Syndrome, Morbid Obesity
The Female Health Dietary Intervention Study
This study has two phases: 1. In phase 1 of the study (8 weeks),the effect of two different low calorie diets on manifestations of PCOS, including risk factors for the metabolic syndrome and cardiovascular risk profile will be…
- Trial name
- FEMIN (NCT00779571)
- Testing
- Crispbread
- Where
- Norway
- Volunteers
- 61 people
- Sponsor
- The Hospital of Vestfold
Morbid Obesity, Hemodynamic Instability
Effects of Low-Flow Anesthesia on Hemodynamic Parameters and Oxygenation in Morbidly Obese Patients
Low-flow anesthesia has been used for years with positive results, but its effects on hemodynamic parameters and oxygenation are not clearly known in high-risk morbidly obese patients who are prone to pulmonary dysfunction…
- Conditions
- Morbid Obesity, Hemodynamic Instability, Bariatric Surgery Candidate
- Trial name
- Oxygenation (NCT03721536)
- Testing
- hemodynamic parameters, arterial blood gase
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Inonu University
Exercise
Effect of Exercise Intervention on Body Composition and Quality of Life in Post-bariatric Surgery Patients
This study will investigate the effectiveness of a rehabilitation program in improving body composition, and quality of life in patients with bariatric surgery in Taiwan. Hypothesis: 1.
- Trial name
- NCT04151836
- Testing
- Exercise education
- Where
- Taiwan
- Volunteers
- 85 people
- Sponsor
- Chang Gung Memorial Hospital