Clinical trials: Obesity/Overweight in Adult
Obesity and Obesity-related Medical Conditions
Efficacy and Safety of Tirzepatide for Weight Management
The goal of this study is to learn if tirzepatide helps people manage their weight safely. It will include adults in Bangladesh who are overweight or obese, with or without type 2 diabetes.
- Trial name
- NCT06918405
- Testing
- Tirzepatide
- Where
- Bangladesh
- Volunteers
- 440 people
- Sponsor
- Chittagong Medical College
Healthy Participants, Obesity
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
The purpose of the study is to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of AZD1043 following single and multiple ascending doses in healthy adult participants living with overweight and/or…
- Trial name
- NCT07511205
- Testing
- AZD1043
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity & Overweight, Gut -Microbiota
Effects of Monday-Thursday Sunnah Fasting on Short-Chain Fatty Acids, GLP-1, Satiety, and Nutritional Status in Obese Males
This quasi-experimental study investigated the effects of 8 weeks of Monday-Thursday Sunnah fasting on fecal short-chain fatty acids (SCFA), fasting total GLP-1, appetite regulation (hunger and satiety area under the curve)…
- Trial name
- NCT07703865
- Testing
- Monday-Thursday Sunnah Dry Fasting
- Where
- Indonesia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Muhammadiyah Jakarta
Obesity, Overweight
Online Platform for Healthy Weight Loss (POEmaS)
Clinical trial to test the efficacy of an online platform based on behavior change principles in promoting weight loss among overweight and obese students and employees of the Federal University of Minas Gerais.
- Trial name
- POEmaS (NCT03435445)
- Testing
- Online platform group, Online dietitian coaching, Control group
- Where
- Brazil
- Volunteers
- 1,276 people
- Sponsor
- Federal University of Minas Gerais
Motor Activity, Overweight and Obesity
The Effect of BMI on Hand Grip Force in Healthy Adults
This study will be conducted to investigate the effect of BMI on hand grip force in healthy subjects. The participants in this study will be 90 healthy subjects with right dominant lower limb (49 females and 49 males) they will…
- Conditions
- Motor Activity, Overweight and Obesity, Hand Injuries
- Trial name
- NCT03753295
- Testing
- Hand Grip Force
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Wafaa Mahmoud Amin
Obesity/Overweight in Adult
Phase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight Subjects
This study is a multicenter, randomized, open-label, parallel-group phase III clinical trial comparing the efficacy and safety of GZR18 Injection and semaglutide (Wegovy®) in adult obese or overweight subjects, aiming to evaluate…
- Trial name
- NCT07150975
- Testing
- GZR18, Semaglutide(Wegovy® )
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Overweight, Obesity
Influence of HDM1005 on Gastric Emptying and Pharmacokinetics of Metformin, Atorvastatin, Warfarin, and Digoxin
The purpose of this study is to characterize the Influence of HDM1005 on gastric emptying and drug-drug interaction of HDM1005 and metformin, atorvastatin, warfarin, and digoxin in overweight/obese adult subjects.
- Trial name
- NCT07502001
- Testing
- Acetaminophen, Metformin, Warfarin
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Overweight or Obesity; Type 2 Diabetes, Weight Loss Maintenance
AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN)
This is a randomized controlled trial to compare the effect of AI-assisted multi-domain lifestyle and continued tirzepatide on body weight loss maintenance.
- Trial name
- NCT07555730
- Testing
- AI assisted multi-domain lifestyle intervention, Tirzepatide
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Huazhong University of Science and Technology
Non-Alcoholic Steatohepatitis
Safety and Tolerability Study of SHP626 in Overweight and Obese Adults
This study will investigate the safety and tolerability of daily dosing regimens of SHP626 in overweight and obese adults.
- Trial name
- NCT02287779
- Testing
- SHP626
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mirum Pharmaceuticals, Inc.
Obesity
Nighttime Macronutrient Choice and Combined Resistance and High-intensity Interval Training
Obesity is recognized as a major public health concern because of its link to potential fatal complications arising from metabolic and cardiovascular diseases.
- Trial name
- NCT01830946
- Testing
- Whey Protein, Combined Resistance and High-Intensity Interval training, Casein Protein
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Florida State University
Obesity, Metabolic Syndrome
Time Restricted Feeding to Reduce Weight and Cardiometabolic Risk
The obesity rate in Malaysia is higher than the average world obesity rate. Central obesity is a component of metabolic syndrome (MetS) which is also made up of dyslipidemia, impaired glucose tolerance, and hypertension.
- Conditions
- Obesity, Metabolic Syndrome, Pre Diabetes
- Trial name
- NCT04243746
- Testing
- Time Restricted Feeding, Standard Care
- Where
- Malaysia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- RCSI & UCD Malaysia Campus
Type 2 Diabetes, Obesity
The Impact of the Glycaemic Index (GI) on Daily Blood Glucose Profiles and Food Intake in Young Chinese Adult Males
This study is carried out to find out the inclusion of high and low glycaemic Index (GI) foods to daily meals impact on 24 hour blood glucose fluctuations and food intake.
- Conditions
- Type 2 Diabetes, Obesity, Prediabetes
- Trial name
- NCT02340507
- Testing
- Rice and bread (high GI), Rice and bread (low GI)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Obesity, Metabolic Disease
Effects of Colchicine in Non-Diabetic Adults With Metabolic Syndrome
Background: Being overweight may cause low-level inflammation. This inflammation may cause some of the medical problems of obesity, like high blood sugar (diabetes) and heart disease.
- Trial name
- NCT02153983
- Testing
- Colchicine 0.6Mg Cap, Colchicine 0.6Mg Tab
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Obesity, Overweight (BMI > 25)
CHANGES IN SLEEP QUALITY AND BODY COMPOSITION FOLLOWING A MULTIMODAL LIFESTYLE INTERVENTION IN OLDER WOMEN
This single-arm pilot study evaluated changes in sleep quality, body composition, biochemical parameters, physical activity, and psychological well-being following a 12-week multimodal lifestyle intervention in overweight and…
- Conditions
- Obesity, Overweight (BMI > 25), Sleep Quality, Body Composition
- Trial name
- NCT07740902
- Testing
- Multimodal Lifestyle Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Saglik Bilimleri Universitesi
Obesity & Overweight
Multimodal Intervention for Weight Management and Health in the Elderly Population
Aging may be accompanied by changes in body composition, muscle strength, metabolic health, and well-being. In older adults with overweight or obesity, strategies that combine physical exercise, behavioral changes, and…
- Trial name
- NCT07820774
- Testing
- Nutritional guidance focused on adopting a high-protein diet., Group Cognitive Behavioral Therapy Intervention, Resistance Training Program
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Universidade Cesumar (UNICESUMAR)
Obesity, Overweight
A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
This is randomized, double-blind, placebo-controlled study of the long-term efficacy, safety, and tolerability of multiple doses of aleniglipron in participants living with overweight or obesity and T2DM.
- Conditions
- Obesity, Overweight, Chronic Weight Management, Type2 Diabetes Mellitus
- Trial name
- NCT07654374
- Testing
- aleniglipron
- Where
- 74 sites in United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Cardiovascular Health, Self-management
MECA Clinical Intervention ( MECA Health360x)
The purpose of this research is to test whether a technology application(Health360x) that lets participants set goals for better health and track health can help participants reduce their heart disease risk.
- Trial name
- MECAH360x (NCT04791618)
- Testing
- Health360x plus health coach, Health360x only (High tech)
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Obesity
A Study of BGM0504 in Participants With Obesity
To evaluate the efficacy and safety of BGM0504 compared with Tirzepatide in adult participants who have obesity without diabetes after 26 weeks of treatment.
- Trial name
- NCT06911203
- Testing
- BGM0504, Tirzepatide
- Where
- China
- Volunteers
- 96 people
- Sponsor
- BrightGene Bio-Medical Technology Co., Ltd.
Type 2 Diabetes (T2DM)
TriGlytza®-01 Versus Metformin in Overweight and Obese Adults With Type 2 Diabetes and Inadequate Glycaemic Control Despite Metformin Therapy
This Phase 2a, randomized, double-blind, active-controlled study will evaluate the safety, tolerability, and preliminary efficacy of TriGlytza®-01 compared with metformin in adults with Type 2 diabetes inadequately controlled…
- Trial name
- RESILIENCE-2a (NCT07139405)
- Testing
- Metformin XR, Celecoxib, Valsartan
- Where
- 3 sites in Australia
- Volunteers
- 48 people
- Sponsor
- Myopharm Limited
Intellectual Disability, Developmental Disability
Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability
People with IDD (intellectual and developmental disability) have very high rates of obesity and die prematurely from cardiometabolic disease.
- Conditions
- Intellectual Disability, Developmental Disability, Obesity
- Trial name
- METIDD (NCT05744479)
- Testing
- Metformin, Lifestyle Intervention
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre for Addiction and Mental Health