Clinical trials: Obesity (BMI>30), open to volunteers
Type 2 Diabetes Mellitus (T2D), Obesity (BMI>30)
Impact of Endoscopic Sleeve Gastroplasty (ESG) in Obese Adults With Type 2 Diabetes (T2D)
The goal of this clinical trial is to determine whether Endoscopic Sleeve Gastroplasty (ESG)-induced weight loss can improve glycemic outcomes and alter the trajectory toward insulin dependence in adults with obesity and…
- Trial name
- MEASURE (NCT07639684)
- Testing
- ESG with OverStitch
- Volunteers
- 50 people
- Sponsor
- Boston Scientific Corporation
Obesity (BMI>30)
OBEDIAM: Therapeutic Patient Education in Adults Living With Obesity, Diabetes, and Metabolic Disorders
The goal of this observational study is to learn about the acceptability and feasibility of a therapeutic patient education program in adults living with an obesity.
- Trial name
- OBEDIAM (NCT07668661)
- Testing
- Therapeutic patient education
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- CHU de Quebec-Universite Laval
Obesity (BMI Equal to or >30), Immune Function
Investigation of Egg Intake and the Relationship Between Gut Microbiome, Metabolic, and Immune Profiles
The purpose of this intervention study is to investigate the effects of daily egg intake on markers of gut health, high-density lipoprotein (HDL), metabolic, and immune cell profiles in adults with body mass indexes (BMI) in…
- Conditions
- Obesity (BMI Equal to or >30), Immune Function, HDL, Gut Microbiome
- Trial name
- NCT07844616
- Testing
- Egg whites, Whole eggs
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Obesity (BMI>30), General Anesthesia
Frontal EEG Dynamics During Anesthesia in Patients With Obesity and Normal Weight
This prospective observational study aims to compare frontal electroencephalographic (EEG) spectral dynamics between patients with obesity and normal weight undergoing general anesthesia.
- Trial name
- NCT07877090
- Testing
- Frontal Electroencephalography Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Duzce University
Cushing Syndrome, Adrenal Insufficiency
Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders
This is a multicentric, prospective, intervention study on circadian genes expression in peripheral blood mononuclear cells as biomarkers of circadian rhythm derangement in patients affected by alterations of endogenous…
- Conditions
- Cushing Syndrome, Adrenal Insufficiency, Cushing Disease, Addison Disease
- Trial name
- CHROnOS (NCT04374721)
- Testing
- circadian gene expression evaluation
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Obesity (BMI>30)
Resistance Training to Prevent Muscle Loss During Treatment With Tirzepatide
Incretin-based pharmacotherapies induce significant weight loss and represent a paradigm shift in obesity treatment. However, particularly fast weight loss may be accompanied by a significant loss of muscle mass, which is…
- Trial name
- RESIST (NCT07777575)
- Testing
- Dual GIP/GLP-1 Receptor Agonist Tirzepatide, Resistance Training
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Technical University of Munich
Obesity / Overweight, Obesity (BMI Equal to or >30)
A PHASE 2A, EXPLORATORY, RANDOMIZED, SINGLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY OF WEIGHT LOSS INDUCED BY NKS-3 IN OBESE ADULTS.
This study is designed as a single-blind, placebo-controlled, randomized, parallel-group trial. Subjects will be randomized in a 2:1 ratio to receive either NKS-3 or matching placebo, with a total planned enrollment of 31…
- Trial name
- SERENITY-1 (NCT07882654)
- Testing
- Investigational product is a modified linoleic acid, named NKS-3. This non-caloric agent, synthetized from linoleic acid, is a fat taste receptors agonist, targeting CD36 with also an impact on GPR120
- Where
- Tunisia
- Volunteers
- 31 people
- Sponsor
- EktaH
Obesity (BMI Equal to or >30), Postmenopausal Symptoms
Time-Restricted Eating and Personalized Energy-Restricted Diet in Obese Postmenopausal Women
This clinical study aims to compare the effects of time-restricted eating and a personalized energy-restricted diet on anthropometric measurements, body composition, biochemical parameters, blood pressure, handgrip strength…
- Conditions
- Obesity (BMI Equal to or >30), Postmenopausal Symptoms, Sleep Quality
- Trial name
- NCT07874399
- Testing
- Time-Restricted Eating, Personalized Energy-Restricted Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University
PCOS (Polycystic Ovary Syndrome), Insulin Resistance
Inositol and Metformin Administration in Mediterranean Diet and Low-Carbohydrate Diets in Women With PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine disorder frequently associated with obesity, insulin resistance (IR), and metabolic dysfunction.
- Conditions
- PCOS (Polycystic Ovary Syndrome), Insulin Resistance, Obesity (BMI>30)
- Trial name
- NCT07770711
- Testing
- Metformin, İnositol, Folic Acid
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dicle University
Obesity (BMI>30), Insulin Resistance
Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity
Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.
- Trial name
- NCT07653464
- Testing
- human insulin
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity (BMI>30), Insulin Resistance
Peripheral Vascular Effects of Insulin in Obesity
Successful completion of this project will advance our understanding of the role sympathetic nervous system overactivity plays in driving skeletal muscle malperfusion during hyperinsulinemia and consequently impaired glucose…
- Trial name
- NCT07874945
- Testing
- human insulin
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity (BMI>30)
Body Mass Index and Outcomes of Ultrasound-Guided Infraclavicular Brachial Plexus Block
This study aims to investigate whether body mass index (BMI) is associated with differences in the time needed to perform an ultrasound-guided infraclavicular nerve block and how well the block works.
- Trial name
- NCT07871994
- Testing
- Ultrasound-guided infraclavicular brachial plexus block
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Obesity (BMI>30), Immune Abnormalities
NutrImmune: Precision Nutrition to Improve Immunity in Individuals With Obesity
Obesity is a complex health condition defined by the World Health Organization (WHO) as an excess of body weight that may be harmful to health.
- Conditions
- Obesity (BMI>30), Immune Abnormalities, Low-grade Inflammation
- Trial name
- NutrImmune (NCT07850206)
- Testing
- Mixed test meal, Biological sampling, Questionnaires
- Where
- 4 sites in France, Germany and 1 more
- Volunteers
- 168 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Obesity (BMI>30)
Comparison Between the Health Effects of an AI-driven Model With Those of Human Professional Guidelines for the Treatment of Obesity
Many non-communicable diseases are diet-related and have a significant impact on public health. It is stated that global dietary shifts are needed to change disease patterns, highlighting the importance of nutrition in addressing…
- Trial name
- NCT07557979
- Testing
- AI-assisted dietitian group (combination), A dietitian-led group (human), AI-only group using ChatGPT Premium
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Gout, Obesity (BMI>30)
Mazdutide for Weight Management and Gout in Adults With Obesity
This is a single-arm, open-label, pre-post controlled study to evaluate the effect of Mazdutide on the annualized flare rate (AFR) in adults with obesity and gout.
- Conditions
- Gout, Obesity (BMI>30), Hyperuricemia, Metabolic Syndrome
- Trial name
- NCT07824895
- Testing
- Mazdutide
- Volunteers
- 30 people
- Sponsor
- Hongwei Jiang
Obstructive Sleep Apnea, Obesity (BMI>30)
Hypercapnic Burden in Adults With Obesity Undergoing Diagnostic Polysomnography for Suspected Obstructive Sleep Apnea
Obesity-related sleep hypoventilation represents a continuum ranging from isolated nocturnal hypoventilation to obesity hypoventilation syndrome.
- Conditions
- Obstructive Sleep Apnea, Obesity (BMI>30), Obesity Hypoventilation Syndrome (OHS), Sleep Hypoventilation
- Trial name
- HBO-POSA (NCT07809061)
- Testing
- Sleep Inertia Questionnaire (SIQ)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Obese Patients (BMI ≥ 30 kg/m²), Anxiety
Therapeutic Potential of a Synbiotic to Improve Mental Health in Subjects With Obesity.
Obese individuals are a particularly vulnerable population for mental health problems, especially depression and anxiety. The aim of this study is to evaluate whether the intake of a synbiotic, composed of prebiotics and…
- Conditions
- Obese Patients (BMI ≥ 30 kg/m²), Anxiety, Depressive Disorder
- Trial name
- NCT06901739
- Testing
- Synbiotic
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Celia Bañuls
Obesity (BMI>30), Heart Failure With Preserved Ejection Fraction (HFPEF)
Pilot Study of Endoscopic Sleeve Gastroplasty for Obese Patients With Heart Failure and Preserved Ejection Fraction
This is a small research study to see whether losing weight with a minimally invasive weight-loss procedure called endoscopic sleeve gastroplasty (ESG) can help improve symptoms of a type of heart failure called HFpEF in adults…
- Trial name
- NCT07798219
- Testing
- Endoscopic sleeve gastroplasty (ESG)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Overweight (BMI > 25), Obesity (BMI>30)
Assess the Effects of Replacing Foods High in Refined Carbohydrates With Avocado on Biomarkers of Inflammation.
The objective of this trial is to assess the effects of replacing foods high in refined carbohydrates, particularly added sugars, with avocado (isocaloric substitution) on biomarkers of inflammation and insulin sensitivity in…
- Conditions
- Overweight (BMI > 25), Obesity (BMI>30), Hs-CRP
- Trial name
- NCT07566325
- Testing
- Avocado, Control
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Obesity (BMI>30), Neuroinflammation
Effect of Tocopherol and Ascorbic Acid on Neuroinflammation Markers Associated With Neuropeptide Expression in the AgRP/NPY and POMC Pathways in Mexican Population With Obesity
This clinical trial will determine whether taking ascorbic acid (vitamin C), α-tocopherol (vitamin E), or both together can lower markers of brain inflammation and change the expression of neuropeptides in Mexican adults with…
- Trial name
- NCT07782411
- Testing
- Ascorbic acid (Vitamin C), tocopherol alpha, Ascorbic acid + tocopherol alpha
- Where
- Mexico
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Autonomous University of Morelos