Clinical trials: Obesity /Overweight
Gestational Weight Gain
A Mobile Health Intervention to Achieve Appropriate Gestational Weight Gain in Overweight/Obese Women
The aim of this trial is to investigate the effectiveness of a mobile health (mhealth) intervention to help overweight and obese women achieve appropriate gestational weight gain (GWG) for their pre-pregnancy body mass index…
- Trial name
- NCT03880461
- Testing
- Lifestyle Intervention
- Where
- 4 sites in United States
- Volunteers
- 1,335 people
- Sponsor
- Kaiser Permanente
Obesity
A Study of Once-Daily Oral Orforglipron (LY3502970) in Japanese Adult Participants With Obesity Disease
The main purpose of this study is to investigate the efficacy and safety of oral orforglipron in participants with obesity disease with obesity-related health problems.
- Trial name
- ATTAIN-J (NCT05931380)
- Testing
- Orforglipron
- Where
- 16 sites in Japan
- Volunteers
- 238 people
- Sponsor
- Eli Lilly and Company
Overweight, Obesity
A Study of LY3502970 in Chinese Participants With Obesity or Are Overweight With Weight-related Comorbidities
The main purpose of this study is to learn about the safety and tolerability of LY3502970 when given to Chinese participants with obesity or overweight with weight-related comorbidities.
- Trial name
- NCT06023095
- Testing
- LY3502970
- Where
- 3 sites in China
- Volunteers
- 24 people
- Sponsor
- Eli Lilly and Company
Healthy, Obese
A Study to Compare Tablets and Capsules of Orforglipron (LY3502970) in Healthy Participants Who Are Obese or Overweight
The main purpose of this study is to see how much of orforglipron (study drug) gets into the bloodstream and how long it takes the body to get rid of it when given as capsules compared to tablets in healthy overweight and obese…
- Conditions
- Healthy, Obese, Overweight, Obesity
- Trial name
- NCT06440980
- Testing
- Orforglipron
- Where
- 7 sites in United States
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Obesity, Obese
Safety and Efficacy of Bimagrumab and Semaglutide in Adults Who Are Overweight or Obese
A phase 2 study to assess the efficacy of bimagrumab alone or in addition to semaglutide to assess efficacy and safety in overweight or obese men and women
- Conditions
- Obesity, Obese, Overweight or Obesity
- Trial name
- NCT05616013
- Testing
- Bimagrumab, Semaglutide
- Where
- 26 sites in United States, Australia and 1 more
- Volunteers
- 507 people
- Sponsor
- Eli Lilly and Company
Overweight and Obesity
Study of Produce Prescription Programs in Adults With Overweight or Obesity Experiencing Nutrition Insecurity
The goal of this study is to understand the best practices for implementing produce prescriptions among adults with overweight or obesity experiencing nutrition insecurity.
- Trial name
- NCT06751563
- Testing
- Behavioral Text Messages and Produce Box Delivery, Behavioral Text Message Program and Produce Voucher
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Johns Hopkins University
Pregnancy Weight Gain, Postpartum Weight Retention
Pragmatic Randomized Clinical Trial to Limit Weight Gain in Pregnancy and Prevent Obesity
Healthy for Two, Healthy for You (H42/H4U) is an innovative evidence-based pregnancy/postpartum health coach intervention that is remotely-delivered (phone coaching using motivational interviewing, web-based platform, mobile…
- Conditions
- Pregnancy Weight Gain, Postpartum Weight Retention, Childhood Obesity, Gestational Diabetes
- Trial name
- H42/H4U (NCT04724330)
- Testing
- Healthy for Two/Healthy for You
- Where
- United States
- Volunteers
- 534 people
- Sponsor
- Johns Hopkins University
Overweight or Obesity
Sleep Extension or Regularity to Reduce Diabetes Risk
The goal of this study is to identify an intervention that improves sleep health and consequently metabolic health by examining whether sleep extension or enforced regularity in short sleepers will have beneficial effects on…
- Trial name
- NCT06128265
- Testing
- Sleep Extension, Sleep Regularity
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Chicago
Overweight and Obesity, Overweight Adolescents
Enhancing BodyWorks: A Canine Health Literacy Module
Dog ownership can serve as a vehicle for large-scale multi-level public health interventions, especially for pediatric overweight and obesity, due to dogs' unique place in children and adolescents' social networks.This study…
- Trial name
- BW (NCT04516252)
- Testing
- BodyWorks Intervention, Canine Curriculum, Ecological Momentary Assessment
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Children's Hospital Los Angeles
Diabetes Mellitus, Type 1, Obesity, Childhood
Family-Based Treatment for Type 1 Diabetes
Type 1 Diabetes carries high burden for affected youth and their families. Advances in insulin therapy and technology have been associated with increased obesity with 1/3 adolescents being overweight/obese.
- Conditions
- Diabetes Mellitus, Type 1, Obesity, Childhood, Overweight, Comorbidities and Coexisting Conditions
- Trial name
- FBTT1D (NCT05756361)
- Testing
- Family-Based Treatment for T1D
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- State University of New York at Buffalo
Overweight and Obesity, Adiposity
Healthy Mothers-Healthy Children Nutrition
Using a randomized two-group, repeated measures experimental design, the goal of the proposed study is to investigate the efficacy of a 12-week nutrition and exercise education, physical activity, coping skills training, and…
- Conditions
- Overweight and Obesity, Adiposity, Nutrient; Excess, Physical Activity
- Trial name
- HMHC (NCT03866902)
- Testing
- Nutrition and Physical Activity Intervention, English for Second Language Intervention
- Where
- United States
- Volunteers
- 578 people, healthy volunteers welcome
- Sponsor
- University of Miami
Obesity, Overweight
A Study of LY3841136 Compared With Placebo in Adult Participants With Obesity or Overweight
The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to investigate weight management efficacy and safety with LY3841136 compared with placebo in adult participants with obesity or…
- Trial name
- NCT06230523
- Testing
- Eloralintide
- Where
- 43 sites in United States
- Volunteers
- 263 people
- Sponsor
- Eli Lilly and Company
Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Disease Risk Factor
Early Add-On Combination of GLP-1 Receptor Agonist and SGLT2 Inhibitor in People With Cardiovascular-Kidney-Metabolic Stage 2-3
This retrospective observational target-trial emulation uses electronic health record data from the TriNetX US Collaborative Network to compare early treatment intensification strategies in adults with obesity, type 2 diabetes…
- Conditions
- Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Disease Risk Factor, Kidney Disease, Type 2 Diabetes
- Trial name
- GLP1-SGLT2-CKM (NCT07465926)
- Testing
- GLP-1 receptor agonist, SGLT2 inhibitor
- Volunteers
- 451,036 people
- Sponsor
- Chung Shan Medical University
Obesity; Overweight
Effect of GLP-1 Analogue ROSE-010 on Appetite in Overweight and Obese Subjects
The primary objective of this study is to assess the efficacy of ROSE-010 on food intake in female subjects with overweight and obesity.
- Trial name
- NCT06621017
- Testing
- ROSE-010 99 mcg, ROSE-010 150 mcg
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rose Pharma Inc
Healthy, Obese
A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese Participants
The main purpose of this study is to determine effect of orforglipron capsule formulation on the amount of digoxin, rosuvastatin, acetaminophen, midazolam, and simvastatin (each given alone and together with orforglipron) that…
- Conditions
- Healthy, Obese, Overweight
- Trial name
- NCT06186622
- Testing
- Orforglipron, Simvastatin, Digoxin
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Overweight, Obesity
A Research Study to See How Well Semaglutide Helps People Who Have a Body Weight Above the Healthy Weight Range
This study will look at how the investigational dose of semaglutide works in helping people with excess body weight, to lose weight.
- Trial name
- STEP12 (NCT06041217)
- Testing
- Semaglutide
- Where
- 21 sites in China, Taiwan
- Volunteers
- 242 people
- Sponsor
- Novo Nordisk A/S
Overweight (BMI > 25), Obesity
SMART Pilot Trial of Glycemic Screening Outreach
Approximately 130 million Americans have prediabetes or type 2 diabetes (T2D) but remain unscreened and/or unaware of their diagnosis.
- Trial name
- NCT06915194
- Testing
- Text message, Patient portal message, Mailed letter
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of California, Los Angeles
Obesity, Childhood, Overweight and Obesity
First Heroes: Engaging Fathers in the First 1000 Days
The First Heroes study plans to influence weight and health trajectories, modify disease risk, and improve health care services for mother-father-infant triads from racial/ethnic minority and health disparity populations.
- Conditions
- Obesity, Childhood, Overweight and Obesity, Social Determinants of Health, Physical Activity
- Trial name
- First Heroes (NCT04477577)
- Testing
- New Parent Intervention, Safety Control
- Where
- United States
- Volunteers
- 657 people
- Sponsor
- Massachusetts General Hospital
Obesity, Overweight
Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in People Who Are Overweight or Living With Obesity (OASIS 1)
This study is being conducted to see if semaglutide tablets can be used as a treatment to help people living with overweight or obesity lose weight. This study will look at the change in participants body weight.
- Trial name
- OASIS 1 (NCT05035095)
- Testing
- Oral semaglutide
- Where
- 56 sites in United States, Canada and 7 more
- Volunteers
- 667 people
- Sponsor
- Novo Nordisk A/S
PTSD, Overweight
MOVE!+UP: Testing a Tailored Weight Management Program for Veterans With PTSD
Posttraumatic Stress Disorder (PTSD) is common among Veterans and results in poor psychological functioning, quality of life, and physical health.
- Conditions
- PTSD, Overweight, Obesity
- Trial name
- NCT04563741
- Testing
- MOVE!+UP, MOVE!
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- VA Office of Research and Development