Clinical trials: Obesity /Overweight
Central Obesity, Obesity
Aerobic Training and Non-Exercise Physical Activity
This study will determine the health benefits of combining exercise training and increasing the amount of physical activity in daily life on the fat around the abdomen, weight, fitness and sensitivity to insulin.
- Trial name
- I-CAN (NCT02010060)
- Testing
- Aerobic Exercise Training, Aerobic Exercise+ Physical Activity
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- East Carolina University
Healthy Diet, Stress
Happy Family, Healthy Kids Program
Happy Family, Healthy Kids program, funded by the Michigan Health Endowment Fund, is a 14-week healthy eating program aimed to foster "Happy Family \& Healthy Kids." The program will target parental emotional eating through a…
- Conditions
- Healthy Diet, Stress, Pediatric Obesity, Intergenerational Relations
- Trial name
- NCT04183179
- Testing
- Happy Family, Healthy Kids Program
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Hepatic Steatosis, Polycystic Ovarian Syndrome
Liver and Fat Regulation in Overweight Adolescent Girls
Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis compared to weight similar women with regular menses. It is unclear if this is related to high testosterone or insulin resistance.
- Conditions
- Hepatic Steatosis, Polycystic Ovarian Syndrome, Obesity
- Trial name
- APPLE (NCT02157974)
- Testing
- Byetta 5Mcg Pen Injection
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Overweight, Obesity
Toddler Overweight Prevention Study Among Low-Income Families
The hypothesis is that toddlers with parents who are randomized to a parenting intervention and toddlers with parents who are randomized to the maternal intervention focused on maternal diet and physical activity will be more…
- Conditions
- Overweight, Obesity, Depression
- Trial name
- TOPS (NCT02615158)
- Testing
- Maternal Physical Activity and Nutrition, Parenting, Child Safety
- Where
- 2 sites in United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Hepatitis
Treating Nonalcoholic Steatohepatitis (NASH) With Metformin
Nonalcoholic Steatohepatitis (NASH) is associated with progressive liver disease, fibrosis, and cirrhosis. Although the cause of NASH is unknown, it is often associated with obesity, type 2 diabetes, and insulin resistance.
- Trial name
- NCT00063232
- Testing
- Metformin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Endothelial Dysfunction
Effects of Body Mass Index on the Hyperemic Response to Regadenoson
We will test the hypothesis that a single dose of Regadenoson will produce equivalent degrees of coronary hyperemia in patients of widely different body size.
- Conditions
- Obesity, Endothelial Dysfunction, Decreased Vascular Flow
- Trial name
- NCT00859833
- Testing
- Adenosine, Regadenoson
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Obesity and Physical Inactivity in Adolescents
Social Exergaming for Healthy Weight in Adolescent Girls
The purpose is to evaluate the feasibility of a 12-week exergaming dance program for adolescent girls. This study combines dancing, video games, and a full body work-out to test if video games can increase physical activity and…
- Trial name
- Klub Kinect (NCT02003963)
- Testing
- Klub Kinect
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Hepatitis
Treating Nonalcoholic Steatohepatitis With Pioglitazone
Nonalcoholic steatohepatitis (NASH) is a common liver disease that resembles alcoholic hepatitis but occurs in persons who drink little or no alcohol.
- Trial name
- NCT00062764
- Testing
- Actos (Pioglitazone)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes, Obesity
Role of Methane in Glycemic Control
The purpose of this study is to determine how certain types of bacteria in the human gut may affect weight gain, and contribute to the development of diabetes.
- Trial name
- NCT01638429
- Testing
- Neomycin, Rifaximin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cedars-Sinai Medical Center
Pre-diabetes
Preventing Diabetes in the Deep South: Extending Partnerships and Adapting Interventions to Reach Rural Communities at High Risk.
Diabetes is responsible for a huge and growing burden of patient suffering and social costs, and the impact of this disease is shared disproportionately by minorities and in rural resource-challenged communities, particularly in…
- Trial name
- NCT04343872
- Testing
- Receive lifestyle modification alone, Metformin therapy
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pediatric Obesity
NOURISH: Nourishing Our Understanding of Role Modeling to Improve Support and Health
The percentage of overweight children between the ages of 6 and 11 has nearly tripled in the last three decades, and rates are even higher among African Americans.Overweight children are at-risk for numerous health problems, thus…
- Trial name
- NOURISH (NCT00628030)
- Testing
- NOURISH, Wellness Group
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Hypertension, Hypertension in Pregnancy
Bridging the Gap From Postpartum to Primary Care
Chronic health conditions affect most older adults. Preventative medicine and risk management strategies, especially when applied earlier in life, are essential to altering the trajectory of a disease and ultimately improving…
- Conditions
- Hypertension, Hypertension in Pregnancy, Diabetes Mellitus, Gestational Diabetes
- Trial name
- NCT05543265
- Testing
- Default appointment scheduling, Targeted messaging, Nudge Reminders
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Massachusetts General Hospital
Bullying, Weight, Body
Cognitive-Behavioral Therapy for Weight-related Bullying (Online Treatment)
This study will perform a clinical trial with adolescents to pilot a new cognitive-behavioral treatment (CBT) for weight-related bullying testing (1) feasibility, (2) acceptability, and (3) initial efficacy.
- Conditions
- Bullying, Weight, Body, Trauma, Psychological
- Trial name
- NCT04587752
- Testing
- CBT for Weight Bullying
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Obesity
Addressing Obesity in Early Care and Education Settings
Childhood obesity is a national epidemic that disproportionately burdens low income and ethnic minority populations. By preschool, nearly one-third of low income children are already overweight or obese, setting the stage for…
- Trial name
- NCT04140032
- Testing
- Multi-level preschool obesity control intervention
- Where
- United States
- Volunteers
- 1,136 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obesity
A Study of Tirzepatide (LY3298176) in Pediatric Participants With Obesity
The main purpose of this study is to evaluate the safety and tolerability of tirzepatide (LY3298176) in pediatric participants with obesity.
- Trial name
- NCT05696847
- Testing
- Tirzepatide
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Eli Lilly and Company
Obesity
Craving and Lifestyle Management Through Mindfulness Study
The purpose of this study is to determine whether a mindfulness-based stress reduction and mindful eating program will lead to reductions in abdominal fat and total weight and improve cell aging in overweight and obese women…
- Trial name
- CALMM (NCT01250509)
- Testing
- Craving and Lifestyle Management through Mindfulness
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity, Critical Illness
Levofloxacin Pharmacokinetics (PK) in the Severely Obese
Obesity is known to affect the concentrations of certain medications in the body. Levofloxacin is a commonly used antibiotic. Based on what the investigators know about levofloxacin and how it moves through the body, obesity may…
- Trial name
- NCT00176306
- Testing
- Levofloxacin 750 mg IV
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Joel Thompson, PhD
Healthy, Obesity, Metabolically
A First in Human (FIH) Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DR10624
DR10624 is an Fc fusion protein tri-agonist with balanced glucagon-like peptide-1 receptor (GLP-1R)/glucagon receptor (GCGR)/ fibroblast growth factor 21 receptor (FGF21R) agonizing activities.
- Trial name
- NCT05378893
- Testing
- DR10624 for injection
- Where
- New Zealand
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Zhejiang Doer Biologics Co., Ltd.
Metabolic Syndrome X
Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion
The Metabolic Syndrome is a high prevalence disease worldwide. About a quarter of the adult population suffers the disease. Resveratrol is a substance found in many plants, including grapes, nuts and wine, but it's also found in…
- Trial name
- NCT02114892
- Testing
- Resveratrol
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- University of Guadalajara
Hernia, Obesity
Evaluation of Surgisis Gold Graft for Incision Reinforcement After Open Bariatric Surgery
The primary objective is to compare the effectiveness of the Surgisis Gold Graft to suture closure alone in preventing an incisional hernia after open bariatric surgery.
- Trial name
- NCT00274625
- Testing
- Surgisis Gold Graft, Control
- Where
- 2 sites in United States
- Volunteers
- 402 people
- Sponsor
- Cook Group Incorporated
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