Clinical trials: Obesity Overweight
Type 2 Diabetes Mellitus
A Study to Investigate Different Doses of 0382 in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.
A Phase 2 study with two cohorts of differing doses designed to evaluate the efficacy, safety and pharmacokinetics (PK) of MEDI0382 in patients with Type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT03244800
- Testing
- MEDI0382
- Where
- 5 sites in Germany
- Volunteers
- 65 people
- Sponsor
- MedImmune LLC
Obesity
Safety, Toleration and Pharmacokinetics of Single Intravenous Doses of Peptide YY in Overweight Adults
The purpose of this trial is to evaluate the safety and tolerability of single escalating doses of Peptide YY3-36 and to determine effects on food intake and serum hormones when administered by intravenous infusion to otherwise…
- Trial name
- NCT00331175
- Testing
- Peptide YY3-36
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Pfizer
Overweight and Obesity
Metabolic Response to Beverages With Various Sweetening Systems Consumed During Meal in Overweight and Obese Subjects
The purpose of this clinical study is to investigate the effect of drinking a sugar-sweetened beverage along with a meal on insulin concentrations and, glucose and lipid metabolism, in overweight and obese subjects, during a…
- Trial name
- AQUAGLU-1 (NCT02932423)
- Testing
- Control product E, Test product A, Test product B
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Danone Global Research & Innovation Center
Obesity, Aging
Variability of Physical Assessments in an Older Population That is Overweight or Obese
Variability of physical assessments in an older population that is overweight or obese.
- Trial name
- NCT05174923
- Testing
- Short Performance Physical Battery (SPPB Test), 30 Second Chair Stand Test (30CST), Hand grip dynamometry
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Versanis Bio, Inc.
Overweight and Obesity
Study of the Intestinal Microbiota During a Real Life Dietary Intervention in Subjects With Overweight or Obesity
Worldwide, 13% of the population had obesity in 2016 and overweight and obesity are recognized as the fifth leading risk factor for death (roughly 5 million deaths per year).
- Trial name
- GUTINSIDE (NCT04822948)
- Where
- France
- Volunteers
- 1,855 people
- Sponsor
- Integrative Phenomics
Obese, Healthy
The Safety, Tolerability and Pharmacokinetic Study of RAY1225
This trial is conducted in China. The aim of the trial is to investigate safety, tolerability, pharmacokinetics and pharmacodynamics of RAY1225
- Trial name
- NCT05835752
- Testing
- RAY1225
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Guangdong Raynovent Biotech Co., Ltd
Metabolism and Nutrition Disorder, Obesity
A First Human Dose Trial Investigating Safety, Tolerability and Pharmacokinetics for Single Doses and Multiple Doses of NNC0165-1562 in Overweight to Obese But Otherwise Healthy Subjects
This trial is conducted in the United States of America. The aim of the trial is to investigate safety, tolerability and pharmacokinetics (the exposure of the trial drug in the body) for single doses and multiple doses of…
- Trial name
- NCT02568306
- Testing
- NNC0165-1562
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Obesity
The Allurion Digital Behaviour Change Intervention
The proposed study is a prospective, non-randomized, pilot study to test the impact of the Allurion Digital Behaviour Change Intervention (DBCI) in participants who have been treated with the Allurion™ Gastric Balloon System.
- Trial name
- NCT05884606
- Testing
- Allurion Digital Behaviour Change Intervention
- Where
- 4 sites in Netherlands, United Kingdom
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Allurion Technologies
Metabolism and Nutrition Disorder, Obesity
Examination of the Safety and Tolerability of NNC 0070-0002-0349 in Overweight/Obese Volunteers
This trial will be conducted in the United States of America (USA). The aim of this clinical trial is to investigate whether NNC 0070-0002-0349 is safe and well tolerated.
- Trial name
- NCT00728455
- Testing
- NNC 0070-0002-0349
- Sponsor
- Novo Nordisk A/S
Obesity
Feasibility Trial of ValenTx Endo Bypass System
The purpose of the study is to provide initial clinical data to support the feasibility of use of the ValenTx Endo Bypass system in enhancing weight loss and co-morbidity resolution in morbidly obese patients.
- Trial name
- NCT01207804
- Testing
- ValenTx Endo Bypass System
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- ValenTx, Inc.
Obesity
Sustainable Weight Loss Study: Nutrition Support Tools and Weight Loss Among Obese People
The purpose of this research study is to determine the effectiveness of nutrition tools to support weight loss among obese individuals. All participation will be based online and there will be no in-person visits.
- Trial name
- NCT04378322
- Testing
- Nutrition and food purchasing tool + telenutrition, Nutrition and food purchasing tool, Nutrition education tool
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Zipongo
Obesity and Overweight
A Randomized Controlled Trial Comparing the Efficacy of Commercial Weight Management Programs
The study compares the effectiveness of three commercial weight management programs. The primary outcome is absolute and percentage weight change at 12-weeks.
- Trial name
- NCT06972277
- Testing
- Commercial weight management program
- Where
- United States
- Volunteers
- 459 people
- Sponsor
- WW International Inc
Obesity
Crave Crush Neuroimaging Study
The purpose of the research is to test whether a gymnemic acids (GA) lozenge will reduce reward region response to intake of high-sugar food and ad lib candy intake and whether the GA lozenge reduced reward region response to…
- Trial name
- NCT02949102
- Testing
- Crave Crush
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Overweight/Obesity
Clinical Study of IBI362 in Healthy Chinese Male Subjects
This is a study to evaluate the pharmacokinetic characteristics and safety of IBI362 lyophilized powder and IBI362 liquid formulation in healthy Chinese male subjects.
- Trial name
- NCT04773977
- Testing
- IBI362 liquid formulation, IBI362 lyophilized powder
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
22q11 Deletion Syndrome, DiGeorge Syndrome
SNP-based Microdeletion and Aneuploidy RegisTry (SMART)
This multi-center prospective observational study is designed to track birth outcomes and perinatal correlates to the Panorama prenatal screening test in the general population among ten thousand women who present clinically and…
- Conditions
- 22q11 Deletion Syndrome, DiGeorge Syndrome, Trisomy 21, Trisomy 18
- Trial name
- SMART (NCT02381457)
- Where
- 21 sites in United States, Australia and 4 more
- Volunteers
- 20,960 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Obesity With Diabetes, Overweight With Diabetes
Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
The primary objective of this study is to demonstrate that ribupatide (KAI-9531) subcutaneous (SC) injection once weekly is superior to placebo on: Percent change in body weight Change in hemoglobin A1c (HbA1c)
- Trial name
- KaiNETIC-2 (NCT07284901)
- Testing
- Ribupatide
- Where
- 173 sites in United States, Argentina and 9 more
- Volunteers
- 1,270 people
- Sponsor
- Kailera
Obesity
Effects of XW003 Versus Liraglutide on Body Weight of Adult Participants With Obesity
XW003 is an acylated human glucagon-like peptide 1 (GLP-1) analogue and is being developed for type 2 diabetes mellitus (T2DM) and obesity management.
- Trial name
- NCT05111912
- Testing
- XW003, Saxenda
- Where
- Australia
- Volunteers
- 206 people
- Sponsor
- Sciwind Biosciences APAC CO Pty. Ltd.
Obstructive Sleep Apnea, Obesity
UBT251 Injection Phase Ⅲ Study (OSA-PAP)
UBT251 will be compared with placebo (an inactive substance identical in appearance) to evaluate its therapeutic effect in participants with moderate-to-severe obstructive sleep apnea maintained on positive airway pressure…
- Trial name
- UNISHAPE-OSA-2 (NCT07806851)
- Testing
- UBT251
- Volunteers
- 150 people
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Gastrointestinal Dysfunction
A Study to Assess the Gut Health Effects of Heat-killed Post-biotics in Overweight and Obese Adults
The present study is a randomized, double-blind (Double dummy), placebo-controlled, parallel-group study to assess the gut health effects of heat-killed post biotics in overweight and obese individuals
- Trial name
- NCT05820737
- Testing
- EF2001, beLP1
- Where
- 9 sites in India
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Overweight, Obesity
RCT to Compare Orlistat and Polyglucosamine for the Management of Overweight and Obesity
This trial compares two treatment methods: 1. Orlistat 60 mg to be taken three times daily one capsule; indicated for weight loss in overweight adults.
- Trial name
- NCT02529631
- Testing
- orlistat 60 mg, polyglucosamine
- Where
- 2 sites in Germany, Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Certmedica International GmbH
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