Clinical trials: Obesity Overweight
Obesity
Laparoscopic Single-Anastomosis Duodenal-Jejunal Bypass With Sleeve Gastrectomy vs Laparoscopic Duodenal Switch
Will a laparoscopic Single-Anastomosis Duodenal-ileal Bypass with Sleeve Gastrectomy produce similar or superior results when compared to a laparoscopic Duodenal Switch, as a primary surgical procedure for weight loss in…
- Trial name
- DSvsSADI (NCT02692469)
- Testing
- Duodenal Switch, Duodenal-ileal Bypass with Sleeve Gastrectomy
- Volunteers
- 140 people
- Sponsor
- McMaster University
Obesity
Gut Permeability-related Inflammation and Cardiovascular Disease Risk in Normal-weight and Metabolically Healthy Obesity
The investigators are examining the extent gut permeability explains observed inflammation in normal-weight and metabolically healthy obesity (and potentially cardiovascular disease risk).
- Trial name
- NCT05308394
- Testing
- No experimental intervention will take place - the study is cross-sectional. Each participant will provide biological samples.
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Oklahoma State University
Bariatric Surgery Candidate, Obesity, Morbid
Genetic Susceptibility to Predict Weight Loss After Bariatric Surgery
Obesity is a complex chronic disease, in which both genetic and environmental factors are involved, that shows a great heterogeneity in the response to different weight loss programs.
- Conditions
- Bariatric Surgery Candidate, Obesity, Morbid, Genetic Predisposition, Metabolic Syndrome
- Trial name
- GENBASU (NCT06226194)
- Where
- Spain
- Volunteers
- 6,966 people
- Sponsor
- Institut de Recerca Biomèdica de Lleida
Hypertension, Diabetes Mellitus, Type 2
Does Early Weight Loss Following Laparoscopic Sleeve Gastrectomy Affect Long-term Outcomes
A study to explore the relationship between early weight loss in the 4 weeks following laparoscopic sleeve gastrectomy and outcomes, in terms of weight loss and comorbidity improvement, 7 years following the surgery.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Gastrostomy, Morbid Obesity
- Trial name
- NCT04235829
- Testing
- Laparoscopic sleeve gastrectomy
- Where
- Israel
- Volunteers
- 156 people
- Sponsor
- Shaare Zedek Medical Center
Obesity
Effects of Exercise on Thyroid Stimulating Hormone Among Class-I Obese Patients With Diabetes Mellitus and Lipid Disorders
Obesity is characterized by an excessive accumulation of body fat that gives rise to significant comorbidities, such as diabetes, hypertension, dyslipidemia, cardiovascular disease, and many cancers.
- Trial name
- NCT06119737
- Testing
- Exercise
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Ziauddin University
Overweight or Obesity
Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IBI362 in Overweight or Obesity Subjects
This trial is conducted in China. The aim of this trial is to investigate Safety, Tolerability, PK and PD for Multiple Doses of IBI362 in Overweight or Obese Male and Female Subjects.
- Trial name
- NCT04440345
- Testing
- IBI362
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Overweight and Obesity
Efficacy of Sprint Interval Training on Anthropometric Measures
Due to the rising problem of overweight and obesity, many strategies are implemented to combat this issue and one of the most common ways is exercise training.
- Trial name
- NCT04323995
- Testing
- Sprint Interval Training
- Where
- Malaysia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Universiti Tunku Abdul Rahman
Sperm Quality, Obesity
Obesity With Sperm Quality in Men With Fertility Need
This study aims to investigate the impact of different types of obesity on sperm quality. Participants will be divided into three groups: a normal BMI group, an obese group without pudendal fat wrapping the testicles, and an…
- Conditions
- Sperm Quality, Obesity, Sex Hormones, Visceral Fat
- Trial name
- NCT06353880
- Testing
- Participants will be categorized into three groups based on BMI and the presence of pudendal fat deposition.
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Yu xiaowei
Diabetes Mellitus, Type 2, Overweight and Obesity
Adaptation of a Digital Weight Loss Intervention Promoting Self-regulation for Use in Type 2 Diabetes
The purpose of this study is to 1) adapt a weight loss app that the Tate team has previously developed to promote PA and diet and adapt them to the needs and perspectives of those with Type 2 Diabetes (T2DM), integrate daily…
- Trial name
- NCT03650088
- Testing
- Behavioral weight loss with digital tools
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of North Carolina, Chapel Hill
PYY, Ghrelin
The Comparison of PYY, Ghrelin, GLP1, Glucose Level, Level of Satiety, and Ad Libitum Intake in Obese and Non-Obese Patients After Breakfast With Balanced Macronutrient Composition
Obesity can occur due to an imbalance of energy. This energy balance is greatly influenced by hunger and satiety. Obese person cannot resist hunger, while non obese can control hunger.
- Conditions
- PYY, Ghrelin, Appetite, Gut Hormones
- Trial name
- NCT03701503
- Testing
- Diet with balance composition to know the effect of a meal to gut hormones in obese and non obese women
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Preeclampsia, Preeclampsia (PE)
Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia
This study's primary purpose is to determine the relationship between aspirin metabolism and markers of metabolic dysfunction among patients at risk for preeclampsia.
- Conditions
- Preeclampsia, Preeclampsia (PE), Preeclampsia (PE) Risk, Obesity and Obesity-related Medical Conditions
- Trial name
- RAMP (NCT06802861)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Nutritional and Metabolic Diseases
Low-calorie Sweeteners and Adipose Signaling
The purpose of this study is to determine whether eight weeks of low-calorie sweetener (LCS) exposure exerts cardiovascular and/or metabolic effects among LCS-naïve overweight and obese adolescents and young adults.
- Trial name
- NCT03125356
- Testing
- Diet Soda
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- George Washington University
Obesity, Osteoarthritis
Symptomatic, Biomechanical and Radiographic Outcomes in Knee Osteoarthritis Following Gastric Bypass Surgery
Weight is a risk factor for knee osteoarthritis Knee osteoarthritis is associated with abnormal gait biomechanics Gait biomechanics are evaluated in gastric bypass patients before and after losing 100 pounds.
- Trial name
- NCT00194051
- Testing
- gastric bypass surgery
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University Hospitals Cleveland Medical Center
Inactivity, Obesity
Consequences of Human Inactivity
Epidemiological studies as well as both longitudinal animal and human inactivity studies indicate that low physical activity is associated with the pathophysiology of type 2 diabetes mellitus (T2DM) and obesity, and recently it…
- Conditions
- Inactivity, Obesity, Type 2 Diabetes
- Trial name
- NCT01828229
- Testing
- female inactivity and hypercaloric diet, inactivity, inactivity and hypercaloric diet
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Overweight or Obesity
Effect of a Modified 5:2 Intermittent Fasting Diet on Population With Overweight or Obesity in China
This study aimed to investigate the effects of the modified 5:2 IF dietary intervention on the Chinese population with overweight or obesity based on a self-controlled clinical trial.
- Trial name
- NCT06552403
- Testing
- A modified 5:2 intermittent fasting diet
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial Tongde Hospital
Cancer Survivor, Central Obesity
Exercise Intervention in Targeting Adiposity and Inflammation With Movement to Improve Prognosis in Breast Cancer
This randomized phase II trial studies how well exercise intervention works in targeting adiposity and inflammation with movement to improve prognosis in stage I-III breast cancer survivors.
- Conditions
- Cancer Survivor, Central Obesity, Estrogen Receptor Positive, Postmenopausal
- Trial name
- NCT03091842
- Testing
- Exercise Intervention, Informational Intervention, Laboratory Biomarker Analysis
- Where
- United States
- Sponsor
- University of Southern California
Atherosclerosis
Search a Correlation Between Lp(a) Rate and TFPI Activity in Obese Patients With Chest Pain Like Angina
Atherosclerotic cardiovascular disease is a leading cause of mortality in our countries. Clinically, symptoms could be chest pain suggesting stable angina.
- Trial name
- NCT01290770
- Testing
- blood sample
- Where
- 3 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Morbid Obesity
Effects of Morbid Obesity and Bariatric Surgery on Brain Inflammation, and Activation of Central Reward System
Background: The investigators have found that obesity and insulin resistance result in significantly increased brain insulin-stimulated glucose uptake, whereas in every other tissue glucose uptake is lower in the obese compared…
- Trial name
- BARIBRAIN (NCT04343469)
- Testing
- Bariatric Surgery (RYGB or LSG)
- Where
- 2 sites in Finland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Overweight and Obesity
Train Your Brain - Executive Function
The purpose of this research is to test if playing games designed to improve an individual's executive function can change their views about the types of foods they eat.
- Trial name
- NCT05938894
- Testing
- online games with various food images, online games with images of flowers and songbirds
- Where
- United States
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Obesity
Delta Healthy Sprouts: Intervention to Promote Maternal Weight Control and Reduce Childhood Obesity in the MS Delta
The Delta Healthy Sprouts Project is a randomized, controlled trial evaluating the enhancement of an existing Mother, Infant, and Early Childhood Home Visiting Program in 150 African American women in their early second trimester…
- Trial name
- NCT01746394
- Testing
- Parents as Teachers Enhanced, Parents as Teachers
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- USDA, Delta Human Nutrition Research Program
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