Clinical trials: Obesity Prevention, open to volunteers
Breast Cancer Risk, Cardiovascular Disease Risk
The RISC Registry--Risk Informed Screening Registry
Chronic diseases such as heart disease, cancer, and diabetes are the leading causes of death and disability in the United States. Six in ten adults have one chronic disease; 4 in 10 have two or more.
- Conditions
- Breast Cancer Risk, Cardiovascular Disease Risk, Cardiometabolic Risk, Diabetes
- Trial name
- RISC (NCT05848856)
- Testing
- Breast Cancer, Cardiometabolic, Cardiovascular Risk Screening and Follow up
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Precision Health Equity Initiative
Diet Intervention, Physical Activity Intervention
Obesity Prevention in Children and Young People Treated for Acute Lymphoblastic Leukaemia with ALLTogether
Background Leukaemia is the most common cancer in children with 800 diagnoses per year in England. To survive, children need strong treatments like chemotherapy and steroids given usually through clinical trials.
- Conditions
- Diet Intervention, Physical Activity Intervention, Standard Care Control
- Trial name
- BREVARY (NCT06846294)
- Testing
- Diet, Diet and physical activity
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Exeter
Childhood Obesity Prevention
Digitally Delivered Child Obesity Prevention for Parents in Home Visiting Programs
The goal of this clinical trial is to determine feasibility and acceptability of a digitally-based obesity prevention intervention for mothers of infants participating in a home visitation program.
- Trial name
- NCT07230808
- Testing
- digital intervention + home visiting curriculum, Home visiting curriculum
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cardiovascular Risk Factors, Insulin Resistance
Pilot Validation of the STELA Preventive Medicine Platform to Reduce Modifiable Health Risk Factors in Adults (CPM-STELA)
This study evaluates a comprehensive digital health platform called STELA, developed at the Center for Preventive Medicine (CPM) of AGEL Hospital Trinec-Podlesi in Czechia.
- Conditions
- Cardiovascular Risk Factors, Insulin Resistance, Obesity, Dyslipidemias
- Trial name
- CPM-STELA (NCT07551960)
- Testing
- STELA Digital Preventive Medicine Platform, Comprehensive Preventive Health Assessment
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Feasibility and Acceptability, Prevention Childhood Obesity
Starting Early to Prevent Obesity Using Telehealth (StEP OUT): Pilot RCT
The goal of this clinical trial is to test an online program that teaches healthy habits during pregnancy and infant to prevent early child obesity in Latino families.
- Trial name
- NCT07254065
- Testing
- StEP OUT, Infant Safety Education
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Northwell Health
Water, Child Nutrition
Water is K'é: Multi-level Intervention to Promote Healthy Beverage Choices Among Navajo Families
The goal of this clinical trial is to understand if a cultural intervention for Navajo families will improve healthy beverage habits, health outcomes, and family cohesion.
- Conditions
- Water, Child Nutrition, Family Dynamics, Healthy Nutrition
- Trial name
- NCT06020027
- Testing
- Water is K'é
- Where
- United States
- Volunteers
- 1,160 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obesity & Overweight, Prediabetes
Precision Nutrition for Obesity and Prediabetes Prevention in Under-supported Communities
This randomized controlled trial will evaluate the effectiveness of a culturally sensitive precision nutrition intervention for improving obesity- and diabetes-related outcomes among African American and Hispanic/Latino adults…
- Trial name
- PNOD (NCT07850531)
- Testing
- Precision Nutrition Intervention, Standard Nutrition Counseling
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Prairie View A&M University
Obesity, Childhood
MEditerranean LIfestyle in Pediatric Obesity Prevention
The current project is a randomized controlled multi-centre clinical trial, in a cohort of children aged 3 to 6 years at baseline and being at obesity risk.
- Trial name
- MELI-POP (NCT04597281)
- Testing
- Lifestyle intervention
- Where
- 3 sites in Spain
- Volunteers
- 738 people, healthy volunteers welcome
- Sponsor
- Luis A. Moreno Aznar
Obesity &Amp; Overweight, Bariatric Surgery
Proof of Concept in the Prevention of Post-bariatric Sarcopenia: Simulated Activation of the "Gravitostat"
Due to its mechanical and metabolic functions, muscle loss leads to resistance to weight loss during caloric restriction, particularly in patients with obesity.
- Trial name
- GRAVITOSARC (NCT07120685)
- Testing
- maintaining mechanical load
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Obesity and Obesity-related Medical Conditions, Obesity and Overweight
MAINTAIN (Mucosal AblatIoN Therapy After INcretins)
The purpose of this study is to assess the effect of gastric fundal mucosal ablation (GFMA) on weight trajectory following discontinuation of once-weekly semaglutide or tirzepatide in adults with obesity.
- Conditions
- Obesity and Obesity-related Medical Conditions, Obesity and Overweight, Obesity Prevention, Obesity Recidivism
- Trial name
- MAINTAIN (NCT06734312)
- Testing
- Gastric Fundal Mucosal Ablation (GFMA)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Dr. Christopher McGowan
Obesity Prevention
Pennington Generation Cohort
The Pennington Generation Cohort is an observational study comprised of Louisiana families. Families will be assessed at baseline for a variety of traits and behaviors, and then followed up over time to try to understand the role…
- Trial name
- NCT06849206
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Cardiovascular Diseases (CVD), Type 2 Diabetes
Epigenetics and NCD Prevention in Kazakhstan: Personalized Approaches and Biological Age Prediction
This study aims to enhance personalized and preventive care for non-communicable diseases (NCDs) in Kazakhstan by examining epigenetic factors, predicting biological age and reproductive function using machine learning, and…
- Conditions
- Cardiovascular Diseases (CVD), Type 2 Diabetes, Chronic Respiratory Diseases, Obesity (Disorder)
- Trial name
- NCT06953180
- Testing
- Genetic: DNA analysis
- Where
- Kazakhstan
- Volunteers
- 6,720 people, healthy volunteers welcome
- Sponsor
- Asfendiyarov Kazakh National Medical University
Kidney Transplant, Overweight or Obese Adults
Feasibility and Plausible Effectiveness of a Lifestyle Intervention in Kidney Transplant Recipients (HEAL)
The goal of this clinical trial is to learn whether if it is feasible to implement a study of patients receiving kidney transplantation, to learn if these patients will complete selective outcomes measurements, and to examine if…
- Conditions
- Kidney Transplant, Overweight or Obese Adults, Glucose Control
- Trial name
- HEAL (NCT06640179)
- Testing
- Standard medical care, Monitoring Contacts, Behavioral Sessions
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Kansas Medical Center
Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene
Evaluation of Impaired Mobility in Chronic Illness Constitution of a Cohort
Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern.
- Conditions
- Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene, Parkinson Disease, Chronic Obstructive Pulmonary Disease, Unspecified
- Trial name
- EVALMOB (NCT04375280)
- Testing
- Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Obesity, Adolescent, Healthy Nutrition
Wakaya: Rising Up for Choctaw Youth Health
Investigators will conduct a two-group randomized waitlist-control trial to assess the efficacy of the Wakaya: Rising Up for Choctaw Youth Health program on improving physical activity, reducing sedentary behaviors and improving…
- Conditions
- Obesity, Adolescent, Healthy Nutrition, Sedentary Behavior, Drug Abuse
- Trial name
- Wakaya (NCT05818384)
- Testing
- Wakaya: Rising Up for Choctaw Youth Curriculum
- Where
- 2 sites in United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Washington
Colorectal Cancer Prevention, Colorectal Adenoma
BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention
This research study is a prospective, single-arm clinical trial to assess the effect of a dietary intervention for more plant-based and less animal-based food intake on secondary bile acid production, gut microbiota, circulating…
- Trial name
- BILMOD (NCT07162337)
- Testing
- Increased Plant-Based Diet and Decreased Animal-Based Diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Weight Gain Trajectory, BMI
Evaluating Care Integration Between Pediatric Primary Care Providers and WIC Nutritionists
This study looks at whether using secure digital systems to share information between pediatric health care providers (during regular well-child visits) and social care providers (during regular visits with WIC nutritionists) can…
- Conditions
- Weight Gain Trajectory, BMI, Responsive Parenting, Diet Quality
- Trial name
- WEE Baby (NCT07494097)
- Testing
- Data integration around responsive parenting, Standard Care (in control arm)
- Where
- United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Penn State University
Childhood Obesity Pevention
School and Family-Based Obesity Prevention in Pakistani Primary School Children
Childhood obesity is increasing rapidly in Pakistan, but there are no large, high-quality studies testing ways to prevent it in schools.
- Trial name
- NCT07616232
- Testing
- School-Family Obesity Prevention Program (SFOPP)
- Where
- Pakistan
- Volunteers
- 2,340 people, healthy volunteers welcome
- Sponsor
- Central South University
Obesity & Overweight, Weight Loss
GLP-1 Medication & Behavioral Health Programs on Weight & Metabolic Outcomes: FLOURISH and THRIVE Prospective Cohort Study
This research program includes two coordinated prospective studies (FLOURISH and THRIVE) evaluating the real-world effectiveness of Noom's digital health programs on weight, cardiometabolic biomarkers, physiological health…
- Conditions
- Obesity & Overweight, Weight Loss, Preventative Health, Body Weight
- Trial name
- FLOURISH (NCT07588984)
- Testing
- Noom Weight, Free Tier, Education-only control
- Where
- United States
- Volunteers
- 2,310 people
- Sponsor
- Noom Inc.
Obesity
Cities for Better Health Childhood Obesity Prevention Initiative
This research project is part of the 'Cities for Better Health Childhood Obesity Prevention Initiative' (CBH COPI). The objective of the CBH COPI initiative is to develop, implement, and evaluate the effectiveness of a package of…
- Trial name
- CBH COPI (NCT06855563)
- Testing
- Community-based intervention packages
- Where
- 6 sites in Australia, Brazil and 4 more
- Volunteers
- 36,000 people
- Sponsor
- Novo Nordisk A/S