Clinical trials: Obesity and Cardiovascular Risk
Type 2 Diabetes, Obesity
A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk.
- Conditions
- Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight
- Trial name
- ACHIEVE-4 (NCT05803421)
- Testing
- Orforglipron, Insulin Glargine
- Where
- 358 sites in United States, Argentina and 14 more
- Volunteers
- 2,749 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type II, Heart Disease
Micro-Clinic Obesity and Metabolic Risk Prevention Program
The purpose of this randomized trial is to study the efficacy of a novel social propagation intervention which integrates social network induction with health education for weight and metabolic control among patients with type 2…
- Conditions
- Diabetes Mellitus, Type II, Heart Disease, Obesity, Hypertension
- Trial name
- NCT01651065
- Testing
- Microclinic Diabetes Education Program, Control
- Where
- United States
- Volunteers
- 494 people
- Sponsor
- Microclinic International
Cardiovascular Disease, Dietary Modification
Effects of Reduction in Saturated Fat on Cholesterol and Lipoproteins in Lean and Obese Persons
A randomized controlled clinical trial comparing the effect of substitution of unsaturated fat from nuts and oils for saturated fat from meat and dairy foods on serum lipids in normal weight and obese subjects with elevated LDL…
- Conditions
- Cardiovascular Disease, Dietary Modification, Cardiovascular Risk Factors
- Trial name
- NCT02589769
- Testing
- unsaturated fat for saturated fat, saturated fat
- Where
- Norway
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Prediabetic State, Obesity
The PRE-D Trial: Effect of Dapagliflozin, Metformin and Physical Activity in Pre-diabetes
The overall objective is to compare the short-term (3 months) effectiveness of three glucose-lowering interventions (dapagliflozin, metformin and physical activity) on glucose variability, body composition, and cardiometabolic…
- Trial name
- NCT02695810
- Testing
- Dapagliflozin, Metformin, Exercise
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Obesity, Cardiovascular Diseases
High-intensity Exercise Training or Multidisciplinary Treatment in Extremely Obese Adolescents
The aim of the present study was to determine the effects of a multidisciplinary approach and intensity-controlled interval training on cardiovascular risk factors in overweight adolescents
- Trial name
- NCT00682266
- Testing
- intensity controlled interval training (AIT), Multidisciplinary approach (MTG)
- Where
- Norway
- Volunteers
- 54 people
- Sponsor
- Norwegian University of Science and Technology
Cardiovascular Diseases, Heart Diseases
Effect of Exercise on Elevated C-reactive Protein Concentrations in Formerly Inactive Adults
The purpose of this study is to determine the effect of exercise training on elevated C-reactive protein (CRP) concentrations, an indicator of inflammation, in initially inactive women and men.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity
- Trial name
- NCT00113061
- Testing
- Exercise
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Renal Transplantation
Interaction Between Rimonabant and Cyclosporine and Tacrolimus
The major cause of premature death in renal transplant recipients is cardio-vascular disease. In addition, obesity is becoming a major problem in this patient population.
- Trial name
- RIMONA-PILOT (NCT00525681)
- Testing
- cyclosporine A, tacrolimus
- Where
- Norway
- Volunteers
- 18 people
- Sponsor
- University of Oslo School of Pharmacy
Overweight
Effects of Medium Chain Triglyceride Oil, Versus Olive Oil, for Weight Loss
The primary aim of this research project is to determine whether the incorporation of food products containing medium chain triglyceride (MCT) oil in a weight-loss program results in a different degree of weight-loss and total…
- Trial name
- Muffin (NCT00529919)
- Testing
- Weight loss
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obesity, Cardiovascular Risk Factor
Healthy Nordic Foods to Prevent Cardiometabolic Risk in Obese Subjects
This project will examine whether long-term consumption of healthy Nordic foods can maintain a healthy weight also after weight loss, and decrease abdominal fat accumulation and cardiometabolic risk.
- Conditions
- Obesity, Cardiovascular Risk Factor, Diet Modification
- Trial name
- NCT03102853
- Testing
- Nordic diet, Control diet
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lund University
Pre-Diabetic, Overweight
Feasibility of an Interval Exercise and Nutrition Intervention to Reduce Cardiovascular Disease Risk Factors
Purpose : Test the feasibility (acceptability, adherence) of a home-based interval exercise training (IET) and nutrition program, as well as its preliminary effects on resting heart rate, blood pressure, fasting glucose, HDL…
- Conditions
- Pre-Diabetic, Overweight, Obesity
- Trial name
- IETnutrition (NCT02482922)
- Testing
- Exercise & Dietary Supplement
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cardiovascular Diseases
EVOC - EVs in Obesity and Cardiometabolic Disease
The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and diseases that affect the heart…
- Trial name
- EVOC (NCT06408961)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Overweight, Obesity
The Impact of Stationary Combined Exercise on Adiponectin and Hs-CRP Levels in Overweight Women
This study looked at whether a specific exercise program can improve inflammatory markers in overweight young women. We tested an eight-week, circuit-style exercise program that combines aerobic and resistance activities (e.g.…
- Conditions
- Overweight, Obesity, Inflammation, Low-Grade, Cardiovascular Diseases, Risk Factors
- Trial name
- SCEX-ADCRP (NCT07230873)
- Testing
- Combined Exercise Group, No Structured Exercise
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Xianjie Zheng
Hypercholesterolemia, Obesity
The Impact of Using a Smartphone Health Application in the Improvement of Cardiovascular Disease Risk Factors
This study investigates the effectiveness of Mobile health application (mHealth apps) in the improvement of cardiovascular disease risk factors including metabolic and behavioral factors.
- Conditions
- Hypercholesterolemia, Obesity, Diabetes Mellitus, Hypertension
- Trial name
- NCT05798442
- Testing
- smartphone health application (Opulse)
- Volunteers
- 410 people
- Sponsor
- Sultan Qaboos University
Hypertension, Elevated Cholesterol
Effects of a 4-week Raw, Plant-based Diet on Anthropometric and Cardiovascular Risk Factors
This study evaluates the effects of a prescribed 4-week raw, plant-based dietary intervention in the treatment of excess body weight, hypercholesterolemia, and hypertension in the clinical setting.
- Conditions
- Hypertension, Elevated Cholesterol, Overweight and Obesity
- Trial name
- NCT03134235
- Testing
- Dietary Intervention
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Texas Woman's University
Cardiovascular Risk Factors, Hyperlipidemia
European Study of Cardiovascular Risk
The main objective of this study is to describe the management of patients with cardiovascular risk factors in primary prevention among different European countries.
- Conditions
- Cardiovascular Risk Factors, Hyperlipidemia, Hypertension, Diabetes
- Trial name
- EURIKA (NCT00882336)
- Where
- 775 sites in Austria, Belgium and 10 more
- Volunteers
- 7,200 people
- Sponsor
- AstraZeneca
Severe Obesity
Effect of Nutritional Intervention and Olive Oil in Severe Obesity
Obesity is a worldwide epidemic with increasing prevalence, specially severe obesity (Body Mass Index (BMI) ≥ 35 kg/m2). It is a multifactorial disease that involves genetic and environmental factors that lead to increased…
- Trial name
- NCT02463435
- Testing
- Nutritional intervention, Nutritional intervention plus olive oil, Olive oil
- Where
- Brazil
- Volunteers
- 229 people
- Sponsor
- Universidade Federal de Goias
Obesity
Obesity, Weight Loss, and Cardiovascular Disease Risk
The goal of the study is to define the roles played by resistance to insulin-mediated glucose disposal (insulin resistance) and circulating plasma insulin concentrations in: 1) ability to lose weight; 2) reduction of risk for…
- Trial name
- NCT00186459
- Testing
- Hypocaloric diet of varying macronutrient composition
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Stanford University
Metabolic Syndrome, Diabetes
Cardiovascular-Kidney-Metabolic Syndrome in Shanghai Zicitizens
The main purpose of this study is to conduct follow-up assessments and update the cardiorenal outcomes among the STONE cohort that was established during 2016-2017.
- Conditions
- Metabolic Syndrome, Diabetes, Obesity and Overweight, Hypertension
- Trial name
- NCT07043166
- Where
- China
- Volunteers
- 4,094 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Body Weight, Obesity
Meta-analysis of the Nordic Dietary Pattern on Cardiometabolic Risk and Cardiovascular Outcomes
The Nordic Diet is a dietary pattern rich in traditional Nordic foods, including berries, grains, and fatty fish common in northern Europe.
- Conditions
- Body Weight, Obesity, Overweight and Obesity, Obesity, Abdominal
- Trial name
- NCT04094194
- Testing
- Nordic diet
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cardiovascular Risk Factor, Obesity
Essential Amino Acids and High Intensity Interval Training
Purpose: The primary purpose is to determine the combined effects of essential amino acids (EAA) supplementation and high intensity interval training (HIIT) on body composition, muscle characteristics, and muscle architecture in…
- Trial name
- NCT04080102
- Testing
- High Intensity Interval Training, Essential Amino Acid, High intensity interval training and essential amino acid supplement
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill