Clinical trials: Obesity in Diabetes
Type 2 Diabetes Mellitus, Obese
Ox Bile- Conjugated Bile Acids Sodium in Type II Diabetes Mellitus
To study the effect of an ileocolonic formulation of ox bile extract on insulin sensitivity, postprandial glycemia and incretin levels, gastric emptying, body weight and fasting serum FGF-19 (fibroblast growth factor) levels in…
- Conditions
- Type 2 Diabetes Mellitus, Obese, Overweight
- Trial name
- NCT02871882
- Testing
- Gastric Emptying test, Mixed Oral Glucose Tolerance test, Conjugated bile acids sodium
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Obesity, Hypertension
Irbesartan Versus Amlodipine: The OBI Study
Objective: 1. To study the effectiveness of irbesartan 300mg and amlodipine 10 mg in 24h ambulatory blood pressure values in obese subjects 2. To study the drug specific effect in arterial stiffness 3.
- Trial name
- OBI (NCT00987662)
- Testing
- Irbesartan, Amlodipine
- Where
- Greece
- Sponsor
- Aristotle University Of Thessaloniki
Metabolic Syndrome
Genetic Assessment of the Patients With Metabolic Syndrome
Metabolic syndrome is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. The exact mechanisms of the complex pathways of metabolic syndrome are not yet completely known.
- Trial name
- GENMetS (NCT01268696)
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Impaired Glucose Tolerance, Pre-diabetes
Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
The purpose of the study is to determine the role of beta-cell function and insulin resistance in the development of impaired glucose tolerance (IGT) and type 2 diabetes in children and adolescents who have an increased risk of…
- Conditions
- Impaired Glucose Tolerance, Pre-diabetes, Childhood Obesity, Insulin Resistance
- Trial name
- NCT00536250
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Yale University
Obesity & Overweight, Diabetes Mellitus, Type 2
Chinese Overweight/Obesity Cohort: Metabolic & Comorbidity Risks
This is a nationwide, multi-center, long-term follow-up study of overweight and obese adults in China. The study aims to recruit approximately 26,000 participants across 39 hospitals to better understand how body weight affects…
- Conditions
- Obesity & Overweight, Diabetes Mellitus, Type 2, Hypertension, Non-alcoholic Fatty Liver Disease (MASLD)
- Trial name
- NCT07884903
- Testing
- No intervention; observational assessment only
- Where
- China
- Volunteers
- 25,974 people
- Sponsor
- Shanxi Bethune Hospital
Type 2 Diabetes, Obesity
Research on Effects of Acute Consumption of Nuts in Obese Diabetic Women
Obesity is a multifactorial disease in which excess body fat accumulation increases the risk of other chronic diseases such as type 2 diabetes.
- Trial name
- REACT-NUT (NCT06710340)
- Testing
- Nuts in the first meeting, Nuts in the second meeting
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Raquel Ballarin
PreDiabetes, Obesity
Effect of Nutritional Supplements on Clinical Outcomes in Patients With Prediabetes and Obesity
This study aims to improve blood glucose and weight in patients with prediabetes and obesity through health education, nutritional supplement interventions, clinical evaluation, and close clinical follow-up.100 patients with…
- Trial name
- NCT05273840
- Testing
- Ivital Control, lifestyle intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ningbo No. 1 Hospital
Type 2 Diabetes, NAFLD
POLY-unsaturated Fatty Acids in the Preservation of Dietary Effects on Hepatosteatosis and Energy Metabolism in Type 2 Diabetes
Basic treatment of type 2 diabetes should focus on diet, physical activity and lifestyle. Nevertheless, in early and late stage of T2DM, lifestyle intervention is mostly substituted by pharmacological intervention, although…
- Conditions
- Type 2 Diabetes, NAFLD, Obesity, Dyslipidemia
- Trial name
- POLYPHEM (NCT03047668)
- Testing
- diet with/without supplementation
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- German Institute of Human Nutrition
Type 2 Diabetes Mellitus
Multiple Ascending Dose Study in Healthy Male Subjects and Overweight to Obese Male and Female Type 2 Diabetes Mellitus (T2DM) Patients
Primary Objective: To assess in healthy adult male subjects: The tolerability and safety of 21-day repeated subcutaneous (SC) doses of SAR425899 including two up titration steps.
- Trial name
- NCT02411825
- Testing
- SAR425899, metformin
- Where
- Germany
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Sanofi
Overweight , Obesity, Type 2 Diabetes Mellitus (T2DM)
Phase 1 Clinical Study of MWN105 Injection in Healthy Chinese Volunteers
This study is a randomized, double-blind, placebo-controlled, single-dose and multiple-dose, dose-escalation phase I clinical trial, aiming to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic…
- Conditions
- Overweight , Obesity, Type 2 Diabetes Mellitus (T2DM), MASH - Metabolic Dysfunction-Associated Steatohepatitis
- Trial name
- NCT07801313
- Testing
- MWN105
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Non-Insulin-Dependent Diabetes Mellitus, Obesity
Efficacy and Safety of ATL-962 in Obese Diabetics
The purpose of this study is to investigate whether ATL-962 induces weight loss in diabetic patients and whether its safety and tolerability profile is superior to that of orlistat in such patients
- Trial name
- NCT00156897
- Testing
- ATL-962, Orlistat
- Where
- 37 sites in Denmark, Finland and 3 more
- Volunteers
- 600 people
- Sponsor
- Alizyme
Obesity, Metabolic Syndrome
Effects of Leptin Replacement in Children
To assess the endocrine and immune effects of leptin replacement in leptin-deficient children, from a consanguineous family. The hypothesis is that leptin replacement will have significant effects on endocrine function.
- Conditions
- Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT00659828
- Testing
- Recombinant methionyl human leptin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Miami
Pre-diabetes, Obesity
The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics
The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant human research participants, and this is further…
- Trial name
- NCT05051436
- Testing
- Mirabegron 50 MG, Tadalafil 10 MG
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Obesity, Type 2 Diabetes Mellitus
Effects of Mulberry Leaves on Glycemic Control in Patients With Obesity and Patients With Type 2 Diabetes
A 12-week, open-label, randomized, controlled trial investigating effect of mulberry leaves plus lifestyle intervention on glycemic control compare with lifestyle intervention alone in patients with obesity and patients with type…
- Trial name
- NCT04691219
- Testing
- Mulberry leaves powder, Diet control
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Chulalongkorn University
Obesity, Diabetes
Effects of Various Bariatric Surgical Procedures on Intestinal TRL Metabolism in Obese Type 2 Diabetic Patients
Rational: The world and french epidemic of obesity and diabetes represents a major problem of public health. The prevalence in France, in the adult population, is 15 % corresponding to 6.9 million people for obesity and 6 %…
- Trial name
- MISTRAL (NCT02332434)
- Testing
- stable isotope enrichment methodology (5,5,5-D3-L-Leucine)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
COVID19, Diabetes Mellitus
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
The disease caused by SARS-CoV-2, has derived a pandemic in which its evolution and complications depend on the immune capacity of the host.
- Conditions
- COVID19, Diabetes Mellitus, Hypertension, Obesity
- Trial name
- NCT04507867
- Testing
- Nutritional support system (NSS), Conventional nutritional support designed by hospital nutritionists
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Anahuac University
Overweight and Obesity, Pre-Diabetes
Stepping Into Lifestyle Changes
The purpose of this study is to promote healthy weight loss among African American women, age 30 or older, who are pre-diabetic and/or have high blood pressure and who live, work, or worship in select rural communities throughout…
- Conditions
- Overweight and Obesity, Pre-Diabetes, High Blood Pressure
- Trial name
- SILC (NCT05625321)
- Testing
- Educational Group Weight Loss Classes, Home Gardening Intervention
- Where
- 2 sites in United States
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cardiomyopathy
Reversal of Obese/Diabetic Cardiomyopathy After Gastric Bypass Surgery
The overall purpose of this study is to evaluate the effect of gastric bypass surgery-induced weight loss on the heart's function and on fat deposits in the heart muscle.
- Trial name
- DRTC (NCT01067209)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
Overweight, Obesity
Stevia Extract and Glucose Homeostasis
This study aims to assess the effect of stevia extract on postprandial glucose and insulin levels in overweight and obese adults when compared to sugar and water.
- Trial name
- NCT04335565
- Testing
- sugar replacements
- Where
- United Kingdom
- Sponsor
- Liverpool Hope University
Diabetes Mellitus, Type 2, Obesity
Weight Loss Clinical Decision Support
Despite steady increases in obesity prevalence, the more than 12 million obese U.S. adults with type 2 diabetes (T2DM) and severe obesity encounter a number of barriers to adopting effective surgical and pharmaceutical…
- Trial name
- WL-CDS (NCT05198765)
- Testing
- BMI-CDS
- Where
- United States
- Volunteers
- 10,120 people
- Sponsor
- HealthPartners Institute
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