Clinical trials: Obesity in Diabetes
Type 2 Diabetes, Obese Diabetics
The Role of CYP8B1 Polymorphisms in Modulating the Biochemical Pathways Affected by SGLT2 Inhibitors in T2DM and Obesity
This study explores the long-term effects of dapagliflozin and empagliflozin on CYP8B1 gene expression and a range of metabolic, oxidative, and inflammatory biomarkers in obese patients with Type 2 Diabetes Mellitus (T2DM).
- Conditions
- Type 2 Diabetes, Obese Diabetics, Obese Patients (BMI ≥ 30 kg/m²)
- Trial name
- CYP8B1-SGLT2-T (NCT07120828)
- Testing
- Empagliflozin (oral), Dapagliflozin (DAPA), Metfomin
- Where
- Iraq
- Volunteers
- 260 people
- Sponsor
- Erbil Polytechnic University
Overweight and Obesity, Diabetes Mellitus, Type 2
AI-Driven Metabolic Cohort in Overweight/Obese Chinese Adults
The goal of this observational cohort study is to delineate the five-year dynamic trajectories of metabolic phenotypes in Chinese adults with overweight or obesity, with or without type 2 diabetes, focusing on transition rates…
- Conditions
- Overweight and Obesity, Diabetes Mellitus, Type 2, Prediabetic State, Metabolic Syndrome
- Trial name
- COMET-AI (NCT07584330)
- Where
- China
- Volunteers
- 2,800 people
- Sponsor
- Zhujiang Hospital
Chronic Liver Disease, Alcohol Use Disorder
Nottingham Community Liver Biomarkers Cohort
Deaths due to advanced liver scarring (liver cirrhosis) continue to increase, and liver disease is now the 3rd leading cause of premature death in the United Kingdom.
- Conditions
- Chronic Liver Disease, Alcohol Use Disorder, Type 2 Diabetes, Persistently Elevated ALT
- Trial name
- NCT02037867
- Testing
- Fibrosis Biomarkers
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- University of Nottingham
Obesity, Diabetes
SOAR-2: Intervening in Obesity Through Reduction of Dietary Branched Chain Amino Acids
One of the primary risk factors for the development of diabetes is obesity. While even moderate weight loss achieved by dieting can lead to improvements in metabolic health, reduced-calorie diets are notoriously difficult to…
- Trial name
- SOAR-2 (NCT04424537)
- Testing
- Control diet, Low branched-chain amino acids(BCAA) diet, Low protein diet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Diabetes Type 2, Diabetes Mellitus
Cryovagotomy Diabetes Trial
The pilot study will assess the feasibility and efficacy of cryoablation procedure to freeze the vagus nerve in obese patients with type 2 diabetes. Aim 1 will focus on changes in glycemic control.
- Conditions
- Diabetes Type 2, Diabetes Mellitus, Obesity
- Trial name
- NCT04276051
- Testing
- Cryoablation of the Vagus Nerve, Lifestyle Intervention
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Emory University
Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH)
How Abnormal Function of Fat Tissue in Type 1 Diabetes Contributes to Fat in the Liver
Steatotic liver disease associated with metabolic dysfunction (MASLD) is a disease caused by excess fat storage in the liver. Excessive fat delivery to the liver and MASLD typically occurs in people with abdominal obesity and…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH), Type 1 Diabetes Mellitus
- Trial name
- AGL14 (NCT07133854)
- Testing
- Imaging PET/MRI, Stable isotope infusions, meal test
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Diabetes Mellitus Type 2, Diabetes Mellitus Type 2 in Obese
The Effects of Nutritional Intervention on Health Parameters in Participants With Type 2 Diabetes Mellitus
The goal of this clinical trial is to evaluate the effects of nutritional intervention on anthropometric, biochemical and cardiovascular parameters in participants with type 2 diabetes mellitus.
- Conditions
- Diabetes Mellitus Type 2, Diabetes Mellitus Type 2 in Obese, Diabetes, Diabetes Mellitus Non-insulin-dependent
- Trial name
- NCT06235762
- Testing
- Nutritional Intervention
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Sao Jose do Rio Preto Medical School
Type 2 Diabetes, Obesity
The VALIDATE-D Study
The purpose of this study is to evaluate whether vitamin D receptor agonist therapy lowers renin-angiotensin system activity.
- Trial name
- VALIDATE-D (NCT01635062)
- Testing
- Calcitriol
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Disease stage3, Chronic Kidney Disease stage4
Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD
Chronic kidney disease (CKD) is the progressive damage to kidney function, associated with an increased risk of cardiovascular diseases, such as stroke or myocardial infarct, particularly in the most severe stages of CKD, in…
- Conditions
- Chronic Kidney Disease stage3, Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 1, Chronic Kidney Disease Stage 2
- Trial name
- ADIPO-CKD (NCT07309094)
- Testing
- GLP-1 receptor agonist, SGLT2 inhibitor, Tirzepatide
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Cardenal Herrera University
Schizophrenia, Obesity
Multi-component Intervention for Diabetes in Adults With Serious Mental Illness
Persons with schizophrenia and other serious mental illnesses have a high risk for type 2 diabetes and an increased risk of premature mortality compared to the general population.
- Conditions
- Schizophrenia, Obesity, Diabetes, Lifestyle Risk Reduction
- Trial name
- MIDAS (NCT03627377)
- Testing
- Multi-component Intervention for Diabetes in Adults with Serious Mental Illness
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of California, San Diego
Type 2 Diabetes Mellitus
Effect of South Beach Diet (SBD™) Using SBD™ Products Compared to the American Diabetic Association (ADA) Diabetes Meal Plan on Body Weight and Satiety in Diabetic Women
The purpose of this study is to examine the effectiveness of the South Beach Diet and products compared to the American Diabetic Association Diabetes Meal Plan.
- Trial name
- NCT00931034
- Testing
- South Beach Diet with South Beach Diet Products, American Diabetes Association Diabetes Meal Plan
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- Mondelēz International, Inc.
Glucose Metabolism Disorders, Diabetes Mellitus, Type 2
Evaluating the Efficacy and Safety of Empagliflozin Addition to Insulin and Oral Antidiabetic Medication (OAD) Regimen in Poorly Controlled Type 2 Diabetes and Obese Patient
The primary aim of this study is to assess the impact of incorporating Empagliflozin, an oral sodium-glucose co-transporter 2 (SGLT2) inhibitor, into the existing therapeutic regimen of Insulin+Metformin+Dipeptidyl peptidase 4…
- Conditions
- Glucose Metabolism Disorders, Diabetes Mellitus, Type 2, Hypoglycemic Agents, Empagliflozin
- Trial name
- NCT06145360
- Testing
- Empagliflozin 10 MG, Insulin+Metformin+DPP4 inhibitor (DPP4I)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- SINA Health Education and Welfare Trust
Obesity, Type 2 Diabetes
Evaluation of Intra-Abdominal Fat in Patients With Type 2 Diabetes Using a Non-Invasive Method
The main aim of this study is to compare 2 different measurements of visceral fat that can be easily used in clinical practice (waist circumference versus bioelectric impedance) in relation to known risk factors of coronary…
- Conditions
- Obesity, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT01283113
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Joslin Diabetes Center
Pre Diabetes, Obesity
Study of the Food Order Behavioral Intervention in Prediabetes
Investigators have previously shown that eating carbohydrates after protein or vegetables resulted in reduced glucose and insulin excursions over 180 min in patients with T2DM and in individuals with prediabetes as well.
- Trial name
- NCT03896360
- Testing
- Food order behavioral intervention plus standard care, Standard Care
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Weill Medical College of Cornell University
Type 2 Diabetes Mellitus, Cardiovascular Disease
Effects of Liraglutide in Young Adults With Type 2 DIAbetes (LYDIA)
There are recent advances in therapies for the treatment of Type 2 Diabetes Mellitus (T2DM) which include the GLP1 analogues and the DPP IV inhibitors.
- Trial name
- LYDIA (NCT02043054)
- Testing
- Liraglutide, Sitagliptin
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Leicester
Metabolic Syndrome, Insulin Resistance
Study of How Exercise or Weight Loss Effects Metabolic Syndrome
The Metabolic Syndrome (MS) is prevalent in the American population and is strongly associated with premature coronary disease. Lifestyle intervention, primarily exercise and dietary changes, are foundational treatment strategies…
- Conditions
- Metabolic Syndrome, Insulin Resistance, Obesity
- Trial name
- NCT00292994
- Testing
- Exercise, Weight Loss
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Yankton Clinical Research Alliance
Host and Microbiome, Pregnancy Outcomes
Human Genes and Microbiota in Early Life
The long-term goal of the Human Genes and Microbiota in Early Life (HuGME) is to explore the short- and long-term effects of maternal microbiota during pregnancy and the microbiota colonization of their offspring early in life…
- Conditions
- Host and Microbiome, Pregnancy Outcomes, Pregnancy Complications, Neurodevelopmental Disorders
- Trial name
- HuGME (NCT06926166)
- Testing
- No intervention
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Lifestyle-related Condition, Obesity
MyLife: A Digital Health Coaching Program
Lifestyle behaviors such as sleep, diet, and physical activity, are implicated in a number of chronic conditions including hypertension, obesity, diabetes, heart failure, and obstructive sleep apnea.
- Conditions
- Lifestyle-related Condition, Obesity, Sedentary Lifestyle, PreDiabetes
- Trial name
- NCT03529903
- Testing
- Health Coaching
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Type 2 Diabetes, Obesity
Lifestyle Intervention in Obese Non-diabetic Adults With a Family History of Diabetes.
The aim of this study is to investigate weather gradual weight loss achieved with healthy lifestyle changes influence hormonal factors affecting appetite and blood glucose control in obese people without presence of diabetes.
- Trial name
- NCT00993603
- Testing
- 8-month group lifestyle programme
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Royal Bournemouth Hospital
Diabetes Mellitus, Intrahepatic Cholestasis of Pregnancy
Magnetic Resonance Imaging and Thermal Imaging of Adiposity in Neonates of Women With Metabolic Diseases
There is limited knowledge about the extent of the impact of maternal metabolic diseases (MD) and/or alterations in maternal serum lipid content upon neonatal lipid distribution and phenotypes.
- Conditions
- Diabetes Mellitus, Intrahepatic Cholestasis of Pregnancy, Metabolic Disease
- Trial name
- MRI-TIME (NCT04890886)
- Testing
- Thermal imaging, Echocardiogram, ECG
- Volunteers
- 80 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
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