Clinical trials: Obesity in Diabetes
Obesity and Diabetes Mellitus, Type 2
A Study to Evaluate the Safety and Efficacy of JNJ-64565111 in Severely Obese Participants With Type 2 Diabetes Mellitus
The purpose of this study is to assess the effects of JNJ-64565111 compared with placebo in severely obese Type 2 Diabetes Mellitus (T2DM) participants after 12 weeks of treatment on: the percentage change in body weight from…
- Trial name
- NCT03586830
- Testing
- JNJ-64565111 Dose Level 1, JNJ-64565111 Dose Level 2, JNJ-64565111 Dose Level 3
- Where
- 27 sites in United States
- Volunteers
- 196 people
- Sponsor
- Janssen Research & Development, LLC
Obesity, Nonalcoholic Fatty Liver
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity.
- Conditions
- Obesity, Nonalcoholic Fatty Liver, Diabetes Type 2, Healthy
- Trial name
- ATM (NCT06335771)
- Testing
- Dietary consultation weight loss intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Vitamin D Deficiency, Diabetes Mellitus
Vitamin D Supplementation on Metabolic Syndrome Indicators Among Older Adults, Alborz Province, Iran
General objective: To assess the effect of vitamin D supplementation on metabolic syndrome among food insecure and vitamin D deficient older adults in Karaj city, Alborz province in Iran.
- Conditions
- Vitamin D Deficiency, Diabetes Mellitus, Hypertension, Lipid Metabolism Disorders
- Trial name
- NCT03193944
- Testing
- D-vitin, soft gelatin capsule (vitamin D3,50000 IU)
- Where
- Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Alborz Medical University
Type I Diabetes
Obesity and Metabolic Surgery in Patients With Type I Diabetes
Obesity is the indication for bariatric surgery in type I diabetes. Interestingly postsurgery the patients improve remarkable in their need for insulin, not only in the daily total insulin dosage but also in the dosage of IU per…
- Trial name
- NCT02612493
- Testing
- Obese patients with type I diabetes
- Volunteers
- 16 people
- Sponsor
- Sana Klinikum Offenbach
Diabetes, Obesity
The Effect of Dairy and Non-dairy Alternatives on Satiety and Post-meal Glycemia in Healthy Young Adults
This study investigates the effects of commercially-available dairy (1% cow's milk and yogurt beverage) and non-dairy alternatives (almond and soy beverages) on satiety and post-meal blood glucose.
- Trial name
- NCT02491814
- Testing
- 1% M.F. Milk, Yogurt Beverage, Soy Beverage
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Metabolic Syndrome, Diabetes
Cardiovascular-Kidney-Metabolic Syndrome in Shanghai Zicitizens
The main purpose of this study is to conduct follow-up assessments and update the cardiorenal outcomes among the STONE cohort that was established during 2016-2017.
- Conditions
- Metabolic Syndrome, Diabetes, Obesity and Overweight, Hypertension
- Trial name
- NCT07043166
- Where
- China
- Volunteers
- 4,094 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Diabetes Mellitus Type 2, Prader Willi Syndrome
Liraglutide Use in Prader-Willi Syndrome
Liraglutide is a glucagon like peptide -1 (GLP-1) agonist, which is approved for use in patients with type 2 diabetes. Studies of liraglutide have shown an appetite suppressive effect and has been associated with weight loss in…
- Trial name
- NCT01542242
- Testing
- Liraglutide
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Vancouver General Hospital
Overweight and Obesity, Insulin Resistance
DHA Supplements to Improve Insulin Sensitivity in Obese Pregnant Women (The Omega-3 Pregnancy Study)
Women with excess adiposity while pregnant are more likely to develop gestational diabetes and high blood pressure during pregnancy than women of healthy weights.
- Conditions
- Overweight and Obesity, Insulin Resistance, Diabetes, Gestational, Hypertension in Pregnancy
- Trial name
- NCT00865683
- Testing
- DHA Supplements
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peer Support and Chronic Disease, Obesity
Peer Support Dyads in Churches
The purpose of this study is to explore how working with a partner can influence participation in a church wellness program. There are many different types of church wellness programs.
- Conditions
- Peer Support and Chronic Disease, Obesity, Type II Diabetes, Cardiovascular Disease
- Trial name
- NCT03463941
- Testing
- Peer Support Dyad Intervention
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duke University
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function.
- Trial name
- NCT06383390
- Testing
- Retatrutide
- Where
- 742 sites in United States, Argentina and 25 more
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
Overweight, Obesity
Effect of Consuming Beans for One Month on Blood Lipids, Satiety, Intake Regulation and Body Weight
This project investigates the effect of regular consumption of commercially available processed white beans (5 cups per week) on food intake, body weight, blood pressure, satiety hormones and glycemic response over a 4-week…
- Conditions
- Overweight, Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT00741923
- Testing
- navy beans added to regular diet
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Toronto
Obesity
Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight.
- Trial name
- MARITIME-1 (NCT06858839)
- Testing
- Maridebart Cafraglutide
- Where
- 243 sites in United States, Argentina and 15 more
- Volunteers
- 3,853 people
- Sponsor
- Amgen
Diabetes (DM), Physical Activity
Effect of Regular Physical Activity in Normal-Weight Individuals With Type 2 Diabetes and Abdominal Obesity
Individuals with T2DM accompanied by abdominal obesity tend to experience worse clinical outcomes. To identify modifiable factors that may improve these outcomes, the investigators conducted a retrospective cohort study using…
- Trial name
- PA-NormalWtDM (NCT07071545)
- Testing
- Regular physical activity, No regular physical activity
- Volunteers
- 249,247 people
- Sponsor
- Samsung Medical Center
Type 2 Diabetes, Obesity
Long-term Effects of Lifestyle Intervention During Pregnancy in High Risk Women and in Their Offspring - Role of Environmental, Genetic and Epigenetic Factors
SUBJECTS: All participants in the RADIEL-study (2008-2011) who delivered (n=535), will be invited to this follow-up study, with their children (age 3-5 years) and the father.
- Conditions
- Type 2 Diabetes, Obesity, Metabolic Syndrome
- Trial name
- NCT02048839
- Where
- Finland
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Glucose Intolerance, Overweight and Obesity
GLP-1 Therapy: The Role of IL-6 Signaling and Adipose Tissue Remodeling in Metabolic Response
This project investigates the anti-obesity mechanisms of glucagon-like peptide-1 (GLP-1) analogs, which are used in the treatment of human obesity and diabetes mellitus.
- Conditions
- Glucose Intolerance, Overweight and Obesity, Drug Effect, Adiposity
- Trial name
- NCT04387201
- Testing
- Cyanocobalamin, Dulaglutide
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiovascular Risk Factor, Prediabetes
Active You: Feasibility of a Unique Physical Activity Program to Prevent Diabetes and Heart Disease
Individuals who are overweight/obese are more vulnerable to type 2 diabetes (T2D). Current evidence suggests that PA, even without dietary prescription, can be efficacious in preventing T2D.
- Conditions
- Cardiovascular Risk Factor, Prediabetes, Overweight and Obesity, Sedentary Behavior
- Trial name
- NCT04621045
- Testing
- The Physical Activity for The Heart (PATH) intervention, Be Active Your Way Booklet
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Hypertension, Diabetes
A Longitudinal Cohort Study to Evaluate Cardiovascular Risk Factors and Disease in Haiti
Investigators will establish a longitudinal cohort of ~3,000 adults >18 years in Port-au-Prince using multistage random sampling, and follow them longitudinally to evaluate the prevalence and incidence of cardiovascular disease…
- Conditions
- Hypertension, Diabetes, Obesity, Kidney Diseases
- Trial name
- NCT03892265
- Testing
- Observational Study
- Where
- Haiti
- Volunteers
- 3,005 people
- Sponsor
- Weill Medical College of Cornell University
Obesity, Diabetes Mellitus, Type 2
Dairy and Non-Dairy Alternatives Comparative on Metabolic Outcomes
The purpose of this study is to compare the acute effects of a single serving of dairy and non-dairy alternatives on post-treatment and post-meal glycemia, appetite, plasma amino acid concentrations, and gastrointestinal hormones…
- Trial name
- NCT05919667
- Testing
- Dairy and plant-based dairy beverages and solids
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Pre Diabetes, Obesity
Effects of Different Types of Carbohydrates in Snacks and Beverages on Glycemia, Insulinemia and Appetite.
The aim of the study is to describe the glycemic, insulinemic and appetitive responses to liquid and solid foods where either soluble fiber or maltodextrin are used as the carbohydrate substrate.
- Trial name
- NCT03279107
- Testing
- Soluble corn fiber, maltodextrin
- Where
- Singapore
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- JeyaKumar Henry
Obesity
HRS9531 Controls Weight Regain in Obese Subjects
This is a single-center, double-blinded, randomized, placebo-controlled phase II study to explore the effectiveness, safety and energy balance mechanism of low-frequency continuous subcutaneous injection of HRS9531 to inhibit…
- Trial name
- NCT06287437
- Testing
- HRS9531
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Shanghai Zhongshan Hospital
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