Clinical trials: Obesity in Diabetes
Obesity
Efficacy and Safety of HDM1005 Compared to Tirzepatide in Obese Adults Without Diabetes
This is a 56-week randomized, open-label, controlled study evaluating the efficacy and safety of the HDM1005 compared to tirzepatide in adults with obesity but without diabetes.
- Trial name
- NCT07521631
- Testing
- HDM1005 dose level 1, HDM1005 dose level 2, HDM1005 dose level 3
- Where
- China
- Volunteers
- 372 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Obesity
HRS9531 Controls Weight Regain in Obese Subjects
This is a single-center, double-blinded, randomized, placebo-controlled phase II study to explore the effectiveness, safety and energy balance mechanism of low-frequency continuous subcutaneous injection of HRS9531 to inhibit…
- Trial name
- NCT06287437
- Testing
- HRS9531
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Shanghai Zhongshan Hospital
Overweight and Obesity, PreDiabetes
Effect of Time-restricted Eating on Behaviour and Metabolism in Overweight Individuals at High Risk of Type 2 Diabetes
The aim of the present study is to investigate effects of 12 weeks time-restricted eating on behaviour and metabolism in individuals with overweight or obesity at high risk of type 2 diabetes.
- Trial name
- RESET (NCT03854656)
- Testing
- Time-restricted eating
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kristine Færch
Diabetes Mellitus, Type 2, Overweight
Getting in Balance: A Workplace Diabetes Prevention Intervention Trial
This study evaluates two group-based Diabetes Prevention Program (DPP) lifestyle interventions delivered in the workplace to individuals at risk for pre-diabetes: 1) an in-person group-based lifestyle intervention; and 2) an…
- Conditions
- Diabetes Mellitus, Type 2, Overweight, Obesity
- Trial name
- GIBW (NCT02589873)
- Testing
- In-Person Diabetes Prevention Program, Online Diabetes Prevention Program
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Diabetes
A Study of CT-388 in Otherwise Healthy Overweight and Obese Adults and Patients With Type 2 Diabetes Mellitus
This is a first-in-human evaluation of CT-388 in a double blind, placebo controlled, randomized, SAD/MAD/MD, safety, tolerance, PK, and PD study when administered as a SC injection in otherwise healthy overweight and obese adult…
- Trial name
- NCT04838405
- Testing
- CT-388
- Where
- 2 sites in Australia, Mexico
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Carmot Therapeutics, Inc.
Obesity, Diabetes
Abu Dhabi Diabetes and Obesity Study
A cross-sectional study investigating the aetiology, mechanisms and associated complications contributing to obesity and diabetes within the UAE population.
- Trial name
- NCT01843959
- Where
- United Arab Emirates
- Volunteers
- 2,130 people, healthy volunteers welcome
- Sponsor
- Imperial College London Diabetes Centre
Type 1 Diabetes, Obesity
Intermittent Fasting in Adults With Type 1 Diabetes
The majority of adults with type 1 diabetes (T1DM) have either overweight or obesity. As such, dietary management has been recommended as an adjunct to insulin treatment to improve glycemic control and facilitate weight loss in…
- Trial name
- NCT06134986
- Testing
- Time restricted eating, Daily calorie restriction
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Illinois Chicago
Vitamin D Deficiency, Type2 Diabetes
Effect of Vitamin D Supplementation on Inflammatory Markers
Previous studies have shown that improving vitamin D status among the elderly may lead to an improvement in some inflammatory markers, especially with patients with type 2 diabetes.
- Trial name
- NCT03782805
- Testing
- cholecalciferol (Euro-Pharm International, Canada)
- Where
- Lebanon
- Volunteers
- 88 people
- Sponsor
- Université d'Auvergne
Obesity & Overweight, Diabetes Mellitus Type 2
Pre-Diagnosis GLP-1 Receptor Agonist Use and Post-Cancer Mortality in Adults With Obesity and Type 2 Diabetes
This study will examine whether the type of diabetes treatment used before cancer diagnosis is associated with survival and serious complications after obesity-associated cancer in adults with obesity and type 2 diabetes.
- Conditions
- Obesity & Overweight, Diabetes Mellitus Type 2, Neoplasms
- Trial name
- NCT07513259
- Where
- Taiwan
- Volunteers
- 203,424 people
- Sponsor
- Chung Shan Medical University
Diabetes Mellitus, Non-Insulin-Dependent
Effect of Laparoscopic Roux-en-Y Gastric Bypass Surgery on Non-severe Obesity With Type 2 Diabetes Mellitus
The effect of roux-en-Y gastric bypass(RYGB) on patients with type 2 diabetes mellitus(T2DM) and a body mass index(BMI)>35kg/m2 is clear.
- Trial name
- NCT02091323
- Testing
- gastric bypass surgery
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Diabetes, Pre-diabetes
Effect of Oral L-arginine 3.32 g a Day on Oxidative Stress Influencing Beta Cell Function and Insulin Resistance.
The objective of this clinical trial is to explore whether L-arginine supplementation with 3.32g/day may enhance antioxidant defenses in overweight and obese patients with pre-diabetes and metabolic syndrome, possibly providing…
- Conditions
- Diabetes, Pre-diabetes, Metabolic Syndrome
- Trial name
- L-BIOARG (NCT06686069)
- Testing
- bioarginina zero
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Federico II University
PreDiabetes, Diabetes Mellitus, Type 2
Oral Endocannabinoids in People With Prediabetes and Diabetes
This study evaluates the relationship of endocannabinoids in saliva with inflammation and oral dysbacteriosis present in people with periodontal disease and prediabetes/type 2 diabetes
- Conditions
- PreDiabetes, Diabetes Mellitus, Type 2, Obesity, Oral Dysbiosis
- Trial name
- SMILE (NCT06040164)
- Testing
- Observational study
- Volunteers
- 60 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Overweight, Obesity
A Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose Weight
This study will look at how well the new medicine CagriSema helps people living with excess body weight and type 2 diabetes losing weight. Participants will either get CagriSema or a dummy medicine.
- Conditions
- Overweight, Obesity, Type 2 Diabetes Mellitus
- Trial name
- REDEFINE 2 (NCT05394519)
- Testing
- Cagrilintide, Semaglutide
- Where
- 179 sites in United States, Austria and 11 more
- Volunteers
- 1,200 people
- Sponsor
- Novo Nordisk A/S
Gestational Diabetes, Obesity
Early Gestational Diabetes Screening in the Gravid Obese Woman
Specific Aim 1: To test the hypothesis that early GDM screening between 14-18 weeks in obese women (body mass index ≥30.0) will result in improved perinatal outcomes.
- Trial name
- EGGO (NCT01864564)
- Testing
- Early Screen
- Where
- 2 sites in United States
- Volunteers
- 962 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cardiovascular Disease Risk, Type 2 Diabetes Risk
The Effect of Pecans on Biomarkers of Risk for Cardiovascular Disease and Diabetes
The objective of this randomized, controlled feeding study is to investigate the potential health benefits of a pecan-containing diet.
- Trial name
- NCT01950806
- Testing
- Pecan-containing diet, Nut-free diet
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Tufts University
Overweight, Obese
UCSD Take Charge Study
The purpose of the Take Charge Study is to determine among overweight and obese men and women with type 2 diabetes whether 1) participating in a commercial weight loss program promotes great weight loss and weight loss…
- Conditions
- Overweight, Obese, Obesity, Diabetic
- Trial name
- NCT01345500
- Testing
- Higher Carbohydrate, Lower Fat Diet, Lower carbohydrate, Higher fat diet, Individualized Counseling
- Where
- 2 sites in United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Type 2 Diabetes Mellitus (T2DM), Food Effect
Food Effect, Efficacy and Safety of MKP10241 in Healthy and Obese Adult Participants, With and Without Diabetes
The goal of this intervention study is to evaluate the safety, tolerability and pharmacokinetics (PK) and pharmacodynamics (PD) of multiple doses of MKP10241 in obese participants with and without T2DM in 3 parts.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Food Effect, Safety and Tolerability, Obesity
- Trial name
- NCT07098663
- Testing
- MKP10241
- Where
- Australia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Mankind Pharma Limited
Polycystic Ovary Syndrome, Insulin Resistance
Insulin Resistance Before and During Pregnancy in Women With Polycystic Ovary Syndrome
The polycystic ovary syndrome (PCOS) affects about 10% of reproductive-age women. Women with PCOS are at a higher risk of gestational diabetes, which may lead to more pregnancy complications.
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Insulin Sensitivity, Obesity
- Trial name
- NCT01475565
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
Pediatric Obesity
Family Focused Community Program to Prevent Type 2 Diabetes in Peripubertal Youth
Over one-third of children and adolescents are overweight and nearly 1 in 5 of them are obese. Metabolic syndrome, a strong predictor of Type 2 diabetes (T2D) and cardiovascular disease (CVD), occurs in up to 44% of obese youth…
- Trial name
- NCT02421198
- Testing
- YMCA Family Diabetes Prevention Program (YFDPP)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Diabetes, Diabetes Mellitus, Type 2
Efficacy and Safety of Metformin and Liraglutide in Obese Subjects With Type 2 Diabetes Previously Treated With an Oral Hypoglycemic Agent
This trial is conducted in the United States of America (USA). The aim of this trial is to determine the dose-response relationship for body weight and five escalating doses of NNC 90-1170 (liraglutide) in subjects with type 2…
- Trial name
- NCT01511198
- Testing
- liraglutide, metformin
- Where
- 39 sites in United States
- Volunteers
- 223 people
- Sponsor
- Novo Nordisk A/S
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.