Clinical trials: Obesity in Pregnancy
Craniopharyngioma, Hypothalamic Obesity
Intranasal Oxytocin in Hypothalamic Obesity
This research study will test if oxytocin, delivered by nasal spray, will promote weight loss in children, adolescents, and adults with Hypothalamic Obesity as compared to a placebo. The study is divided into two parts.
- Trial name
- NCT02849743
- Testing
- Syntocinon
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Shana McCormack, MD
Gestational Diabetes Mellitus
Trial of Diet in Gestational Diabetes Mellitus: Metabolic Consequences to Mother and Offspring
The rapidly rising risk of gestational diabetes pregnant women demands that an effective diet strategy be developed due to the high risk of fetal overgrowth, which places the newborn at increased risk for childhood obesity and…
- Trial name
- CHOICE (NCT02244814)
- Testing
- Low Carbohydrate/Conventional, Choosing Healthy Options in Carbohydrate Energy
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Colorado, Denver
Polycystic Ovary Syndrome
Spironolactone Plus Metformin in Polycystic Ovary Syndrome
The investigators examined whether a combined therapy with low-dose spironolactone plus metformin is more effective than metformin alone in 52 overweight/obese Polycystic Ovary Syndrome (PCOS) patients.
- Trial name
- NCT01526616
- Testing
- Metformin, Metformin plus Spironolactone
- Volunteers
- 56 people
- Sponsor
- University Magna Graecia
Type 2 Diabetes Mellitus, Obesity
Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes
Type 2 diabetes (T2D) in youth is increasing in prevalence in parallel with the obesity epidemic. In the US, almost half of patients with renal failure have DKD, and ≥80% have T2D.
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Bariatric Surgery Candidate, Nephropathy
- Trial name
- IMPROVE-T2D (NCT03620773)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 mg/mL, Vertical Sleeve Gastrectomy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Colorado, Denver
Pregnant Women, Gestational Diabetes
Physical Acvitiy in Pregnancy
The goal of this observational study is to learn how a physically active lifestyle during pregnancy affects placental development and function.
- Conditions
- Pregnant Women, Gestational Diabetes, Obese But Otherwise Healthy Participants, Overweight (BMI > 25)
- Trial name
- NCT07356180
- Testing
- Pregnancy Physical Activity Questionnaire (PPAQ)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Adiposity
Maternal Lipids and Offspring Adiposity at 5-7 Years
This study investigates the associations between measured maternal lipids (Total cholesterol, LDL-cholesterol , triglycerides and high-density lipoprotein cholesterol) at 28 weeks' gestation and offspring adiposity at 5-7 years.
- Trial name
- HAPO (NCT03317522)
- Volunteers
- 1,224 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Infections Joint Prosthetic, Overweight or Obesity
Antibiotic Prophylaxis in High-Risk Arthroplasty Patients
To determine the effectiveness of a 7-day course of an oral, prophylactic antibiotic on the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk…
- Conditions
- Infections Joint Prosthetic, Overweight or Obesity, MSSA Colonization, MRSA
- Trial name
- NCT04297592
- Testing
- Cephalexin, Doxycycline, Cefadroxil
- Where
- 2 sites in United States
- Volunteers
- 4,618 people
- Sponsor
- Mayo Clinic
Oxytocin Deficiency, Hypopituitarism
Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study)
Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function.
- Conditions
- Oxytocin Deficiency, Hypopituitarism, Hypothalamic Obesity, Pituitary Dysfunction
- Trial name
- NCT05319301
- Testing
- Melatonin
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Gynecologic Disease
Comparison of Two Ventilation Modes With Laryngeal Mask Airway Guardian
The purpose of this study is to compare volume- and pressure- controlled ventilation with laryngeal mask airway Guardian in obese patients undergoing laparoscopic gynecologic surgery in terms of ventilatory efficacy, airway leak…
- Trial name
- wang002 (NCT02097628)
- Testing
- tidal volume, peak airway pressure
- Volunteers
- 40 people
- Sponsor
- Haiyun Wang
Obesity, Polycystic Ovary Syndrome
Effect of Diet Plus Sibutramine on Hormonal and Metabolic Features in Overweight and Obese Women With PCOS
Studies on the effect of sibutramine, an anti-obesity drug, on hormonal and metabolic features of women with polycystic ovary syndrome (PCOS) are lacking.
- Trial name
- NCT00463112
- Testing
- Sibutramine
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hippocration General Hospital
Body Weight, Polycystic Ovary Syndrome
The Effect of Obesity on Endometrium in PCOS
The effect of Polycystic Ovary Syndrome (PCOS) with or without obesity has received a few attentions. There is a lack of evidence to whether the BMI affects the endometrial blood flow, which is necessary for implantation.
- Trial name
- OB-PCO (NCT02694419)
- Testing
- Doppler evaluation
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Maternal Obesity, Gestational Weight Gain
Lifestyle and Pregnancy: The Clinical Effect of Lifestyle Intervention During Pregnancy in Obese Women
Obesity is a serious and increasing health problem in the Western World with about one third of all pregnant women in Denmark being overweight. Among these are more than 11% severe obese.
- Conditions
- Maternal Obesity, Gestational Weight Gain, Obstetric Complications
- Trial name
- LiP (NCT00530439)
- Testing
- Lifestyle intervention, Control, Physical activity, dietetic counselling
- Where
- Denmark
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Gestational Diabetes, Overweight and Obesity
Educational Intervention in the First 18 Months of Life to Prevent/Manage Obesity of Children After Gestational Diabetes
In order to evaluate the effect of an educational intervention on mothers with gestational diabetes and their offspring in the first 18 months of life, The intervention will be applied to mothers with gestational diabetes, and a…
- Trial name
- NCT04493177
- Testing
- Educational intervention, Conventional treatment Guia de Practica Clinica IMSS-029-08
- Where
- Mexico
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Chronic Kidney Disease, Diabetes
Inflammatory Cytokines and Oxidative Stress Biomarkers in Diabetic Chronic Kidney Disease Patients
This research intends to analyze how a 12-week adjustment in lifestyle influences inflammatory cytokines and oxidative stress indicators in overweight individuals diagnosed with type 2 diabetes and moderate CKD
- Trial name
- intervention (NCT07657286)
- Testing
- aerobic treadmill exercises
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Badr University
Atherosclerosis, Cardiovascular Disease
A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event
The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased…
- Conditions
- Atherosclerosis, Cardiovascular Disease, Obesity, Hypertension
- Trial name
- CLARITY-CRP (NCT07783802)
- Testing
- Clazakizumab
- Where
- 46 sites in United States, Argentina and 2 more
- Volunteers
- 120 people
- Sponsor
- Eli Lilly and Company
Polycystic Ovary Syndrome
Effect of UC Versus EA on Sex Hormones in Obese Infertile Patients With PCOs
The aim of this study is to determine the difference between the effect of Ultrasound Cavitation and Elctroacupuncture on sex hormones in obese infertile patients with poly cystic ovarian syndrome ………………………………………………………………………
- Trial name
- NCT04875312
- Testing
- Ultrasound cavitation in group A, Electro acupuncture in group B
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Abdel Hamid elgaedy
Childhood Obesity, Adiposity
Lifestyle in Pregnancy and Offspring
Children born to obese women are at risk of increased adiposity and later adverse metabolic outcomes. We have conducted a follow-up study on an existing clinical trial, called the LiP study (Lifestyle in Pregnancy), registration…
- Conditions
- Childhood Obesity, Adiposity, Body Composition, Metabolic Risk Factors
- Trial name
- LiPO (NCT01918319)
- Testing
- Lifestyle intervention
- Where
- Denmark
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Pregnancy, Obesity
An Optimized Programming of Healthy Children (APPROACH)
The Nutrition Research Unit at Copenhagen University Hospital Herlev will during the fall 2013 initiate a randomized and controlled intervention study engaging 390 obese pregnant women.
- Conditions
- Pregnancy, Obesity, Gestational Age and Weight Conditions, Maternal Care for Excessive Fetal Growth
- Trial name
- NCT01894139
- Testing
- High-Protein/Low-GI Diet, Low-protein/High-GI Diet
- Where
- Denmark
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Metabolic Syndrome (MetS), Obesity & Overweight
Validating Integrative Multi-omics Approaches in Metabolic Syndrome-related Diseases
This study aims to validate integrative multi-omics approaches for understanding complications related to metabolic syndrome. By combining genetic, transcriptomic, metabolomic, and microbiome data from participants with and…
- Conditions
- Metabolic Syndrome (MetS), Obesity & Overweight, Cardiovascular Diseases (CVD), Chronic Kidney Disease
- Trial name
- NCT07248371
- Testing
- No intervention
- Where
- Taiwan
- Volunteers
- 6,266 people
- Sponsor
- Chang Gung Memorial Hospital
Pregnancy, Obesity
Effect of Probiotics (Vivomixx®) on Weight, Microbiota and Glucose Tolerance in Obese Pregnant Women and Their Newborn
The purpose of the study is to investigate if the probiotics Vivomixx® can affect gestational weight gain, microbiota and pregnancy complications in pregnant obese women and birth weight body composition of their infants.
- Conditions
- Pregnancy, Obesity, Gestational Diabetes Mellitus
- Trial name
- POP (NCT02508844)
- Testing
- Vivomixx®
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital