Clinical trials: Obesity in Pregnancy, open to volunteers
Cesarean Section, Surgical Wound Infection
Timing of Cesarean Wound Dressing Removal on Wound Healing in Women With BMI ≥ 30 kg/m²
Cesarean delivery is one of the most common surgical procedures in obstetric care. Women with obesity (body mass index [BMI] of 30 kg/m² or higher) are at increased risk for postoperative wound complications, including surgical…
- Conditions
- Cesarean Section, Surgical Wound Infection, Wound Healing, Obesity
- Trial name
- NCT07846930
- Volunteers
- 726 people
- Sponsor
- Assiut University
Bariatric Surgery Candidate, Kidney Stone
GI Oxalate Absorption
This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one week.
- Trial name
- NCT05356000
- Testing
- Special low-oxalate diet followed by all-day visit to University of Chicago research clinic
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Chicago
Gestational Diabetes, Pregnancy, High Risk
Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.
- Conditions
- Gestational Diabetes, Pregnancy, High Risk, Overweight and Obesity
- Trial name
- iGDM (NCT05124808)
- Testing
- Intensive glycemic targets, Standard glycemic targets
- Where
- 5 sites in United States
- Volunteers
- 828 people
- Sponsor
- Indiana University
Morbid Obesity, Pregnancy
Induction of Labor in Morbidly Obese Patients
The goal of this randomized control trial is to compare different doses of Misoprostol (25 mcg vs 50 mcg) in induction of labor (IOL) in morbidly obese patients with BMI >40.
- Trial name
- NCT06199154
- Testing
- Misoprostol
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Maryland, Baltimore
Intrauterine Hyperglycemia, Pregnancy Outcomes
The Born in Guangzhou Cohort Study (BIGCS)
The Born in Guangzhou Cohort Study (BIGCS) was established to investigate the short- and long-term effects of exposure in early life on health consequences in Guangzhou, China.
- Conditions
- Intrauterine Hyperglycemia, Pregnancy Outcomes, Neurodevelopment, Immune Development
- Trial name
- BIGCS (NCT02526901)
- Testing
- No intervention
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Chronic Kidney Disease stage3, Chronic Kidney Disease stage4
Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD
Chronic kidney disease (CKD) is the progressive damage to kidney function, associated with an increased risk of cardiovascular diseases, such as stroke or myocardial infarct, particularly in the most severe stages of CKD, in…
- Conditions
- Chronic Kidney Disease stage3, Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 1, Chronic Kidney Disease Stage 2
- Trial name
- ADIPO-CKD (NCT07309094)
- Testing
- GLP-1 receptor agonist, SGLT2 inhibitor, Tirzepatide
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Cardenal Herrera University
Cardiometabolic Diseases, Obesity
Prenatal Programming of Childhood Obesity and Cardio Metabolic Disorders
This is a prospective 11-17 -years follow-up of two existing pregnancy cohort (PREDO) and prevention (RADIEL) studies. The main objective is to investigate the associations between maternal overweight, obesity, hypertensive…
- Trial name
- NCT05223530
- Where
- Finland
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Chronic Kidney Disease
A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease
The study evaluates the safety of different doses of a new medicine called NNC0519 0130. It also looks into how the medicine may improve kidney function in participants with chronic kidney disease with or without type 2 diabetes…
- Trial name
- NCT06717698
- Testing
- NNC0519-0130, Semaglutide
- Where
- 147 sites in United States, Argentina and 12 more
- Volunteers
- 465 people
- Sponsor
- Novo Nordisk A/S
Atypical Endometrial Hyperplasia, Fertility Issues
Weight Management Plus LNG-IUS/Megestrol Acetate in Endometrial Atypical Hyperplasia
To investigate the efficacy of weight management plus levonorgestrel intrauterine system (LNG-IUS) or megestrol acetate (MA) in obese patients with endometrial atypical hyperplasia (EAH) asking for conservative therapy.
- Conditions
- Atypical Endometrial Hyperplasia, Fertility Issues, Overweight and Obesity
- Trial name
- NCT05316493
- Testing
- Intensive Lifestyle Intervention (ILI), Megestrol Acetate 160 MG Oral Tablet, Levonorgestrel-Releasing Intrauterine Contraceptive System (Mirena), 52 Mg
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Xiaojun Chen
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Obese
Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome
Girls and women 12-35 years old with obesity and polycystic ovarian syndrome who are on or off metformin, will receive a glucagon like peptide-1 receptor agonist intervention for 10 months to induce metabolic changes, weight loss…
- Trial name
- RESTORE (NCT05819853)
- Testing
- Semaglutide Injectable Product (Wegovy and/or Ozempic)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Hypertension (HTN), Diabetes (DM)
Team-Based Shared Decision-Making Program in Cardiovascular-Kidney-Metabolic Health (Healthy Heart - CKM)
The investigators are proposing a new team-based shared decision-making (SDM) program. The goal of this study is to see whether this program is practical and whether it may help adults with cardiometabolic risk factors and…
- Conditions
- Hypertension (HTN), Diabetes (DM), Hyperlipidaemia, Kidney Disease
- Trial name
- SDM in CKM (NCT07662616)
- Testing
- Team-based shared decision-making
- Volunteers
- 94 people
- Sponsor
- Johns Hopkins University
Obesity; Chronic Kidney Disease; Albuminuria
Study on the Efficacy and Safety of Initial Combination of Finerenone and Semaglutide in Non-Diabetic Adult Patients With Obesity Complicated by Chronic Kidney Disease With Albuminuria
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate whether starting finerenone together with semaglutide provides an additional reduction in urinary albumin-to-creatinine ratio…
- Trial name
- NCT07849348
- Testing
- Finerenone, Semaglutide
- Volunteers
- 266 people
- Sponsor
- Peking University People's Hospital
Overweight or Obesity, Pregnancy Related
Better Lifestyle Counseling for African American Women During Pregnancy
The purpose of this randomized controlled trial is to establish the effectiveness of a culturally targeted and individually tailored behavioral intervention to promote maternal glucose metabolism in African American women.
- Conditions
- Overweight or Obesity, Pregnancy Related, Sleep Disturbances, Sleep Hygiene
- Trial name
- BETTER (NCT05234125)
- Testing
- Better, Birth Prep
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Illinois Chicago
Cardiovascular Diseases (CVD), Type 2 Diabetes
Epigenetics and NCD Prevention in Kazakhstan: Personalized Approaches and Biological Age Prediction
This study aims to enhance personalized and preventive care for non-communicable diseases (NCDs) in Kazakhstan by examining epigenetic factors, predicting biological age and reproductive function using machine learning, and…
- Conditions
- Cardiovascular Diseases (CVD), Type 2 Diabetes, Chronic Respiratory Diseases, Obesity (Disorder)
- Trial name
- NCT06953180
- Testing
- Genetic: DNA analysis
- Where
- Kazakhstan
- Volunteers
- 6,720 people, healthy volunteers welcome
- Sponsor
- Asfendiyarov Kazakh National Medical University
Pre-Eclampsia, Obesity
Weight Loss Following an Episode of Pre-eclampsia Using a Dissociated or Hypocaloric Diet in Overweight or Obese Patients
In view of the known link between pre-eclampsia, overweight/obesity and chronic kidney disease, the aim is to offer for obese and overweight patients to reduce their BMI without reducing lean body mass.
- Trial name
- POPADIPE (NCT06067906)
- Testing
- Hypocaloric diet, Dissociated diet
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier le Mans
Polycystic Ovary Syndrome (PCOS), Obesity
Effects of GLP-1RAs on Fertility Outcomes in Obese Women With PCOS
The goal of this clinical trial is to examine whether GLP1-RA and healthy lifestyle education in women with PCOS and obesity prior to fertility treatment improves live birth rate and other reproductive, maternal and perinatal…
- Conditions
- Polycystic Ovary Syndrome (PCOS), Obesity, Infertility, Female
- Trial name
- NCT07687667
- Testing
- GLP-1 receptor agonist, Metformin
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Peking University Third Hospital
Craniopharyngioma, Child
SEMAFORCRANIO : Multicenter, Double-blind, Parallel, Randomized Controlled Trial of the Efficacy of Semaglutide in Hypothalamic Obesity Secondary to Craniopharyngioma in Children Aged 12 to 17 Years
Craniopharyngioma (CP) is a rare embryonic brain tumor of the sellar and parasellar region. Despite its benign histologic characteristics, it is locally aggressive and may cause severe morbidity from invasion into adjacent…
- Trial name
- SEMAFORCRANIO (NCT07845994)
- Testing
- Semaglutide (Wegovy) weekly injection
- Where
- 17 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
PCOS (Polycystic Ovary Syndrome)
The Effects of the Mediterranean Diet and Synbiotics in Polycystic Ovary Syndrome
This study will look at whether a reduced-calorie Mediterranean-style eating plan, together with a synbiotic supplement, can improve health measures and quality of life in women who have polycystic ovary syndrome (PCOS) and are…
- Trial name
- NCT07342946
- Testing
- Synbiotic Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Atlas University
Coronary Artery Disease, Diabete Mellitus
Assessment and Management of Multiple Drug Use in Elderly Chronic Disease Patients
The purpose of this observational study is to understand the impact of polypharmacy on the prognosis of elderly patients with chronic diseases.
- Conditions
- Coronary Artery Disease, Diabete Mellitus, Chronic Kidney Disease, Hypertension
- Trial name
- NCT07180368
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xijing Hospital
Maternal Obesity, Hypoxia Neonatal
Impact of Maternal Body Mass Index on Infant Hypoxic Events at Time of Delivery ,Cross-sectional Study.
Offspring from overweight or obese mothers appear to be at up to 38% increased risk of being admitted to the neonatal intensive care unit than the offspring of mothers with a normal BMI.
- Trial name
- NCT06917833
- Testing
- compare infant hypoxic events in both groups
- Volunteers
- 544 people
- Sponsor
- Ain Shams University