Clinical trials: Obesity-Hypoventilation Syndrome (OHS)
Obstructive Sleep Apnea, Obesity (BMI>30)
Hypercapnic Burden in Adults With Obesity Undergoing Diagnostic Polysomnography for Suspected Obstructive Sleep Apnea
Obesity-related sleep hypoventilation represents a continuum ranging from isolated nocturnal hypoventilation to obesity hypoventilation syndrome.
- Conditions
- Obstructive Sleep Apnea, Obesity (BMI>30), Obesity Hypoventilation Syndrome (OHS), Sleep Hypoventilation
- Trial name
- HBO-POSA (NCT07809061)
- Testing
- Sleep Inertia Questionnaire (SIQ)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Obesity Hypoventilation Syndrome (OHS), Chronic Obstructive Lung Disease
Telemedical Assistance in Automatic Titration of Oxygen for Intensive Care Patients
The goal of this clinical trial is to clinically validate a system for the monitoring of patients' respiratory function and automated oxygen treatment proposal using non-invasive ventilation devices in the treatment of intensive…
- Conditions
- Obesity Hypoventilation Syndrome (OHS), Chronic Obstructive Lung Disease, Interstitial Lung Disease, Pneumonia
- Trial name
- Smartassistant (NCT06090149)
- Testing
- PHASE 1 Lowenstein medical BiLevel Prisma 25ST device: withount oxygen support., PHASE 2. Continous/Bilevel positive airway presure with additional oxygen support by Devilbiss 525 KS oxygen concentrator
- Where
- Latvia
- Volunteers
- 30 people
- Sponsor
- Pauls Stradins Clinical University Hospital
OHS, Hypercapnic Respiratory Failure
Cardiac and Respiratory Function With Non-invasive Ventilation
To assess patients with hypercapnic respiratory failure using echocardiography,cardiac output measurements and markers of neural respiratory drive (EMGpara) prior to, during and after non-invasive ventilation (NIV) initiation…
- Trial name
- CARE-NIV (NCT02699112)
- Testing
- Parasternal EMG (EMGpara) and Transthoracic Echocardiography
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obesity Hypoventilation Syndrome (OHS)
Functional Capacity, Sleep Quality, and Cognitive Function in Obesity Hypoventilation Syndrome
Introduction: Obesity Hypoventilation Syndrome (OHS) is defined as the coexistence of obesity (BMI ≥ 30 kg/m²), daytime hypercapnia (PaCO₂ > 45 mmHg) in the absence of other causes of hypoventilation, and sleep-disordered…
- Trial name
- NCT07147153
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Bezmialem Vakif University
Hypercapnic Respiratory Failure, Pulmonary Disease, Chronic Obstructive
Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor
The study is an open, prospective, single center clinical observational pilot investigation. The aim is to compare the carbon dioxide values measured by the IscAlert sensor, which is inserted in proximity to the nasal mucosa.
- Conditions
- Hypercapnic Respiratory Failure, Pulmonary Disease, Chronic Obstructive, Neuromuscular Diseases, Obesity Hypoventilation Syndrome (OHS)
- Trial name
- DISCO (NCT06367686)
- Testing
- IscAlert sensor
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- The Hospital of Vestfold
Bronchial Asthma, Bronchiectasis
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
Research is being conducted into chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, and bronchiectasis.
- Conditions
- Bronchial Asthma, Bronchiectasis, ILD, COPD
- Trial name
- NCT07060079
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
Obesity Hypoventilation Syndrome
A Trial of Rehabilitation in Obesity Hypoventilation Syndrome (OHS)
Obesity is an escalating problem in the UK and a proportion of these patients have a condition known as Obesity Hypoventilation Syndrome (OHS).
- Trial name
- NCT01483716
- Testing
- Rehabilitation
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obesity Hypoventilation Syndrome (OHS)
Pathophysiology of Hypoventilation in Obesity and Effects of Bariatric Intervention
Breathing is impacted by obesity. Early changes are characterised by significant breathing abnormalities during sleep (a condition called sleep disordered breathing, the most common of which is obstructive sleep apnoea).
- Trial name
- PHOEBI (NCT04025528)
- Testing
- Bariatric Surgery
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obesity Hypoventilation Syndrome (OHS), Obesity
The Effect of Sarcopenic Obesity on Sleep in Individuals With Obesity Hypoventilation Syndrome
Obesity Hypoventilation Syndrome(OHS) is characterized by daytime hypercapnia and sleep-disordered breathing without other causes of hypoventilation in individuals with a body mass index above 30 kg/m2.
- Conditions
- Obesity Hypoventilation Syndrome (OHS), Obesity, Hypoventilation, Respiration Disorders
- Trial name
- NCT06136533
- Testing
- Assessment-OHS, Assessment-Sarcopenic Obesity With OHS
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istanbul University
Obesity Hypoventilation Syndrome
Non Invasive Ventilation : Efficacy of a New Ventilatory Mode in Patients With OHS
In 2012, it has announced the availability of the new ventilator (BiPAP- A40), which could offer potential advantages over fixed level pressure support, in particular, in patients with obesity hypoventilation syndrome (OHS).
- Trial name
- NCT01757444
- Testing
- BiPAP - A40, BiPAP - ST
- Where
- 11 sites in France
- Volunteers
- 60 people
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Obesity Hypoventilation Syndrome
Respiratory Muscle Strength in Patients With Obesity Hypoventilation Syndrome (OHS) or With a Precursor of the Disease
Using an extensive set of both volitional and non-volitional tests of respiratory muscle function and strength it is the aim of this study to identify potential determinants for the development of obesity hypoventilation to…
- Trial name
- NCT03854058
- Testing
- magnetic phrenic nerve stimulation
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Obesity Hypoventilation Syndrome (OHS)
Average Volume-assured Pressure Support as Rescue Therapy in Obesity Hypoventilation Syndrome
It remains unclear whether CPAP therapy should be prescribed if significant hypoxemia persists during CPAP titration, despite optimization of upper airway obstructive events, if maximum CPAP pressure is reached.
- Trial name
- AVAPS (NCT06442163)
- Testing
- AVAPS study was performed within 1 week of the CPAP titration attempt failure, using the auto-titrating EPAP (AE), the OmniLab Advanced +, System One device (Philips Respironics, Murrysville, PA, U.S.
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United Kingdom
Chronic hypercapnic respiratory failure (CHRF) in the context of Chronic Obstructive Pulmonary Disease (COPD) and Obesity Hypoventilation Syndrome (OHS) is associated with increased mortality.
- Conditions
- Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome (OHS), Nasal High Flow
- Trial name
- NCT05167201
- Testing
- Nasal High Flow
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Euthyroid Sick Syndrome, Obesity Hypoventilation Syndrome (OHS)
Euthyroid Sick Syndrome in Obesity Hypoventilation Syndrome
The goal of this observational study is to learn about the frequency and clinical impact of Euthyroid Sick Syndrome (ESS) in patients with Obesity Hypoventilation Syndrome (OHS) who are admitted to the intensive care unit (ICU)…
- Trial name
- NCT06983418
- Where
- Egypt
- Volunteers
- 49 people
- Sponsor
- Mansoura University
Hypercapnic Respiratory Failure, Sleep Disordered Breathing
Remote Monitoring to Improve Low Adherence in Non-invasive Ventilation
Patients are invited to participate in a trial to test a new way to optimise long-term use of non-invasive ventilation using remote monitoring.
- Conditions
- Hypercapnic Respiratory Failure, Sleep Disordered Breathing, COPD, Obesity Hypoventilation Syndrome (OHS)
- Trial name
- READ-NIV (NCT04884165)
- Testing
- Remote monitoring of home mechanical ventilation (NIV) using SRETT, Home mechanical ventilation (NIV) without remote monitoring
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome (OHS)
Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation
To evaluate the safety and effectiveness of the Automatic Expiratory Positive Airway Pressure (Auto-EPAP) feature versus manual expiratory positive airway pressure (EPAP) in the Vivo 45 LS Ventilator.
- Conditions
- Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome (OHS), Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Diseases (NMD)
- Trial name
- Vivo NOVA (NCT06560411)
- Testing
- Non-Invasive Ventilation
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Breas Medical, Inc.
COPD (Chronic Obstructive Pulmonary Disease), Obesity Hypoventilation Syndrome (OHS)
Assessment of Breathing Pattern During NIV
COPD and OHS are respiratory conditions that disrupt normal breathing. Positive airway pressure, specifically Non-Invasive Ventilation (NIV), has been shown to improve breathing and reduce symptoms in patients with these…
- Trial name
- NCT06682286
- Testing
- NIV mask A, NIV mask B
- Where
- New Zealand
- Volunteers
- 40 people
- Sponsor
- Fisher and Paykel Healthcare
Sleep Apnea, Obstructive, Obesity Hypoventilation Syndrome (OHS)
Evaluation of An Optical Measurement Algorithm Combined With Patient and Provider Input to Reduce Mask Exchanges During Initial Positive Airway Pressure Therapy
Continuous positive airway pressure and non-invasive ventilation are common treatment modalities for obstructive sleep apnea, central sleep apnea, and chronic alveolar hypoventilation from a variety of causes.
- Conditions
- Sleep Apnea, Obstructive, Obesity Hypoventilation Syndrome (OHS), Sleep Apnea Syndromes
- Trial name
- NCT04688125
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Mayo Clinic
Neuromuscular Disorders, Chest Wall Disorders
Response to NonInvasive Mechanical Ventilation According to the Breathing Pattern
The purpose of this study is to determine whether breathing pattern (specifically the inspiratory time/total respiratory cycle value) has an influence over the response to the noninvasive mechanical ventilation.
- Conditions
- Neuromuscular Disorders, Chest Wall Disorders, Obesity Hypoventilation Syndrome (OHS)
- Trial name
- NCT01991535
- Testing
- Spontaneous Ventilation Mode, Controlled Ventilation Mode, Simulator Ventilation Mode
- Where
- Spain
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Obesity-hypoventilation Syndrome, Resting Energy Expenditure
Resting Energy Expenditure in Patients With OHS Treated With Long-term NIV
This study aims to compare, in subjects with obesity-hypoventilation syndrome (OHS) treated by long-term non-invasive ventilation (NIV), resting energy expenditure (REE) in spontaneous breathing and under NIV.
- Conditions
- Obesity-hypoventilation Syndrome, Resting Energy Expenditure, Long-term Non-invasive Ventilation
- Trial name
- NCT04474587
- Testing
- Indirect calorimetry
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva