Clinical trials: Observational, open to volunteers
Alzheimer Disease, Mild Cognitive Impairment
Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
Electrical activity in the brain known as "gamma" brainwaves help connect and process information throughout the brain. These gamma waves are diminished in Alzheimer's disease.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia, Cognition Disorders in Old Age
- Trial name
- AlzLife (NCT03657745)
- Testing
- Combination of 40Hz light and cognitive therapy (ALZLIFE)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Light LLC
Pancreas Cancer, Exosomes
ExoLuminate Study for Early Detection of Pancreatic Cancer
ExoLuminate is a nationally-enrolling registry study designed for earlier detection of cancer in patients at elevated risk or clinically-suspicious for pancreatic ductal adenocarcinoma (PDAC).
- Conditions
- Pancreas Cancer, Exosomes, Extracellular Vesicles, Pancreatic Neoplasms
- Trial name
- NCT05625529
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Biological Dynamics
Facial Paralysis, Peripheral
The Effectiveness and Safety of Integrative Korean Medicine Treatment for Bell's Palsy
This is an observational study that evaluate the effectiveness and safety of Korean integrative treatments in patients with peripheral facial nerve palsy.
- Trial name
- NCT04905745
- Testing
- Korean integrative medicine
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Jaseng Medical Foundation
Menstrual Migraine
Fremanezumab for the Prevention of Menstrually-related Migraine Attacks
The goal of this observational study is to compare, in real-world clinical practice, the effect of fremanezumab on menstrual migraine to the effect of fremanezumab on non-perimenstrual attacks.
- Trial name
- FROMM (NCT06659120)
- Testing
- Fremanezumab
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Relapsing Multiple Sclerosis (RMS)
Kesimpta (Ofatumumab) in Greek Multiple Sclerosis Patients - an Observational Study
This study is a single-country, non-interventional, multicenter, observational study, mainly based on primary data collection to assess the effect of ofatumumab on clinical parameters of Multiple Sclerosis (MS) in a routine…
- Trial name
- CHRONOS (NCT06486779)
- Testing
- Ofatumumab
- Where
- 15 sites in Greece
- Volunteers
- 160 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Her 2 Positive Breast Cancer
Real-world Bicohort Observational Study of a Pertuzumab Biosimilar in the Treatment of Breast Cancer: in the Neoadjuvant Setting and in First-line Metastatic Disease
The goal of this observational study is to describe the real-world utilization patterns of a pertuzumab biosimilar and to evaluate its clinical outcomes in patients with breast cancer in both neoadjuvant and metastatic settings.
- Trial name
- PERTUREAL (NCT07542496)
- Where
- 2 sites in Algeria
- Volunteers
- 1,000 people
- Sponsor
- Société Algérienne de Formation et Recherche en Oncologie
Sedation, Endoscopy
Opioid-Free Versus Opioid-Based Sedation for Endoscopic Procedures
This study will compare two different sedation approaches used during gastroscopy, colonoscopy, and endoscopic retrograde cholangiopancreatography (ERCP).
- Conditions
- Sedation, Endoscopy, Colonoscopy, Endoscopic Retrograde Cholangiopancreatography (ERCP)
- Trial name
- NCT07649746
- Testing
- Dexmedetomidine, Remifentanil
- Volunteers
- 80 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Healthy, Major Depressive Disorder (MDD)
Neurobiological and Genomic Predictors of Relapse in Depression
The goal of this observational study is to test whether the discontinuation of antidepressant medications for patients with depression can be decided after the normalization of biological parameters.
- Trial name
- MDD (NCT07328373)
- Testing
- Antidepressant Medications
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Mehmet Kemal Arikan
Lung Cancer (NSCLC)
Inflammation, Cachexia and Therapeutic Response in Lung Cancer Treated With Immune Checkpoint Inhibitors: Exploratory Observational Study
Lung cancer is the leading cause of cancer-related death in France and globally, with 2.48 million new cases diagnosed in 2022, accounting for nearly 13% of global cancer incidence.
- Trial name
- LCab (NCT07004868)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
Carcinoma, Non-Small-Cell Lung
A Study of Clinical Outcomes in Participants With EGFR Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) in a Real-World Setting
The purpose of this study is to describe the clinical and health-related outcomes of amivantamab-containing regimens for the treatment of common epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC…
- Trial name
- LEPIDOPTERA (NCT07230691)
- Where
- 90 sites in Austria, Belgium and 6 more
- Volunteers
- 380 people
- Sponsor
- Janssen Research & Development, LLC
Gastroesophageal Reflux Disease, Hiatal Hernia
Preoperative Predictors of Symptom Improvement After Laparoscopic Fundoplication
Laparoscopic fundoplication is the standard operation for gastroesophageal reflux disease (GERD) that does not respond adequately to medication, and it relieves reflux symptoms in most patients who are carefully selected for it.
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Esophagitis, Peptic, Barrett Esophagus
- Trial name
- NCT07809620
- Testing
- Laparoscopic Nissen fundoplication, Laparoscopic Toupet fundoplication
- Where
- Egypt
- Volunteers
- 470 people
- Sponsor
- Minia University
Sarcopenia, Anemia Associated With Chronic Kidney Disease (CKD)
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients
Sarcopenia, abbreviated as muscle loss, is a prevalent complication among patients with chronic kidney disease (CKD), particularly those with end - stage renal disease (ESRD). It significantly impacts patients' quality of life.
- Conditions
- Sarcopenia, Anemia Associated With Chronic Kidney Disease (CKD), Dialysis Patients
- Trial name
- HIF-PHI (NCT07162090)
- Testing
- Roxadustat, Recombinant human erythropoietin (EPO)
- Volunteers
- 60 people
- Sponsor
- Tianjin Medical University General Hospital
Travel-Related Illness
Observational Study of Travellers Pathologies
Traveling to emerging countries is associated with a significant risk of encountering health issues specific to the destination, such as gastrointestinal and respiratory infections, malaria episodes, and road traffic…
- Trial name
- EOP (NCT06701890)
- Testing
- Blood sample collection, Fecal sample collection
- Where
- France
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Cervical Cancer
Detection of Peritoneal Metastases by Diagnostic LAparoscopy in Patients With Locally Advanced Cervical Carcinoma
The study hypothesizes that specific subgroups of LACC patients, (AJCC stage T3/T4, grade 3 tumors, and para-aortic lymph node involvement), have a higher prevalence of peritoneal metastasis.
- Trial name
- SOLAR (NCT06832397)
- Testing
- Diagnostic laparoscopy
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Delirium
Perioperative EEG-Monitoring and Postoperative Delirium in Patients Undergoing Cardiovascular Surgery
Postoperative delirium is common in patients undergoing cardiovascular surgery and associated with poor outcomes. However the pathogenesis of postoperative delirium is poorly understood.
- Trial name
- NCT04832568
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Huazhong University of Science and Technology
Brain Injuries
Construction of a Prognostic Model for Severe Brain-Injured Patients Based on Integrated Metabolic-Neurological Monitoring
This is a prospective, observational cohort study aimed at constructing a machine learning-based prognostic model for severe brain-injured patients.
- Trial name
- CPM-Brain (NCT07198490)
- Volunteers
- 50 people
- Sponsor
- Xingui Dai
Urinary Stone
2D:4D Digit Ratio and Urinary Stone Disease
This prospective observational case-control study will investigate whether the 2D:4D digit ratio is associated with urinary stone disease.
- Trial name
- NCT07736924
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Emrah Kızılay
Polycythemia Vera, ET (Essential Thrombocythemia)
MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs)
The MPN PROGRESSion Registry is a multi-year, observational research study designed to improve understanding of myeloproliferative neoplasms (MPNs)-a group of rare, chronic blood cancers that include polycythemia vera (PV)…
- Conditions
- Polycythemia Vera, ET (Essential Thrombocythemia), Polycythemia Vera (PV), Essential Thrombocythemia (ET)
- Trial name
- NCT07362225
- Where
- 2 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- MPN Research Foundation
Observational Study, Geniculate Artery
Prospective Observational Study Of Geniculate Artery Embolization For Symptomatic Knee Osteoarthritis In A Cancer Population
To explore associations with demographics/clinical factors; assess trajectories via annual follow-up; evaluate healthcare utilization and barriers; oversample >10-year survivors.
- Conditions
- Observational Study, Geniculate Artery, Embolization, Symptomatic Knee Osteoarthritis
- Trial name
- NCT07807943
- Testing
- SOC (Standard of care)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Cardiovascular Events, MACE
Tezspire Cardiac Events PASS
The aim of this study is to evaluate the risk of serious adverse cardiovascular events in adolescent and adult patients with severe asthma taking tezepelumab compared to a population receiving standard of care treatment for…
- Trial name
- TRESPASS (NCT06951867)
- Testing
- Tezepelumab
- Where
- 4 sites in United States, Denmark and 2 more
- Volunteers
- 16,640 people
- Sponsor
- AstraZeneca
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