Clinical trials: Obsessive Compulsive Disorder
Obsessive-compulsive Disorder
Topiramate Augmentation in the Treatment of Obsessive-Compulsive Disorder
A 12-week program to examine the effectiveness of topiramate in adjunctive treatment for adults with obsessive-compulsive disorder and who are currently on serotonin reuptake inhibitor medications (ages 18-65).
- Trial name
- NCT00211744
- Testing
- topiramate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Montefiore Medical Center
Trichotillomania
Testing a New Therapy for Trichotillomania
This study will test the effectiveness of a new behavioral therapy for adults with trichotillomania (compulsive hair pulling).
- Trial name
- NCT00872742
- Testing
- Acceptance enhanced behavior therapy (AEBT), Psychoeducation and supportive therapy (PST)
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Wisconsin, Milwaukee
Obsessive-Compulsive Disorder
Internet-delivered CBT for Paediatric OCD
The purpose of this study is to investigate if therapist-guided internet-delivered cognitive behavioral therapy (ICBT) in a stepped-care approach is an effective and cost-effective treatment in reducing OCD symptoms for children…
- Trial name
- NCT03263546
- Testing
- Internet-delivered cognitive behavioral therapy (ICBT), Cognitive behavioral therapy (CBT)
- Where
- 2 sites in Sweden
- Volunteers
- 152 people
- Sponsor
- Karolinska Institutet
Obsessive-Compulsive Disorder
Digital Mindfulness-Based Therapy for Obsessive-Compulsive Disorder
This randomized controlled trial aims to evaluate the effects of digital mindfulness-based therapy in people with obsessive-compulsive disorder and to explore its possible psychological and neurophysiological mechanisms.
- Trial name
- dMBT-OCD (NCT07701616)
- Testing
- Digital Mindfulness-Based Therapy, Routine Pharmacological Treatment
- Where
- 2 sites in China
- Volunteers
- 150 people
- Sponsor
- Central South University
Autoimmune Disease, Mental Disorder
Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections
Bacteria carry substances on their surface called antigens. When antigens come into contact with the right kinds of cells in the body an immune reaction is caused.
- Conditions
- Autoimmune Disease, Mental Disorder, Obsessive Compulsive Disorder, Streptococcal Infection
- Trial name
- NCT00001658
- Testing
- Amoxicillin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Mental Health (NIMH)
Obsessive-Compulsive Disorder
Digital Health Interventions for Obsessive Compulsive Disorder (OCD)
The investigators are testing two digital health interventions for obsessive compulsive disorder (OCD). The investigators hope that these digital health programs will increase access to treatment for OCD.
- Trial name
- NCT04136626
- Testing
- Perspectives OCD, The Health and Well-Being Program
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Obsessive-Compulsive Disorder
Effect of the French Version If the Metagognitive Bibliotherapy Program "MYMCT" on Obsessive-compulsive Symptoms
Obsessive-compulsive disorder (OCD) is a psychiatric illness characterized by the presence of obsessions and/or compulsions. Without effective treatment, symptoms tend to worsen and become chronic.
- Trial name
- M-TOC (NCT06494735)
- Testing
- MyMCT
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Obsessive-Compulsive Disorder (OCD)
DBS for Treatment-resistant Obsessive-compulsive Disorder
The primary purpose of this study is to investigate the effect of deep brain stimulation (DBS) implantation targeting the anteromedial region of subthalamic nucleus (amSTN), or nucleus accumbens (NAc), or bed nucleus of the stria…
- Trial name
- NCT06360991
- Testing
- Deep brain stimulation (DBS)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Obsessive Compulsive Disorder
Pilot Study of Minocycline (NPL-2003) in Adults With Obsessive-Compulsive Disorder (OCD)
Obsessive-compulsive disorder (OCD) is a common psychiatric illness that affects up to 2-3% of the population. People with OCD experience anxiety-provoking, intrusive thoughts, known as obsessions, and feel compelled to perform…
- Trial name
- NCT00728923
- Testing
- NPL-2003
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- New York State Psychiatric Institute
Anxiety Disorder, Obsessive-Compulsive Disorder
Definitive Selection of Neuroimaging Biomarkers in Anxiety Disorder and Obsessive-compulsive Disorder: A Longitudinal Functional Magnetic Resonance Imaging （fMRI） Study With Paroxetine Treatment
To explore reliable neuroimaging biomarkers for anxiety disorder and OCD,and whether there are shared imaging biomarkers between different subtypes of anxiety disorder and OCD, the investigators included30 drug-naive general…
- Trial name
- NCT03894085
- Testing
- Paroxetine
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Central South University
Obsessive Compulsive Disorder
Comparison of Effects Between Conventional Dose and High Dose Escitalopram on Clinical Improvement in Patients With Obsessive-compulsive Disorder
OBJECTIVE: The objective of this study is to compare the effect and safety of conventional dose (20mg) and high dose (40mg) of escitalopram in patients with obsessive-compulsive disorder (OCD).
- Trial name
- NCT00723060
- Testing
- escitalopram
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Seoul National University Hospital
Obsessive-Compulsive Disorder
Phase II Randomized Study of Intravenous Versus Oral Clomipramine in Patients With Obsessive Compulsive Disorder
OBJECTIVES: I. Evaluate the efficacy of intravenous versus oral pulse loading of clomipramine (CMI) followed by a 12-week course of maintenance therapy in patients with obsessive compulsive disorder.
- Trial name
- NCT00004310
- Testing
- Clomipramine
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- National Center for Research Resources (NCRR)
Obsessive-Compulsive Disorder
The Efficacy and Safety of ALIC/NAcc-DBS for Treatment-refractory OCD
The present study aims to explore the efficacy and safety of DBS targeted the combination of the anterior limb of internal capsule and nucleus accumbens (ALIC/NAcc-DBS) to refractory OCD, based on multicenter, randomized…
- Trial name
- NCT04967560
- Testing
- deep brain stimulation
- Where
- 7 sites in China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Mental Disorder Diagnosed in Childhood, Obsessive Compulsive Disorder
Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup)
A subgroup of patients with childhood-onset obsessive-compulsive disorder (OCD) and/or tic disorders has been identified who share a common clinical course characterized by dramatic onset and symptom exacerbations following group…
- Conditions
- Mental Disorder Diagnosed in Childhood, Obsessive Compulsive Disorder, Streptococcal Infection, Tic Disorder
- Trial name
- NCT00001359
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Mental Health (NIMH)
Obsessive Compulsive Disorder, Major Depressive Disorder
Integrating Pharmacogenomic Testing Into a Child Psychiatry Clinic
The purpose of this study is to examine the feasibility, acceptability, and utility of pharmacogenomic (PGX) testing (specifically for the cytochrome P450 2D6 and 2C19 genes) prior to initiating treatment with an antidepressant…
- Conditions
- Obsessive Compulsive Disorder, Major Depressive Disorder, Anxiety
- Trial name
- PGX (NCT02855580)
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obsessive-Compulsive Disorder, Treatment Resistant Disorders
Rituximab for Obsessive-compulsive Disorder. (RITS-PO-2019)
This study evaluates the addition of rituximab to 12 patients diagnosed with treatment resistant obsessive-compulsive disorder in an open trial.
- Trial name
- NCT03983031
- Testing
- Rituximab
- Where
- 2 sites in Sweden
- Volunteers
- 11 people
- Sponsor
- Region Örebro County
Anorexia Nervosa, Obsessive-compulsive Disorder
Neural Links Between OCD and Anorexia
Individuals with anorexia nervosa (AN) have long been observed to demonstrate symptoms in common with obsessive-compulsive disorder (OCD), in particular, an obsessive fear of normal weight leading to dangerous food restriction…
- Trial name
- NCT02085057
- Testing
- Functional Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obsessive-Compulsive Disorder
Alternative Treatment to Reduce Chronicity in OCD: Research Into Brain Response and Adequacy of Treatment
Rationale: Obsessive-Compulsive Disorder (OCD) is a disabling neuropsychiatric disorder that often has a chronic disease course.
- Trial name
- arrIBA (NCT03929081)
- Testing
- Inference Based Approach (IBA), Cognitive Behavioural Therapy (CBT)
- Where
- 7 sites in Netherlands
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- GGZ Centraal
Obsessive-Compulsive Disorder
Electrical Stimulation of the Internal Capsule for Intractable Obsessive-compulsive Disorder (OCD)
This study will evaluate the safety and effectiveness of deep brain stimulation in treating people with severe and otherwise treatment-resistant obsessive-compulsive disorder.
- Trial name
- NCT01061983
- Testing
- Medtronic Activa Deep Brain Stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Butler Hospital
Obsessive-Compulsive Disorder, Pain, Intractable
Psychosocial, Behavioral, and Radiologic Changes Following Radiosurgery for Benign Neurologic Disease
A number of studies from the literature suggest important behavioral, psychosocial, or radiologic changes occur following significant neurologic events or interventions such as stroke, neurosurgery, medications, radiation…
- Conditions
- Obsessive-Compulsive Disorder, Pain, Intractable, Depression
- Trial name
- NCT04688554
- Testing
- fMRI and DTI, Behavioral questionnaires, Disease-Specific Patient-Reported Outcomes
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Vanderbilt University Medical Center