Clinical trials: Obsessive Compulsive Disorders
Obsessive-Compulsive Disorder
Neurocircuit Mechanisms of OCD Across the Lifespan
Obsessive-compulsive disorder (OCD), characterized by intrusive thoughts (obsessions) and related behavioral rituals (compulsions), is a common psychiatric illness that often emerges in childhood and causes life-long disability…
- Trial name
- NCT02437773
- Testing
- Cognitive Behavioral Therapy - Adolescents, Stress Management Therapy - Adolescents, Optional CBT - Adolescents
- Where
- United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Anxiety Disorders, Depressive Disorder
Transdiagnostic Treatment Personalization
The primary purpose of this study is to explore whether the efficiency of treatment for anxiety and depressive disorders can be increased using two discrete strategies: personalized skill ordering and 2) treatment discontinuation…
- Conditions
- Anxiety Disorders, Depressive Disorder, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder
- Trial name
- NCT04584879
- Testing
- Standard UP Treatment, Capitalization UP Treatment, Compensation UP Treatment
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shannon E. Sauer-Zavala
Obsessive-Compulsive Disorder
The Gut Microbiota in Obsessive-Compulsive Disorder
This study will examine the gut microbiota and serum inflammatory markers in patients with Obsessive-Compulsive Disorder vs. healthy controls.
- Trial name
- NCT02285699
- Testing
- SSRIs
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- McMaster University
Anxiety Disorders
Transdiagnostic Treatment for Anxiety Disorders in Two Cities of México
This study evaluates the effectiveness of The Unified Transdiagnostic Protocol, a psychological treatment for the intervention of a broad range of anxiety disorders.
- Trial name
- NCT03916315
- Testing
- Transdiagnostic Treatment
- Where
- 2 sites in Mexico
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Obsessive Compulsive Disorder
Assessing the Effects of a Neurobehavioral Intervention on Symptoms of Obsessive Compulsive Disorder
This experiment will examine if the use of computerized tasks that train individuals to control their attention more effectively will predict individual differences in obsessive-compulsive symptoms, rumination and BDNF change.
- Trial name
- CCT-OC (NCT01414023)
- Testing
- Cognitive Control Training, Peripheral Vision Task
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Obsessive-Compulsive Disorder
Cognitive Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder
This study will examine the way cognitive behavioral therapy changes the structure of the brain in patients with obsessive-compulsive disorder and will thereby determine what makes cognitive behavioral therapy an effective…
- Trial name
- NCT00748761
- Testing
- Cognitive Behavioral Therapy (CBT), Waitlist
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obsessive-Compulsive Disorder (OCD)
Intensive Cognitive-Behavioral Therapy For Obsessive-Compulsive Disorder
Even with the best available treatments for obsessive-compulsive disorder (OCD), most patients only partially recover and many patients do not respond at all.
- Trial name
- NCT01368510
- Testing
- Intensive Cognitive Behavioral Therapy (CBT), Waitlist
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obsessive-Compulsive Disorder, Generalized Anxiety Disorder
The Role of Cognitive Control in the Transdiagnostic Conceptualization of "Intrusive Thoughts"
The investigators are examining whether difficulties with cognitive control (i.e., the ability to stop one's thought process and shift attention) is a common problem across three types of repetitive, negative thinking: obsessions…
- Conditions
- Obsessive-Compulsive Disorder, Generalized Anxiety Disorder, Major Depressive Disorder
- Trial name
- NCT03414619
- Testing
- Cognitive Control Tasks and Script Driven Imagery
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Obsessive-Compulsive Disorder
Decision-making Impairments in OCD: An Integrated Behavioral Economics Model
The investigators are examining whether conditions of ambiguity during decision-making may prime intolerance of uncertainty beliefs (i.e., difficulties coping with ambiguity, unpredictability, and the future) and lead to impaired…
- Trial name
- NCT03420495
- Testing
- Decision-Making Tasks
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Obsessive-Compulsive Disorder
The Study of the Pathogenesis and Cognitive Behavioral Group Therapy in Obsessive-Compulsive Disorder
This study intends to explore the pathogenesis of obsessive-compulsive disorder(OCD) by using biological technologies such as genetics and imaging, and to evaluate the efficacy of group cognitive behavioural therapy in OCD among…
- Trial name
- NCT02739061
- Testing
- cognitive behavioral group therapy, sertraline, fluvoxamine, cognitive behavioral group therapy and drug therapy
- Where
- China
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
Background: PANS is an illness that comes on suddenly in children. The full name is Pediatric Acute-Onset Neuropsychiatric Syndrome. It can cause sudden obsessive-compulsive behaviors.
- Trial name
- NCT03507218
- Where
- 8 sites in United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Obsessive Compulsive Disorder
Neural Mechanisms of CBT Response in Hoarding Disorder
The purpose of this research is to measure changes in brain activity with functional magnetic resonance imaging (fMRI) before and after cognitive-behavioral therapy for compulsive hoarding.
- Trial name
- NCT01956344
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Autism, Asperger's Syndrome
Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety
Autism spectrum disorders affect as many as 1 out of 88 children and are related to significant impairment in social, adaptive, and school functioning.
- Conditions
- Autism, Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified, Generalized Anxiety Disorder
- Trial name
- NCT01919970
- Testing
- Cognitive Behavioral Therapy, Treatment as usual
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Obsessive Compulsive Disorder, Major Depressive Disorder
Integrating Pharmacogenomic Testing Into a Child Psychiatry Clinic
The purpose of this study is to examine the feasibility, acceptability, and utility of pharmacogenomic (PGX) testing (specifically for the cytochrome P450 2D6 and 2C19 genes) prior to initiating treatment with an antidepressant…
- Conditions
- Obsessive Compulsive Disorder, Major Depressive Disorder, Anxiety
- Trial name
- PGX (NCT02855580)
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obsessive-Compulsive Disorder
Mindfulness Meditation Utilizing an EEG Biofeedback Device for the Treatment for Obsessive Compulsive Disorder
The Frederick W. Thompson Anxiety Disorders Centre has experienced significant demand for services related to the treatment of Obsessive Compulsive Disorder (OCD), resulting in a significant wait time for service.
- Trial name
- NCT03273699
- Testing
- Mindfulness
- Where
- Canada
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Obsessive-Compulsive Disorder
Control and Reward Circuits in Obsessive Compulsive Disorder
The purpose of this study is to examine the brain functioning of OCD patients and healthy controls before and after treatment with Exposure and Response Prevention (EXRP) therapy.
- Trial name
- NCT02221518
- Testing
- Exposure & Response Prevention (EX/RP)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder, Obsessive-Compulsive Disorder
Bioequivalence Study of Paroxetine Tablets and Paxil® Under Fasting and Fed Conditions in Chinese Healthy Volunteers
The objective of this study is to compare the rate and extent of absorption of paroxetine hydrochloride 20 mg tablets (test) and Paxil® (reference) administered as 20 mg tablet under fed conditions.
- Conditions
- Major Depressive Disorder, Obsessive-Compulsive Disorder, Panic Disorder, Social Anxiety Disorder
- Trial name
- NCT03504475
- Testing
- Paroxetine Hydrochloride Tablet 20 mg, Paxil® 20 mg
- Where
- 2 sites in China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Body Dysmorphic Disorder, Obsessive-compulsive Disorder
Oxytocin Administration in BDD and OCD
The purpose of the current study is to investigate the effect of an acute administration of intranasal oxytocin, relative to placebo, on social cognitive impairments among individuals with body dysmorphic disorder and…
- Trial name
- NCT02671266
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anxiety, Obsessive Compulsive Disorder
Virtual Reality System to Increase Access to Exposure Therapy for Anxiety and OCD
Cognitive Behavioral Therapy with fear provoking exposures is the most effective therapy for anxiety disorders. Investigators aim to enhance this therapy with the use of virtual reality exposures and to make therapy more…
- Trial name
- NCT02713516
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obsessive Thoughts
Study of the Efficacy of GGRO: a Novel Cognitive Training App
The aim of the present study was to evaluate the efficacy of GGRO reducing OCD related maladaptive beliefs and OCD symptoms. Specifically, a randomized controlled trial with crossover design was carried out in non-clinical…
- Trial name
- GGRO (NCT03571464)
- Testing
- GGRO Mobile App
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of Valencia