Clinical trials: Obsessive Compulsive Disorders
OCD
Effects of Sertraline on Brain Connectivity in Adolescents With OCD
The investigators will examine how treatment with sertraline for 12 weeks impacts frontal-striatal-thalamic circuitry (FSTC) in this OCD sample.
- Trial name
- NCT02797808
- Testing
- Sertraline, No Intervention
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obsessive-Compulsive Disorder in Children, Social Anxiety Disorder of Childhood
Parent-based Treatment for Youth With Anxiety and Obsessive-compulsive Disorder
Anxiety and obsessive-compulsive disorders are the most common mental health disorders in childhood and adolescence. A parenting intervention for youth with anxiety, called Supportive Parenting of Anxious Childhood Emotions…
- Conditions
- Obsessive-Compulsive Disorder in Children, Social Anxiety Disorder of Childhood, Obsessive-Compulsive Disorder in Adolescence, Separation Anxiety
- Trial name
- NCT04922502
- Testing
- Standard SPACE, Bibliotherapy, low therapist contact SPACE
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Autism, Asperger's Syndrome
Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders
Autism spectrum disorders affect as many as 1 out of 150 children and are related to significant impairment in social, adaptive, and school functioning.
- Conditions
- Autism, Asperger's Syndrome, Generalized Anxiety Disorder, Social Phobia
- Trial name
- NCT01178385
- Testing
- Cognitive-behavioral therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Anxiety, Obsessive-Compulsive Disorder
Virtual Reality System for Anxiety and OCD
Cognitive Behavioral Therapy with fear provoking exposures is the most effective therapy for anxiety disorders. The investigators aim to enhance this therapy with the use of virtual reality exposures.
- Trial name
- NCT03636022
- Testing
- VR System, Control
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Minnesota HealthSolutions
Autism, Asperger's Syndrome
Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism
Due to the considerable prevalence of anxiety in youth with autism spectrum disorders, this study seeks to establish the efficacy of a modified cognitive behavioral therapy protocol in 50 adolescents versus other available…
- Conditions
- Autism, Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified, Generalized Anxiety Disorder
- Trial name
- NCT01563003
- Testing
- Cognitive Behavioral Therapy, Treatment as usual
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Anxiety Disorders in Youth With Autism, Asperger's Syndrome, and Pervasive Developmental Disorder Not Otherwise Specified
Cognitive Behavioral Therapy (CBT) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents
Comorbid anxiety disorders affect as many as 80% of youth with autism spectrum disorders, causing substantial distress and impairment over and above the autism spectrum diagnosis alone.
- Trial name
- NCT01177969
- Testing
- Cognitive-Behavioral Therapy, Wait-list
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Hoarding Disorder
Cognitive Rehab and Exposure Treatment for Hoarding
This project will utilize a novel behavioral intervention for hoarding disorder that takes into account age and neurocognitive factors.
- Trial name
- CREST (NCT02402647)
- Testing
- Cognitive Rehabilitation and Exposure/Sorting Treatment (CREST), Exposure Therapy (ET)
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Anxiety Disorders, Post Traumatic Stress Disorder
Increasing Treatment Efficacy Using SMART Methods for Personalizing Care
The proposed study will determine the feasibility, tolerability, and acceptability of a study that tests: 1) personalized treatment delivery (i.e., module sequencing and treatment discontinuation timing) aimed at increasing the…
- Conditions
- Anxiety Disorders, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder
- Trial name
- NCT04642898
- Testing
- Standard UP Treatment, Capitalization UP Treatment, Compensation UP Treatment
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Shannon E. Sauer-Zavala
Autism, Asperger's Syndrome
Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety
Autism spectrum disorders affect as many as 1 out of 88 children and are related to significant impairment in social, adaptive, and school functioning.
- Conditions
- Autism, Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified, Generalized Anxiety Disorder
- Trial name
- NCT01919970
- Testing
- Cognitive Behavioral Therapy, Treatment as usual
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of South Florida
OCD, Decision-Making
Arbitration Between Habitual and Goal-directed Behavior in Obsessive-compulsive Disorder: Circuit Dynamics and Effects of Noninvasive Neurostimulation
People utilize two behavioral strategies, goal-directed and habitual, when engaging in value-based decision-making that involves rewarding or punishing outcomes.
- Conditions
- OCD, Decision-Making, tDCS, fMRI
- Trial name
- NCT04075890
- Testing
- transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obsessive Compulsive Disorder
Overlapping Neural Circuits in Pediatric OCD
The purpose of this study is to examine the brain functioning of children and adolescent with OCD before and after treatment with Exposure and Response Prevention (EXRP) therapy.
- Trial name
- NCT02421315
- Testing
- CBT treatment for OCD based on Exposure & Response Prevention (EX/RP) and when indicated medication treatment
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Obsessive-compulsive Disorder
D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
Cognitive-behavioral therapy (CBT) has proven efficacy for treatment of pediatric obsessive-compulsive disorder (OCD). Yet, CBT does not help all children and those who benefit often remain symptomatic upon treatment completion.
- Trial name
- NCT00864123
- Testing
- Cognitive-behavioral therapy, D-cycloserine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Body Dysmorphic Disorder, Obsessive-compulsive Disorder
Oxytocin Administration in BDD and OCD
The purpose of the current study is to investigate the effect of an acute administration of intranasal oxytocin, relative to placebo, on social cognitive impairments among individuals with body dysmorphic disorder and…
- Trial name
- NCT02671266
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Obsessive Compulsive Disorder
Videophone Administered Cognitive-Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder
Although cognitive-behavioral therapy (CBT) is the most effective intervention for pediatric obsessive-compulsive disorder (OCD), many people do receive CBT initially.
- Trial name
- NCT00881465
- Testing
- Cognitive-behavioral therapy, Wait-list control
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Autism Spectrum Disorders, Autism
Psychotherapy for Anxiety in Children With Autism Spectrum Disorder
Anxiety disorders affect 40 to 50% of children with autism spectrum disorders (ASD), contributing to substantial distress and impairment.
- Conditions
- Autism Spectrum Disorders, Autism, Asperger's Syndrome, Pervasive Developmental Disability - Not Otherwise Specified
- Trial name
- TAASD (NCT02028247)
- Testing
- Personalized Cognitive-behavioral therapy, Standard Practice Cognitive-behavioral therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Obsessive-compulsive Disorder
D-cycloserine Augmentation of Cognitive Behavioral Therapy (CBT) for Pediatric Obsessive-compulsive Disorder (OCD)
The investigators are conducting a randomized double-blind placebo-controlled study to assess the efficacy of d-cycloserine augmentation of cognitive-behavioral therapy for the treatment of pediatric obsessive compulsive…
- Trial name
- NCT01411774
- Testing
- Cognitive-behavioral therapy, d-cycloserine
- Where
- 2 sites in United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of South Florida