Clinical trials: Obstetric Bleeding
Postpartum Hemorrhage
Misoprostol for the Treatment of Postpartum Hemorrhage
The purpose of this study is to test whether misoprostol is as effective as oxytocin for treating primary postpartum hemorrhage (PPH) with uterine atony as the suspected cause in two circumstances: 1) where women have received…
- Trial name
- NCT00116350
- Testing
- Misoprostol, Oxytocin
- Where
- 6 sites in Burkina Faso, Ecuador and 3 more
- Volunteers
- 1,786 people
- Sponsor
- Gynuity Health Projects
Post Partum Hemorrhage
Use of TXA to Prevent Postpartum Hemorrhage
Postpartum hemorrhage (PPH) occurs in up to one in ten deliveries worldwide and is the leading cause of maternal morbidity and mortality.
- Trial name
- TAPPH-1 (NCT03069859)
- Testing
- TXA (1g)
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Sunnybrook Health Sciences Centre
Postpartum Hemorrhage, Immediate Postpartum Hemorrhage
Safety and Effectiveness of the KOKO Device to Treat Primary Abnormal Postpartum Uterine Bleeding or Hemorrhage
The purpose of this study is to evaluate the safety and effectiveness of the KOKO™ device in the control and reduction of primary abnormal postpartum uterine bleeding or hemorrhage.
- Conditions
- Postpartum Hemorrhage, Immediate Postpartum Hemorrhage, Hemorrhage, Postpartum
- Trial name
- SERENE (NCT06452355)
- Testing
- KOKO Device
- Where
- 17 sites in United States
- Volunteers
- 73 people
- Sponsor
- KOKO Medical Inc.
Postpartum Hemorrhage
Carbetocin Versus Oral Tranexamic Acid Plus, Buccal Misoprostol on Blood Loss After Vaginal Delivery
Excessive bleeding at or after childbirth accounts for about half of all the post-partum maternal deaths in developing countries and is the single most important cause of maternal mortality worldwide.
- Trial name
- NCT03708497
- Testing
- carbetocin, Tranexamic acid plus misoprostol, misoprostol
- Where
- 2 sites in Egypt
- Volunteers
- 360 people
- Sponsor
- Aswan University Hospital
Cesarean Section Complications
Buccal Misoprostol and Intravenous Tranexamic Acid During Emergent Cesarean Delivery
Purpose to evaluate the effects of buccal misoprostol with or without intravenous tranexamic acid (TA) in comparison with placebo on reducing post-partum hemorrhage in pregnant women undergoing emergent cesarean section
- Trial name
- NCT03777696
- Testing
- Misoprostol, TA
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- hany farouk
Placenta Accreta
Internal Iliac Artery Occlusion in Placenta Accreta
This is a randomized study to assess the efficacy of prophylactic bilateral internal iliac artery occlusion performed prior to planned surgical management for placenta accreta spectrum (PAS).
- Trial name
- NCT04423263
- Testing
- Bilateral internal iliac artery balloon occlusion, Control
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Voon Hian Yan
Obstetric Complication, Postpartum Hemorrhage
Antibiotics During Intrauterine Balloon Tamponade Placement
The goal of this study is to identify whether antibiotics given at the time of placement of an intrauterine balloon tamponade (IBT) will result in reduction of the risk of endometritis.
- Conditions
- Obstetric Complication, Postpartum Hemorrhage, Postpartum Endometritis
- Trial name
- NCT03478163
- Testing
- CeFAZolin 1000 MG, Clindamycin 900 MG in 6 ML Injection
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cedars-Sinai Medical Center
Postpartum Hemorrhage
Clinical Study to Assess the Equivalence of Tranexamic Acid vs Oxytocin in Reducing the PPH (TRANOXY2015)
The purpose of this study was to evaluate that the tranexamic acid (TXA)Intravenous and oral, is equivalent oxytocin (OXY),intramuscularly, in reducing the blood loss in post partum period (mL) in patients at the end of pregnancy…
- Trial name
- TRANOXY2015 (NCT02503319)
- Testing
- Tranexamic Acid, Oxytocin
- Sponsor
- Azienda U.S.L. 1 di Massa e Carrara
Postpartum Hemorrhage
Rectal Misoprostol for Reducing Blood Loss in Elective Cesarean Section
This randomized controlled trial aims to evaluate the efficacy of adding preoperative rectal misoprostol to standard oxytocin for reducing intraoperative and postoperative blood loss in women undergoing elective cesarean section.
- Trial name
- NCT07188207
- Testing
- Oxytocin
- Volunteers
- 282 people
- Sponsor
- Assiut University
Blood Loss Massive, Post Operative Hemorrhage
Evaluation of the Quantra QStat System in Obstetric Patients
This pilot study will assess the performance of the Quantra System with the QStat Cartridge versus standard of care coagulation testing in bleeding pregnant women at delivery.
- Trial name
- NCT05875987
- Testing
- Quantra System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- HemoSonics LLC
Blood Loss, Surgical, Postpartum Hemorrhage
Ideal Time of Oxytocin Infusion During Cesarean Section
This study will evaluate if the timing of oxytocin administration in cesarean deliveries will affect the amount of maternal blood loss.
- Conditions
- Blood Loss, Surgical, Postpartum Hemorrhage, Bleed Pregnancy, Pregnancy Related
- Trial name
- I-TOPICS (NCT03246919)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Loyola University
Postpartum Hemorrhage
A Program to Evaluate Riastap® and FIBTEM® for the Early Control and Treatment of Postpartum Hemorrhage (PERFECT PPH)
In this prospective, single-center, randomized, placebo-controlled, double-blind clinical trial, parturients with primary PPH are eligible for treatment with fibrinogen concentrate following both vaginal delivery and cesarean…
- Trial name
- PERFECT PPH (NCT02528708)
- Testing
- fibrinogen concentrate
- Sponsor
- Yale University
Miscarriage, Preterm Birth
Progesterone for the Prevention of Miscarriage and Preterm Birth in Women With First Trimester Bleeding: PREEMPT Trial
Miscarriages and preterm births are common and serious events affecting women, families, and healthcare systems on many levels. One of the risk factors for miscarriage and preterm birth is bleeding in the first trimester of…
- Trial name
- NCT02145767
- Testing
- Progesterone
- Where
- 7 sites in Canada
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Postpartum Hemorrhage
Tranexamic Acid in Preventing Postpartum Hemorrhage in High Risk Pregnancies During Elective Cesarean Section
postpartum hemorrhage (PPT) represents one of the major causes of maternal mortality . Tranexamic acid is used in many studies in management of PPH in combination with ecobolics.
- Trial name
- NCT03351686
- Testing
- Tranexamic Acid
- Volunteers
- 140 people
- Sponsor
- Mansoura University
Postpartum Hemorrhage
THUMB: Multi-centre Cluster Trial for Caesarean Section Haemorrhage
The quality improvement project evaluating the delivery of a perioperative care complex intervention to improve haemorrhage-related outcomes in patients undergoing caesarean section.
- Trial name
- NCT07005349
- Testing
- Quality improvement program
- Where
- South Africa
- Volunteers
- 2,400 people
- Sponsor
- Bruce Biccard
Postpartum Hemorrhage
IV vs IM Oxytocin in the Third Stage of Labor for Prevention of Postpartum Hemorrhage
The study will evaluate whether prophylactic oxytocin administered in the third stage of labor via IV infusion results in a lower mean blood loss compared to IM injection.
- Trial name
- NCT01608958
- Testing
- Oxytocin
- Where
- 3 sites in Ecuador, Turkey (Türkiye) and 1 more
- Volunteers
- 653 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Postpartum Hemorrhage
Balloon Tamponade for Atonic Primary Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is responsible for around 25% of maternal mortality worldwide reaching as high as 60% in some countries.PPH can also be a cause of long-term severe morbidity, and approximately 12% of women who survive…
- Trial name
- UBT (NCT02430155)
- Testing
- Bakri balloon, Condom loaded foley's catheter
- Volunteers
- 66 people
- Sponsor
- Assiut University
Post-Abortion, Hemorrhage, Obstetric
Oxytocin Receptor Expression in Pregnancy
This study aims to determine when during gestation oxytocin receptor (OXTR) expression increases in the myometrium, which will contribute new insight to the management of obstetric hemorrhage and our understanding of normal and…
- Trial name
- NCT03907735
- Testing
- Myometrial tissue sample collection
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Placenta Accreta
Efficacy of Hydrogen Peroxide ( H2O2) in Controlling Placental Site Bleeding in Caesarian Delivery for Placenta Previa / Accreta Spectrum ( PAS)
Placenta accreta spectrum (PAS), encompassing the terms placenta accreta, increta, and percreta; abnormally invasive placenta; morbidly adherent placenta; and invasive placentation, is a leading cause of life-threatening…
- Trial name
- NCT06030492
- Testing
- packing placental site with hydrogen peroxide soaked towels, normal Saline
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neonates Premature
Longterm Outcome of Children With Neonatal Intra-Ventricular or Intra-Cranial Hemorrhage
Intraventricular hemorrhage (IVH) is the most commonly recognized cerebral lesion on ultrasound in extremely preterm infants. Papile classification is commonly used to grade the severity of IVH.
- Trial name
- NEONATAL ICH (NCT03019692)
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Laniado Hospital