Clinical trials: Obstetric Bleeding
Cesarean Section Complications
Tranexamic Acid Plus Buccal Misoprostol on Blood Loss During and After Cesarean Delivery
Postpartum hemorrhage (PPH) is potentially life-threatening and is a significant contributor to maternal mortality and morbidity especially in developing countries.
- Trial name
- NCT03710304
- Testing
- Oxytocin, Tranexamic acid plus misoprostol, misoprostol
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Aswan University Hospital
Placenta Accreta, Post Partum Hemorrhage
Tourniquet Reduces Blood Loss in Postpartum Hemorrhage During Hysterectomy for Placenta Accreta
Monocentric prospective observational study comparing the use of tourniquet in low uterus segement versus standard procedure in hysterectomy owing to placenta accreta
- Conditions
- Placenta Accreta, Post Partum Hemorrhage, Blood Loss Massive
- Trial name
- NCT03707132
- Testing
- Tourniquet: Folley catheter in the low segment of the uterus
- Volunteers
- 43 people
- Sponsor
- University Tunis El Manar
Premature Birth, Mortality
Trial to Evaluate a Specified Type of Apgar (TEST-APGAR) Follow Up Study
A specified version of the Apgar-Score, that can be used in newborns under resuscitation, was developed and its value to predict chronic damage in preterm infants will be tested.
- Conditions
- Premature Birth, Mortality, Apgar Score
- Trial name
- NCT01186627
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- Technische Universität Dresden
Intraventricular Hemorrhage of Prematurity, Complications of Prematurity
Cerebral Oxygenation and Autoregulation in Preterm Infants
Premature infants are at high risk for variations in blood pressure and oxygenation during the first few days of life. The immaturity of the premature brain may further predispose these infants to death or the development of…
- Trial name
- Early NIRS (NCT02147769)
- Testing
- NIRS monitoring
- Where
- 7 sites in United States
- Volunteers
- 111 people
- Sponsor
- Stanford University
Post Partum Hemorrhage
Misoprostol Before and After Cesarean Section
comparison of the effect of misoprostol before and after cesarean on the blood loss
- Trial name
- NCT03463070
- Testing
- rectal misoprostol 600mg
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- sarah mohamed hassan
Postpartum Hemorrhage
Comparison Between Preoperative Vaginal and Postoperative Sublingual Misoprostol for Prevention of Postpartum Hemorrhage During Cesarean Section
Cesarean section (CS) is one of the most frequently performed operative interventions worldwide [1]. Cesarean section rates increase each year throughout the world.
- Trial name
- NCT06765473
- Testing
- Misoprostol
- Volunteers
- 400 people
- Sponsor
- Assiut University
Postpartum Hemorrhage, Obesity
Oxytocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With BMI ≥ 40kg/m2
Postpartum hemorrhage (PPH) due to uterine atony is a major cause of maternal morbidity and mortality. Uterotonic drugs are used to improve the muscle tone of the uterus after birth, and these are effective at reducing the…
- Trial name
- NCT03957083
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Placenta Previa
Sonographic Parameters and Risk of Antepartum Hemorrhage in Asymptomatic Women With Placenta Previa: A Cohort Study
The aim of this study is to evaluate the effectiveness of ultrasonographic parameters (cervical length, placental thickness and distance placental edge from internal os of the cervix) in predicting the risk of antepartum…
- Trial name
- NCT05802251
- Testing
- Ultrasonographic parameters
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Ain Shams University
Postpartum Hemorrhage
Prediction of Uterine Atony After Vaginal Delivery by Elastography
Prospective study evaluating the feasibility of shear-wave elastography of the uterus during the third stage of labour and following placental delivery.
- Trial name
- NCT04267783
- Testing
- Shear wave elastography
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Postpartum Hemorrhage
Carbetocin at Elective Cesarean Delivery Part 3
Post-partum hemorrhage (PPH) is a major cause of maternal death worldwide. Oxytocin is the most common uterotonic drug used to prevent and treat PPH in North America, however, there are some limitations to its use.
- Trial name
- NCT01651130
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
Prophylactic Amnioinfusion for Prevention of Postpartum Hemorrhage
The purpose of this study is to decrease the likelihood of composite postpartum hemorrhage (PPH) morbidity, which consists of i) Estimated or quantified blood loss of 1,500 mL or more, ii) transfusion of any blood products or…
- Trial name
- PURPOSE (NCT06691945)
- Testing
- Saline delivered using an intrauterine pressure catheter (IUPC)
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- The University of Texas Health Science Center, Houston
Respiratory Distress Syndrome, Intraventricular Haemorrhage
Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth
Administration of steroid to the mother in imminent preterm delivery is a known effective practice to decrease the risk of respiratory distress syndrome and intraventricular haemorrhage in preterm infants if given with a week of…
- Trial name
- NCT00295464
- Testing
- Betamethasone sodium phos (drug)
- Where
- 10 sites in Finland
- Volunteers
- 440 people
- Sponsor
- University of Oulu
Intact Cord Placental Delivery, Delayed Cord Clamping
Intact Cord Placental Delivery vs Delayed Cord Clamping
The management of the third stage of labour plays a critical role in neonatal transition. Uninterrupted Intact Cord Clamping (UICC), is a clinical approach where the umbilical cord remains unclamped until the placenta is…
- Conditions
- Intact Cord Placental Delivery, Delayed Cord Clamping, Standard Delayed Cord Clamping, Timing of Cord Clamping
- Trial name
- TTC (NCT07713277)
- Where
- Italy
- Volunteers
- 1,979 people, healthy volunteers welcome
- Sponsor
- Azienda ULSS 8 Berica
Postpartum Hemorrhage
Investigating the Association of Shock Index and Hemoglobin Variation With Postpartum Hemorrhage After Vaginal Deliveries
Postpartum hemorrhage (PPH) is a leading cause of maternal mortality and morbidity, and is most commonly caused by poor uterine tone after delivery of the baby and placenta.
- Trial name
- NCT03432767
- Testing
- Non-invasive hemoglobin monitor
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Mayer-Rokitansky-Kuster Syndrome, Asherson's Syndrome
INvestigational Study Into Transplantation of the Uterus
Observational study on cohort of 10 women undergoing uterine transplantation using deceased donors
- Conditions
- Mayer-Rokitansky-Kuster Syndrome, Asherson's Syndrome, Postpartum Hemorrhage, Cervical Cancer
- Trial name
- INSITU (NCT04244409)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Womb Transplant UK
Postpartum Hemorrhage, Second Line Management
Surgical Management of Postpartum Haemorrhage Without Embolization
Postpartum haemorrhage is the main cause of maternal mortality. The aim of investigators' study was to evaluate the practice of hemostatic surgery (arterial ligation, uterine compression or hysterectomy) when the embolization of…
- Conditions
- Postpartum Hemorrhage, Second Line Management, Uterine Arteries Embolization, Surgical Management of Haemorrhage
- Trial name
- NCT03517800
- Testing
- Arterial embolization and/or surgical management.
- Where
- France
- Volunteers
- 716 people
- Sponsor
- University Hospital, Montpellier
Superficial Injuries Involving Head With Neck
The Relationship Between Isolated Head Trauma During Pregnancy and Preterm Birth
Pregnant patients who presented to the Emergency Department of Şanlıurfa Training and Research Hospital with isolated head trauma due between January 2018 and January 2024 were included in the study and followed up with until the…
- Trial name
- PB (NCT06685549)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Sanliurfa Education and Research Hospital
Postpartum Hemorrhage
Rotational Thromboelastometry for the Transfusion Management of Postpartum Hemorrhage After Vaginal or Cesarean Delivery
The aim of this study is to evaluate the impact of a rotational thromboelastometry (ROTEM®)-based transfusion protocol during postpartum hemorrhage (PPH) after vaginal or cesarean delivery.
- Trial name
- NCT03064152
- Testing
- Rotational Thromboelastometry
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cesarean Section Complications
Reducing Blood Loss During Cesarean Hysterectomy for Placenta Accreta Spectrum
PAS is an obstetrics condition that is closely linked with massive obstetrical hemorrhage with a varied incidence about once in every 533 live births.
- Trial name
- NCT03570710
- Testing
- intravenous tranexamic acid, Topical tranexamic acid, Normal saline
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Aswan University Hospital
Post Partum Hemorrhage
Tranexamic Acid for Prevention of Postpartum Haemorrhage: a Dose-finding Study
Published trials on tranexamic acid (TxA) for prevention have used a variety of fixed (0.5gm or 1gm) and body-weight adjusted (10mg/kg or 15mg/kg) doses of TxA.
- Trial name
- NCT03565276
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Mount Sinai Hospital, Canada