Clinical trials: Obstetric Bleeding
Immediate Postpartum Hemorrhage
Intrauterine Tamponade With a Belfort-Dildy Balloon in the Treatment of Immediate Postpartum Hemorrhage
The purpose of this study is to evaluate the impact of early intrauterine tamponade with a Belfort-Dildy balloon catheter in immediate postpartum hemorrhage(IPPH) after vaginal delivery and refractory to first-line uterotonic…
- Trial name
- TUB (NCT02226731)
- Testing
- Early Belfort-Dildy Balloon, Late Belfort-Dildy balloon
- Where
- France
- Volunteers
- 405 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Skin to Skin Contact
The Effect of Skin to Skin Contact on Postpartum Hemorrhage, Pain And Breastfeeding
The aim of this study was to determine the effect of postpartum hemorrhage, pain and onset of early breastfeeding so that the skin applied at the third stage of birth is in contact with the skin.
- Trial name
- NCT04425096
- Testing
- Skin to skin contact
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Uterine Atony, Uterine Atony With Hemorrhage
Calcium Chloride for Prevention of Uterine Atony During Cesarean
In this pilot study, investigators will administer calcium chloride or placebo to pregnant women undergoing Cesarean delivery who have been identified as high risk for hemorrhage due to poor uterine muscle contraction, or atony.
- Conditions
- Uterine Atony, Uterine Atony With Hemorrhage, Cesarean Section Complications
- Trial name
- NCT03867383
- Testing
- Calcium Chloride
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Postpartum Hemorrhage
Carbetocin at Cesarean Delivery for Labor Arrest
In 2009, the Society of Obstetricians and Gynecologists Canada, which produces national clinical guidelines on important women's health issues, recommended that a bolus of carbetocin 100 mcg into your vein should be used at…
- Trial name
- NCT01725243
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Bilateral Uterine Artery Ligation, Intrapartum or Postpartum Hemorrhage
Bilateral Uterine Artery Ligation After Intrapartum or Postpartum Hemorrhage on Ovarian Reserve Markers and Pregnancy Outcome
The aim of this study is to assess the possible negative effects of uterine artery ligation on ovarian reserve markers and subsequent pregnancy outcomes
- Conditions
- Bilateral Uterine Artery Ligation, Intrapartum or Postpartum Hemorrhage, Ovarian Reserve Markers, Pregnancy Outcome
- Trial name
- NCT05647538
- Testing
- Bilateral uterine artery ligation
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Post Partum Bleeding
Balloon Catheters in Cases of Abnormal Placentation
Placenta accreta is a relatively rare event, in which the placenta is abnormally implanted into the uterine myometrium. The most significant complication is intense bleeding, mainly during labor.
- Trial name
- Accreta (NCT01373255)
- Testing
- internal iliac catheterization
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- HaEmek Medical Center, Israel
Postpartum Haemorrhage
Fibrinogen Concentrate as Initial Treatment for Postpartum Haemorrhage: A Randomised Clinically Controlled Trial
Severe maternal bleeding is a serious complication of birth and causes 125.000 deaths worldwide each year. The investigators aim to investigate if early treatment with fibrinogen concentrate versus saline can reduce the incidence…
- Trial name
- FIB-PPH (NCT01359878)
- Testing
- Fibrinogen Concentrate, Isotonic Saline
- Where
- 4 sites in Denmark
- Volunteers
- 249 people
- Sponsor
- Copenhagen University Hospital at Herlev
Neonatal Mortality, Omphalitis
Newborn Care Kit to Save Lives in GB, Pakistan
Neonatal deaths account for almost half of all deaths in children under 5 years of age. Pakistan has the world's highest neonatal mortality rate (NMR), and many of these deaths are preventable.
- Conditions
- Neonatal Mortality, Omphalitis, Post-Partum Hemorrhage
- Trial name
- iNCK (NCT04798833)
- Testing
- Integrated Newborn Care Kit (iNCK)
- Where
- 2 sites in Pakistan
- Volunteers
- 19,344 people
- Sponsor
- The Hospital for Sick Children
Postpartum Hemorrhage, Twin Pregnancy
Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage
The goal of this clinical trial is to learn if the drug carbetocin works better than standard care to prevent heavy bleeding after childbirth in people carrying twin pregnancies.
- Trial name
- CUTT-PPH (NCT07401524)
- Testing
- Carbetocin, Oxytocin
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center
Postpartum Hemorrhage, Cesarean Section Complications
Placental Removal Method And Uterine Massage On Preventing Postpartum Hemorrhage
Postpartum hemorrhage is the leading cause of maternal deaths in all over the world, especially in developing and underdeveloped countries. Medical and surgical methods exist for management of bleeding.
- Conditions
- Postpartum Hemorrhage, Cesarean Section Complications, Uterine Atony
- Trial name
- NCT06192836
- Testing
- Manual Removal 1, Manual Removal 2, Controlled Cord Traction 1
- Where
- Turkey (Türkiye)
- Volunteers
- 361 people
- Sponsor
- Busra Lekesiz
Analgesia, Obstetrical, Postpartum Hemorrhage
Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
In this randomized, double-blind control trial to evaluate the effect of ketorolac given at the time of cord clamp has on estimated blood loss and postcesarean pain control.
- Conditions
- Analgesia, Obstetrical, Postpartum Hemorrhage, Opioid Use, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT02509312
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Post Partum Hemorrhage
Oxytocin in Cesarean Delivery
In this study the investigators hypothesize that infused combinations of oxytocin and ergometrine will exhibit fewer cardiac and neurological side effects than equipotent infusion of oxytocin alone.
- Trial name
- NCT01236482
- Testing
- Oxytocin versus oxytocin-ergometrine
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Hadassah Medical Organization
Postpartum Hemorrhage, Twin
Carbetocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With Twin Pregnancy.
Poor uterine tone after the birth of a baby can cause excess bleeding (called postpartum hemorrhage or PPH). This is a major cause of maternal death worldwide.
- Trial name
- NCT04182360
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Bilateral Iliac Artery Ligation, Postpartum Hemorrhage
Influence of BIIAL Following PPH on Dorsal Clitoral Artery Blood Flow and FSFI
Dorsal clitoral artery Doppler examinations in women with bilateral internal iliac artery ligation due to postpartum hemorrhage (study group) and age-matched healthy puerperal women were performed regularly in the postoperative…
- Trial name
- NCT02409602
- Testing
- Doppler ultrasonographic examination
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Placenta Accreta
Bilateral Uterine Artery Ligation in PPC Technique for Management of PAS
Aim of the study Primary outcomes: 1. The effect of bilateral uterine artery ligation in reducing intraoperative bleeding in women underwent PPC as a conservative surgical technique. 2. Decrease surgical time.
- Trial name
- NCT05314595
- Testing
- bilateral uterine artery ligation
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Assiut University
Prematurity, Bronchopulmonary Dysplasia
Inhaled Nitric Oxide and Neuroprotection in Premature Infants
The purpose of this study is to determine whether inhaled nitric oxide improves the neurological outcome for premature infants.
- Conditions
- Prematurity, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage, Periventricular Leukomalacia
- Trial name
- NOVA2 (NCT00515281)
- Testing
- inhaled nitric oxide, oxygen
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- University of Chicago
Uterine Atony, Post-partum Hemorrhage
Comparison of Two Doses of Carbetocin for Prevention of Uterine Atony, During Elective Cesarean Section
The purpose of this study is to evaluate the effectiveness of two doses of carbetocin (50 mcg vs 100 mcg) in preventing uterine atony during elective cesarean section.
- Trial name
- NCT01630187
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Laval University
Healthy Participants
Rate of Tranexamic Acid Administration on Blood Pressure (RateTXA) Study.
Tranexamic acid is a well-established treatment for post-partum hemorrhage. This study aims to examine the effect of tranexamic acid administration rates on blood pressure changes over 1 minute compared to 10 minutes in healthy…
- Trial name
- RateTXA (NCT06356948)
- Testing
- Tranexamic Acid (TXA)
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Infertility Unexplained, Abnormal Uterine Bleeding
Diagnostics of Chronic Endometritis in Infertility
Chronic endometritis (CE) is characterized by the presence of atypical plasma cell infiltrates (CD138 positive) in the endometrial stroma.
- Conditions
- Infertility Unexplained, Abnormal Uterine Bleeding, Intrauterine Disorder
- Trial name
- NCT05946655
- Testing
- Ofloxacin + Metronidazole
- Where
- Poland
- Volunteers
- 102 people
- Sponsor
- Jagiellonian University
Post Partum Hemorrhage
Prophylactic Tranexamic Acid To Reduce Blood Loss During Caesarean Delivery.
Postpartum hemorrhage continues to be the leading cause of maternal morbidity and mortality. Globally, it is responsible for 25% of all pregnancy-related deaths. PPH is unpredictable and may occur in the absence of risk factors.
- Trial name
- NCT06604325
- Testing
- Tranexamic acid injection
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Aligarh Muslim University