Clinical trials: Obstetric Labor
Vulvodynia, Mycoses
Prospective Data Bank Creation to Study Vaginal Conditions
The purpose of this study is to identify and elucidate the pattern and perhaps role of atypical proteins, cytokines and vaginal microbial flora in the pathogenic mechanisms involved in the development of vulvodynia, recurrent…
- Conditions
- Vulvodynia, Mycoses, Bacterial Vaginosis, Preterm Labor
- Trial name
- CRIPB-13-002 (NCT01829204)
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Perineal Trauma, Pelvic Floor Dysfunction
Pelvic Floor Training Program and Perineal Trauma During Vaginal Birth
This study aims to determine whether a structured pelvic floor muscle training program during pregnancy can reduce perineal trauma during vaginal birth.
- Conditions
- Perineal Trauma, Pelvic Floor Dysfunction, Labor Complications, Pelvic Floor Muscle Training
- Trial name
- PFTP (NCT07292948)
- Testing
- Pelvic Floor Muscle Training Program
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mehmet Incebıyik
Pregnancy Related, Labor Complication
Mechanical Dilation of the Cervix in a Scarred Uterus
To determine if mechanical labour induction can offer a safer and effective alternative to prostaglandins to women with previous caesarean section attempting trial of labour after caesarean (TOLAC).
- Conditions
- Pregnancy Related, Labor Complication, Cesarean Section; Dehiscence
- Trial name
- MEDICS (NCT03471858)
- Testing
- Cervical balloon, Prostaglandins
- Where
- Singapore
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Singapore
Preterm Labor (24 GA - 32 GA)
Identification of Spontaneous Delivery Markers
The investigators project aims to identify, in pregnant women, discriminating molecules to allow an early detection of women who will spontaneously deliver prematurely, suitable in routine clinical practice.
- Trial name
- TrophY2 (NCT02225717)
- Testing
- Cervicovaginal swab
- Where
- France
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fetal Hypoxia, Fetal Distress
Trans-Abdominal Fetal Pulse Oximetry - EFS-IDE
The Lumerah System, developed and manufactured by Raydiant Oximetry, Inc., is a non-invasive fetal pulse oximeter that measures fetal arterial oxygen saturation using safe, non-invasive, transabdominal near-infrared spectroscopy.
- Conditions
- Fetal Hypoxia, Fetal Distress, Fetal Conditions, Fetal Complications
- Trial name
- NCT06405984
- Testing
- Fetal Oxygenation Measurements
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Raydiant Oximetry, Inc.
Cesarean Delivery Affecting Fetus, Labor Dystocia
Early Diagnosis and Intervention for Fetal Malposition in Active Labor and Its Impact on Mode of Delivery
The goal of this randomized trial is to test if changing a person's position in labor can increase the chances of delivering their baby vaginally.
- Conditions
- Cesarean Delivery Affecting Fetus, Labor Dystocia, Labor Complication
- Trial name
- NCT05881629
- Testing
- Maternal position change to side-lying lateral with peanut ball, Free maternal position
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Hypotension, Labor Complication
Leg Elevation to Prevent Hypotension During Labor
When hypotension is related to epidural placement, this can occur within 15-60 minutes after placement. The purpose of this study is to build upon this preliminary work and to use a randomized controlled trial to examine the…
- Trial name
- NCT05674838
- Testing
- Leg Elevation
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Preterm Labor
Ibuprofen Versus Indomethacin Following Emergent Cerclage Placement
Cervical insufficiency is defined as painless cervical dilation in the second trimester. Cervical insufficiency can ultimately lead to second trimester loss of pregnancy.
- Trial name
- TOCO (NCT04726085)
- Testing
- Indomethacin 150mg, Ibuprofen 2400mg
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Woman's
Post-Abortion, Hemorrhage, Obstetric
Oxytocin Receptor Expression in Pregnancy
This study aims to determine when during gestation oxytocin receptor (OXTR) expression increases in the myometrium, which will contribute new insight to the management of obstetric hemorrhage and our understanding of normal and…
- Trial name
- NCT03907735
- Testing
- Myometrial tissue sample collection
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Hypotension, Labor Complication
Pre-epidural Sequential Compression Devices (SCDs) to Prevent Hypotension During Labor
When hypotension is related to epidural placement, this can occur within 15-60 minutes after placement. The purpose of this study is to build upon this preliminary work and to use a randomized controlled trial to examine the…
- Trial name
- NCT05250960
- Testing
- SCD
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Labor Dystocia, Labor Complication
The Norwegian World Health Organisation Labour Care Guide Trial (NORWEL)
Appropriate and timely care during birth is critical to the survival and health of women and their babies. In 2020, the World Health Organization (WHO) presented the Labour Care Guide (LCG) as the new recommended tool for…
- Conditions
- Labor Dystocia, Labor Complication, Labor Onset and Length Abnormalities, Labor (Obstetrics)--Complications
- Trial name
- NORWEL (NCT05791630)
- Testing
- the labour care guide (LCG)
- Where
- 10 sites in Norway
- Volunteers
- 23,650 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust
Preterm Birth, Preterm Labor
To Optimize Antenatal Management of Women With Pre Term Labor Using Amniocentesis
Implementation of prediction models of risk of spontaneous delivery within 7 days or of intra-amniotic infection in women with preterm labor and intact membranes
- Conditions
- Preterm Birth, Preterm Labor, Intra-amniotic Infection, Amniocentesis Affecting Fetus or Newborn
- Trial name
- OPTIM-PTL (NCT04831086)
- Testing
- Steroid Drug, Tocolytic Agents
- Where
- Spain
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Preterm Birth, Preterm Premature Rupture of Membrane
Amniochorionic Membrane Cells in the Maternal Blood as a Biomarker for Preterm Birth
Globally, preterm birth (15 mill. per year) is the leading cause of under-5 child mortality (1 mill. per year) and morbidity. Important pathways include preterm labor contractions, Preterm Prelabor Rupture of the Fetal Membranes…
- Conditions
- Preterm Birth, Preterm Premature Rupture of Membrane, Preterm Labor
- Trial name
- NCT04705935
- Where
- Denmark
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Preterm Labor, Preterm Birth
Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs
This prospective, randomized, controlled study evaluates the safety and efficacy of a preterm birth (PTB) prevention strategy versus standard of care pregnancy management to reduce the incidence of adverse pregnancy outcomes.
- Trial name
- PRIME (NCT04301518)
- Testing
- Multimodal intervention strategy
- Where
- 18 sites in United States
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- Sera Prognostics, Inc.
Preterm Labor, PreTerm Birth
Electrical Inhibition of Human Preterm Contractions
The purpose of this study is to explore a new method to stop preterm uterine contractions using an electrical device. The device, an "electrical pacemaker for the uterus," has been approved by the Food and Drug Administration…
- Conditions
- Preterm Labor, PreTerm Birth, Preterm Labor With Delivery Nos
- Trial name
- NCT02983240
- Testing
- Electrical Uterine Pacemaker
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- e-Bio Corp
Premature Birth, Obstetric Labor, Premature
Welch Emotional Connection Screen (WECS) in the NICU
The purpose of this study is to assess knowledge about emotional connection, attitude about relational health, and efficacy of Welch Emotional Connection Screen (WECS) training in the NICU.
- Trial name
- NCT04922242
- Testing
- Welch Emotional Connection Screen for Neonatal Intensive Care Unit, NICU WECS Training
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Columbia University
Obstetric Labor Complications, Cardiovascular Diseases in Pregnancy
Transthoracic Echocardiography of Ventricular Function of Parturients in Labor
This echocardiography study will characterize heart structure and function during labor. Imaging of the heart during the stress of labor could increase detection of subclinical cardiovascular disease using advanced imaging…
- Conditions
- Obstetric Labor Complications, Cardiovascular Diseases in Pregnancy, Cardiovascular Risk Factor
- Trial name
- NCT04481503
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Gestational Diabetes, Hypertension in Pregnancy
Sleep Improvement Therapy Affects Pregnancy Outcomes in Chinese Singletons and Twins by Improving Sleep Quality
During pregnancy, the physical and psychological changes of pregnant women, hyperemesis gravidarum, uterine compression, frequent urination, hip or pelvic pain, back pain, leg cramps, gastroesophageal reflux, changes in mental…
- Conditions
- Gestational Diabetes, Hypertension in Pregnancy, Preterm Labor, NICU Infants
- Trial name
- NCT06687044
- Testing
- Sleep restriction, Stimulation control, Cognitive therapy
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Jun Wei
Postoperative Pain, Obstetric Pain
Lidocaine Patches After Cesarean Section
The aim of this study is to investigate the impact of using lidocaine patches after cesarean section on pain control and opioid use in the immediate post-operative period.
- Conditions
- Postoperative Pain, Obstetric Pain, Opioid Use
- Trial name
- LPACS (NCT04443569)
- Testing
- Lidocaine patch
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Yale University
Preterm Labor, Preterm Labor With Preterm Delivery in Third Trimester
The Effect of Facilitated Tucking After Vaginal Delivery on Late Preterm Stress, Comfort and Physiological Parameters
Objective: It is aimed to examine the effect of facilitated tucking after vaginal delivery on late preterm stress, comfort and physiological parameters. Design: The study was designed randomized controlled study.
- Conditions
- Preterm Labor, Preterm Labor With Preterm Delivery in Third Trimester, Preterm Spontaneous Labor With Preterm Delivery
- Trial name
- NCT05430321
- Testing
- Assessment of physiological parameters, Assessment of Stress, Assessment of Comfort
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa