Clinical trials: Obstruction of Biliary Tree
Bile Duct Obstruction, Extrahepatic, Cancer of the Pancreas
Self-expandable Metal Stents Versus Multiple Plastic Stents for Palliation of Biliary Obstruction
A randomised clinical trial to compare the clinical efficacy of multiple plastic stents to fully covered self expanding metal stents in the palliation of distal malignant biliary obstruction in patients with irresectable tumours.
- Conditions
- Bile Duct Obstruction, Extrahepatic, Cancer of the Pancreas, Cancer of the Bile Duct, Biliary Stricture
- Trial name
- NCT03821025
- Testing
- Biliary stent
- Where
- South Africa
- Volunteers
- 150 people
- Sponsor
- University of Cape Town
Malignant Distal Biliary Obstruction, Malignant Biliary Obstruction
12-mm Partial Covered Versus Bare Self-Expandable Metallic Stents for Malignant Distal Biliary Obstruction
Metallic stents are commonly used for biliary drainage in patients with unresectable malignant distal biliary obstruction. However, it is unclear whether a 12-mm partially covered self-expandable metallic stent or a 12-mm bare…
- Conditions
- Malignant Distal Biliary Obstruction, Malignant Biliary Obstruction, Biliary Obstruction
- Trial name
- PCSEMS-12 (NCT07559968)
- Testing
- 12-mm partially covered self-expandable metallic stent, 12-mm bare self-expandable metallic stent
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Chung-Ang University Hospital
Cholestasis, Extrahepatic
A Study of the WallFlex™ Biliary Fully-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction
The overall objective of this study is to assess the functionality of the WallFlex™ Biliary Fully-covered stent as a palliative treatment for malignant bile duct obstruction.
- Trial name
- NCT00433771
- Testing
- WallFlex™ Biliary Fully Covered Metal Stent placement
- Where
- 10 sites in United States
- Volunteers
- 74 people
- Sponsor
- Boston Scientific Corporation
Malignant Biliary Obstruction
EUS - Guided Choledocho-duodenostomy Versus ERCP With Covered Metallic Stents in Patients With Unresectable Malignant Distal Common Bile Duct Strictures
EUS - guided choledocho-duodenostomy (ECDS) is an established option for bile duct drainage in unresectable malignant distal CBD strictures when endoscopic retrograde cholangiopancreatography (ERCP) fails.
- Trial name
- DRAMBO (NCT03000855)
- Testing
- EUS-guided choledocho-duodenostomy, Endoscopic retrograde cholangiopancreatography with covered metallic stent
- Where
- 6 sites in Australia, Belgium and 3 more
- Volunteers
- 77 people
- Sponsor
- Chinese University of Hong Kong
Malignant Biliary Obstruction
Evaluation of a New Metal Biliary Stent of 12-mm Diameter: a Case Control Study
Biliary stent allows the drainage of the bile ducts palliatively or preoperatively in the event of malignant biliary stenosis, and a biliary calibration in the event of benign stenosis.
- Trial name
- BIGDIAM (NCT04405752)
- Testing
- 12-mm metallic biliary stent, 10-mm metallic biliary stent
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Institut Paoli-Calmettes
Cerebral Hypoperfusion, Cerebral Occlusion
Evaluation of Cerebral Blood Flow and Cerebral Oxygenation With Transcranial Doppler and NIRS in Laparoscopic Cholecystectomy Cases
The goal of this clinical trial is to test intracranial blood flow and cerebral oxygenisation changes in patients who have pneumoperitoneum in laparoscopic cholecystectomy procedure.
- Conditions
- Cerebral Hypoperfusion, Cerebral Occlusion, Cholecystitis; Gallstone, Cholecystitis/Cholelithiasis
- Trial name
- NIRS L/C (NCT06036498)
- Testing
- Near Infrared Spectrophotometry Device, Transcranial Doppler Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Uludag University
Malignant Hepatobiliary Neoplasm
Endoscopic Ultrasonography Guided Biliary Drainage
Endoscopic ultrasonography is a widely accepted modality for the diagnosis of gastrointestinal and pancreatic-biliary diseases. Endoscopic ultrasonography-guided biliary drainage has attracted attention as an alternative…
- Trial name
- NCT03195075
- Testing
- Endoscopic ultrasonography guided biliary drainage, Percutaneous trans-hepatic biliary drainage
- Volunteers
- 40 people
- Sponsor
- Assiut University
Biliary Stricture
A Study of Endobiliary Radiofrequency Ablation in Malignant Biliary Obstructions
The purpose of this study is to assess the impact of temperature-sensitive radiofrequency ablation (RFA) immediately before biliary stent placement on duration of biliary stent patency and re-intervention free survival.
- Trial name
- NCT05826639
- Testing
- Temperature-sensitive radiofrequency ablation, No intervention
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Mayo Clinic
Malignant Biliary Obstruction, Hepatocellular Carcinoma
Efficacy and Safety of a Fully Covered Self-Expandable Metal Stent for Unresectable HCC
The effectiveness and safety of fully covered metal stent in malignant biliary obstruction caused by HCC are still unknown. These would be clarified in this prospective cohort study.
- Trial name
- NCT05729867
- Testing
- Endoscpic biliary drainage using fully covered metal stent
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Cholangiocarcinoma, Pancreas Cancer
RFA for Malignant Biliary Obstruction
Pancreatic cancer and cholangiocarcinoma are the most common causes of malignant biliary obstruction. They are diseases of increasing incidence and unfavorable prognosis.
- Trial name
- NCT03166436
- Testing
- Radiofrequency ablation, Biliary stenting
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Cholangiocarcinoma
Comparison of Biliary Stenting Alone vs. Stenting With Photodynamic Therapy (PDT) During ERCP
This study entails retrospective and prospective review of data from a database protocol. Data gathered will be then analyzed for a set amount of patients. In this study, the investigators will compare biliary stenting vs.
- Trial name
- PDT (NCT01439685)
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Malignant Biliary Obstruction
EUS-guided Hepatico-gastrostomy Using a Novel Lumen Apposing Metal Stent
EUS-guided biliary drainage is gaining popularity as a means of achieving endoscopic drainage in patients with failed endoscopic retrograde cholangiopancreatography (ERCP) 1.
- Trial name
- NCT05169398
- Testing
- EUS-guided hepaticogastrostomy
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Malignant Biliary Obstruction
A Prospective Randomized Study for Efficacy of Uncovered Double Bare Metallic Stent Compared to Uncovered Single Bare Metallic Stent in Malignant Biliary Obstruction
Our study is the prospective randomized study for efficacy of uncovered double bare metallic stent compared to uncovered single bare metallic stent in malignant biliary obstruction
- Trial name
- NCT01869894
- Testing
- metallic biliary stent insertion (double bare - S&G Biotech.), metallic biliary stent insertion (single bare - S&G Biotech.), metallic biliary stent insertion (single bare - Taewoong Medical.)
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Yonsei University
Malignant Biliary Obstruction
PROceeding With Advanced Techniques in Case of Distal Malignant Biliary Obstruction and Difficult Biliary Cannulation comparEd With Therapeutic-EUS: the PROMETHEUS Trial
Endoscopic retrograde cholangiopancreatography (ERCP) stands as the primary approach for addressing jaundice in individuals with distal malignant biliary obstruction.
- Trial name
- PROMETHEUS (NCT06550973)
- Testing
- pre-cut biliary sphincterotomy/fistulotomy, double guide wire (DGW) technique
- Volunteers
- 220 people
- Sponsor
- Istituto Clinico Humanitas
Bile Duct Obstruction
Flushing of Internalized Percutaneous Transhepatic Biliary Drainage Catheters
Percutaneous transhepatic biliary drainage (PTBD) is a drainage method for biliary obstruction. Patients with a PTBD catheter often need multiple re-interventions because of symptoms of catheter obstruction such as pain…
- Trial name
- FLUSH (NCT04915703)
- Testing
- Flushing of PTBD catheter
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Erasmus Medical Center
Intrahepatic Cholangiocarcinoma, Cholangiocarcinoma of the Extrahepatic Bile Duct
Radioactive Stents for Treatment of Unresectable Biliary Tract Cancer
The purpose of this study is to determine whether radioactive stents and common used plastic stents are effective and safety in the treatment of unresectable biliary tract cancer.
- Conditions
- Intrahepatic Cholangiocarcinoma, Cholangiocarcinoma of the Extrahepatic Bile Duct, Ampullary Carcinoma, Biliary Obstruction
- Trial name
- NCT02238613
- Testing
- radioactive stent, plastic stent
- Where
- China
- Volunteers
- 140 people
- Sponsor
- 307 Hospital of PLA
Unresectable Pancreatic Cancer, Cholangiocarcinoma Non-resectable
RFA RCT for Pancreatic or Bile Duct Cancer
Malignant obstructive jaundice is a common complication of advanced stage pancreatic adenocarcinoma and cholangiocarcinoma. Over 50% of common bile duct (CBD) obstructions are due to malignancy, and the majority of neoplasms are…
- Trial name
- RFARCT (NCT02166190)
- Testing
- Radiofrequency Ablation using EndoHPB Probe, Stenting only
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Weill Medical College of Cornell University
Biliary Obstruction, Acute Cholecystitis
Prevention of Acute Cholecystitis With ETGBD
The goal of this clinical trial is to learn about Efficacy of the ETGBD parallel insertion with fully covered self-expandable metal stent for preventing acute cholecystitis in patients with low cystic duct insertion.
- Trial name
- NCT06287112
- Testing
- Endoscopic transpapillary gallbladder drainage (ETGBD)
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Hospital
Jaundice
Biliary Drainage in Patients With Duodenal Metal Stent
This is a retrospective study to evaluate the outcomes of endoscopic biliary drainage according to the timing of distal malignant biliary obstruction (MBO) in relation to gastric outlet obstruction (GOO) and the location of GOO.
- Trial name
- NCT02376907
- Testing
- Biliary drainage
- Where
- 25 sites in China, Hong Kong and 7 more
- Volunteers
- 200 people
- Sponsor
- Tokyo University
Biliary Condition
Difficult Biliary Cannulation in Patients With Distal Malignant Biliary Obstruction: an Underestimated Problem
Endoscopic retrograde cholangiopancreatography (ERCP) is the primary therapeutic procedure for many bilio-pancreatic diseases, and requires the first crucial step of the successful deep cannulation of the common bile duct through…
- Trial name
- DBC 01 (NCT04709666)
- Testing
- Endsocopic Retrograde ColangioPancreatography (ERCP)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Istituto Clinico Humanitas