Clinical trials: Obstructive Apnea
Pediatric Sleep Apnea
Clinical Predictors of Pediatric OSAHS
The purpose of this study is to develop adequate and satisfactory tools using reliable clinical and physical factors in predicting pediatric obstructive sleep apnea/hypopnea syndrome (OSAHS) and allow greater access to…
- Trial name
- PEDOSA (NCT02627937)
- Where
- Taiwan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Obstructive Sleep Apnea, Pathophysiology
Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study A
In obstructive sleep apnea, the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood.
- Trial name
- NCT01728974
- Testing
- Pharyngeal topical anesthesia
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Mechanism of Endothelial Dysfunction in Obstructive Sleep Apnea (OSA)
The investigators hypothesized that patients with Obstructive Sleep Apnea (OSA) who are free of any cardiovascular disease will have early microcirculatory changes that are unique to OSA, and therefore would resolve with…
- Trial name
- NCT01027078
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Obstructive Sleep Apnea, Hypertension
Molecular Profile of Cardiovascular Risk in Obstructive Sleep Apnea Patients: Personalized Predictive Model.
Evaluation of anthropometric, clinical and biological profile in four groups that represents transversely the natural history of Obstructive Sleep Apnea (OSA) and its associated cardiovascular comorbidities: non-OSA, OSA without…
- Conditions
- Obstructive Sleep Apnea, Hypertension, Cardiovascular Diseases
- Trial name
- NCT03513926
- Testing
- Continuous Positive Airway Pressure
- Where
- Spain
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Obstructive Sleep Apnea Syndrome, Obesity
Portable Monitoring Device for the Diagnosis of Sleep Apnea in Obese Patients
Introduction The portable monitoring system (PMS) recording of cardiopulmonary parameters (level III of ASDA) has been validated in subjects with high probability of Obstructive Sleep Apnea (OSA) without comorbidities.
- Trial name
- NCT01455077
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Associacao Fundo de Incentivo a Psicofarmcologia
Obstructive Sleep Apnea of Adult
Pilot Study of the MultiSense Patch to Record Cardiopulmonary Data During Sleep and Wake Cycles
The investigators are proposing to use a wearable device, MultiSenseTM, developed by Rhythm Diagnostic Systems, Inc. which has many sensors inside in a "Band-Aid" like strip in order to see if it can help diagnose capabilities in…
- Trial name
- NCT02222103
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Obstructive Sleep Apnea of Adult, Hypoxia, Brain
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
- Conditions
- Obstructive Sleep Apnea of Adult, Hypoxia, Brain, Sleep Apnea, Sleep Disorder
- Trial name
- NCT03255408
- Testing
- Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Obstructive Sleep Apnea
Counterfactual Thinking and Decision-making in OSA Syndrome
The aim of this research is to verify the ability of counterfactual thinking about medical decisions in individuals with obstructive sleep apnea syndrome when compared with healthy individuals
- Trial name
- CT_OSAS (NCT05768633)
- Testing
- Counterfactual Inference Test
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Obstructive Sleep Apnea, Pre-diabetes
CPAP and Glucose Metabolism in Non-Diabetic OSA Subjects
The purpose of the current study is to investigate whether alleviation of OSA by CPAP positively impacts glucose metabolism in non-diabetic patients.
- Trial name
- NCT05335083
- Testing
- CPAP
- Where
- 2 sites in Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research
Obstructive Sleep Apnea Syndrome
Ketamine Infusion for Pediatric Patients With Obstructive Sleep Apnea Syndrome (OSAS) After Tonsillectomy
The study will evaluate the post-operative morphine-sparing effect, pain reduction, and side effects of a continuous ketamine infusion after tonsillectomy in pediatric patients.
- Trial name
- KOSATA (NCT02425202)
- Testing
- Ketamine, Saline infusion
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Obstructive Sleep Apnea Syndrome
Cerebral Blood Flow and Childhood Obstructive Sleep Apnea
Obstructive sleep apnea syndrome (OSAS) causes hypoxemia and hypercapnia, which may impair cerebral blood flow and cause deficits in behavior.
- Trial name
- NCT02995837
- Testing
- Sleep Study, Neurocognitive Testing, CBF During Wakefulness
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Obstructive Sleep Apnea (OSA)
Level 3 Validation Study
This study will compare the output of a new Level 3 polysomnography system against in-laboratory polysomnography.
- Trial name
- NCT07688603
- Testing
- Comparison 1: Level 1 Polysomnography: Cadwell/Alice, Comparison 2: Level 3 Test: Berry Sleep Apnea Screening Monitor
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Windsor Sleep Disorders Clinic
Recurrent Tonsillitis, Peritonsillar Abscess
Auricular Acupuncture for The Treatment of Post-Tonsillectomy Pain
The goal of this study is to assess the role of battlefield acupuncture in the reduction of pain scores status post adult tonsillectomy.
- Conditions
- Recurrent Tonsillitis, Peritonsillar Abscess, Obstructive Sleep Apnea
- Trial name
- NCT01790477
- Testing
- Auricular Acupuncture
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Obstructive Sleep Apnea
Mediterranean Diet Versus Standard Diet on Candiormetabolic Indicator in Patients With Apnea
Introduction. Worldwide, obstructive sleep apnea is estimated to affect one in seven individuals. Patients with OSA present chronic low-grade inflammation related to arteriosclerosis.
- Trial name
- NCT06782737
- Testing
- Dietetic interventión with mediterranean diet
- Where
- Mexico
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Obstructive Sleep Apnea
Humidification Needs
A study undertaken to investigate mouth leak for airway discomfort/dryness while using CPAP. This study will also measure how much humidification is required to treat subsequent upper airway discomfort/dryness from mouth leak by…
- Trial name
- NCT03247907
- Testing
- Condition A: CPAP with No Humidification, Condition B: CPAP with No Humidification, Condition C: CPAP with Cold Passover
- Where
- New Zealand
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fisher and Paykel Healthcare
Bruxism, Temporomandibular Joint Disorders
Aspects Associated With Obstructive Sleep Apnea, Bruxism and Orofacial Pain
This study evaluated the influence of the sleep bruxism (SB), awake bruxism (AB) and obstructive sleep apnea syndrome (OSAS) on the signs and symptoms of temporomandibular disorders (TMD).
- Conditions
- Bruxism, Temporomandibular Joint Disorders, Obstructive Sleep Apnea Syndrome
- Trial name
- NCT03766464
- Testing
- Evaluation of TMD and pain sensitivity, Evaluation of SB, Evaluation of AB
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Obstructive Sleep Apnea
Memory Consolidation in Obstructive Sleep Apnea
The overarching goal of the research proposed here is to test the hypothesis (i) that the pathophysiological mechanisms of OSA lead to deterioration in sleep-dependent memory consolidation across memory systems, with the genetic…
- Trial name
- NCT01800786
- Testing
- CPAP
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Organic Pediatric Obstructive Sleep Apnea
Nasal Expiratory Positive Airway Pressure for the Treatment of Pediatric Obstructive Sleep Apnea Syndrome
This study will evaluate effectiveness and adherence of the nasal expiratory positive airway pressure (NEPAP) device as an an alternate therapy for children with Obstructive Sleep Apnea Syndrome (OSAS).
- Trial name
- NCT01768065
- Testing
- Nasal Expiratory Positive Airway Pressure Device
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Obstructive Sleep Apnea (OSA)
Fractional Exhaled Nitric Oxide as Possible Non - Invasive Biomarker to Assess Obstructive Sleep Apnea Severity
Aim of work 1. Primary aim: Asses correlation between FeNO level, OSA severity 2. Secondary aim: Clarifying FeNO's role as a biomarker to assess airway inflammation, Cut off value prediction to moderate and severe OSA and its…
- Trial name
- NCT07606898
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tanta University
Obstructive Sleep Apnea
The Role of the Device Operating Under the Continuous Positive Airway Pressure in the Recovery Process of Cochlea
Hypothesis: Patients with obstructive sleep apnea syndrome (OSAS) have cochlear receptor cells damage because of prolonged, recurrent hypoxia.
- Trial name
- NCT05362890
- Testing
- DEVICE OPERATING UNDER THE CONTINOUS POSITIVE AIRWAY PRESSURE
- Where
- Croatia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mirjana Grebenar Cerkez