Clinical trials: Obstructive Apnea
Sleep Apnea, Obesity
Upper Airway of Women With Obstructive Sleep Apnea After Bariatric Surgery
Evaluation of upper airway with Magnetic Resonance and polysomnographic at the pre and post operative of 23 women having undergone bariatric surgery (with the Y-Roux technique) for treatment of obesity.
- Trial name
- NCT05669469
- Testing
- Bariatric surgery
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- Michel Burihan Cahali
Severe Obstructive Sleep Apnea (Apnea Hypopnea Index > 30 Events/Hour), Hypertension
Study of Cardiovascular Disease and Obstructive Sleep Apnea
The purpose of this study is to determine if two medicines (allopurinol and losartan) can influence heart and blood vessel health compared to placebo in patients with sleep apnea who are using continuous positive airway pressure…
- Trial name
- CVD/OSA (NCT01637623)
- Testing
- Losartan, Allopurinol
- Where
- 4 sites in United States
- Volunteers
- 87 people
- Sponsor
- University of Wisconsin, Madison
Obstructive Sleep Apnea, Obesity
Effect of Nasal Positive Airway Pressure Versus Standard Care on Oxygenation and Ventilation During Propofol-based Sedation for Colonoscopy in Patients With High Risk of Airway Obstruction
The purpose of this study is to to compare oxygenation and ventilation on spontaneously ventilating obese patients or those with diagnosed or undiagnosed Obstructive sleep apnea (OSA) undergoing day colonoscopy under Propofol…
- Trial name
- NCT05524220
- Testing
- Standard care with a facemask., SuperNO2VA™EtCO2 (Nasal Oxygenating Ventilating Apparatus)
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obstructive Sleep Apnea of Adult
Use of Intraoral Suction and Its Effects on Obstructive Sleep Apnea
To learn whether stabilization of the tongue using intraoral suction is tolerable and what effects this approach has on sleep parameters in obstructive sleep apnea.
- Trial name
- NCT05489562
- Testing
- Intraoral Suction
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Boston Healthcare System
Airway Edema, Obstructive Sleep Apnea
Comparison of the Effect of Supine and Prone Position on the Ultrasonographic Airway Measurements
The aim of this study is to compare the preoperative and postoperative ultrasonographic measurements of patients undergoing in the prone position and the change in upper airway edema.
- Conditions
- Airway Edema, Obstructive Sleep Apnea, Respiratory Complication
- Trial name
- NCT05197400
- Testing
- preoperative airway ultrasonography, postoperative airway ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Obstructive Sleep Apnea of Child
SleepPOSAtive Trial
This is a randomized crossover trial of children diagnosed with positional obstructive sleep apnea (POSA) on a baseline polysomnogram (PSG).
- Trial name
- NCT05499455
- Testing
- Positional Sleep Belt, Control
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- The Hospital for Sick Children
Obstructive Sleep Apnea (OSA)
The Efficacy of a New Mathematical Formula to Predict Continuous Positive Air Pressure With an Oronasal Mask Interface.
Subjects will all have a two week baseline period in which they will use a nasal mask using an air view CPAP machine (which records all data).
- Trial name
- NCT02816255
- Testing
- Full Face Mask with same CPAP Pressure, Full Face Mask with new Pressure
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Weill Medical College of Cornell University
Obstructive Sleep Apnea
The Effects of Oral Appliance Therapy on Masseter Muscle Activity in Obstructive Sleep Apnea
Previous studies have shown that contractions of the jaw-closing masseter muscle (MAS) often occur shortly after respiratory events during sleep in obstructive sleep apnea (OSA) patients.
- Trial name
- NCT02011425
- Testing
- mandibular advancement appliance
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Université de Montréal
Obstructive Sleep Apnea
Assessment of the Impact of a Stepped Mouthpiece on the Upper Airways Measured Through Acoustic Pharyngometry
Mandibular advancements during tidal breathing, achieved through a stepped mouthpiece design, affect the size of the upper airways in subjects with and without Obstructive Sleep Apnea.
- Trial name
- NCT01069068
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Doctor's Directive Strategies Inc.
Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea
Effect of CPAP on Abnormal Gastroesophageal Reflux and Lung Inflammation in IPF
This study will evaluate the effect of CPAP therapy on esophageal pH and lung inflammation in patients with idiopathic pulmonary fibrosis (IPF) and sleep apnea.
- Conditions
- Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea, Gastro Esophageal Reflux
- Trial name
- NCT05359965
- Testing
- Positive Airway Pressure
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Arizona
Obstructive Sleep Apnea
A Study of Sex Differences in Neurocirculatory Control
The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).
- Trial name
- NCT06261034
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Sleep Apnea Syndromes, Sleep Apnea, Obstructive
Short Life Agents in Balanced Anesthesia on Obstructive Sleep Apnea Syndrome
The investigators aim to assess the respiratory effect of short half-life agents in balanced anesthesia on patients suffering from non-treated or suspected obstructive sleep apnea syndrome (OSA) We will study the impact on OSA of…
- Trial name
- DESAT (NCT02717780)
- Testing
- Fentanyl and sevoflurane, Remifentanil and desflurane
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Obstructive Sleep Apnea (OSA), OSA
Automated Manual Lymphatic Drainage Therapy to Improve Glymphatic Function in OSA Patients
The purpose of this research is to investigate whether enhancing systemic lymphatic drainage improves glymphatic function in patients with obstructive sleep apnea (OSA).
- Conditions
- Obstructive Sleep Apnea (OSA), OSA, Obstructive Sleep Apnea
- Trial name
- NCT07301762
- Testing
- Automated manual lymphatic drainage therapy (AMLDT) device
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnea, Down Syndrome
Medications for Obstructive Sleep Apnea to Improve Cognition in Children With Down Syndrome
This is an open-label study of the combination of atomoxetine and oxybutynin (ato-oxy) in children with Down syndrome and obstructive sleep apnea (OSA) documented by polysomnography (PSG).
- Trial name
- MOSAIC (NCT05933603)
- Testing
- Atomoxetine and Oxybutynin (ato-oxy)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Arizona
Sarcoidosis, Obstructive Sleep Apnea
Obstructive Sleep Apnoea in Sarcoidosis
Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Fatigue is a common problem in sarcoidosis affecting between 50% and 80% of patients, and thus represents a major impairment of their quality of life.
- Conditions
- Sarcoidosis, Obstructive Sleep Apnea, Fatigue, Sleepiness
- Trial name
- OSASA (NCT04156789)
- Testing
- Home sleep apnea testing
- Where
- Switzerland
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Malcolm Kohler
Hypertension, OSA - Obstructive Sleep Apnea
Primary Prevention Long-term Registry Study in OSA and Hypertension. Survival Analysis 2010-2022
Hypertension and obstructive sleep apnea (OSA) are both common conditions that independently increase the risk cardiovascular disease including atrial fibrillation, ischemic heart disease, heart failure and stroke.
- Conditions
- Hypertension, OSA - Obstructive Sleep Apnea, MACE, Survival Analysis
- Trial name
- DISCOVERY-HT (NCT06930989)
- Testing
- Positive airway pressure (PAP)
- Where
- Sweden
- Volunteers
- 148,467 people
- Sponsor
- Vastra Gotaland Region
Obstructive Sleep Apnea, Excessive Daytime Sleepiness
BF2.649 in Patients With OSA, Still Complaining of EDS and Refusing to be Treated by CPAP.
Multicenter randomized double blind study versus placebo during 12 weeks with at first, an escalating dose period followed by stable dose period at the selected dose.
- Trial name
- HAROSA2 (NCT01072968)
- Testing
- BF2.649
- Where
- France
- Volunteers
- 268 people
- Sponsor
- Bioprojet
Anesthesia, General Anesthesia
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, lidocaine, and gabapentin can help reduce postoperative respiratory depression in the…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Postoperative Complications
- Trial name
- NCT02987985
- Testing
- Acetaminophen, gabapentin, Acetaminophen, Ketamine , Lidocaine , Dexmedetomidine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Saskatchewan
OSA, Heart Failure
Impact of Early Diagnosis and Treatment of OSA on Hospital Readmission in Hospitalized Cardiac Patients
The purpose of this study is to determine whether early diagnosis of obstructive sleep apnea and initiation of and adherence to CPAP therapy in hospitalized cardiac patients would impact 30-day hospital readmission rates.
- Conditions
- OSA, Heart Failure, Myocardial Infarction, Arrhythmia, Cardiac
- Trial name
- CV Readmit (NCT03647891)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Obstructive Sleep Apnea Syndrome
Correlation Between Friedman Classification and the Apnea Hypopnea Index (AIH) in a Population With Obstructive Sleep Apnea Syndrome (OSAS)
Introduction: OSAS is an important disease in the actual medic scene. It is important for correlation with chronic cardiovascular disease that leaves an increase in morbimortality and socioeconomic disability to patients with…
- Trial name
- FriedmAIH (NCT00883025)
- Where
- Brazil
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Irmandade da Santa Casa de Misericoridia de Limeira
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