Clinical trials: Obstructive Chronic Bronchitis With Acute Exacerbation
Respiratory Tract Infections
Evaluation of the Treatment With Klacid SR in Patients With Acute Tracheitis, Tracheobronchitis and Bronchitis, Acute Exacerbation of Chronic Bronchitis and Mild Community-acquired Pneumonia in Common Clinical Practice in Ukraine
To describe the relief of symptoms, tolerability, and compliance of treatment with Klacid® sustained release (SR) at a dose of 1000 mg once daily in patients with acute tracheitis, acute tracheobronchitis, acute bronchitis, or in…
- Trial name
- KLARAINE (NCT01095978)
- Testing
- Clarithromycin (Klacid SR)
- Where
- 126 sites in Ukraine
- Volunteers
- 2,822 people
- Sponsor
- Abbott
Lung Diseases, Bronchitis, Chronic
Intermittent Moxifloxacin Therapy For The Prevention Of Acute Exacerbations In Patients With Chronic Bronchitis
Moxifloxacin, is being tested at approximately 60 study centres in 15 countries to determine if this drug, when taken periodically in addition to the patients normal treatment, is effective at reducing the number of flare-ups of…
- Trial name
- NCT00473460
- Testing
- Avelox (Moxifloxacin, BAY12-8039)
- Where
- 78 sites in United States, Andorra and 13 more
- Volunteers
- 1,404 people
- Sponsor
- Bayer
Bronchitis, Chronic
Telithromycin: in the Treatment of Acute Exacerbation of Chronic Bronchitis in Adult Outpatients With COPD
Non-inferiority efficacy of telithromycin versus azithromycin
- Trial name
- NCT00538148
- Testing
- Telithromycin
- Volunteers
- 668 people
- Sponsor
- Sanofi
Bronchitis, Chronic
A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Acute Symptoms of Chronic Bronchitis
This study was performed to confirm that a single 2.0-g dose of azithromycin SR is at least as effective as 7 days of levofloxacin 500 mg/day in adults with acute exacerbation of chronic bronchitis Secondary objectives: To assess…
- Trial name
- NCT00644449
- Testing
- azithromycin SR (Zithromax; compound: CP-62,993), levofloxacin
- Where
- 75 sites in United States, Brazil and 11 more
- Volunteers
- 551 people
- Sponsor
- Pfizer
Bronchitis, Chronic
Telithromycin in Acute Exacerbation of Chronic Bronchitis
Study objectives: to document the clinical efficacy of telithromycin(800 mg per day for 5 days) at Test Of the Cure (TOC)visit (D12-D19), in acute exacerbation of chronic bronchitis.
- Trial name
- NCT00288223
- Testing
- Telithromycin
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Sanofi
Pulmonary Disease, Chronic Obstructive, Pulmonary Disease, Obstructive
Mortality and Symptom Burden Post Hospitalisation With COPD
Chronic Obstructive Pulmonary Disease (COPD) is a common progressive lung disease which causes breathlessness and frequent exacerbations, with patients often requiring hospitalisation.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Pulmonary Disease, Obstructive, Emphysema, Chronic Bronchitis
- Trial name
- MoSHCOPD (NCT03657121)
- Where
- 2 sites in United Kingdom
- Volunteers
- 447 people
- Sponsor
- Northumbria Healthcare NHS Foundation Trust
Obstructive Chronic Bronchitis With Acute Exacerbation
Respiratory Therapy in COPD Exacerbations
The purpose of this study is to determine effectiveness, feasibility and safety/tolerance of Respiratory Therapy in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease.
- Trial name
- TRESEPOCAS (NCT02125747)
- Testing
- No Respiratory Therapy, Respiratory Therapy
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Parc de Salut Mar
Chronic Bronchitis
PERSPECTIVE: Telithromycin - Acute Exacerbation of Chronic Bronchitis
Primary Objective: The primary objective of the study is to demonstrate the superiority of telithromycin over azithromycin and over cefuroxime axetil in the reduction of Streptococcus pneumoniae (Sp) strains resistant to…
- Trial name
- NCT00132938
- Testing
- telithromycin
- Where
- 8 sites in United States, Belgium and 6 more
- Volunteers
- 5,660 people
- Sponsor
- Sanofi
Chronic Bronchitis
Moxifloxacin Versus Amoxicillin Clavulanic Acid in Treatment of Acute Exacerbation of Chronic Bronchitis
A study to assess the safety and efficacy of moxifloxacin compared to that of amoxicillin-clavulanic acid for the treatment of subjects with acute exacerbation of chronic bronchitis.
- Trial name
- NCT00656747
- Testing
- Avelox (Moxifloxacin, BAY12-8039), Amoxicillin clavulanic acid
- Where
- 220 sites in Andorra, Argentina and 29 more
- Volunteers
- 1,372 people
- Sponsor
- Bayer
Tracheitis, Tracheobronchitis
Evaluation of the Treatment With Klacid®SR in Patients With Lower Respiratory Tract Infection
The aim of this post-marketing observational study (PMOS) is to describe the relief of symptoms, tolerability and compliance of treatment with Klacid®SR in a dose 1000 mg once daily in patients with lower respiratory tract…
- Conditions
- Tracheitis, Tracheobronchitis, Bronchitis, Chronic Bronchitis
- Trial name
- NCT01108185
- Where
- 158 sites in Slovakia
- Volunteers
- 3,181 people
- Sponsor
- Abbott
Bronchitis, Chronic
A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Cefuroxime Axetil in the Treatment of Adults With Persistent Bronchitis Experiencing Rapid Onset of Severe Worsening of Symptoms Caused by Bacteria
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with cefuroxime axetil, another antibiotic, in the treatment of adults with chronic bronchitis experiencing rapid…
- Trial name
- NCT00269932
- Testing
- levofloxacin
- Volunteers
- 485 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Obstructive Chronic Bronchitis With Acute Exacerbation
STI Combined to Valsalva Maneuver for the Diagnosis of Left Ventricular Dysfunction in COPD Exacerbations
The aim of this investigation was to assess the value of Systolic Time Intervals (STIs) as a method of detecting Left Ventricular Dysfunction (LVD) in patients admitted to the emergency department for cute exacerbations of…
- Trial name
- STICOPD (NCT02481908)
- Testing
- STI measurements at baseline and under Valsalva maneuver
- Where
- Tunisia
- Volunteers
- 189 people
- Sponsor
- University of Monastir
Pulmonary Disease, Chronic Obstructive
Sputum Colour Charts to Guide Antibiotic Self-treatment of Acute Exacerbation of COPD (Colour COPD)
The primary objective of this study is to determine if a sputum colour chart can aid patient self-management of COPD exacerbations, such that use of the chart is non-inferior to usual care with respect to hospital admissions.
- Trial name
- NCT04705233
- Testing
- sputum colour chart
- Where
- United Kingdom
- Volunteers
- 2,954 people
- Sponsor
- University of Birmingham
Bronchitis, Bronchitis, Chronic
A Study of the Safety and Effectiveness of Levofloxacin Compared With Cefaclor in the Treatment of Adults With Chronic Bronchitis Experiencing Rapid Onset of Worsening of Symptoms Caused by Bacteria
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with cefaclor, another antibiotic, in the treatment of adults with chronic bronchitis experiencing rapid onset of…
- Trial name
- NCT00257140
- Testing
- levofloxacin
- Volunteers
- 367 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
COPD, COPD Exacerbation Acute
The Italian Registry of Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a treatable but debilitating medical condition associated with persistent symptoms and chronic airflow obstruction.
- Conditions
- COPD, COPD Exacerbation Acute, Comorbid Chronic Lung Disease on Heart Failure, Mortality
- Trial name
- ICoRe (NCT06652776)
- Testing
- Pharmacological treatment
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Milan
COPD Exacerbation
Ceftidoren Versus Levofloxacin in the Treatment of Patients With Acute Exacerbations of Chronic Bronchitis (AECB)
40 outpatients with exacerbations of Chronic Obstructive Pulmonary Diseases (COPD) will be enrolled in a multi-centre, open-label, randomised, pilot study.
- Trial name
- NCT01467297
- Testing
- ceftidoren, levofloxacin
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Chronic Bronchitis
A Trial to Evaluate the Efficacy and Safety of Faropenem Medoxomil In the Treatment of Chronic Bronchitis
Identifying the role of antibiotics in the treatment of subjects with a microbiologically documented acute exacerbation of chronic bronchitis (AECB) is the purpose of this clinical trial.
- Trial name
- NCT00255983
- Testing
- Faropenem medoxomil
- Where
- United States
- Volunteers
- 491 people
- Sponsor
- Replidyne
COPD, Exacerbation
CRP-guided Antibiotic Treatment in COPD Exacerbations Admitted to the Hospital
Rationale: Acute exacerbations are key events in chronic obstructive pulmonary disease (COPD), resulting in poorer quality of life. Causes include irritants, viruses and bacterial pathogens.
- Conditions
- COPD, Exacerbation, Bronchitis, Sputum
- Trial name
- CATCH (NCT01232140)
- Testing
- CRP-guided antibiotic treatment
- Where
- Netherlands
- Volunteers
- 220 people
- Sponsor
- Medical Center Alkmaar
Bronchitis
Outcome Study to Evaluate Klaricid XL® (Clarithromycin Modified Release) in Patients With Acute Exacerbation of Chronic Bronchitis
The objective of this study was to evaluate the role of Klaricid XL (clarithromycin modified release) in the treatment of acute exacerbation of chronic bronchitis (AECB) and its impact on improving the quality of life.
- Trial name
- NCT01354938
- Testing
- Clarithromycin modified release 500 mg
- Where
- 28 sites in Pakistan
- Volunteers
- 220 people
- Sponsor
- Abbott
Chronic Bronchitis
A Trial To Evaluate Two Antibiotics For The Treatment Of Acute Exacerbation Of Chronic Bronchitis (AECB)
This trial is a research drug study to compare the effects of two antibiotics for the treatment of acute exacerbation of chronic bronchitis
- Trial name
- NCT00254566
- Testing
- Moxifloxacin, Azithromycin SR
- Where
- 34 sites in China, Malaysia and 4 more
- Volunteers
- 398 people
- Sponsor
- Pfizer