Clinical trials: Obstructive Chronic Pulmonary Disease
Chronic Obstructive Pulmonary Disease, COPD
Incorporation of Genetic Expression of Airway Epithelium With CT Screening for Lung Cancer
Lung cancer, largely the result of cigarette smoking, is the leading cause of cancer death in the United States, killing over 160,000 people in 2010, more than breast, colorectal, and prostate cancer combined.
- Trial name
- NCT01982149
- Testing
- Group 1, Group 2, Group 3
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Asthma, COPD
MUlti-nuclear MR Imaging Investigation of Respiratory Disease-associated CHanges in Lung Physiology
Lung magnetic resonance imaging (MRI) with proton and inhaled inert gases has demonstrated a clinical ability to provide valuable structural and functional information in lung disease.
- Conditions
- Asthma, COPD, Covid19, Long COVID
- Trial name
- MURDOCH (NCT04872309)
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Chronic Respiratory Disease, Chronic Obstructive Pulmonary Disease
High-Intensity Interval Alternating Concentric-Eccentric Training in Chronic Respiratory Disease
This randomized controlled trial aims to evaluate the effects of high-intensity interval training incorporating alternating concentric and eccentric cycling on functional performance in adults with chronic respiratory disease…
- Trial name
- Effects of Hig (NCT07867535)
- Testing
- Alternating Concentric-Eccentric High-Intensity Interval Training, Concentric High-Intensity Interval Training, Usual Care
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Fu Jen Catholic University Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Temple Health Chest Initiative (THCI 2.0)
Chronic obstructive pulmonary disease is highly prevalent globally, with considerable morbidity and mortality associated. In the US, it is the 4th leading cause of death, as well as contributing to significant costs on healthcare…
- Trial name
- NCT06933758
- Testing
- Determine COPD prevalence utilizing spirometry along with CT scans and symptom assessments in the THCI lung cancer screening populatio
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Temple University
COPD, Acute Respiratory Failure
Revefenacin in Acute Respiratory Insufficiency in COPD
RARICO is a pragmatic, randomized, controlled, double-blinded, multi-center trial evaluating the safety and feasibility of nebulized revefenacin in comparison to nebulized ipratropium in patients with COPD and acute respiratory…
- Trial name
- RARICO (NCT04315558)
- Testing
- Revefenacin Inhalation Solution [Yupelri], Ipratropium Bromide
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of California, Los Angeles
Chronic Obstructive Pulmonary Disease (COPD)
A Pragmatic Cluster Trial of a Tailored Intervention to Improve COPD Management
Background: Chronic Obstructive Pulmonary Disease (COPD) remains a major health problem, which is strongly related to smoking. Despite publication of guidelines on the prevention and treatment of COPD, not all COPD patients…
- Trial name
- TICD-COPD (NCT01893476)
- Testing
- Implementation educational programme
- Where
- Poland
- Volunteers
- 540 people
- Sponsor
- Medical University of Lodz
Chronic Obstructive Pulmonary Disease
Effects of Tiotropium on Walking Capacity in Patients With COPD
This study was designed to test the following hypothesis: A) The acute and long-term (3 weeks) bronchodilator-induced changes in exercise tolerance and in the physiological response during the endurance shuttle walk will be…
- Trial name
- NCT01307189
- Testing
- Tiotropium
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Laval University
Chronic Obstructive Pulmonary Disease (COPD)
Validation of Structured Light Plethysmography - Health and Disease
Validation of Structured Light Plethysmography (SLP) in patients with conditions such as Chronic Obstructive Pulmonary Disease (COPD) that effect breathing and in healthy participants.
- Trial name
- SLP-RespDis (NCT02626468)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pneumacare Ltd
COPD
A Pilot Study of the Use of 129Xe and 1H MRI to Measure the Modulation of Eosinophil-Related Inflammation by Mepolizumab In COPD
The investigators aim to recruit 32 people with COPD who have frequent exacerbations and high eosinophil counts which indicates "asthmatic type" inflammation and treat them for a year with mepolizumab.
- Trial name
- SUMMER (NCT05138250)
- Testing
- Mepolizumab 100 MG
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Chronic Obstructive Pulmonary Disease (COPD)
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
This Phase IIb dose-ranging study will evaluate the efficacy and safety of 2 different doses of AZD6793 compared with placebo tablets in participants with moderate to very severe chronic obstructive pulmonary disease.
- Trial name
- PRESTO (NCT07082738)
- Testing
- AZD6793
- Where
- 367 sites in United States, Argentina and 22 more
- Volunteers
- 987 people
- Sponsor
- AstraZeneca
Hypertension, Pulmonary, Pulmonary Disease, Chronic Obstructive
Single Dose Study in Patients With Chronic Obstructive Pulmonary Disease (COPD) Associated Pulmonary Hypertension.
This study is to demonstrate the safety, tolerability, pharmakokinetic and pharmacodynamic effect of a single oral dose of BAY63-2521 in patients with pulmonary hypertension due to chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00640315
- Testing
- Riociguat (Adempas, BAY63-2521) 1.0 mg, Riociguat (Adempas, BAY63-2521) 2.5 mg
- Where
- 7 sites in Germany
- Volunteers
- 23 people
- Sponsor
- Bayer
COPD, COPD (Chronic Obstructive Pulmonary Disease)
How Nocturnal Hypoventilation Predicts Long-term Response to Non-invasive Ventilation in Hypercapnic COPD Patients
The study is an observational, single-center, prospective cohort study aiming to evaluate respiratory mechanics data, as well as clinical and functional parameters commonly used in clinical practice in patients with COPD and…
- Conditions
- COPD, COPD (Chronic Obstructive Pulmonary Disease), Hypercapnia, Hypercapnic Respiratory Failure, COPD
- Trial name
- HYPONIV (NCT07414108)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
COPD Patients
Comparing the Efficacy of Symbicort® pMDI and Formoterol Turbuhaler in Reducing Exacerbations in Patients With Cronic Obstructive Pulmonary Disease
Comparing the efficacy of Symbicort® pMDI and Formoterol Turbuhaler in reducing exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- RISE (NCT02157935)
- Testing
- Symbicort, Formoterol turbohaler
- Where
- 371 sites in United States, Argentina and 9 more
- Volunteers
- 2,026 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease (COPD), Chronic Obstructive Lung Disease
Mindfulness-based Cognitive Therapy for Chronic Obstructive Pulmonary Disease
The purpose of the study is to determine the efficacy of mindfulness-based cognitive therapy (MBCT) as an add-on to pulmonary rehabilitation (treatment as usual, TAU) in chronic obstructive pulmonary disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Chronic Obstructive Lung Disease, Chronic Obstructive Airway Disease, Chronic Bronchitis
- Trial name
- NCT02042976
- Testing
- Mindfulness-based cognitive therapy, Pulmonary rehabilitation
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- University of Aarhus
Chronic Obstructive Pulmonary Disease
Investigation of the Effectiveness of Upper Limb Exercise in COPD Patients
The aim of the study is to investigate the efficacy of upper limb exercise training in Chronic Obstructive Pulmonary Disease (COPD) patients.
- Trial name
- NCT03863717
- Testing
- Arm Endurance Exercise Training, Control
- Where
- Cyprus
- Volunteers
- 44 people
- Sponsor
- European University Cyprus
CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA
Inhaler Lung Deposition in Chronic Obstructive Pulmonary Disease (COPD)
Patients with chronic obstructive pulmonary disease (COPD) experience breathing difficulties because the airways deep in their lungs become narrowed. COPD patients use inhaler drugs to provide relief from breathlessness.
- Conditions
- CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA, HEALTHY SUBJECTS
- Trial name
- NCT01721291
- Testing
- SALBUTAMOL
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Imperial College London
COPD
Patient's Perception in Symptoms Related to Morning Activity Based on Chronic Obstructive Lung Disease
The aim of this study is to assess the perception of chronic obstructive pulmonary disease (COPD) patients in symptoms related to morning activities.
- Trial name
- SYMBOL (NCT00894426)
- Where
- 3 sites in South Korea
- Volunteers
- 150 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease, Heart Failure
Health in Smart Rurality: Impact on Coordination of Care of Telemonitoring and Data Centralization of Frailty Patients
Chronic diseases are frequent (around 10% of the total population and 30% after 60 years) and accelerate age-related functional decline.
- Trial name
- HIS2R (NCT04866550)
- Testing
- Data collection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Université de Reims Champagne-Ardenne
Lung Disease, Chronic Obstructive Pulmonary Disease (COPD)
Lung Disease Collection (Qatar): Evaluation of the Lungs of Individuals With Lung Disease
The purpose of this protocol is to obtain biologic samples from the blood and lungs from patients with lung diseases in order to study the causes and indications of these disorders, learn how these lung disease manifest and…
- Conditions
- Lung Disease, Chronic Obstructive Pulmonary Disease (COPD), Asthma
- Trial name
- Q-LD (NCT00504738)
- Where
- Qatar
- Volunteers
- 75 people
- Sponsor
- Weill Medical College of Cornell University
Pulmonary Disease, Chronic Obstructive
A Dangerous Triad in Ageing and in Chronic Obstructive Pulmonary Disease (COPD) - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition
The investigators have taken part in the development of simple muscle function tests and studied physical training and energy turnover in patients with chronic obstructive pulmonary disease, COPD.
- Trial name
- NCT01179178
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Göteborg University
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