Clinical trials: Obstructive Coronary Artery Disease
Non-Obstructive Coronary Atherosclerosis, Ischemia
INOCA Spanish National Registry
Coronary atherosclerosis is the most common cause of ischaemic heart disease. About 40-50% of patients with symptoms and documented ischaemia on non-invasive tests do not show obstructive coronary artery disease on coronary…
- Conditions
- Non-Obstructive Coronary Atherosclerosis, Ischemia, Coronary Disease
- Trial name
- ESP-INOCA (NCT06327672)
- Where
- 3 sites in Spain
- Volunteers
- 1,000 people
- Sponsor
- Eva Rumiz González
Primary Prevention of Atherosclerotic Cardiovascular Disease
A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.
CKJX839D12302 is a pivotal Phase III study designed to test the hypothesis that treatment with inclisiran sodium 300 milligram (mg) subcutaneous (s.c.) administered on Day 1, Day 90, and every 6 months thereafter in patients at…
- Trial name
- NCT05739383
- Testing
- Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL
- Where
- 983 sites in United States, Argentina and 40 more
- Volunteers
- 14,012 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study C
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- NCT04791267
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Microvascular Angina
Effect of ACE-Inhibition on Microvascular Function in Women With Assessed Microvascular Dysfunction
The aim of this study is to explore effects of long term treatment with ACE-inhibitor on the small vessel function assessed by coronary flow reserve (CFR) by transthoracic echocardiography and flow mediated dilation in…
- Trial name
- NCT02525081
- Testing
- Ramipril (ACE-inhibitor)
- Where
- Denmark
- Volunteers
- 63 people
- Sponsor
- Bispebjerg Hospital
Lung Diseases, Sleep Apnea Syndromes
Sleep Heart Health Study (SHHS) Data Coordinating Center
To test whether sleep-disordered breathing is associated with an increased risk of coronary heart disease, stroke, all-cause mortality, and hypertension.
- Conditions
- Lung Diseases, Sleep Apnea Syndromes, Cardiovascular Diseases, Heart Diseases
- Trial name
- SHHS (NCT00005275)
- Volunteers
- 6,441 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Chronic Obstructive Pulmonary Disease
Is COPD a Risk Factor for Cardiovascular Disease?
Patients with chronic obstructive pulmonary disease suffer from significant cardiovascular morbidity and mortality. This study wants to determine whether chronic obstructive pulmonary disease might be a risk factor for coronary…
- Trial name
- NCT02162095
- Where
- Switzerland
- Volunteers
- 162 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease, Acute Coronary Syndromes
Screening for Chronic Obstructive Pulmonary Disease in Patients With Acute Coronary Syndromes
Several studies and registries suggested that the concomitant presence of acute coronary syndromes (ACS) and chronic obstructive pulmonary disease (COPD) is significantly associated with poor prognosis.
- Trial name
- SCAP (NCT02324660)
- Testing
- screening test
- Where
- Italy
- Volunteers
- 137 people
- Sponsor
- University Hospital of Ferrara
Myocardial Infarction, Diarrhea (Dysentery)
Improving the Quality of Private Sector Health Care in West Bengal
The rural healthcare market in much of the developing world is composed largely of informal private providers. These private providers often have little to no certifiable medical training.
- Conditions
- Myocardial Infarction, Diarrhea (Dysentery), Asthma
- Trial name
- NCT02291575
- Testing
- Training, Control
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Abdul Latif Jameel Poverty Action Lab
Ischemic Heart Disease, Coronary Microvascular Disease
MCG for Suspected INOCA Confirmed by Thermodilution-Derived CFR
This study will be an observational registry to investigate the ability of magnetocardiography (MCG) in determining the presence of myocardial ischemia with the absence of obstructive coronary artery disease, by using an invasive…
- Conditions
- Ischemic Heart Disease, Coronary Microvascular Disease, Angina
- Trial name
- MICRO(T) (NCT06139094)
- Testing
- CardioFlux Magnetocardiography
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- Genetesis Inc.
Virus-HIV
Coronary Artery Disease (CAD) in Suppressed HIV-infected
HIV-infected patients with intermediate-high risk have a high prevalence of CAD and a substantial proportion of obstructive CAD.
- Trial name
- NCT02898896
- Testing
- blood test
- Where
- France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Montpellier
Heart Failure, Arteriosclerosis of Coronary Artery Bypass Graft or Other Coronary Reperfusion
PAC-IC-SAOS Obstructive Sleep Apnea Syndrome and Ventricular Function
The aim of this clinical trial is to evaluate the effect of obstructive sleep apnea syndrome (OSAS) treatment in heart failure patients following coronary artery bypass graft (CABG) surgery or other coronary reperfusion.
- Conditions
- Heart Failure, Arteriosclerosis of Coronary Artery Bypass Graft or Other Coronary Reperfusion, Sleep Apnea, Obstructive
- Trial name
- PAC-IC-SAOS (NCT01900379)
- Testing
- CPAP treatment
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Grenoble
OSA - Obstructive Sleep Apnea, Coronary Microvascular Dysfunction (CMD)
The Correlation Between Obstructive Sleep Apnea-Related Nocturnal Hypoxemia Parameters and Coronary Microvascular Dysfunction: A Prospective Cohort Study (SLEEP-CMD)
In a cohort of patients with suspected myocardial ischemia undergoing sleep studies, the objectives of this study were: 1. To determine the association between various obstructive sleep apnea (OSA)-related nocturnal hypoxemia…
- Conditions
- OSA - Obstructive Sleep Apnea, Coronary Microvascular Dysfunction (CMD), Coronary Artery Disease (CAD)
- Trial name
- SLEEP-CMD (NCT07315399)
- Testing
- Polysomnography
- Where
- China
- Volunteers
- 560 people
- Sponsor
- Beijing Anzhen Hospital
Ischemic Heart Disease, Coronary Microvascular Disease
MCG as a Noninvasive Diagnostic Strategy for Suspected INOCA (MICRO2)
A prospective, multicenter, observational, single-arm trial to validate CardioFlux MCG's ability to diagnose myocardial ischemia caused by coronary microvascular dysfunction in patients with suspected ischemia and confirmed no…
- Conditions
- Ischemic Heart Disease, Coronary Microvascular Disease, Angina, Myocardial Ischemia
- Trial name
- MICRO2 (NCT06212466)
- Testing
- CardioFlux
- Where
- 8 sites in United States
- Volunteers
- 136 people
- Sponsor
- Genetesis Inc.
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study B, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790617)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 183 people
- Sponsor
- University of Calgary
Complications of Diabetes Mellitus, Coronary Artery Disease
Clinical Observation of Coronary Arterial Microcirculation Dysfunction in Diabetic Patients With Non- Obstructive Coronary Artery Disease
The purpose of this study is to investigate the prevalence and degree of coronary arterial microcirculaiton dysfunction of non- obstructive coronary artery disease in patients with type 2 diabetes.
- Trial name
- NCT02748980
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shaanxi Provincial People's Hospital
Coronary Artery Disease
Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events
CKJX839D12303 is a research study to determine if the study treatment, called inclisiran, in comparison to placebo taken in addition to statin medication can effectively reduce the total amount of plaque formed in the heart's…
- Trial name
- V-PLAQUE (NCT05360446)
- Testing
- Inclisiran sodium 300 mg
- Where
- 89 sites in United States, Argentina and 16 more
- Volunteers
- 610 people
- Sponsor
- Novartis Pharmaceuticals
Coronary Artery Disease
Screening For Asymptomatic Obstructive Coronary Artery Disease Among High-Risk Diabetic Patients Using CT Angiography, Following Core 64
Patients with a known history of diabetes mellitus and no prior documented evidence of cardiovascular disease will be evaluated for inclusion in the study.
- Trial name
- faCTor-64 (NCT00488033)
- Testing
- CT Angiography
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Intermountain Health Care, Inc.
Acute Myocardial Infarction, Non-Obstructive Coronary Atherosclerosis
Myocardial Infarction With Non-Obstructive Coronary Arteries in the Greek Population
The MINOCA-GR registry will be the first nationwide study aiming to obtain data regarding prevalence, demographics, clinical profile, previous anginal status, presence of cardiovascular risk factors, management and outcomes in…
- Conditions
- Acute Myocardial Infarction, Non-Obstructive Coronary Atherosclerosis, Ischemic Heart Disease, Angina Pectoris
- Trial name
- MINOCA-GR (NCT04186676)
- Testing
- MINOCA registry, CCTA Phenotypes
- Where
- 3 sites in Greece
- Volunteers
- 60 people
- Sponsor
- AHEPA University Hospital
Chronic Non-communicable Disease
Risk Factors at Chronic Non-communicable Diseases in People of Working Age
Objectives: to study the clinical and demographic characteristics of working age persons, to highlight the main factors of non-communicable diseases (NCDs), to identify NCDs with physical examination, laboratory tests…
- Trial name
- FORTUNE (NCT06812767)
- Testing
- electrocardiography, analysis for glucose and cholesterol in the capillary blood, detection of microalbumuria
- Where
- Russia
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Microvascular Angina, Vasospastic Angina
Transcutaneous Electrical Nerve Stimulation in Patients With Angina and Non-Obstructive Coronary Arteries
In patients with angina pectoris undergoing a coronary angiography (CAG) up to 40% do not have obstructive coronary artery disease (CAD).
- Trial name
- TENS-ANOCA (NCT06401291)
- Testing
- Transcutaneous Electrical Nerve Stimulation
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Catharina Ziekenhuis Eindhoven