Clinical trials: Obstructive Coronary Artery Disease
Coronary Artery Disease, Chronic Obstructive Pulmonary Disease
ComparisoN of ticAgrelor vs. Clopidogrel in endoTHeliAl Function of COPD patieNts
This is an investigator-initiated, prospective, single-centre, randomised, phase II, open-label study, testing the superiority of ticagrelor, as compared to clopidogrel, in modulating on-P2Y12 treatment platelet reactivity…
- Trial name
- NATHAN-NEVER (NCT02519608)
- Testing
- Aspirin 100 mg, Ticagrelor, Clopidogrel
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- University Hospital of Ferrara
Myocardial Infarction
Internet-based Treatment of Stress and Anxiety in Myocardial Infarction With Non-obstructive Coronary Arteries
Patient with myocardial infarction with non-obstructive coronary arteries and takotsubo syndrome often have high levels of stress and anxiety. At present there are no treatment alternatives in this group of patients.
- Trial name
- e-SMINC (NCT04178434)
- Testing
- Internet-based CBT intervention
- Where
- Sweden
- Volunteers
- 64 people
- Sponsor
- Per Tornvall
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Coronary Artery Disease
PREventive Invasive Strategy for Obstructive Coronary Artery Disease With Vulnerable Plaque Evaluated by CoroNary Computed Tomography Angiography-2
The PREVENT-2 trial is to determine whether an initial invasive strategy-consisting of early coronary angiography (CAG) with intent for preventive percutaneous coronary intervention (PCI) in addition to optimal medical therapy…
- Trial name
- PREVENT-2 (NCT07569692)
- Testing
- Initial Invasive Strategy, Initial Conservative Strategy
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Duk-Woo Park, MD
Angina Pectoris, Coronary Heart Disease
Evaluate the Efficacy and Safety of MUSK Pill on Coronary Microvascular Dysfunction
Objective to evaluate the effect of Shexiang Baoxin Pill on myocardial ischemia in patients with coronary microvascular dysfunction (non obstructive coronary heart disease) through a randomized, double-blind, placebo-controlled…
- Conditions
- Angina Pectoris, Coronary Heart Disease, X Syndrome, Angina, Non Obstructive Coronary Artery Disease
- Trial name
- NCT04984954
- Testing
- MUSK pill
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Heart Disease, Brain Vascular Accident
A Single Center of Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease
The primary objective of this study is to assess the safety and effectiveness of stenting in the treatment of obstructive carotid artery disease.
- Conditions
- Heart Disease, Brain Vascular Accident, Carotid Artery Disease, Carotid Stenosis
- Trial name
- NCT00178672
- Testing
- Angioguard XP distal protection device, Heart Catheterization -Angioplasty, stenting
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- The University of Texas Health Science Center, Houston
Angina, Stable, Angina Pectoris, Variant
Coronary Microvascular Function and CT Coronary Angiography (CorCTCA)
Angina in patients without obstructive coronary artery disease (CAD) is a clinical conundrum and patient management is heterogeneous. Hypothesis: Abnormal coronary function is common and clinically relevant in this population.
- Conditions
- Angina, Stable, Angina Pectoris, Variant, Microvascular Angina
- Trial name
- CorCTCA (NCT03477890)
- Testing
- Stratified medicine involving a diagnostic intervention
- Where
- 3 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- NHS National Waiting Times Centre Board
COPD, Coronary Artery Calcification
Quebec Lung Cancer Screening PLUS Trial
Does an educational intervention for untreated COPD and cardiovascular disease which is integrated in an existing lung cancer screening program improve guideline concordant medication adherence at 12 months
- Trial name
- QLC+ (NCT05444062)
- Testing
- Educational material and treatment recommendations for patients, general practitioners and pharmacists
- Where
- Canada
- Volunteers
- 330 people
- Sponsor
- Nicole Ezer, MD, FRCPC, MPH
Atherosclerosis, Coronary Artery Disease
Chlamydia and Mycoplasma in Coronary Artery Disease
To test the association between anti-Chlamydia serum titers and anti-Mycoplasma antibodies with Acute Coronary Syndromes.
- Conditions
- Atherosclerosis, Coronary Artery Disease, Chlamydia Infections, Mycoplasma Infections
- Trial name
- NCT00561028
- Testing
- blood sample analysis - mycoplasma and chlamydia antibodies
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Hospital de Base
Cerebrovascular Accident, Cancer
Multidisciplinary Inpatient Palliative Care Intervention
Palliative care is believed to improve care of patients with life-limiting illnesses. This study evaluated the impact of a multi-center randomized trial of a palliative care team intervention on the quality and cost of care of…
- Conditions
- Cerebrovascular Accident, Cancer, Coronary Arteriosclerosis, Heart Failure, Congestive
- Trial name
- NCT00325611
- Testing
- Multidisciplinary palliative care team met with patient
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Kaiser Permanente
Angina, Acute Bronchiolitis
Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care
Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France…
- Conditions
- Angina, Acute Bronchiolitis, Acute Bronchitis, COPD Exacerbation (AECOPD)
- Trial name
- GRASP (NCT07359287)
- Testing
- Antibiotic prescribing according to guidelines
- Where
- France
- Volunteers
- 4,500 people
- Sponsor
- University Hospital, Caen
Acute Coronary Syndrom, Chronic Obstructive Pulmonary Syndrom
Pneumological Acute Coronary Syndrom (ACS) Phenotyping Aachen
In this open, monocentric, observational study acute coronary syndrom (ACS) patients will be characterized by pneumological examination concerning a concomitant chronic obstructive pulmonary disease (COPD).
- Trial name
- PAPA (NCT02587481)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Angina Attacks, Non Obstructive Coronary Artery Disease
The Anti-Anginal Effects of N-Acetylcysteine (NAC) in Patients with Angina and Non-Obstructive Coronary Arteries (ANOCA)
The goal of this clinical trial is to determine if N-acetylcysteine (NAC) can reduce angina frequency in women with Angina with Non-Obstructive Coronary Arteries (ANOCA).
- Trial name
- NANA (NCT06890507)
- Testing
- N-Acetylcysteine (NAC)
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- University of Adelaide
HIV Infections, Hypertension
ENHANCE-EvideNce Led Co-created HeAlth Systems interventioNs for MLTCs CarE
The goal of this study is to determine the effect of the ENHANCE intervention in improving clinical outcomes and evaluating the effects of the intervention on implementation processes and outcomes.
- Conditions
- HIV Infections, Hypertension, Diabetes Mellitus, Asthma
- Trial name
- ENHANCE (NCT06248190)
- Testing
- ENHANCE intervention (health systems)
- Where
- 32 sites in South Africa
- Volunteers
- 1,837 people
- Sponsor
- University of KwaZulu
Myocardial Ischemia
MCG for Non-Obstructive Myocardial Ischemia
The aim of this prospective study is to identify Non-Obstructive Myocardial Ischemia of patients who have acute chest pain using Magnetocardiography.
- Trial name
- NCT07657546
- Testing
- Magnetocardiography
- Where
- China
- Volunteers
- 3,786 people
- Sponsor
- Qilu Hospital of Shandong University
Heart Disease, COPD
Outpatient Rehabilitation Programmes for Myocardial Ischemia, Heart Failure, and COPD: Satisfaction, Participation, Test Outcomes, and Factors Associated With Positive Changes in Test Results as Well as Level of Participation
Aim The aim of this project is to investigate the level of participation, satisfaction, changes in tests, and factors associated with these results in existing rehabilitation programmes at North Zealand Hospital and in the…
- Trial name
- NCT07591792
- Volunteers
- 840 people
- Sponsor
- Nordsjaellands Hospital
Osteoarthritis, Knee, Osteoarthritis, Hip
Personalized Exercise Therapy and Self-management Support for Patients With Multimorbidity
Chronic conditions such as knee or hip osteoarthritis (OA), chronic obstructive pulmonary disease (COPD), heart failure (HF), coronary heart disease (CHD), hypertension, type 2 diabetes mellitus (T2DM) and depression are among…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Heart Failure, Coronary Heart Disease
- Trial name
- MOBILIZE (NCT04645732)
- Testing
- Personalized exercise therapy and self-management support program, Usual care
- Where
- 16 sites in Denmark
- Volunteers
- 228 people
- Sponsor
- University of Southern Denmark
Coronary Artery Disease, Coronary Artery Disease (Left Main)
µQFR for Branch Stenosis After Single Stent in Bifurcation Lesions
Murray-law based single-view quantitative flow ratio (µQFR) has been recommended for guiding percutaneous coronary intervention (PCI) in selective patients.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (Left Main), Obstructive Coronary Artery Disease, Stent Implantation
- Trial name
- NCT07116083
- Where
- China
- Volunteers
- 290 people
- Sponsor
- Shanghai Zhongshan Hospital
Atrial Fibrillation, Obstructive Sleep Apnea
Mechanisms for Atrial Fibrillation in Obstructive Sleep Apnea
Atrial fibrillation (AF) is the most common rhythm disorder and involves an increased risk of cardiovascular disease and death, impaired quality of life and a high proportion of healthcare consumption.
- Conditions
- Atrial Fibrillation, Obstructive Sleep Apnea, Hypertension, Autonomic Dysfunction
- Trial name
- AF-MiTriSto (NCT06465134)
- Testing
- No intervention
- Where
- 3 sites in Italy, Sweden
- Volunteers
- 300 people
- Sponsor
- Danderyd Hospital
Atherosclerosis, Coronary Artery Disease
Efficacy CompariSon of Pre-stenting Atherectomy Versus Scoring ballooN for calcifieD Coronary Lesions Coronary Lesions
Design: The proposed study is a randomized study comparing the relative effectiveness of three lesion modification strategies (RA, SBS, or OAS) in the treatment of obstructive CCLs using the change in lumen size measurements…
- Trial name
- ECSPAND (NCT02819531)
- Testing
- Rotational atherectomy, Orbital atherectomy, Scoring balloon system
- Volunteers
- 30 people
- Sponsor
- North Texas Veterans Healthcare System