Clinical trials: Obstructive Defecation Syndrome
Surgery, Obstructive Defecation Syndrome
Mental Health Outcome After Surgery for Obstructed Defecation Syndrome (ODS)
Background: Obstructed Defecation Synsdrome (ODS) causes people to strain and sometimes need help to go to the toilet. They think about going to the toilet a lot, which makes their lives worse.
- Conditions
- Surgery, Obstructive Defecation Syndrome, Mental Health Issue, Depression/Anxiety
- Trial name
- MentODSSurg (NCT06502184)
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Evangelisches Klinikum Köln Weyertal gGmbH
Constipation
A Study to Evaluate the Effects of a Natural Supplement in Adults With Chronic Functional Constipation
Constipation is common in the general population, especially in women and in the elderly. Hard stool is a complaint often associated with constipation, which suggests that stool softening would provide a major benefit in the…
- Trial name
- NCT02073006
- Testing
- Natural Fibre Supplement
- Where
- Ireland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Atlantia Food Clinical Trials
Obstructive Defecation Syndrome, Chronic Constipation
Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS)
The primary purpose of this study is to determine how effective and how durable STARR (stapled transanal rectal resection) surgery is in relieving symptoms of intractable constipation associated with obstructive defecation…
- Conditions
- Obstructive Defecation Syndrome, Chronic Constipation, Rectocele, Intussusception
- Trial name
- NCT00256984
- Testing
- Stapled Transanal Resection (STARR) with Transtar (PROXIMATE®) 33 mm Circular Stapler
- Where
- 7 sites in United States
- Volunteers
- 75 people
- Sponsor
- Ethicon Endo-Surgery
Chronic Constipation
Evaluate the Safety and Efficacy of a 5-HT4 Agonist in Chronic Constipation (ACCORD Trial)
Study 0038 compares the safety and effectiveness of an investigational drug, TD-5108 with placebo (a sugar pill) for the treatment of chronic constipation.
- Trial name
- NCT00391820
- Testing
- TD-5108
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Alfasigma S.p.A.
Defecation Disorder, Constipation - Functional
Barriers to Rectal Irrigation in Defaecatory Dysfunction
Rectal irrigation is the introduction of warm tap water through the anal canal into the rectum to initiate defaecation. NICE recommends that rectal irrigation be considered in patients with constipation(1) and faecal incontinence…
- Conditions
- Defecation Disorder, Constipation - Functional, Constipation by Outlet Obstruction, Faecal Incontinence
- Trial name
- NCT06569446
- Testing
- There is no intervention. This a qualitative study to explore barriers to rectal irrigation
- Volunteers
- 34 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obstructive Defecation Syndrome
Effect of Low Level Laser Therapy on Women With Obstructive Defecation Syndrome
Obstructive defecation syndrome (ODS) is a condition in which a person has difficulty completely emptying the rectum during bowel movements.
- Trial name
- NCT07771218
- Testing
- Nutritional Modification, Biofeedback Training, Low Level Laser Therapy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Obstructive Defecation Syndrome, Postoperative Constipation
PEG3350 vs Senna After Urogyn Surgery
The goal of this study is to evaluate whether polyethylene glycol 3350 (PEG3350) versus senna is better at relieving postoperative constipation after urogynecologic surgery.
- Trial name
- NCT06825260
- Testing
- Senna, Polyethylene glycol 3350
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Health, New York
Obstructive Defecation Syndrome, Chronic Constipation
Laparoscopic Ventral Mesh Rectopexy Combined With or Without Stapled Trans-anal Rectal Resection for Obstructed Defecation Syndrome
Obstructed defecation syndrome (ODS) is a common problem in women. Rectal prolapse and rectocoele are frequently identified in patients with ODS.
- Conditions
- Obstructive Defecation Syndrome, Chronic Constipation, Rectal Prolapse
- Trial name
- NCT03060330
- Testing
- Modified Laparoscopic Ventral Mesh Rectopexy, Modified Laparoscopic Ventral Mesh Rectopexy Combined with Stapled Trans-anal Rectal Resection
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Renmin Hospital of Wuhan University
Hemorrhoids, Defecation Disorder
Efficacy of Stapled Hemorrhoidopexy for the Treatment of Obstructive Defecation Syndrome
The objective of this study is to assess the efficiency of the procedure for hemorrhoidal prolapse and pexia in alleviating symptoms of defecatory obstruction among patients with grade II to IV mucohemorrhoidal prolapse.
- Trial name
- NCT06294470
- Testing
- Ballon expulsion test, Colonic transit time, Stapled hemorrhodopexy
- Where
- Venezuela
- Volunteers
- 34 people
- Sponsor
- Universidad Central de Venezuela
Constipation by Outlet Obstruction, Pelvic Organ Prolapse
Early Safety of Resection Rectopexy and Sacrocolpopexy
Obstructive defecation syndrome (ODS) defines a disturbed defecation process frequently associated with pelvic organ prolapse (POP) in women.
- Conditions
- Constipation by Outlet Obstruction, Pelvic Organ Prolapse, Urinary Incontinence
- Trial name
- RRPSCPcomb (NCT05910021)
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Evangelisches Klinikum Köln Weyertal gGmbH
Rectal Prolapse, Fecal Incontinence
Clinical Outcomes of Rectopexy for Rectal Prolapse
This study evaluates the clinical outcomes of patients who underwent rectopexy for rectal prolapse, ODS or FI. Rectopexy is a surgical procedure used to restore and fix the rectum in its normal position.
- Conditions
- Rectal Prolapse, Fecal Incontinence, Rectopexy, Obstructive Defecation Syndrome
- Trial name
- NCT07848308
- Testing
- anterior mesh rectopexy
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- Lukas Marti
Rectocele, Pelvic Organ Prolapse
Fat Injection for Rectocele Treatment: A Novel Approach
This clinical trial aims to evaluate the effectiveness of autologous fat grafting as a novel treatment for rectocele, a condition characterized by the herniation of rectal tissue into the posterior vaginal wall.
- Conditions
- Rectocele, Pelvic Organ Prolapse, Obstructive Defecation Syndrome
- Trial name
- NCT06604702
- Testing
- Autologous Fat Injection for Rectocele
- Volunteers
- 25 people
- Sponsor
- Cairo University
Malignant Pain, Non-malignant Pain
To Demonstrate Equivalence in Analgesic Efficacy & Bowel Function Between OXN PR Higher Dose & Lower Dose Tablet Strengths in Subjects With Non-cancer or Cancer Pain
This study is aimed to demonstrate equivalence between combinations of lower strength OXN PR tablets (OXN PR LST) and single higher strength OXN PR tablets (OXN PR HST) taken at the same overall daily dose.
- Trial name
- NCT02321397
- Testing
- Oxycodone, Naloxone
- Where
- Germany
- Volunteers
- 155 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Rectocele, Obstructive Defecation Syndrome
Functional and Sexual Outcomes After Laparoscopic Ventral Mesh Rectopexy for Complex Rectocele
The ideal surgical strategy for treating complex rectocele remains a topic for debate, with the transanal, transperineal, and transvaginal approach and the abdominal approach being at conflict with one another.
- Trial name
- NCT05894226
- Testing
- laparoscopic ventral mesh rectopexy
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Mansoura University
Obstructive Defecation Syndrome, Outlet Obstruction
Dynamic MRI Evaluation Post Operative Stapled Trans Anal Rectal Resection (STARR) Procedure
The purpose of this study is to assess the effects of the Stapled Trans Anal Rectal Resection (STARR) procedure for patients with obstructive defecation syndrome.
- Trial name
- NCT00655382
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic