Clinical trials: Obstructive Sleep Apnea, open to volunteers
Obstructive Sleep Apnea
KPAP vs EPR for Comfort
The KPAP EPR Home is a randomized, crossover study in which subjective comfort will be compared between SleepRes APAP + KPAP and ResMed APAP + EPR.
- Trial name
- NCT07530510
- Testing
- APAP + KPAP, APAP + EPR
- Volunteers
- 24 people
- Sponsor
- SleepRes Inc.
Chronic Kidney Diseases, OSAS (Obstructive Sleep Apneas Syndrome)
The Outcome of Chronic Kidney Disease Patients With Obstructive Sleep Apnea Syndrome
Obstructive sleep apnea (OSA) is highly prevalent in chronic kidney disease (CKD) patients and strongly linked to obesity, metabolic syndrome, and type 2 diabetes.
- Trial name
- NCT06971874
- Testing
- No intervention
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Obstructive Sleep Apnea
Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA
Polysomnography (PSG) and drug-induced sleep endoscopy (DISE) are widely used diagnostic studies for assessing obstructive sleep apnea (OSA) severity and collapse patterns of the upper airway anatomy during sleep.
- Trial name
- NCT05501236
- Testing
- Grass S88 Muscle Stimulator
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Gastroesophageal Reflux Disease
Mandibular Advancement Devices for Reflux in Obstructive Sleep Apnea
The purpose of this randomized clinical trial is to learn if a mandibular advancement device (a type of oral appliance) can help reduce nighttime acid reflux in adults with obstructive sleep apnea.
- Trial name
- MAD-ROSA (NCT07049315)
- Testing
- Mandibular Advancement Device, Lower Oral Device Without Mandibular Advancement
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Tuiuti University of Paraná
Ischemic Stroke, Obstructive Sleep Apnea
The Recovery in Stroke Using PAP Study
The proposed study is a randomized controlled trial among an anicipated 180 participants with acute ischemic stroke and mod/severe OSA diagnosed by ambulatory polysomnography (PSG) comparing PAP treatment with usual care…
- Trial name
- RISE-UP (NCT04130503)
- Testing
- PAP, HLE
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Yale University
Obstructive Sleep Apnea (OSA)
INFORMing Patients With Oximetry Data to Improve MAD Engagement
Obstructive sleep apnea (OSA) is common and associated with impaired daytime functioning, reduced quality of life and increased cardiovascular, metabolic and perioperative risk.
- Trial name
- INFORM (NCT07564310)
- Testing
- Narval MRD device, MyNarval intervention (Narval CC MAD + O2 ring + MyNarval smartphone application),
- Volunteers
- 120 people
- Sponsor
- ResMed
Obstructive Sleep Apnea
Endotypic Traits and Obstructive Sleep Apnea Surgery
This study will examine factors associated with outcomes after soft palate surgery and medications (acetazolamide, eszopiclone) that may treat other potential causes of obstructive sleep apnea (loop gain, arousal threshold).
- Trial name
- NCT05953610
- Testing
- Acetazolamide 500 MG QHS, Eszopiclone 3 mg QHS
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of California, Los Angeles
OSA - Obstructive Sleep Apnea
Multidisciplinary Network OSA Code (Obstructive Apnea Syndrome): Digital Operative Model in Public Health for an Early Diagnosis and Therapy Monitoring
Obstructive Sleep Apnea Syndrome (OSAS) is a sleep related breathing disorder with high epidemiological impact (9-38% of general population), more frequently reported in male gender and increasing with the age.
- Trial name
- DOMOSA (NCT06677580)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Obstructive Sleep Apnea, Obstructive Sleep Apnea (OSA)
Identification of Biomarkers of Obstructive Sleep Apnea.
Obstructive sleep apnea (OSA) is a common sleep disorder associated with intermittent hypoxia, systemic inflammation, oxidative stress, and an increased risk of cardiovascular and metabolic diseases.
- Conditions
- Obstructive Sleep Apnea, Obstructive Sleep Apnea (OSA), Obstructive Sleep Apnea (OSAS), Obstructive Sleep Apnea (SAOS)
- Trial name
- NCT07723144
- Testing
- Positive Airway Pressure (PAP) Therapy
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Obstructive Sleep Apnea
Enhancing PAP Adherence Among Spanish-speaking Hispanic Adults With OSA
This study seeks to enhance long-term positive airway pressure (PAP) adherence among Spanish-speaking Hispanic adults, a group with known PAP outcomes disparities.
- Trial name
- NCT05618444
- Testing
- Automated Management (AM)
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Geisinger Clinic
Sleep Apnea Syndrome (OSAS), Orthognathic Surgical Procedures
Splintless Versus Conventional Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea
The goal of this clinical trial is to find out whether using a splintless surgical approach improves the accuracy of maxillomandibular advancement (MMA) surgery for treating obstructive sleep apnea (OSA) in adults.
- Conditions
- Sleep Apnea Syndrome (OSAS), Orthognathic Surgical Procedures, Sleep Apnea - Obstructive
- Trial name
- SvCMAS (NCT07598461)
- Testing
- Splintless MMA surgery, Splint MMA surgery
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Obstructive Sleep Apnea, Coronary Disease
Patients with Coronary Artery Disease or At High Cardiovascular Risk: Measuring Compliance with Treatment for Obstructive Sleep Apnea Syndrome
Obstructive sleep apnea (OSA) is a sleep disorder characterised by partial or total obstruction of the oro-pharyngeal carrefour during sleep.
- Conditions
- Obstructive Sleep Apnea, Coronary Disease, Cardiovascular Diseases
- Trial name
- PACOAM (NCT06568159)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Obesity &Amp; Overweight, Hypertension
A Prospective Randomnised Controlled Trial Comparing Overall Patient Compliance in a Bariatric Surgical Pathway Using the Standard Versus a More Intensified and Interactive Version of the "Get Ready" Smartphone Application.
The aim of this study is to assess the impact of a newly intensified digital platform following bariatric surgery. This will be measured using several questionnaires.
- Conditions
- Obesity &Amp; Overweight, Hypertension, Obstructive Sleep Apnea (OSAS), Diabetes Mellitus ( Type 1 and Type 2)
- Trial name
- NCT07297342
- Testing
- GetReady application, Intensified GetReady application
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Sint Dimpna Ziekenhuis Geel
Obstructive Sleep Apnea (OSA), Exercise Snacks
Exercise Interventions in Obstructive Sleep Apnea Syndrome
Obstructive Sleep Apnea Syndrome (OSA) is a condition characterized by repeated pauses or reductions in breathing during sleep, which can negatively affect sleep quality, daytime functioning, and physical capacity.
- Conditions
- Obstructive Sleep Apnea (OSA), Exercise Snacks, Physical Activity, Circadian Rhythm
- Trial name
- NCT07634029
- Testing
- Aerobic Exercise Training, Exercise Snacking
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Istanbul University - Cerrahpasa
Apnea, Obstructive
EFFECT OF A SUBSTANCE P ANTAGONIST ON THE SECRETION OF ALDOSTERONE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME AND ARTERIAL HYPERTENSION
Obstructive sleep apnea syndrome (OSAS) is associated with hyperaldosteronism with elevated plasma aldosterone/renin ratio, the physiopathological mechanism of which remains uncertain.
- Trial name
- APHOS3 (NCT06462287)
- Testing
- Aprepitant 125 and 80Mg Oral Capsule
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Rouen
Obstructive Sleep Apnea (OSA), Snoring
OSAHS Screening in Diverse Populations
The goal of this prospective observational study is to learn about the current prevalence of obstructive sleep apnea-hypopnea syndrome in community population, patients with specific diseases and special population from China.
- Conditions
- Obstructive Sleep Apnea (OSA), Snoring, Prevalence, Questionnaires and Surveys
- Trial name
- NCT07736872
- Testing
- patients with hypertension, diabetes, cardiovascular and cerebrovascular diseases, chronic obstructive pulmonary disease, asthma and other OSA related comorbidities.
- Where
- 2 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Kang Wu
Sleep Apnea, Obstructive
Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea
Prospective, interventional cohort study of drug-induced sleep endoscopy (DISE) to evaluate the upper airway in a cohort of obstructive sleep apnea (OSA) surgical patients.
- Trial name
- NCT00695214
- Testing
- Propofol sedation
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of California, Los Angeles
Chronic Obstructive Pulmonary Disease Exacerbation, Obstructive Sleep Apnea Exacerbation
Non-invasive Ventilation or CPAP in OSA-COPD Following Admission for an Acute Hypercapnic Respiratory Failure
Chronic obstructive pulmonary disease (COPD) is a major public health problem with 212.3 million prevalent cases of COPD worldwide and 3.3 million deaths related to COPD in 2019.
- Trial name
- NCT07047092
- Testing
- Non-invasive Ventilation (NIV), Continous Positive Airway Pressure (CPAP)
- Where
- France
- Volunteers
- 386 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea (OSA)
Evaluation of the Diagnostic Capacity of a Smart Mattress Versus Conventional Polysomnography
This project aims to develop and evaluate an innovative, non-invasive diagnostic system based on a smart mattress for detecting obstructive sleep apnea (OSA), as well as assessing overall sleep quality and identifying periodic…
- Trial name
- NCT07432919
- Testing
- Integrated polysomnographic assessment with smart mattress.
- Where
- 2 sites in Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospital San Pedro de Logroño
Mild Obstructive Sleep Apnea, Snoring
Study to Examine the Effect of Silicone Mouth Tape on Snoring and Mild Sleep Apnea.
Snoring is a common problem caused by vibration of tissues in the throat region during sleep. Although snoring is sometimes dismissed as a minor nuisance rather than a medical disorder, several studies indicate that snoring can…
- Trial name
- MTASSA (NCT06587256)
- Testing
- Mouth Tape
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University