Clinical trials: Obstructive Sleep Apnea (OSAS)
Obstructive Sleep Apnea
A Phase II Pilot Study of the Trillium Full Face Mask
This will be a single-center, open-label randomized crossover design pilot study to evaluate the clinical safety, clinical performance, and clinical benefit of the Trillium full face mask
- Trial name
- NCT06932055
- Testing
- Trillium Full Face Mask, AirFit F20
- Volunteers
- 40 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Obesity, Sleep Apnea, Obstructive
Pragmatic Obstructive Sleep Apnea Weight Loss Trial Assessing Effectiveness and Reach
Prevalent obesity related conditions like obstructive sleep apnea (OSA) represent an important opportunity to improve population health. OSA reduces quality of life and is associated with greater risk for cardiovascular disease.
- Trial name
- POWER (NCT05104450)
- Testing
- lifestyle intervention
- Where
- United States
- Volunteers
- 696 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea, Stroke
Diagnosis and Treatment of Sleep Apnea in Cerebrovascular Disease
Sleep apnea is common among Veterans with cerebrovascular disease (stroke or transient ischemic attack [TIA]), leads to hypertension, and is associated with recurrent stroke and death.
- Conditions
- Obstructive Sleep Apnea, Stroke, Transient Ischemic Attack, Hypertension
- Trial name
- Go To Sleep (NCT00984308)
- Testing
- CPAP Therapy for Newly Diagnosed Obstructive Sleep Apnea (OSA)
- Where
- 2 sites in United States
- Volunteers
- 225 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea
Real-time Attended Home-polysomnography Through Telematic Data Transmission
The purpose of this study is to develop an efficient home-based polysomnography device, which allows, through GPRS,continuous real-time monitoring from the sleep lab based in the hospital, in order to decrease the failure rate of…
- Trial name
- sleepbox (NCT01471626)
- Testing
- polysomnograph Dream and Sleep Box
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Non Alcoholic Fatty Liver Disease
The Role of Obstructive Sleep Apnea in Children With Fatty Liver Disease
The purpose of this study is to examine whether CPAP therapy can reduce or eliminate hepatic fat accumulation in obese children and adolescents.
- Trial name
- NCT02134522
- Testing
- Continuous positive airway pressure (CPAP).
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Yale University
Obstructive Sleep Apnea (OSA)
Safety and Tolerability of Gefapixant (MK-7264) in Participants With Obstructive Sleep Apnea (MK-7264-039)
The purpose of this study is to assess the safety and tolerability of multiple dose administration of gefapixant (MK-7264) in participants with moderate to severe obstructive sleep apnea (OSA).
- Trial name
- NCT03882801
- Testing
- Gefapixant
- Where
- 5 sites in United States, Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Obstructive Sleep Apnea, Delayed Emergence From Anesthesia
Evaluation of Modafinil vs Placebo for Treatment of Anesthesia Delayed Emergence in Obstructive Sleep Apnea
The purpose of this study is to determine whether modafinil use in patients with obstructive sleep apnea will improve postoperative delayed emergence after general anesthesia.
- Trial name
- ModOSA (NCT02494102)
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Milton S. Hershey Medical Center
Sleep Disorders, Obstructive Sleep Apnea
Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression
The primary objective of the study is to evaluate whether armodafinil at a target dosage of 200 mg/day is more effective than placebo treatment in improving excessive sleepiness in patients with obstructive sleep apnea/hypopnea…
- Conditions
- Sleep Disorders, Obstructive Sleep Apnea, Major Depressive Disorder, Dysthymic Disorder
- Trial name
- NCT00518986
- Testing
- armodafinil
- Where
- 62 sites in United States
- Volunteers
- 249 people
- Sponsor
- Cephalon
Myalgia, Apnea, Obstructive Sleep
Temporomandibular Disorder (TMD) Pain in Response to Jaw Advancement in People With TMD and Obstructive Sleep Apnea
The purpose of this study is to characterize the course of temporomandibular disorder (TMD) pain in adults with TMD and obstructive sleep apnea (OSA), all of whom are being treated with mandibular advancement splint (MAS)…
- Trial name
- NCT02685202
- Testing
- Mandibular advancement splint
- Volunteers
- 9 people
- Sponsor
- University of North Carolina, Chapel Hill
Sleep Apnea, Obstructive, Down Syndrome
A Pilot Study to Evaluate the Hypoglossal Nerve Stimulator in Adolescents With Down Syndrome and Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) affects up to 1% of the general pediatric population and is associated with adverse behavior and quality of life, as well as long term cardiopulmonary system complications.
- Trial name
- NCT02344108
- Testing
- Inspire® Upper Airway Simulation System (Model 3028 IPG )
- Where
- 5 sites in United States
- Volunteers
- 42 people
- Sponsor
- Christopher Hartnick, M.D.
Respiratory Complication, Obstructive Sleep Apnea
Applying Best Clinical Practices to Patients at High Risk of Respiratory Complications
The purpose of this study is to: 1. Perform a retrospective analysis on data contained in the UCLA Perioperative Data Warehouse on the incidence of respiratory dysfunction in the post-operative care unit (PACU) before and after…
- Trial name
- NCT04263363
- Testing
- Sugammadex 100 MG/ML [Bridion]
- Where
- United States
- Volunteers
- 12,248 people
- Sponsor
- University of California, Los Angeles
Obstructive Sleep Apnea, Obesity
Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial
The purpose of this study is to assess the feasibility of conducting a comparative effectiveness study comparing a medical versus surgical approach to the initial management of obstructive sleep apnea (OSA) in the setting of…
- Trial name
- ABC (NCT01187771)
- Testing
- Laparoscopic Gastric Banding, Continuous Positive Airway Pressure
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- University of Pittsburgh
Obstructive Sleep Apnea
Evaluation of an Incentive-based Intervention to Improve 90-day Adherence in PAP-Naive Patients
This is a prospective, randomized, open-label study to evaluate effectiveness of applying financial and social incentives via a smartphone-based app in helping participants achieve adherence to PAP therapy.
- Trial name
- Project Dahlia (NCT03851094)
- Testing
- Wellth app
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- ResMed
Lung Diseases, Sleep Apnea Syndromes
Apnea Positive Pressure Long-Term Efficacy Study
The purpose of this study is to determine the effectiveness of nasal continuous positive airway pressure (CPAP) therapy for the treatment of obstructive sleep apnea syndrome (OSAS).
- Conditions
- Lung Diseases, Sleep Apnea Syndromes, Sleep
- Trial name
- APPLES (NCT00051363)
- Testing
- Active CPAP
- Where
- 5 sites in United States
- Volunteers
- 1,105 people
- Sponsor
- Stanford University
Obesity, Premature Recovery From Anesthesia
Armodafinil (Nuvigil), Postoperative Recovery of OSA (Obstructive Sleep Apnea) and Obese Patients
Obstructive sleep apnea (OSA) and obesity is associated with increased perioperative morbidity and mortality. This group of patients is at risk of perioperative desaturations which can be worsened by perioperative sedatives and…
- Trial name
- NCT02478580
- Testing
- Nuvigil
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Texas Southwestern Medical Center
Obstructive Sleep Apnea, Obesity
Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep Apnea
The purpose of this study is to evaluate the effect and safety of tirzepatide in participants with moderate to severe obstructive sleep apnea and obesity who are both unwilling or unable to use Positive Airway Pressure (PAP)…
- Trial name
- SURMOUNT-OSA (NCT05412004)
- Testing
- Tirzepatide
- Where
- 58 sites in United States, Australia and 8 more
- Volunteers
- 469 people
- Sponsor
- Eli Lilly and Company
Obstructive Sleep Apnea
Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications
Sugammadex or neostigmine are given at the end of the surgery to reverse neuro muscular blocking drugs (NMBD). This study will evaluate whether reversal of NMBD with sugammadex is associated with faster recovery than neostigmine…
- Trial name
- Sugammadex (NCT03679611)
- Testing
- Sugammadex Sodium, Neostigmine
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
OSA - Obstructive Sleep Apnea
Parallel Arm Trial of AD109 and AD504 In Patients With OSA
This is a phase 2 randomized double-blind placebo-controlled parallel-arm dose finding study to compare fixed dose combinations of AD109 and AD504 to atomoxetine or placebo in Obstructive Sleep Apnea.
- Trial name
- MARIPOSA (NCT05071612)
- Testing
- AD109, AD504, Atomoxetine Hydrochloride
- Where
- 25 sites in United States
- Volunteers
- 294 people
- Sponsor
- Apnimed
Obstructive Sleep Apnea Syndrome, Restless Leg Syndrome
Prevalence of OSAS in Chinese Elderly and Its CPAP Compliance
Objective: Obstructive sleep apnoea syndrome (OSAS) is a common form of sleep-disordered breathing (SDB) causing sleep fragmentation, daytime sleepiness, cognitive function impairment, and poor health status in addition to…
- Trial name
- NCT02085720
- Testing
- CPAP therapy
- Where
- Hong Kong
- Volunteers
- 819 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
Metabolic Impact of Intermittent CPAP
Obstructive sleep apnea is a risk factor for diabetes and cardiovascular disease, by unknown mechanisms. The investigators hypothesize that sleep apnea changes glucose and lipid metabolism during sleep, which over time could lead…
- Trial name
- MIIC (NCT02824263)
- Testing
- CPAP withdrawal
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Johns Hopkins University