Clinical trials: Obstructive Sleep Apnea Syndrome (OSAS)
Healthy, Obstructive Sleep Apnea
Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea and Healthy Controls.
Obstructive sleep apnea syndrome is complicated by considerable cardiovascular morbidity and mortality, at least partly due to hypertension.
- Trial name
- NCT00291993
- Where
- 3 sites in Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
OSA
Pharyngeal Muscle Control Mechanisms of Atomoxetine-plus-oxybutynin in Obstructive Sleep Apnea
Current therapies available for obstructive sleep apnea (OSA) have varying degrees of efficacy due to the complex nature of the disorder.
- Trial name
- NCT05944965
- Testing
- Atomoxetine 80 mg plus Oxybutynin 5 mg, Atomoxetine 80 MG
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Apnea, Obstructive
Intermitent Hypoxia and Its Pathophysiology Consequences in the Sleep Apnea-Hypopnea Syndrome.
Clinical trial on the effect of continuous positive pressure (CPAP). Objectives: 1) To assess the total or partial recovery of oxidative and inflammatory damage after recovering IH.
- Trial name
- NCT04444778
- Testing
- CPAP
- Where
- 2 sites in Spain
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Alberto Alonso Fernandez
Obstructive Sleep Apnea
Simulated In-House Usability Study of Eclipse Continuous Positive Airway Pressure (CPAP) Device
The study is designed to assess the usability of a novel CPAP human interface compared to a traditional nasal mask. Human subjects will interact with two different CPAP interfaces including a traditional CPAP mask and the 2nd…
- Trial name
- NCT05570747
- Testing
- Usability
- Where
- 3 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Bleep, LLC
Osa Syndrome
Safety and Efficacy of Esmketamine Versus Dexmedetomidine
A comparative study on the safety and efficacy of esmketamine versus Dexmedetomidine during drug induced sleep endoscopy in children with positional obstructive sleep apnea: A consort-prospective, randomized, controlled clinical…
- Trial name
- NCT04877639
- Testing
- Esmketamine,Dexmedetomidine
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Obstructive Sleep Apnea
Derivation and Validation of a Combination of BOSTON Score and DES-OSA Score for Selection of OSA Patients.
Derivation and Validation of a combination of BOSTON score and DES-OSA score to exclude OSA or to confirm OSA in patients.
- Trial name
- NCT03983564
- Testing
- Cutoff Validation
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Astes
Obstructive Sleep Apnea of Adult
Change in Tongue Strength and Fatigue After Upper Airway Stimulation Therapy
Upper airway stimulation (UAS) is an effective surgical alternative for patients with obstructive sleep apnea (OSA) who fail continuous positive airway pressure (CPAP) therapy.
- Trial name
- NCT03980158
- Where
- Germany
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Obstructive Sleep Apnea, Insulin Resistance
Exploring the Role of Adipocyte Fatty Acid Binding Protein in the Association of Obstructive Sleep Apnea and Metabolic Dysfunction
Adipocyte fatty acid binding protein (A-FABP) is a member of the FABP super family, is abundant in adipocytes and macrophages. Regulatory functions of A-FABP in lipid and glucose metabolism have been described, and it is…
- Conditions
- Obstructive Sleep Apnea, Insulin Resistance, Metabolic Syndrome, Inflammation
- Trial name
- NCT01173432
- Testing
- continuous positive airway pressure
- Where
- Hong Kong
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Obstructive Sleep Apnea
A Study to Learn More About How Safe BAY2586116 is, How it Affects the Body, How it Moves Into, Through and Out of the Body at Different Doses in Healthy Japanese Male Participants After Taking Single and Multiple Doses Through the Nose
BAY2586116 is a new drug in development for the treatment of obstructive sleep apnea. This is a condition that causes breathing to repeatedly stop and start during sleep due to blocked upper airways.
- Trial name
- NCT04872387
- Testing
- BAY2586116
- Where
- Japan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bayer
Airway Edema, Obstructive Sleep Apnea
Comparison of the Effect of Supine and Prone Position on the Ultrasonographic Airway Measurements
The aim of this study is to compare the preoperative and postoperative ultrasonographic measurements of patients undergoing in the prone position and the change in upper airway edema.
- Conditions
- Airway Edema, Obstructive Sleep Apnea, Respiratory Complication
- Trial name
- NCT05197400
- Testing
- preoperative airway ultrasonography, postoperative airway ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Apnea, Sleep
Effects of CPAP on Cognitive Function, Neurocognitive Architecture and Function in Patients With OSA: The SMOSAT Trial
Multiple clinical studies have indicated that obstructive sleep apnea (OSA), the most common chronic sleep disorder, may affect neurocognitive function, and that treatment for continuous positive airway pressure (CPAP) has some…
- Trial name
- NCT02886156
- Testing
- CPAP, BSC
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Obstructive Sleep Apnea, Diagnostic Imaging
The Role of Sub-mental Ultrasonography in Diagnosing Obstructive Sleep Apnea and Its Correlation With Subjective Scales
The investigators hypothesize that sub-mental ultrasonography measures are strongly correlated with the severity of Obstructive Sleep Apnea Syndrome and the related specific subjective scales.
- Conditions
- Obstructive Sleep Apnea, Diagnostic Imaging, Ultrasound
- Trial name
- NCT03832244
- Testing
- Sub-mental ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Bartin State Hospital
Sleep Apnea
Cerebrovascular Reactivity in Obstructive Sleep Apnea (OSA) Subjects
Obstructive sleep apnea (OSA) is a prevalent sleep breathing disorder in the general population in which recurrent collapse of the upper airway occurs during sleep.
- Trial name
- NCT01133717
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Treatment for Obstructive Sleep Apnea
Comparison of Two Techniques of Combination Therapy for Treatment of Obstructive Sleep Apnea (OSA)
To study the effects of two combination therapies for patients with obstructive sleep apnea (OSA) who have been both intolerant to Positive Airway Pressure (PAP) therapy and sub-therapeutic to oral appliance therapy.
- Trial name
- NCT04029311
- Testing
- Nuance Pro, autoPAP, TAP PAP
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Joseph Adame
Dysphagia, OSA
Obstructive Sleep Apnea (OSA), Oral Frailty, Dysphagia, Continuous Positive Airway Pressure (CPAP)
The purpose of this study is to evaluate the effects of the CPAP treatment on oral frailty and dysphagia among OSA patients.
- Conditions
- Dysphagia, OSA, CPAP
- Trial name
- NCT05977296
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Chronic Kidney Disease, Obstructive Sleep Apnea
Nocturnal Blood Pressure - Central and Peripheral 24-h Blood Pressure in Chronic Kidney Disease.
A new study have shown that high nighttime blood pressure (BP) and/or non-dipping (lack of fall in blood pressure during nighttime) is a strong predictor for the risk of cardiovascular disease and mortality in patients with…
- Trial name
- NOSA (NCT01951196)
- Where
- Denmark
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Erling Bjerregaard Pedersen
Obstructive Sleep Apnea, Mild Cognitive Impairment
Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Obstructive sleep apnea (OSA) is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation and leads to cardiometabolic and neurocognitive…
- Conditions
- Obstructive Sleep Apnea, Mild Cognitive Impairment, Subjective Cognitive Impairment
- Trial name
- NCT06089096
- Testing
- Home Sleep Apnea test (HSAT)
- Where
- Hong Kong
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Apnea, Obstructive Sleep, SARS CoV 2 Infection
Impact of Sleep Disorders on Innate Immunity in COVID-19 Patients
Sleep is an important modulator of the immune response, whereby sleep disturbances (ie, poor sleep quality, insufficient sleep and/or primary sleep disorder, obstructive sleep apnea (OSA)) contribute to inflammatory disease risk…
- Trial name
- NCT06341374
- Testing
- Influvac Tetra
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Parc Taulí Hospital Universitari
Obstructive Sleep Apnea
Exercise Intolerance in Obstructive Sleep Apnea Syndrome Patients
The syndrome of obstructive sleep apnea (OSAS) is a public health problem that affects 2 to 4% of the general population. The patients with OSAS frequently complain of intolerance to exercise muscle fatigue and a significant even…
- Trial name
- EXAOS (NCT00837018)
- Testing
- physical exercise program
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Sleep Apnea, Ventricular Arrythmias
Sleep Apnea-hypopnea Syndrome (SAHS) and Ventricular Arrhythmias
Hypothesis: The CPAP treatment diminishes the effect of ventricular arrhythmias in patients with ischemic heart disease or dilated myocardiopathy, systolic ventricular disfunction and sleep apnea-hypopnea syndrome…
- Conditions
- Sleep Apnea, Ventricular Arrythmias, Systolic Left Ventricle Dysfunction
- Trial name
- SAHS-ICD (NCT00765713)
- Testing
- Nasal continuous positive airway pressure
- Where
- 3 sites in Spain
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Paz