Clinical trials: Obstructive Sleep Apnea of Adult
Obstructive Sleep Apnea of Adult
Inflammatory Markers in Obstructive Sleep Apnea (OSA) Patients.
The aim of our study was to assess the levels of inflammatory biomarkers in a large sample of OSA patients and to investigate any correlation between these markers with clinical and polysomnographic (PSG) parameters.
- Trial name
- NCT03070769
- Testing
- Venous blood collection for biomarkers measurements
- Where
- Greece
- Volunteers
- 1,053 people, healthy volunteers welcome
- Sponsor
- University of Crete
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obstructive Sleep Apnea of Adult
An Extension Study to Assess the Long-term Safety of the Genio® System
The objective of this study is to assess the long-term safety of the Genio® system in adult OSA patients with and without complete concentric collapse of the soft palate who have successfully been implanted with the Genio IS in a…
- Trial name
- OLE (NCT05939141)
- Testing
- Genio System
- Where
- 7 sites in Australia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Nyxoah S.A.
Obstructive Sleep Apnea of Adult
Impact of Intermittent Hypoxia on the Function of the Phagocytes
Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included as well as healthy controls without OSA.
- Trial name
- NCT03618719
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Obstructive Sleep Apnea of Adult
Comparative Study of the ANNE™ One System to Diagnose Obstructive Sleep Apnea
The main objective of this study is to evaluate the accuracy of the ANNE Sleep system for the diagnosis of obstructive sleep apnea (OSA) in adults
- Trial name
- NCT04643782
- Testing
- ANNE Sleep
- Where
- 4 sites in United States
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Sleep Apnea, Obstructive
Effect of Dalfampridine (4-AP) on Genioglossus Muscle Activity in Healthy Adults
In this protocol the investigators will test the effect of dalfampridine (a potassium channel blocker) on genioglossus muscle activity (EMG GG) during wakefulness and sleep in healthy control subjects.
- Trial name
- APIGLOSS (NCT02656160)
- Testing
- Dalfampridine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Influenza
Tissue-specific Responses to Influenza Immunization and Their Relation to Blood Biomarkers (SLVP032)
The investigators collected blood and lymphoid tissues routinely discarded during surgery from adults after a routine seasonal influenza vaccination to determine how immune memory develops at the actual site of infection, and how…
- Trial name
- NCT03023709
- Testing
- Fluzone®, FluMist®
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obstructive Sleep Apnea, Dementia
The Effect of OSA on Brain Waste Clearance
Recent ground-breaking research has shown that clearance of toxic neuro-metabolites from the brain including the proteins β-Amyloid (Aβ) and tau that form dementia causing plaques and tangles is markedly impaired when sleep is…
- Conditions
- Obstructive Sleep Apnea, Dementia, Cognitive Impairment
- Trial name
- NCT05606991
- Testing
- CPAP Withdrawal
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research
Obstructive Sleep Apnea of Adult
A Cross-sectional Study Examining Adipose Tissue in Obstructive Sleep Apnea
Studies show that sleep apnea increases the risk of cardiovascular disease and is associated with obesity. However, it is unclear how sleep apnea affects fat tissue.
- Trial name
- NCT03307330
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnea
Lifestyle Interventions for Seniors With Apnea
The overall goal of this study is to determine the efficacy of a lifestyle intervention, consisting of a weight loss diet and exercise on sleep apnea in older adults.
- Trial name
- NCT01422863
- Testing
- Lifestyle Intervention
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Obstructive Sleep Apnea, Inflammation
A Community Study of the Risk for Obstructive Sleep Apnea and Respiratory Inflammation in an Adult Chinese Population
We aimed to investigate the relationship between obstructive sleep apnea (OSA) risk and respiratory inflammation evaluated by the exhaled breath condensate （EBC）interleukin-6 IL-6 and plasma SP-D, based on the Berlin…
- Conditions
- Obstructive Sleep Apnea, Inflammation, Exhaled Breath Condensate, Surveys and Questionnaires
- Trial name
- NCT04832711
- Where
- China
- Volunteers
- 1,270 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Obstructive Sleep Apnea, Healthy Subjects
Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep Apnea
This study will be conducted to determine whether lemborexant as compared to placebo decreases the peripheral oxygen saturation during total sleep time in healthy adult and elderly participants after a single dose of treatment…
- Trial name
- NCT03471871
- Testing
- Lemborexant 10 mg, Lemborexant 25 mg
- Where
- 11 sites in United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Obstructive Sleep Apnea of Adult, Mild Cognitive Impairment
The Relationship Between Obstructive Sleep Apnea and Alzheimer's Disease: Evidence and Effectiveness
The research plan to enroll 15 simple snoring patients (apnea/hypopnea <5, control group), 30 severe OSA patients (apnea/hypopnea >30, treatment group), and 15 mild cognitive impairment patients (comparative group).
- Trial name
- OSA (NCT05433883)
- Testing
- sleep surgery
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Schizoaffective Disorder, Schizophrenia
Obstructive Sleep Apnea Treatment in Serious Mental Illness
Serious mental illnesses (SMI) like schizophrenia and bipolar disorder are two of the most disabling and costly chronic illnesses worldwide.
- Conditions
- Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Obstructive Sleep Apnea of Adult
- Trial name
- NCT05457127
- Testing
- Automatic Positive Airway Pressure (APAP)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Opiod Use Disorder, Obstructive Sleep Apnea
Effects of Mental Tasks on Breathing Patterns in Adults Using Chronic Opioids vs Non-opioid Users.
The goal of this observational study is to find out if using your brain for a mental task changes how you breathe. Researchers want to compare three groups of adults: people who take opioid pain medicine every day, people with…
- Trial name
- AWAKE (NCT07829055)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea, Sleep Apnea
Validity and Reliability of the 6-Minute Pegboard and Ring Test (6PBRT) in Adults With Obstructive Sleep Apnea Syndrome
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by recurrent upper airway obstruction during sleep, leading to intermittent hypoxia and sleep fragmentation.
- Trial name
- NCT07465874
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mardin Artuklu University
Obstructive Sleep Apnea
The Effectiveness of Smartphone Application on the Serevity of Obstructive Sleep Apnea
A two-year study design is formulated. The overall aim of this study is to examine the effectiveness of the care model combing smartphone application on improve obstructive apnea in obesity adults.
- Trial name
- NCT05127239
- Testing
- Smartphone Application with lifestyle modification Intervention
- Where
- Taiwan
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Chang Gung University of Science and Technology
Obstructive Sleep Apnea
Sleep Apnea Study in Adults Using DreamPort-Eclipse and a Traditional Nasal Mask
The Randomized Controlled Trial of Bleep DreamPort-Eclipse Study is a two-arm, randomized, prospective, non-blinded study to assess the effectiveness of the novel CPAP human interface design to improve leak, AHI, and pressure…
- Trial name
- NCT05818540
- Testing
- Eclipse novel CPAP mask, ResMed P-10 mask
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Bleep, LLC
Obstructive Sleep Apnea of Adult, Hypoxia, Brain
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
- Conditions
- Obstructive Sleep Apnea of Adult, Hypoxia, Brain, Sleep Apnea, Sleep Disorder
- Trial name
- NCT03255408
- Testing
- Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Obstructive Sleep Apnea of Adult, Pregnancy Related
Mandibular Advancement Device (MAD) in Pregnant Women With Obstructive Sleep Apnea (OSA)
We propose a single-arm trial to test the patient uptake and preliminary efficacy of MAD in a sample of 10 pregnant women with mild-to-moderate OSA.
- Trial name
- OBMAD (NCT06256640)
- Testing
- Mandibular advancement Device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System