Clinical trials: Obstructive Sleep Apnea of Child
Asthma, Wheeze
The Development of Novel Clinical Tests to Diagnose and Monitor Asthma in Preschool Children
The study will ascertain the ability of preschool lung function tests to distinguish healthy children from those with wheeze, and to differentiate phenotypes of wheezy children (high and low risk for asthma as defined by API) in…
- Conditions
- Asthma, Wheeze, Obstructive Sleep Apnea, Food Allergy
- Trial name
- WheezyER (NCT02743663)
- Testing
- Bronchodilator response, Allergy Skin Test, Multiple-Breath Washout
- Where
- Canada
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Obstructive Sleep Apnea, Malocclusion
Premolar Extractions for Obstructive Sleep Apnea in Children With Overjet
This research aims to provide pediatric patients with polysomnography (a sleep study) before and after orthodontic treatment to determine if the extraction of upper premolars for treating excessive overjet results in an increase…
- Trial name
- NCT04946201
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mohamed Bazina
Autism Spectrum Disorder (ASD), Obstructive Sleep Apnea (OSA)
Portable Sleep Monitors in Children With Autism Spectrum Disorder
The goal of this study is to evaluate the ability of a portable sleep monitor to detect obstructive sleep apnea in children with autism spectrum disorder (ASD). The main study objectives are to: 1.
- Trial name
- PrSM (NCT07367022)
- Testing
- Portable sleep monitor (Nox T3s)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Lena Xiao
Attention-deficit/Hyperactivity Disorder, Autonomic Nervous System Imbalance
Brain Tissue Integrity and Autonomic Function Alterations in Childhood OSA and ADHD, and After Adenotonsillectomy.
Obstructive sleep apnea (OSA) and attention-deficit/hyperactivity disorder (ADHD) are two common, severe disorders in children. Unfortunately, pediatric OSA is closely associated with ADHD, and both diseases can cause cognitive…
- Conditions
- Attention-deficit/Hyperactivity Disorder, Autonomic Nervous System Imbalance, Obstructive Sleep Apnea of Child
- Trial name
- NCT04732572
- Testing
- Sleep and healthy lifestyle education, Other supportive care, Adenotonsillectomy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Apnea Syndrome, Obstructive Sleep Apnea
Analysis of Mandibular Movements in Ventilated Children With Sleep Apnea Syndrome
Obstructive Sleep Apnea is a common medical condition in children. Diagnosis is based on polysomnography . We conducted an open prospective non randomised clinical trial to assess the efficacy of a new medical device called…
- Trial name
- AMANDA (NCT05908188)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Grenoble
Pediatric Sleep Disordered Breathing, Obstructive Sleep Apnea
Pediatric/Adolescent WatchPAT 400 Reliability Pilot Study
The goal of this clinical trial is to learn whether a newer sleep-testing device gives results that closely match the standard overnight sleep study, in children and adolescents ages 6-18 who are being evaluated for possible…
- Trial name
- NCT07851402
- Testing
- WatchPAT 400
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Milton S. Hershey Medical Center
Obstructive Sleep Disordered Breathing
Prediction of Tongue Base Obstruction During Sleep
This study investigates the hypothesis that, in children, tongue motor functions can predict both the anatomical site and the degree of upper airway obstruction contributing to obstructive sleep-disordered breathing.
- Trial name
- PTOS (NCT06792045)
- Testing
- Physiotherapist assessment, ENT assessment, Drug-Induced Sleep Endoscopy
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Université Catholique de Louvain
Obstructive Sleep Disordered Breathing
Characterization of the Tongue in Children With Obstructive Sleep-disordered Breathing
The tongue plays a key role in maintaining upper airway patency during sleep, mainly through the genioglossus, the principal pharyngeal dilator muscle.
- Trial name
- NCT07861230
- Testing
- Cross-sectional assessment
- Where
- Belgium
- Volunteers
- 39 people
- Sponsor
- Université Catholique de Louvain
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Malocclusion
Multi-disciplinary Diagnosis and Treatment Process and Evaluation System for Children With Sleep Disordered Breathing and Malocclusion
The aim of this study is to compare the efficacy and safety of drug therapy, tonsillar adenoidectomy only, orthodontic treatment only and tonsillar adenoidectomy plus orthodontic treatment in children with obstructive sleep apnea…
- Trial name
- NCT03451318
- Testing
- Mometasone Furoate Nasal Spray, tonsillar adenoidectomy, Maxillary expander plus Twin-Block
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Stomotological Hospital
Sleep Disorder; Breathing-Related, Snoring
Intranasal Steroid as Medical Therapy For Sleep-Disordered Breathing in Children
MIST+ is studying a nasal spray to see if it will reduce the need for surgery for snoring. Children aged 3-12 are invited to take part.
- Conditions
- Sleep Disorder; Breathing-Related, Snoring, Obstructive Sleep Apnea of Child, Sleep Disorders in Children
- Trial name
- MIST+ (NCT05382494)
- Testing
- Mometasone Furoate 50mcg Nasal Spray, Sodium Chloride 0.9 % Nasal Spray
- Where
- 2 sites in Australia
- Volunteers
- 130 people
- Sponsor
- Murdoch Childrens Research Institute
Sleep Disorder; Breathing-Related, Central Apnea
Transcutaneous CO2 Monitoring at Home for Children With Neuromuscular Disease
There is an unmet demand for the evaluation of nocturnal hypoventilation in children with NMD. An ambulatory screening tool that can reliably facilitate timely diagnosis and treatment in these children would be invaluable.
- Conditions
- Sleep Disorder; Breathing-Related, Central Apnea, Neuromuscular Diseases, Obstructive Sleep Apnea
- Trial name
- NCT03478566
- Testing
- Transcutaneous CO2 monitoring
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- The Hospital for Sick Children
Apnea, Obstructive
Evaluation of Reliability and Validity of Reflectance Pulse Oximeter in Screening Children With Obstructive Sleep Apnea
Polysomnography (PSG) has some disadvantages, such as time-consuming, effort-consuming, long appointment time and high cost. During PSG examination, multiple sensors need to be placed in the patient's head, face, neck, chest and…
- Trial name
- NCT05001464
- Testing
- reflectance pulse oximeter
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Obesity, Obstructive Sleep Apnea Syndrome
Pilot Study to Assess the Effectiveness of Tonsil and Adenoidectomy (T+A) in Overweight Children and Adolescents
Obesity has reached epidemic proportions in the United States with roughly 20% of American children being overweight and has serious consequences such as sleep apnea.Additionally, obesity is known to result in the earlier onset…
- Trial name
- NCT00222963
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Rochester
Obstructive Sleep Apnea, Down Syndrome
Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)
The overall objective of this randomized clinical trial is to test the effectiveness of a personalized approach to the surgical treatment of OSA in children with Down syndrome (DS).The estimated prevalence of obstructive sleep…
- Trial name
- TOPS-DS (NCT05508971)
- Testing
- DISE-Directed Surgery, Adenotonsillectomy
- Where
- 7 sites in United States
- Volunteers
- 304 people
- Sponsor
- Oregon Health and Science University
Obstructive Sleep Apnea Syndrome
Systemic Steroids Plus Antibiotics in Sleep Apnea Syndrome in Children
The purpose of this study is to investigate the effect of treatment with a steroid and antibiotic on the size of the tonsils and symptoms of children with OSAS.
- Trial name
- NCT00456339
- Testing
- Prednisolone and amoxicillin/clavulanate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Chicago
Laryngomalacia, Sleep Apnea, Obstructive
Laryngomalacia, Examinations and Quality of Life in Children Before and After Treatment With Follow-up After 1 Year
Laryngomalacia is the most frequent cause of stridor in children under 1 year. The airway obstruction generates turbulent airway flow and creates the characteristic high-frequency stridor sound.
- Conditions
- Laryngomalacia, Sleep Apnea, Obstructive, Sleep Apnea, Ear, Nose and Throat Disorder
- Trial name
- NCT06464757
- Where
- 2 sites in Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Obstructive Sleep Apnea of Child
Surgical Versus Nonsurgical Treatment on Quality of Life for Children With Controversial OSA Diagnoses
Obstructive sleep apnea (OSA) is a disease characterized by repeated partial or complete upper airway collapse during sleep, accompanied by arousals or oxygen desaturation.
- Trial name
- NCT03370731
- Testing
- adenotonsillectomy, Nonsurgical management
- Where
- 4 sites in China
- Volunteers
- 60 people
- Sponsor
- Beijing Tongren Hospital
Sleep Apnea, Obstructive
Is Change in Mouth Opening Related to Change in Quality of Life in Children With Type 1 Obstructive Sleep Apnea After Adenotonsillectomy?
The goal of this clinical trial is to learn if changes in quality of life are linked to changes in mouth opening after adenotonsillectomy in a group of children who were diagnosed with Type 1 Obstructive Sleep Apnea (OSA1).
- Trial name
- JawChild (NCT06973928)
- Testing
- Measures of jaw activity using the Jawac
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Groupe Adène
Infrared-thermal-imaging
Evaluation of Infrared Thermal Imaging in Diagnosis of OSAHS in Children
OSAHS is a common sleep breathing disorder in children, with the same incidence as childhood asthma, and is mainly caused by upper airway stenosis caused by tonsil/adenoid hyperplasia.
- Trial name
- NCT05830227
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- State Key Laboratory of Respiratory Disease
Nasal Obstruction, Nasopharyngeal Obstruction
Administration of Dexamethasone in PONV Prophylaxis in Children Undergoing Adenotomy
Adenotomy, together with tonsillectomy, belongs among the most frequently performed surgical procedures in paediatric patients. These surgical procedures are associated with the second highest incidence of post-operative nausea…
- Conditions
- Nasal Obstruction, Nasopharyngeal Obstruction, Snoring, Apnea, Obstructive
- Trial name
- NCT03398044
- Testing
- Dexamethasone
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Ostrava