Clinical trials: Obstructive Sleep Apnoea Hypopnoea Syndrome
Obstructive Sleep Apnea
Impact of Interface With/Without Oral Appliance of Sleep Apnea Treatment
CPAP is the most effective treatment of obstructive sleep apnea. Oro-nasal masks may be used in case of mouth leaks but these are associated with higher positive pressure needs and lower compliance to treatment.
- Trial name
- NCT01889472
- Testing
- Nasal mask and oral appliance vs oro-nasal mask during autoCPAP therapy
- Where
- 3 sites in Canada, France
- Volunteers
- 15 people
- Sponsor
- Laval University
Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA), Hypertension , β1 Subunit of Maxi-k+ Channel and Cardiovascular Risk
To describe the relationship between OSA and clinical Hypertension (performing ABPM), endothelial dysfunction (performing flowmetry), and its relation at the basic research (determining the β1 subunit in Peripheral Leukocytes in…
- Trial name
- OSAS (NCT01791270)
- Testing
- Continuous positive airway pressure (CPAP) therapy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Angeles Sanchez Armengol
Physical Activity, Obstructive Sleep Apnea
Telecoaching to Improve Physical Activity in Patients With Obstructive Sleep Apnea
Patients with obstructive sleep apnea (OSA) are less physically active than healthy controls. First choice of treatment for OSA is continuous positive airway pressure (CPAP) therapy with an improvement in oxygen saturation and…
- Trial name
- NCT03205878
- Testing
- Telecoaching, CPAP
- Volunteers
- 102 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obstructive Sleep Apnea, Atherosclerosis
Early Signs of Atherosclerosis in Obstructive Sleep Apnea: Effects of Treatment
Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes, including acute myocardial infarction and stroke. Atherosclerosis is an important step for these events.
- Trial name
- NCT00400543
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Sleep Apnea
Effects of Suvorexant in Participants With Obstructive Sleep Apnea (MK-4305-036)
This study will evaluate the safety, tolerability, and effect of multiple doses of suvorexant (MK-4305) on respiratory function in participants with mild to moderate obstructive sleep apnea (OSA) compared to administration of…
- Trial name
- NCT01300455
- Testing
- Suvorexant
- Volunteers
- 26 people
- Sponsor
- Merck Sharp & Dohme LLC
Obstructive Sleep Apnea
TipTraQ Home Sleep Test Validation Study, Duke
A validation study has been designed to assess the performance of a home sleep test device, TipTraQ, for screening sleep apnea. The study involves participants wearing the TipTraQ device on their fingertip during a traditional…
- Trial name
- NCT06351878
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- PranaQ Pte. Ltd.
Obstructive Sleep Apnea Syndrome
Physical Status of OSA Patients
To investigate the differences in postural stability, anxiety/depression, and quality of life of the patients according to the severity of Obstructive Sleep Apnea Syndrome.
- Trial name
- OSASRehab (NCT05051514)
- Testing
- Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Okan University
Obstructive Sleep Apnea
Validation of a Ring-type Wearable Device
Study name: Validation of a Ring-type Wearable Device for Blood Oxygen Monitoring and Obstructive Sleep Apnea Syndrome Screening in Adult Chinese.
- Trial name
- NCT05746338
- Testing
- Ring-type wearable device, Overnight polysomnography
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Sleep Apnea, Obstructive Sleep Apnea
Sleep Quality Evolution: Dreem Under CPAP
Continuous positive airway pressure (CPAP) has a caricatural effect in reducing nocturnal respiratory abnormalities and improving the micro-and macrostructure of sleep.
- Trial name
- NCT05197855
- Testing
- Deem 3 Headband
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea, Adherence, Patient
Increasing Adherence to Oral Appliance Therapy for Obstructive Sleep Apnea
Obstructive sleep apnea is a chronic condition that has serious health consequences including increased risk of hypertension, type-2 diabetes, heart disease, stroke and reduced life expectancy.
- Trial name
- NCT05038215
- Testing
- adherence promotion techniques, Routine Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
OSA, Malocclusion
Changes of the Upper Airway Volume After Orthognathic Surgery
The aim of the present project is to analyze the impact from orthognathic surgery on the upper airway respiratory volume. The primary objective is comparison of differences in the in the airway changes due to maxillary movements…
- Conditions
- OSA, Malocclusion, Dentofacial Deformities
- Trial name
- NCT05060133
- Testing
- Orthognathic Surgery
- Where
- Sweden
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Lund University Hospital
Hypertension, Endothelial Dysfunction
CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients.
The aim of this study is to examine how effective CPAP treatment and treatment with nebivolol are respectively on reducing blood pressure and on endothelial dysfunction in patients suffering from obstructive sleep apnea and…
- Conditions
- Hypertension, Endothelial Dysfunction, Obstructive Sleep Apnea
- Trial name
- NEBOSA (NCT01771406)
- Testing
- Nebivolol, Continuous positive airway pressure (CPAP)
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sleep Apnea, Sleep Apnea, Obstructive
A Study to Determine the Flow Changes And/or AHI Reduction When Stimulating Two Targets (neural And/or Muscular) for the Treatment of Obstructive Sleep Apnea in Adult Subjects
This Proof-of-Concept study will collect acute and sub-acute flow and/or AHI data following the placement of lead arrays under direct vision.
- Conditions
- Sleep Apnea, Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Sleep Disorder
- Trial name
- NCT06635265
- Testing
- Target Stimulation (HGN, AC, GG, Strap muscles)
- Where
- Australia
- Volunteers
- 3 people
- Sponsor
- Invicta Medical Inc.
Obstructive Sleep Apnea, Tonsillitis
Hydromorphone vs Fentanyl in Children Undergoing Tonsillectomy Surgery
A RCT to compare hydromorphone versus fentanyl for pain control following tonsillectomy or adenotonsillectomy surgery.
- Trial name
- NCT04230681
- Testing
- Hydromorphone, Fentanyl
- Where
- United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
OSA
Pharyngeal Muscle Control Mechanisms of Atomoxetine-plus-oxybutynin in Obstructive Sleep Apnea
Current therapies available for obstructive sleep apnea (OSA) have varying degrees of efficacy due to the complex nature of the disorder.
- Trial name
- NCT05944965
- Testing
- Atomoxetine 80 mg plus Oxybutynin 5 mg, Atomoxetine 80 MG
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)
multi-center, randomized, double-blind, placebo-controlled, dose-finding, 4-arm, parallel assignment study to evaluate the efficacy of three different doses of sulthiame (STM) compared to placebo on sleep apnea activity in adult…
- Trial name
- NCT05236842
- Testing
- Sulthiame
- Where
- Belgium
- Volunteers
- 298 people
- Sponsor
- Desitin Arzneimittel GmbH
Obstructive Sleep Apnea
Obstructive Sleep Apnea Airway Evaluation
Current practice guidelines recommend obstructive sleep apnea (OSA) patients to stay in the post anesthetic care unit (PACU) until the risk of respiratory depression has subsided.
- Trial name
- NCT03361553
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Obstructive Sleep Apnea
Cervical Collar for Patients With Moderate Obstructive Sleep Apnea
This study evaluates treatment effect of Cervical Collar (CC) in moderate obstructive sleep apnea.The investigators believe that stabilization of the neck by using a CC during sleep helps sustain airway patency.
- Trial name
- NCT03754270
- Testing
- Advice in lifestyle, Cervical collar
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Uppsala University
Obstructive Sleep Apnea
Fentanyl Test in Children's Adenotonsillectomy
The purpose of this study is to discuss the relationship between the result of fentanyl test and required dosage of morphine for children with OSAS after adenotonsillectomy；and to evaluate the ability of predicting requested…
- Trial name
- NCT02484222
- Testing
- Fentanyl
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Recent Acute Myocardial Infarction
Impact of the Obstructive Sleep Apnea Syndrome (OSAS) on the Ventricular Remodeling After Acute Myocardial Infarction
Coronary artery disease is a common and serious disease, the leading cause of death worldwide. Obstructive sleep apnea syndrome (OSAS) is common and often under-diagnosed in coronary artery disease where it could be involved in…
- Trial name
- SAS-IDM (NCT02439294)
- Testing
- Without Obstructive Sleep Apnea (syndrome), Mild or moderate Obstructive Sleep Apnea (syndrome), Severe Obstructive Sleep Apnea (syndrome)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Montpellier
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