Clinical trials: Obstructive Ventilation Disorder
Obstructive Sleep Apnea Syndrome
Correlation Between Friedman Classification and the Apnea Hypopnea Index (AIH) in a Population With Obstructive Sleep Apnea Syndrome (OSAS)
Introduction: OSAS is an important disease in the actual medic scene. It is important for correlation with chronic cardiovascular disease that leaves an increase in morbimortality and socioeconomic disability to patients with…
- Trial name
- FriedmAIH (NCT00883025)
- Where
- Brazil
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Irmandade da Santa Casa de Misericoridia de Limeira
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Canadian Consortium on Airway Mucus Occlusions in Asthma, COPD and Chronic Cough
Chronic lung diseases affect one in five Canadians, causing symptoms such as cough, breathlessness, and wheeze. Despite advancements in medical care, these conditions not only impact individuals and their close circles but also…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Chronic Cough (CC)
- Trial name
- CANMuc (NCT06858748)
- Testing
- Observational
- Where
- 7 sites in Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obstructive Sleep Apnea of Adult, Mild Cognitive Impairment
The Relationship Between Obstructive Sleep Apnea and Alzheimer's Disease: Evidence and Effectiveness
The research plan to enroll 15 simple snoring patients (apnea/hypopnea <5, control group), 30 severe OSA patients (apnea/hypopnea >30, treatment group), and 15 mild cognitive impairment patients (comparative group).
- Trial name
- OSA (NCT05433883)
- Testing
- sleep surgery
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Obstructive Sleep Apnea, Breathing, Sleep-Disordered
Cheeks Appearance as a Novel Predictor of Obstructive Sleep Apnea The CASA Score Study
Cheeks appearance is a screening tool developed based on cheeks observation to identify volume, flaccidity or both to predict people with probable obstructive sleep apnea.
- Conditions
- Obstructive Sleep Apnea, Breathing, Sleep-Disordered, Muscle Weakness, Muscle Disorder
- Trial name
- CASA (NCT04980586)
- Testing
- CASA score protocol to Non-obstructive sleep apnea Group, CASA score protocol to Mild obstructive sleep apnea Group, CASA score protocol to Moderate obstructive sleep apnea Group
- Where
- Brazil
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Asthma, Cough
Mannitol-Induced Cough Challenge in Healthy Controls and Subjects With Mild Allergic Asthma
The study aim is to investigate if changes in osmolarity using mannitol challenge can evoke coughing reproducibly in mild allergic asthmatics compared with healthy controls and if salbutamol can affect this.
- Trial name
- MICC (NCT03620422)
- Testing
- Mannitol, Salbutamol 5mg/mL, Sodium Chloride 0.9% Inhl 3Ml
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obstructive Sleep Apnea
PAP Systems External Clinical Studies (ECS)
This is a pre-market study for ongoing product development aiming to explore the usability and performance of the study PAP systems.
- Trial name
- NCT06562205
- Testing
- PAP System A (with Amalfi) then PAP System B (with CLA11), PAP System B (with CLA11) then PAP System A (with Amalfi)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ResMed
Obstructive Sleep Apnea
Impact of Myofuntional Therapy Program on Increasing Tongue Strength and Improving Sleep Apnea
This Research studies for compare muscle strength among OSA patients who treat with myofunctional therapy program in Rajavithi hospital
- Trial name
- NCT05043389
- Testing
- myofunctional therapy program
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Obstructive Sleep Apnea Syndrome, Polycystic Ovary Syndrome
Effect of Obstructive Sleep Apnea Syndrome on Insulin Sensitivity and Cardiovascular Risk in PCOS Adolescents
Polycystic ovary syndrome (PCOS) is one of the most common disease caused by hormonal imbalance and is also associated with overweight and obesity. It affects 5-10% of adolescent girls and women capable of having children.
- Conditions
- Obstructive Sleep Apnea Syndrome, Polycystic Ovary Syndrome, Sleep Apnea
- Trial name
- NCT01840618
- Testing
- Nasal Continuous positive airway pressure (CPAP)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Obstructive Sleep Apnea
Comparison of Physical Activity Regimens as Treatments for Obstructive Sleep Apnea
The purpose of this study is to compare the efficacy of two different physical activity regimens as complementary or alternative treatment options for the treatment of obstructive sleep apnea.
- Trial name
- NCT00956423
- Testing
- moderate-intensity aerobic and resistance training, low-intensity stretching
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Obstructive Sleep Apnea of Newborn
Nasal and Oronasal Mask in Severe OSA Patients With Nasal Free Airflow of Obstruction
The obstructive sleep apnea (OSA) affects between 10% to 25% of the adults. Continuous positive airway pressure (CPAP) is the first choice of treatment in severe OSA.
- Trial name
- NCT02274194
- Testing
- Nasal CPAP, Oronasal CPAP
- Where
- 2 sites in Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Obstructive Sleep Apnea (OSA), OSA
Diagnosing Obstructive Sleep Apnea Using Electromyography of the Muscles of the Mouth
The investigators will establish how well a novel, quick, and painless way of measuring muscle activity from the mouth and throat works for detecting sleep apnea.
- Conditions
- Obstructive Sleep Apnea (OSA), OSA, Healthy Volunteers, Electromyography
- Trial name
- NCT06944782
- Testing
- Electromyography (EMG) of the Oropharynx
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea
Unveiling the Neural Mechanisms of 5-HT7 in Sleep Apnea Induced by Arousal Dysregulation
Obstructive sleep apnea (OSA), recognized as a highly prevalent sleep breathing disorder with severe complications, features a complex etiology.
- Trial name
- NCT06608888
- Testing
- MRI
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Mask Ventilation, Airway Obstruction Upper
The Articulated Oral Airway as an Aid to Mask Ventilation
The Articulating Oral Airway (AOA) is a novel oral airway which actively displaces the tongue, allowing for a greater cross-sectional area for mask ventilation.
- Conditions
- Mask Ventilation, Airway Obstruction Upper, Airway Management
- Trial name
- NCT03144089
- Testing
- Articulated Oral Airway, Guedel oral airway (active comparator)
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ron Abrons
Pulmonary Disease, Chronic Obstructive
Effects of Tiotropium on Breathing Capacity and Exercise Limitation in Early Stages of Chronic Obstructive Pulmonary Disease
Optimal clinical management in early stages of COPD is not established. Tiotropium has been shown to improve exercise tolerance during (CWR) cycle ergometry with GOLD stage II to IV COPD, improvements in constant speed treadmill…
- Trial name
- NCT01072396
- Testing
- Tiotropium
- Where
- 15 sites in United States, Canada
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Bruxism, Sleep, Obstructive Sleep Apnea
Association Between Obstructive Sleep Apnea and Bruxism
The objective of this retrospective observational study will be to investigate the between the Obstructive Sleep Apnea Syndrome (OSAS) and Sleep Bruxism (SB), in individuals diagnosed through polysomnography (PSG).
- Trial name
- NCT03810248
- Where
- Brazil
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Obstructive Sleep Apnea
Obstructive Sleep Apnea Among Somali-Americans
The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences.
- Trial name
- Somali OSA (NCT04124848)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnoea, Primary Open Angle Glaucoma
PAIR Study-PAP And IOP Relationship: Study 1
Lowering of the pressure in the eye (intraocular pressure, IOP) is the only proven treatment for Primary Open-angle Glaucoma (POAG).
- Trial name
- PAIR (NCT03127813)
- Testing
- Application of continuous positive airway pressure (CPAP)
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Papworth Hospital NHS Foundation Trust
Obstructive Sleep Apnea (OSA)
Tailored Treatment to Enhance Risk Perception in Sleep Apnea
Obstructive Sleep Apnea (OSA) is seen in approximately 6% of Americans. It is a serious medical condition with significant medical and psychological consequences, including diabetes, hypertension, and cardiovascular disease.
- Trial name
- NCT02314858
- Testing
- Brief Personalized Video (BPV), Non-Personalized Video (NPV), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Sleep Apnea, Obstructive, Sleep Apnea, Central
Variable Dead Space Rebreathing Device to Treat Sleep Apnea
The purpose of this pilot study is to determine the feasibility of using a novel treatment for sleep apnea in which the patient's own exhaled CO2 is tightly controlled and used in a rebreathe system to reduce sleep disordered…
- Trial name
- NCT03552133
- Testing
- Smart CO2
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Asthma, Obesity
Study of the Physiology of the Asthma of the Obese Subjects. Breathing Obesity Asthma Study (BOA)
Asthma is more frequent in obese women, but the mechanisms underlying the causes of this increased frequency are unknown and are different from usual asthma pathophysiology (associated with allergy).
- Trial name
- BOA (NCT00577733)
- Where
- France
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris