Clinical trials: Obstructive Ventilation Disorder
Obstructive Sleep Apnea, Sleep Apnea
Validity and Reliability of the 6-Minute Pegboard and Ring Test (6PBRT) in Adults With Obstructive Sleep Apnea Syndrome
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by recurrent upper airway obstruction during sleep, leading to intermittent hypoxia and sleep fragmentation.
- Trial name
- NCT07465874
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mardin Artuklu University
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Polycystic Ovary Syndrome (PCOS) and Sleep Apnea
Polycystic ovary syndrome (PCOS) affects 5-10% of women in the United States. Its onset is usually at the time of puberty with manifestations of menstrual irregularity, hirsutism, and obesity.
- Trial name
- NCT00203996
- Testing
- continuous positive airway pressure (CPAP), depot leuprolide plus estrogen/progestin replacement, pioglitazone
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Obstructive Sleep Apnea
Effect of Interscalene Block on Obstructive Sleep Apnea in Shoulder Surgery Patients
Obstructive Sleep Apnea (OSA) is when a person stops breathing repeatedly during sleep. Breathing stops because the airway collapses and prevents air from getting into the lungs.This airway closure results in a decrease in the…
- Trial name
- NCT02034370
- Testing
- Lung-function spirometry test, Overnight sleep test
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Atrial Fibrillation, Obstructive Sleep Apnea
Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study
The investigators hypothesize that Obstructive Sleep Apnea (OSA) is an independent risk factor for atrial fibrosis development. The investigators aim to prove the presence of atrial fibrosis on Delayed Enhancement Magnetic…
- Trial name
- NCT04814420
- Testing
- Delayed enhancement magnetic resonance imaging (DE-MRI)
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tulane University
Chronic Obstructive Pulmonary Disease
Combined Effects of Blow Bottle Device and Postural Drainage in Moderate to Severe Elderly COPD Patients
It will be a randomized clinical trial. Age of selected subjects will be between 40 to 70 years. Data will be collected from Wazirabad institute of cardiology. There will be 2 groups i.e.
- Trial name
- NCT06476769
- Testing
- blow bottle technique, percussion
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Impact of Early Diagnosis and Treatment of OSA on Hospital Readmission in Hospitalized COPD Patients
The purpose of this study is to determine whether early diagnosis of OSA and initiation of and adherence to CPAP therapy in patients hospitalized for chronic obstructive pulmonary disease reduce 30-day hospital readmission rates.
- Trial name
- COPD Readmit (NCT03647462)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Obstructive Sleep Apnea
Effect of Longitudinal Sleep Monitoring on Diagnosis and Treatment Decision in Patients With Suspected Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a highly prevalent sleep-disordered breathing disease, caused by recurrent episodes of partial or complete collapse of the upper airway during sleep, resulting in intermittent hypoxia, fragmented…
- Trial name
- ELSA (NCT03819361)
- Testing
- pulse-oximetry
- Where
- Switzerland
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Malcolm Kohler
Asthma
Mechanical Heat Recovery Ventilation on House Dust Mite Sensitive Asthma
Asthma has become increasingly common in the UK, demanding our consideration of the cause. Many patients with asthma are allergic to house dust mites, which thrive in modern housing.
- Trial name
- NCT00148096
- Testing
- Mechanical Heat Recovery Ventilation
- Where
- United Kingdom
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Sleep Apnea
Sideward Turning Beds for Sleep Apnea
The aim of this feasibility study is to compare different settings of a custom-made automated bed with respect to their ability to induce a change in the sleeping position of the user.
- Trial name
- NCT04265118
- Testing
- Sidewards Tilting Bed
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Sleep Disordered Breathing, Obstructive Sleep Apnea
An Investigation to Test a Prototype Nasal Mask in the Home Setting
This investigation is a prospective non-blinded and non-randomized clinical investigation. This investigation is to test the interpretation of user instructions of a prototype nasal mask on participants.
- Trial name
- NCT03752580
- Testing
- User Instructions of novel nasal mask
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea, Cardiovascular Disease
Metabolic Profiling in Patients With Obstructive Sleep Apnea: From Plasma to Hypoxic Cell Model of Peripheral Monocyte
This three-year project aims to 1. Profile the differentially expressed metabolites in healthy patients with severe Obstructive sleep apnea (OSA) before and after six-month continuous positive airway pressure (CPAP) treatment 2.
- Trial name
- NCT02130050
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pediatric Sleep Apnea, Obstructive Sleep Apnea
Photobiomodulation for Pediatric Hypertrophic Tonsils
Pediatric obstructive sleep apnea is a medical condition where a child has great difficulty with breathing, or stops breathing all together, while asleep.
- Conditions
- Pediatric Sleep Apnea, Obstructive Sleep Apnea, Tonsils Hypertrophy
- Trial name
- NCT05459935
- Testing
- PBM Tonsil Arm
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Sleep Apnea, Obstructive Sleep Apnea
Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep Apnea
The aim of this study is to substantially reduce overall postoperative morbidity and mortality associated with obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive Sleep Apnea, Postoperative Complications
- Trial name
- NCT03109418
- Testing
- Ketamine, Control
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Sleep Apnea, Obstructive, Occlusal Splints
Comparing Two Mandibular Positioning Techniques for Dental Sleep Appliances
This is a prospective study that directly compares the use of speech vs an anterior protrusive technique for mandibular positioning.
- Trial name
- NCT05553860
- Testing
- Speech positioning technique
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Mild Cognitive Impairment, Obstructive Sleep Apnea
Evaluation of Trazodone in OSA-MCI
Alzheimer's disease (AD) is a progressive and multifactorial neurodegenerative disease. Before progressing to AD, individuals may experience mild cognitive impairment (MCI).
- Trial name
- NCT05209035
- Testing
- Trazodone
- Where
- Hong Kong
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea, Dementia
The Effect of OSA on Brain Waste Clearance
Recent ground-breaking research has shown that clearance of toxic neuro-metabolites from the brain including the proteins β-Amyloid (Aβ) and tau that form dementia causing plaques and tangles is markedly impaired when sleep is…
- Conditions
- Obstructive Sleep Apnea, Dementia, Cognitive Impairment
- Trial name
- NCT05606991
- Testing
- CPAP Withdrawal
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research
Cardiopulmonary Disease
SGA for TEE: Safe Alternative to Deep Sedation for Patients With High-risk Cardiopulmonary Disease.
Increasingly, transesophageal echos (TEEs) are being done on high risk patients. A TEE is a short procedure done with deep sedation, but poses an increased risk of apnea/ hypoxemia in those with pulmonary disease.
- Trial name
- SGA-TEE (NCT04939220)
- Testing
- TEE with SGA, TEE with Deep Sedation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Chronic Obstructive Pulmonary Disease, Muscle Oxygenation
The Effect of Clinical Parameters on Muscle Oxygenation in Patients With COPD
The aim of this study is to examine the peripheral muscle oxygenation of patients with Chronic Obstructive Pulmonary Disease at rest, during submaximal exercise and recovery, and to examine the effects of disease severity and…
- Conditions
- Chronic Obstructive Pulmonary Disease, Muscle Oxygenation, Disease Severity, Respiratory Function
- Trial name
- NCT06041126
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Non-invasive Ventilation, Pediatric Pulmonary Disease
High-flow Nasal Cannula Flow Rates, Severe Bronchiolitis
Objective: The investigators aimed to compare the heated humidified high-flow nasal cannula (HHHFNC) flow rate of 1-L/kg/min (1L) with 2-L/kg/min (2L) in patients with severe bronchiolitis presenting to the pediatric emergency…
- Trial name
- NCT03859947
- Testing
- Heated humidified high-flow nasal cannula
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Ali Yurtseven
Obstructive Sleep Apnoea, Obesity
Peripheral Vascular Function in Obstructive Sleep Apnoea
Peripheral vascular function is impaired in people with obstructive sleep apnoea who are untreated compared with age-, weight- and sex-matched healthy controls.
- Trial name
- NCT01619748
- Where
- 2 sites in United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust