Clinical trials: Obstructive Ventilation Disorder
Respiratory Failure
Last 3 Months of Life in Home Ventilated Patients
To verify with a specific questionnaire, the families' perceived quality of end-of-life care and of dying in the last 3 months of life of 168 patients (Chronic Obstructive Pulmonary Disease-Amyotrophic Lateral Sclerosis…
- Trial name
- NCT00553046
- Testing
- survey administration
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione Salvatore Maugeri
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial
Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest
This study is meant to compare the amount of oxygen required for hypoxemia relief between current standard of care (oxygen only) and oxygen with the addition of high flow air for Chronic Obstructive Pulmonary Disease (COPD)…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial, Pulmonary Fibrosis, Hypoxemia
- Trial name
- NCT04170062
- Testing
- Nasal Delivery of High-Flow Air and Oxygen Therapy, Nasal Delivery of Oxygen Therapy
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Johns Hopkins University
Obstructive Sleep Apnea (OSA), CPAP
Sleep Apnea Biomarkers and Adherence to Continuous Positive Airway Pressure
Obstructive sleep apnea (OSA) is commonly assessed using the apnea-hypopnea index, although this measure does not fully reflect cardiovascular risk or the physiological impact of the disease.
- Conditions
- Obstructive Sleep Apnea (OSA), CPAP, Biomarkers for Prediction of OA Treatment Efficacy
- Trial name
- BIOSA (NCT07792746)
- Testing
- Continuous Positive Airway Pressure
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Clinique du Millenaire
Sleep Apnea, Obstructive
eXciteOSA for Treatment of Moderate Obstructive Sleep Apnea
The objective of this study is to assess the efficacy of the eXciteOSA device amongst a sample of patients with moderate OSA. The study is a multi-center, prospective, open-label, randomized, parallel-arm trial of eXciteOSA…
- Trial name
- ELMO (NCT05252156)
- Testing
- eXciteOSA
- Where
- 7 sites in United States
- Volunteers
- 62 people
- Sponsor
- Signifier Medical Technologies
Shift-Work Sleep Disorder, Insomnia
Fire Fighter Fatigue Management Program: Operation Healthy Sleep
Firefighters work some of the most demanding schedules known under highly stressful and demanding conditions. The need to work frequent extended shifts and long work weeks leads to acute and chronic partial sleep deprivation as…
- Conditions
- Shift-Work Sleep Disorder, Insomnia, Restless Leg Syndrome, Obstructive Sleep Apnea
- Trial name
- NCT01988129
- Testing
- Sleep disorders education and screening
- Where
- United States
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Apnea, Diabetes
Hyperglycemic Profiles in Obstructive Sleep Apnea: Effects of PAP Therapy
This is a randomized control trial in people with diabetes and obstructive sleep apnea who will be randomly assigned for 3 months to PAP therapy along with healthy lifestyle and sleep education or healthy lifestyle and sleep…
- Trial name
- HYPNOS (NCT02454153)
- Testing
- REMStar Positive Airway Pressure, LifeStyle Counseling
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Johns Hopkins University
Obstructive Sleep Apnea
Adherence to Health Coaching with Wearable Devices: Enhancing Patient Engagement and Outcomes
The goal of this clinical trial is to learn how integrating health and wellness coaching (HWC) with Continuous Positive Airway Pressure (CPAP) therapy affects adherence to treatment and overall health outcomes in individuals with…
- Trial name
- NCT06525337
- Testing
- STANDARDCARE (STAND) group, CONTROL (CON) group
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Coastal Carolina University
Obstructive Sleep Apnea
The Continuous Positive Airway Pressure Effect on Rho-associated Coiled-coil Containing Kinases Activity.
The ROCK (Rho-associated coiled-coil containing kinases) play a critical role in the pathogenesis of cardiovascular diseases and left ventricle hypertrophy (LVH).
- Trial name
- NCT05014529
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
A Study to Understand the Accuracy of a New Breathing Device Compared to Standard Testing for Asthma and COPD
The diagnosis of either asthma or chronic obstructive pulmonary disease (COPD) is currently based on a combination of symptoms, different lung tests and sometimes a 'trial by treatment'.
- Trial name
- STARDUST (NCT07253883)
- Testing
- Partial pressure of CO2 during tidal breathing, FENO, Spirometry
- Where
- United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
COPD
COPD Exacerbations
Detecting exacerbations to prevent a severe and / or to early treat an exacerbation is crucial in patients with COPD in order to prevent hospitalization.
- Trial name
- NCT02798575
- Testing
- Astral 150 ventilator
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- RWTH Aachen University
Ischemic Stroke, Obstructive Sleep Apnea
Obstructive Sleep Apnea Treatment From Acute to Chronic Phase of Stroke
The study aims to evaluate whether early treatment of obstructive sleep apnea with continuous positive airway pressure in ischemic stroke patients has a favorable effect on functional recovery.
- Trial name
- ATACS (NCT07044830)
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 425 people
- Sponsor
- Hospital das Clínicas de Ribeirão Preto
Fatigue, Multiple Sclerosis
Continuous Positive Airway Pressure (CPAP) for Fatigue in Patients With Multiple Sclerosis (MS) and Obstructive Sleep Apnea (OSA)
Fatigue is a symptom present in 76 to 92% of people with multiple sclerosis (MS). Fatigue is usually described as an overwhelming sense of tiredness, lack of energy, and feeling of exhaustion which is different from sleepiness.
- Conditions
- Fatigue, Multiple Sclerosis, Sleep Apnea
- Trial name
- NCT01563900
- Testing
- Auto-titration CPAP
- Where
- United States
- Sponsor
- Northwestern University
Obstructive Sleep Apnea
Acetazolamide Add-On Therapy to OSA Surgery
Surgical procedures are routinely performed as an alternative to continuous positive airway pressure treatment in patients with obstructive sleep apnea (OSA). However, the response to surgery is often variable.
- Trial name
- ACTOS (NCT04227093)
- Testing
- Acetazolamide
- Where
- Belgium
- Volunteers
- 26 people
- Sponsor
- University Hospital, Antwerp
Bronchiolitis
Pulmonary Aeration and Muscle Thickening Fraction: Association of Electrical Impedance Tomography and Ultrasound
The goal of this prospective clinical study is to evaluate the effect of different High Flow Nasal Cannula (HFNC) flow rates on diaphragm, rectoabdominal, and oblique thickening fraction, and to determine whether this effect…
- Trial name
- NCT06376487
- Testing
- Flow rate evaluation
- Where
- Brazil
- Volunteers
- 82 people
- Sponsor
- Hospital Israelita Albert Einstein
Fever, COPD
The Application of a Wireless Sensor Technology for Vital Statistics in CHILDREN AND ADULTS
The primary outcome for this project will be the development of a small, non-invasive wireless sensor that is linked to a conventional computer that can be used in health care for monitoring of acute and chronic health problems.
- Conditions
- Fever, COPD, Obesity, Congenital Heart Disease
- Trial name
- NCT01845506
- Testing
- Cardiorespiratory monitor, Wireless pressure sensor
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Obesity & Overweight, Respiratory Depression
Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs
Drug overdose is a national crisis. The primary cause of death associated with opioids is opioid-induced respiratory depression.
- Conditions
- Obesity & Overweight, Respiratory Depression, Intranasal Drug Administration, Oxytocin
- Trial name
- ORCHID (NCT07902752)
- Testing
- Intranasal Oxytocin 40 i.u.
- Volunteers
- 100 people
- Sponsor
- George Washington University
Hypertension
Long-term Cardiovascular Outcomes in Patients With RH and OSA With or Without Treatment With CPAP
Objectives: Main objective: To assess the impact of obstructive sleep apnea (OSA) and its treatment on cardiovascular outcomes (morbidity and mortality) in patients with resistant hypertension (RH).
- Trial name
- SARAH (NCT03002558)
- Where
- Spain
- Volunteers
- 591 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Snoring, Mouth Breathing
Does myTAP Oral Appliance Therapy Including a Mouth Shield Lessen Periodontitis in Mouth-Breathers Who Snore?
Mouth breathing, snoring and poor sleep can contribute to and worsen periodontitis (gum disease). The purpose of this study is to test whether the myTAP oral appliance with a mouth shield (OA+) can lessen periodontal symptoms in…
- Conditions
- Snoring, Mouth Breathing, Daytime Sleepiness, Periodontitis
- Trial name
- OAplusPerio (NCT06797089)
- Testing
- Oral appliance therapy plus scaling and root planing on left or right of mouth
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Chronic Obstructive Pulmonary Disease, Acute Exacerbation Copd
COPD Exacerbation Blood and Urine Biomarkers Study
This will be a prospective study examining serum levels of MMP-13 and alpha-1 antitrypsin as well as other biomarkers as well as urine biomarkers of smoking status and collagen degradation in the COPD patient population.
- Conditions
- Chronic Obstructive Pulmonary Disease, Acute Exacerbation Copd, Alpha-1 Anti-trypsin Deficiency
- Trial name
- NCT03823443
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
Diabetes Mellitus, Type 2 Diabetes Mellitus
Qatar Universal Diabetes Outcomes (QUDOS) Study
QUDOS is a cross-sectional population study aiming to answer key questions about diabetes and its complications in Qatar as well as identify factors associated with the development and progression of diabetes complications.
- Trial name
- QUDOS (NCT02660476)
- Where
- Qatar
- Volunteers
- 475 people
- Sponsor
- Weill Cornell Medical College in Qatar