Clinical trials: Obstructive Ventilation Disorder
Obstructive Sleep Apnea, Atherosclerosis
Early Signs of Atherosclerosis in Obstructive Sleep Apnea: Effects of Treatment
Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes, including acute myocardial infarction and stroke. Atherosclerosis is an important step for these events.
- Trial name
- NCT00400543
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Obstructive Pulmonary Function, Restrictive Pulmonary Function
Study to Compare the Pharmacokinetics and Pharmacodynamics of ASA Powder for Oral Inhalation With Non-enteric-coated Chewable Aspirin in Adult Subjects With Obstructive or Restrictive Pulmonary Function
The goal of this clinical trial is to compare the pharmacokinetics (PK) pharmacodynamics (PD), safety and tolerability of acetylsalicylic acid powder for oral inhalation (I-ASA) with non-enteric-coated chewable aspirin (C-ASA) in…
- Trial name
- NCT05625347
- Testing
- single dose (100 mg) of ASA, single dose (162 mg) of non-enteric-coated chewable aspirin tablets
- Where
- 4 sites in United States
- Volunteers
- 4 people
- Sponsor
- Vectura, Inc.
COPD Exacerbation, Non-invasive Ventilation
Effect of Noninvasive High Frequency Oscillatory Ventilation on Improving CO2 Clearance in COPD Patients
High-frequency oscillatory ventilation (HFOV), as an ideal lung-protecting ventilation method, has been gradually used in neonatal critical care treatment, and is currently recommended as a rescue method for neonatal acute…
- Trial name
- NCT05721833
- Testing
- Non-invasive high-frequency oscillatory, Noninvasive Bilevel Positive Pressure Ventilation
- Volunteers
- 12 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Obstructive Sleep Apnea Syndrome
PErsonalized and Adaptive Kinesthetic stImulation Therapy, Based on Cardio-respiratory Holter moNitoring, for Sleep Apnea syndrOmes
This study aims at quantifying the performance of kinesthetic stimulation to reduce the burden of obstructive sleep apneas and hypopneas.
- Trial name
- EKINOx (NCT02789748)
- Testing
- Kinesthetic stimulation
- Where
- 4 sites in France
- Volunteers
- 42 people
- Sponsor
- LivaNova
Cardiovascular Diseases, COPD
The Cartagena Cohort Study
Cardiovascular and respiratory diseases are the first and third cause of death, respectively. Cardiovascular risk is known to increase in groups with impaired lung function; however, the mechanisms behind this association are not…
- Conditions
- Cardiovascular Diseases, COPD, Lung Function Decreased, Atherosclerosis
- Trial name
- CaReS (NCT05339048)
- Testing
- Genetic risk variants, Diet, Physical activity
- Where
- Colombia
- Volunteers
- 619 people, healthy volunteers welcome
- Sponsor
- Universidad de Cartagena
Cancer, COPD
SELF-BREATHE RCT for Chronic Breathlessness
A feasibility RCT comprising two groups: 1. Intervention (SELF-BREATHE in addition to standard NHS care) 2. Control group (standard / currently available NHS care)
- Conditions
- Cancer, COPD, Asthma, Bronchiectasis Adult
- Trial name
- NCT04574050
- Testing
- SELF-BREATHE
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- King's College Hospital NHS Trust
Obstructive Sleep Apnea
Effect of Montelukast Therapy in Obstructive Sleep Apnea(OSA) Children
The investigators leading hypotheses are: Oral therapy with montelukast may lead to improved sleep study findings in children with mild to moderate Obstructive Sleep Apnea Syndrome (OSAS) who require surgical removal of adenoids…
- Trial name
- 32543 (NCT01027806)
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Chicago
Sleep Apnea, Obstructive, Healthy
Swallowing in OSA & CPAP Intolerance
This study has two parts: an observational part and an interventional part. The goal of the observational part of the study is to look for variations in swallowing in adults with obstructive sleep apnea (OSA) and in adults who…
- Trial name
- SLP-PAP (NCT06786117)
- Testing
- SLP swallowing exercises, myofunctional exercises
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Denise Dewald
Obstructive Sleep Apnea
The Evaluation of the Toffee Nasal Pillows Mask for the Treatment of Obstructive Sleep Apnea
This investigation is a prospective, non-randomized, non-blinded study. This investigation is designed to evaluate the performance, comfort and ease of use of the F\&P Toffee nasal pillows mask amongst obstructive sleep apnea…
- Trial name
- NCT03242148
- Testing
- Toffee Nasal Pillows Mask
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Fisher and Paykel Healthcare
Chronic Obstructive Pulmonary Disease
The Differences of Muscle Activity Between Patients With COPD and Healthy Adults
The purpose of this study attempts to investigate the differences and relationships of respiratory parameters, muscle activity, and dyspnea during ADL between patients with COPD and age-matched healthy participants.
- Trial name
- NCT04146948
- Testing
- no intervention
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
COPD, Non-invasive Ventilation
NIV Reduces CBF in COPD Patients Without Cognitive Function
Objectives: Investigate the acute NIV effects on CBF and cognitive functions in COPD patients. Methods: Nine non-hypercapnic stable COPD subjects (FEV1/FVC < lower limit of normal) and twelve healthy controls were enrolled.
- Conditions
- COPD, Non-invasive Ventilation, Cognitive Impairment, Cerebral Blood Flow
- Trial name
- NCT03149835
- Testing
- Non-invasive ventilation
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Ceara
Pulmonary Emphysema
Collateral Ventilation Effects on Response to AeriSeal System Treatment in Upper Lobe Predominant Emphysema
This study will evaluate the effects of baseline collateral ventilation status on outcomes following treatment with AeriSeal System in patients with advanced upper-lobe predominant heterogenous emphysema.
- Trial name
- CV+/- (NCT01520740)
- Testing
- Emphysematous Lung Sealant
- Where
- 13 sites in Germany, Israel
- Volunteers
- 100 people
- Sponsor
- Aeris Therapeutics
Asthma
The Asthma Breathing Record Study
The study involves a new device, called 'N-Tidal C', which uses a method that has the potential to predict when asthma attacks are about to happen. The device works by accurately measuring an individual's exhaled CO2 waveform.
- Trial name
- ABRS (NCT04504838)
- Where
- United Kingdom
- Volunteers
- 124 people
- Sponsor
- TidalSense
Obstructive Sleep Apnea-hypopnea
The Study of Sleep Disordered Breathing in Patients With Interstitial Lung Diseases
This was a cross-sectional observational study to evaluate the prevalence and predictive factors of SDB in ILD and to analyze the relationship between polysomnography (PSG) findings, pulmonary function, disease severity…
- Trial name
- NCT06012526
- Testing
- Polysomnography
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Beni-Suef University
Obstructive Sleep Apnea
Safety and Effectiveness of Slow Wave Device for the Treatment of Obstructive Sleep Apnea
This is a safety and efficacy trial for a Slow Wave, Inc. UASD oral appliance for the treatment of Obstructive Sleep Apnea. This trial will recruit 60-80 participants through our IRB partner.
- Trial name
- NCT06519149
- Testing
- Slow Wave UASD
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Slow Wave, Inc.
Chronic Obstructive Pulmonary Disease
Effects of NIMV on the Health Status of Chronic Obstructive Pulmonary Disease (COPD )Patients
In this proposal, we will implement a randomized controlled trial to determine whether nocturnal NIMV applied for 3 months: 1) improves (disease-specific) health related quality of life (HRQL) of COPD patients compared to a…
- Trial name
- NCT00114426
- Testing
- non-invasive mechanical ventilation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Obstructive Sleep Apnea
Mask Study: One-handed vs. Two Handed Technique in Children
During induction of anesthesia in children, the investigators have observed significant variability in mask holding technique at our institution among different anesthesia practitioners.
- Trial name
- NCT03215121
- Testing
- One handed mask airway, switch to two hands, Two handed mask airway + jaw thrust, Two handed mask airway, switch to one hand
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Allergic Rhinitis, Sleep Disorder
Establishing the Collaborative Care Model for Pediatric Allergic Rhinitis With Sleep Disorder
The purpose of study is to compared the impact of the integrative care clinic to ordinary western medicine among patients of moderate persistent allergic rhinitis combined with sleep disorder and establishing the collaborative…
- Trial name
- NCT05031793
- Testing
- TCM, Western medicine
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- China Medical University Hospital
Asthma, Sleep Apnea Syndromes
Service Development: Assessing Non-attendance Rates in Outpatient Clinics
Many studies have shown a high non-attendance rate in hospital outpatient clinics. The investigators have found a non-attendance rate of 25% in their asthma clinics and would like to investigate whether a reminder phone call will…
- Conditions
- Asthma, Sleep Apnea Syndromes, Tuberculosis, COPD
- Trial name
- NCT00129649
- Testing
- Telephone reminder call
- Where
- United Kingdom
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obstructive Sleep Apnea
Lifestyle Interventions for Seniors With Apnea
The overall goal of this study is to determine the efficacy of a lifestyle intervention, consisting of a weight loss diet and exercise on sleep apnea in older adults.
- Trial name
- NCT01422863
- Testing
- Lifestyle Intervention
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
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