Clinical trials: Occlusion, Cerebrovascular
Atherosclerosis, Cardiovascular Diseases
Dietary Antioxidants and Atherosclerosis
To examine the role of dietary antioxidants in the etiology of atherosclerosis in both sexes and in whites and Blacks.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Carotid Stenosis
- Trial name
- NCT00005412
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Carotid Stenosis
Recurrent Carotid Stenosis
To determine whether recurrent stenosis following carotid endarterectomy could be reduced by pre- and post-operative oral administration of platelet-inhibiting drugs.
- Conditions
- Cardiovascular Diseases, Carotid Stenosis, Cerebrovascular Disorders, Heart Diseases
- Trial name
- NCT00000527
- Testing
- aspirin, dipyridamole
- Sponsor
- Emory University
Carotid Stenosis
Perioperative GFAP and Neurological Complications After Carotid Endarterectomy
This prospective, single-center observational study will evaluate whether blood levels of glial fibrillary acidic protein (GFAP), a protein associated with injury to supporting cells in the brain, are related to neurological…
- Trial name
- NCT07843979
- Testing
- Serum GFAP Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Filiz Ata
Alzheimer Disease, Vascular Dementia
A Study of the Safety and Effectiveness of Galantamine Versus Placebo in the Treatment of Patients With Vascular Dementia or Mixed Dementia
The purpose of this study is to evaluate the safety and efficacy of galantamine (a drug for treating dementia) compared to placebo in the treatment of patients with dementia related to cerebrovascular disease (vascular dementia)…
- Trial name
- NCT00261573
- Testing
- galantamine hydrobromide
- Volunteers
- 593 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Brain Vascular Disorders, Coronary Artery Disease
Detection of Ultrasound Contrast Signals in the Cerebral Circulation
To Determine whether transcranial ultrasound can detect the presence of intravenously injected microbubbles used routinely for dobutamine stress echocardiography.
- Trial name
- NCT00579241
- Testing
- Ultrasound on Temporal Bone
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Ischemic Stroke
Total Posterior-circulation Infarct Volume in Basilar Artery Stroke
Preprocedural predictors of outcome in patients with acute basilar artery occlusion (ABAO) who underwent endovascular treatment (EVT) remain controversial.
- Trial name
- TPCIV-ABAO (NCT04650022)
- Testing
- Mechanical thrombectomy
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Montpellier
Carotid Artery Plaque
TMAO and Atherosclerosis in HIV
In the present study, the investigators sought to prospectively examine the associations of plasma levels of TMAO (trimethylamine oxide), choline, betaine, dimethylglycine, and sarcosine with risk of incident carotid artery…
- Trial name
- NCT03416257
- Testing
- No intervention
- Volunteers
- 737 people
- Sponsor
- Albert Einstein College of Medicine
Acute Stroke
Effect of Music Listening on Stress in Acute Stroke
Investigation on changes in the neurochemical stress parameters in acute stroke. 30 patients are recruited in the stroke unit, blood samples are collected at fixed intervals during the first two days.
- Trial name
- MUKU3-1 (NCT05859841)
- Testing
- Music listening, Control
- Where
- Finland
- Volunteers
- 32 people
- Sponsor
- Turku University Hospital
Intracranial Atherosclerosis
An International Registry of the Wingspan™ Stent System for the Treatment of Intracranial Atherosclerotic Stenosis
The IRISS study is designed to collect clinical and angiographic outcomes data when stenting intracranial atherosclerotic lesions using the Wingspan™ Stent System with Gateway™ PTA Balloon Catheter in routine clinical practice.
- Trial name
- IRISS (NCT00929383)
- Testing
- Wingspan Stent System with Gateway PTA Balloon Catheter
- Where
- 19 sites in France, Germany
- Volunteers
- 82 people
- Sponsor
- Stryker Neurovascular
Acute Ischemic Stroke
EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions (ESCAPE-MeVO Trial)
Stroke occurs when a blood clot causes a blockage in a blood vessel (artery) within the brain. This type of stroke is called an ischemic stroke and carries a high risk of disability or death. Stroke must be treated very fast.
- Trial name
- ESCAPE-MeVO (NCT05151172)
- Testing
- endovascular thrombectomy (EVT), Standarad medical care
- Where
- 53 sites in United States, Canada and 2 more
- Volunteers
- 530 people
- Sponsor
- Dr. Michael D Hill
Intracranial Atherosclerosis
The Efficacy and Safety of Intracranial Stent (Tonbridge) in Endovascular Treatment of Symptomatic Intracranial Atherosclerotic Stenosis
The purpose of this study is to verify the efficacy and safety of the Intracranial Stent (Tonbridge) in endovascular treatment of symptomatic intracranial atherosclerotic stenosis.
- Trial name
- NCT05757505
- Testing
- Intracranial Stent (Tonbridge), Wingspan Stent System (Stryker Neurovascular)
- Where
- 13 sites in China
- Volunteers
- 200 people
- Sponsor
- Ton-Bridge Medical Tech. Co., Ltd
Cerebral Atherosclerosis
High-Resolution Assessment of Extracranial Plaques in a Multiple Centers Evolocumab Randomized Study
This study intends to explore the therapeutic effect of PCSK9i Evolocumab on atherosclerotic plaques in cerebral arteries (including carotid and vertebral arteries) compared with intensive statin treatment, and monitor the…
- Trial name
- NCT05585151
- Testing
- Evolocumab 140 MG/ML, Intensive statin treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Carotid Stenosis, Carotid Artery Diseases
Early Warning and Optimization Strategy in Carotid Endarterectomy
Carotid endarterectomy has been proven effective in prevention of cerebral vascular events in patients with severe carotid artery stenosis (symptomatic,>50%;asymptomatic,60%).
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Stroke, Vascular Diseases
- Trial name
- NCT01210937
- Testing
- CEA and TCD monitoring
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
CVD
EEG/MECG/EMG Evaluating the Severity of Aortic Stenosis, Heart Failure and Ischemic Stroke Through an Artificial Intelligenceassisted System.
The specific objectives and methods of this project are: (1) To test the feasibility and accuracy of integrating EEG, MECG and EMG for detecting the severity of diseases such as aortic stenosis, heart failure and ischemic stroke.
- Trial name
- NCT05716659
- Where
- Taiwan
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Carotid Artery Stenosis
The Effects of Dexmedetomidine and Remifentanil on Carotid Patients
We propose to test whether intraoperative administration of dexmedetomidine will reduce hemodynamic control in the intra- and post-operative periods and reduces PACU analgesic requirements in patients undergoing carotid…
- Trial name
- NCT00335972
- Testing
- Remifentanil, Dexmedetomidine
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- The Cleveland Clinic
Stroke, Ischemic, Large Vessel Occlusion
Biomarkers algOrithm for strOke diagnoSis and Treatment Resistance Prediction
Triage of acute ischemic stroke (AIS) patients is critical, to decrease time to treatment, and improve functional outcome. The therapeutic standard of care for AIS consecutive to large vessel occlusion (LVO) is the association of…
- Trial name
- BOOST (NCT04726839)
- Testing
- Standard of care for stroke management and evaluation of functionnal outcome at 3 months
- Where
- 4 sites in France
- Volunteers
- 3,880 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Acute Ischemic Stroke
The MRI-based Evaluation of Safety and Efficacy of EVT and SMT: A Retrospective, Multicenter Study
Acute Basilar Artery Occlusion (ABAO), a condition with a high risk of mortality or disability (up to 80%). The safety and efficacy of endovascular thrombectomy (EVT) in ABAO remains uncertain due to inconsistent evidence from…
- Conditions
- Stroke, Acute Ischemic Stroke, Ischemic Stroke
- Trial name
- NCT06236828
- Testing
- Mechanical Thrombectomy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Intracranial Arteriosclerosis, Cognitive Impairment
Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2x2 Factorial, Randomized, Parallel-Group, Multicenter Trial
This study aims to evaluate whether digital cognitive training and/or PCSK9 inhibitor-enhanced lipid-lowering therapy on top of moderate-intensity statin can improve cognitive function in patients with intracranial…
- Trial name
- NCT07605130
- Testing
- Rosuvastatin, Ezetimibe, Recaticimab
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Peking Union Medical College Hospital
Carotid Artery Stenosis
Evaluation of the Roadsaver Stent Used in Conjunction With the Nanoparasol Embolic Protection System for Carotid Artery Stenosis
A prospective, multicenter, single-arm, open label clinical study to evaluate the safety and effectiveness of MicroVention, Inc.
- Trial name
- NCT02657707
- Testing
- Roadsaver™ Carotid Artery Stent Device, Nanoparasol® Embolic Protection System
- Where
- 37 sites in United States
- Volunteers
- 295 people
- Sponsor
- Microvention-Terumo, Inc.
Depression, Pain
Efficacy of Pain Treatment on Depression in Patients With Dementia
The purpose of this study is to determine whether pain treatment can reduce symptoms of depression in patients suffering from dementia and depression. Depression is commonly diagnosed in patients with dementia.
- Conditions
- Depression, Pain, Dementia
- Trial name
- DEP-PAIN-DEM (NCT02267057)
- Testing
- Paracetamol, Buprenorphine
- Where
- Norway
- Volunteers
- 163 people
- Sponsor
- University of Bergen
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