Clinical trials: Occlusion, Cerebrovascular
Brain Diseases, Cardiovascular Diseases
pRESET for Occlusive Stroke Treatment
Compare the safety and effectiveness of pRESET to Solitaire in the treatment of stroke related to large vessel occlusion
- Conditions
- Brain Diseases, Cardiovascular Diseases, Central Nervous System Diseases, Cerebrovascular Disorders
- Trial name
- PROST (NCT03994822)
- Testing
- Mechanical Thrombectomy using the pRESET Thrombectomy device, Mechanical Thrombectomy using the Solitaire Revascularization Device
- Where
- 24 sites in United States, Germany
- Volunteers
- 340 people
- Sponsor
- phenox Inc.
COPD, Coronary Artery Disease
The Impact of Post Discharge One-Time Home Visit: Bridging the Gap Between Hospital and Home.
A single post-hospital discharge home visit by a geriatric nurse practitioner or geriatric fellow can bridge the gap and ease the transition for elderly frail patients returning home after hospital admission.
- Conditions
- COPD, Coronary Artery Disease, Diabetes Mellitus, Stroke
- Trial name
- NCT00276367
- Sponsor
- Maimonides Medical Center
Ischemic Stroke
SITS (Safe Implementation of Treatments in Stroke) Open Artery by Thrombectomy in Acute Occlusive Stroke Study
Ischemic stroke, i.e. irreversible damage of a part of the patient's brain, is caused by the formation of blood clot in the major vessel which gives blood supply to a certain part of the brain.
- Trial name
- SITS Open (NCT02326428)
- Testing
- Stent retriever endovascular device for thrombectomy, Intravenous thrombolysis by alteplase (Actilyse) (optional)
- Where
- Sweden
- Volunteers
- 341 people
- Sponsor
- Karolinska Institutet
Dementia, Vascular
Perfusion by Arterial Spin Labelling Following Single Dose Tadalafil in Small Vessel Disease (PASTIS) Trial
Could Tadalafil improve blood flow in deep brain tissue and potentially improve cognitive function in patients with cerebral small vessel disease
- Trial name
- PASTIS (NCT02450253)
- Testing
- Tadalafil, Cognitive functioning tests, Neuropsychological tests
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- St George's, University of London
Stroke, Vascular Occlusion
REperfusion Therapy for Acute Ischemic STrOke Due to Large aRtEry Occlusion
The aim of the study was to establish a clinical and advanced imaging database of acute ischemic stroke patients treated with mechanical thrombectomy due to large vessel occlusion of anterior circulation within 24 hours from…
- Conditions
- Stroke, Vascular Occlusion, Endovascular Treatment, Mechanical Thrombectomy
- Trial name
- RESTORE (NCT05311605)
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Artery Stenosis
Gao's Triple Eversion Carotid Endarterectomy
Carotid endarterectomy (CEA), an important surgical approach for managing carotid plaque, has evolved over more than 70 years but still cannot be applied to all tandem carotid lesions (TCLs) because of the wide range of these…
- Trial name
- NCT06722222
- Testing
- Gao's triple eversion carotid endarterectomy
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Head and Neck Cancer, Carotid Artery Stenosis
Carotid Ultrasound to Identify Head and Neck Cancer Survivors With High Cardiovascular Risk After Radiation Therapy
The purpose of this research study is to understand how radiation therapy may affect blood vessels in the neck called the carotid arteries.
- Conditions
- Head and Neck Cancer, Carotid Artery Stenosis, Cardiovascular Complication
- Trial name
- NCT05490875
- Testing
- Carotid ultrasound, Blood draw, Survey
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
Dementia, Mild Cognitive Impairment
Stories in the Moment: Dance Program for People Living With Dementia
This study is designed to evaluate the impact on the quality of life and wellbeing of a person-centered online dance program on people living with dementia or MCI and care partners. The duration of the study will be 1 year.
- Conditions
- Dementia, Mild Cognitive Impairment, Alzheimer Disease, Lewy Body Disease
- Trial name
- NCT06221202
- Testing
- Stories in the Moment Dance Program - Online
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- DanceStream Projects
Glaucoma, Retinal Vascular Disorder
Study of Human Ocular Hemodynamics by Holography Dopple
Prospective, interventional, non-randomized, open-label study, multi-center, Gehan-designed study with sequential inclusions in each subgroup, ranging from 4 subjects to a maximum 37 subjects per subgroup included
- Trial name
- HoLoEye (NCT06989996)
- Testing
- Images Acquisition
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Cognitive Decline, Dementia
MIND Diet Intervention and Cognitive Decline
Phase III randomized controlled trial designed to test the effects of a 3-year intervention of the MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) on cognitive decline and brain neurodegeneration among 600…
- Conditions
- Cognitive Decline, Dementia, Alzheimer Disease, Vascular Dementia
- Trial name
- MIND (NCT02817074)
- Testing
- MIND Diet, Mild Weight Loss
- Where
- 2 sites in United States
- Volunteers
- 604 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Carotid Artery Plaque, Diagnosis
Preoperative Identification of the Histologically "Vulnerable" Plaque Using Non-invasive Imaging, Biomechanical Assessment and Baroreflex Evaluation in Patients With Severe Carotid Stenosis
Carotid artery stenosis due to atherosclerotic plaques accounts for an important cause of ischemic stroke. Current research seeks to risk stratify asymptomatic patients by characterizing rupture-prone plaques.
- Trial name
- PREDICT (NCT05566080)
- Testing
- Carotid endarterectomy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Policlinico S. Donato
Acute Ischemic Stroke, Endovascular Thrombectomy
The Prediction of Hemorrhage Transformation by Cerebral Autoregulation in AIS Patient After Endovascular Thrombectomy
This observational study was designed for observe the cerebral hemodynamics and dynamic cerebral autoregulation (dCA) after endovascular thrombectomy (EVT) in acute ischemic stroke (AIS) patients.
- Conditions
- Acute Ischemic Stroke, Endovascular Thrombectomy, Dynamic Cerebral Autoregulation
- Trial name
- PHASE (NCT06361017)
- Testing
- endovascular thrombectomy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xuanwu Hospital, Beijing
Carotid Artery Stenoses
Pre- and Post-operative Brain MRI in Carotid Endarterectomy
Patients undergoing carotid endarterectomy in the Department of Vascular Surgery at Oslo University Hospital are consecutively included in this evaluation og pre- and postoperative brain MRI.
- Trial name
- NCT04029259
- Testing
- Brain MRI
- Volunteers
- 320 people
- Sponsor
- Oslo University Hospital
Ischaemic Stroke, Alzheimer's Disease
Cognition And Neocortical Volume After Stroke
Stroke and dementia are two of the most common and disabling conditions worldwide, responsible for an enormous and growing burden of disease.
- Conditions
- Ischaemic Stroke, Alzheimer's Disease, Vascular Dementia
- Trial name
- CANVAS (NCT02205424)
- Where
- 3 sites in Australia
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- The Florey Institute of Neuroscience and Mental Health
Stroke, Aortic Valve Stenosis
INTERvention With Cerebral Embolic Protection in Transcatheter Aortic Valve Implantation (INTERCEPTavi)
The study aims to evaluate the processes of a pilot single-centre randomised controlled trial (RCT) of carbon-dioxide flushing of transcatheter aortic valves (TAVI-CO2) versus standard saline flushing of valves (TAVI-S) and…
- Conditions
- Stroke, Aortic Valve Stenosis, Silent Cerebral Infarct, Vascular Brain Injury
- Trial name
- INTERCEPTavi (NCT05146037)
- Testing
- CO2 and saline flushing, Saline flushing
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Atrial Fibrillation, AFib
Stroke Feasibility Study
This is a feasibility study to assess the safety and efficacy of the AtriCure AtriClip when placed via Minimally Invasive Surgical Deployment to the Left Atrial Appendage.
- Trial name
- NCT01997905
- Testing
- AtriClip LAA Exclusion Device
- Where
- 7 sites in United States
- Volunteers
- 13 people
- Sponsor
- AtriCure, Inc.
Age Related Cognitive Decline, Alzheimer's Disease
n-3 PUFA for Vascular Cognitive Aging
Brain scans can help identify changes that appear to increase risk for cognitive decline and dementia. Some of these brain changes are thought to reflect actual damage to the small blood vessels that support normal brain…
- Conditions
- Age Related Cognitive Decline, Alzheimer's Disease, Vascular Dementia, Endothelial Dysfunction
- Trial name
- NCT01953705
- Testing
- Omega 3 PUFA
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Vascular Dementia, Cerebral Small Vessel Diseases
Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment
Cerebral small vessel disease is a common cause of cognitive impairment. Remote ischemic pre-conditioning (RIC) is a technique to induce brief periods of limb ischemia-reperfusion that is hypothesized to increase tolerance of the…
- Conditions
- Vascular Dementia, Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischaemic Disease, Vascular Cognitive Impairment
- Trial name
- TRIC-VCI (NCT04109963)
- Testing
- Remote ischemic conditioning
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Disease Management, Diabetes Complications
Determining Rates of Cardiovascular Complications Among Patients of a Managed Diabetes Care Program
The primary objective of this study is to identify whether cardiovascular complication rates are lower in patients who participate in managed diabetes care, in comparison to provincial and national rates.
- Conditions
- Disease Management, Diabetes Complications, Diabetic Vascular Complications, Diabetic Neuropathy
- Trial name
- DECIDE (NCT00498147)
- Testing
- ADEC Program
- Where
- Canada
- Volunteers
- 1,213 people
- Sponsor
- Group Health Centre
Mild Cognitive Impairment, Alzheimer Disease
Predicting the Conversion From Mild Cognitive Impairment to Dementia
Mild cognitive impairment (MCI) is believed to be the early stage of dementia. The investigators assume that some psychological and imaging risks may predict the conversion.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Dementia, Vascular
- Trial name
- PCMCItoD (NCT01823666)
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Dongzhimen Hospital, Beijing
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